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Intraosseous fixation implant and preparation method thereof

A technology of implants and drugs, applied in the field of medical devices, can solve problems such as poor blood supply, difficult to sterilize drug concentration, etc., and achieve the effect of rapid release in the early stage, long-term sustained release drug effect, and elimination of infection

Inactive Publication Date: 2015-07-01
SHANGHAI MICROPORT ORTHOPEDICS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Of course, in actual clinical application, systemic drug intake is generally used to prevent infection, but due to poor blood supply in the surgical area after surgery, it is difficult to form an effective bactericidal drug concentration in the corresponding area

Method used

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  • Intraosseous fixation implant and preparation method thereof
  • Intraosseous fixation implant and preparation method thereof
  • Intraosseous fixation implant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Absorbable rods are prepared by compression molding and then machined into bone screws. Prepare a mixed solution of polylactic-co-glycolic acid (PLGA) and vancomycin (the ratio of PLGA to vancomycin is 10:1), put it into the spray paint tank of the spray testing machine and spray it on the bone plate prepared in the previous process Above, the atomization pressure is 11psi, the spraying time is 40s, the interval time is 5min, and the number of spraying is 12 times. The second layer (surface layer) is to prepare a quick-release hydrophilic layer. The carrier uses hyaluronic acid, equipped with a hyaluronic acid aqueous solution with a concentration of 0.1%, and the mass ratio of drug to hyaluronic acid is 1:10. The time is 30s, the interval time is 4min, and the number of spraying is 10 times. After spraying, dry in a vacuum oven until the sample has a constant weight.

Embodiment 2

[0037] Absorbable plates are prepared by compression molding and then machined into small four-hole plates (e.g. figure 2 shown). Prepare a mixed solution of polylactic acid and gentamicin (the ratio of polylactic acid and gentamicin is 2:1), put it into the spray paint tank of the spray testing machine and spray it on the bone plate prepared in the previous process, the atomization pressure 10psi, spraying time 20s, interval time 3min, spraying times 10 times. The second layer (surface layer) is to prepare a quick-release hydrophilic layer. The carrier uses hyaluronic acid, equipped with a hyaluronic acid aqueous solution with a concentration of 0.1%, and the mass ratio of drug to hyaluronic acid is 1:10. The time is 30s, the interval time is 4min, and the number of spraying is 15 times. After spraying, dry in a vacuum oven for 3 days until the sample has a constant weight.

Embodiment 3

[0039]Prepare absorbable screws by injection molding technology, then prepare a mixed solution of polylactic acid and tobramycin (the ratio of polylactic acid and tobramycin is 3:1), put it into the spray paint tank of the spray testing machine and spray it to the previous process for preparation On a good bone nail, the atomization pressure is 12psi, the spraying time is 20s, the interval time is 5min, and the number of spraying times is 15 times. The second layer (surface layer) is to prepare a quick-release hydrophilic layer. The carrier is gelatin, equipped with a gelatin aqueous solution with a concentration of 0.15%, and the mass ratio of drug to gelatin is 1:10. The coating rate is 20 mm / min, the number of dip coatings is 3 times, and the interval time is 30 minutes. After the dip coating is completed, it is dried in a vacuum oven for 3 days until the sample has a constant weight.

[0040] Effect example

[0041] The absorbable bone plate of the present invention has a...

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Abstract

An intraosseous fixation implant and a preparation method therefor. In the intraosseous fixation implant, a biodegradable polymer material is used as a substrate, a drug coating is loaded on the surface of the substrate, the drug coating has a double-layer structure, the first layer close to the substrate is a slow-release drug layer, and the second layer on the outer side of the first layer is a quick-release hydrophilic layer. The intraosseous fixation implant has triple functions of being antibacterial, absorbable and fixable.

Description

technical field [0001] The invention belongs to the field of medical equipment. Specifically, the present invention relates to a bone internal fixation implant and a preparation method thereof. Background technique [0002] Traditional bone internal fixation implants are generally made of metal alloys with high rigidity and strength, such as stainless steel and titanium alloys. Metals have good biocompatibility and high strength and fatigue resistance. However, these commonly used metals cannot be degraded and absorbed. After bone fixation and fracture healing, a second operation is required to remove them. At the same time, the elastic modulus of metal is much higher than that of bone, which will destroy the normal stress environment of human bone healing and cause stress shielding effect, which not only hinders the rapid formation of callus at the fracture site, but also leads to osteoporosis and other complications. In severe cases, it may cause refracture. In additio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/08A61L31/16
CPCA61L27/40A61L27/14A61L27/34A61L27/16A61L31/16A61L31/06A61L31/10A61L2300/406A61L2420/08C08L67/04C08L5/08
Inventor 耿芳张隽潘礼存林忠
Owner SHANGHAI MICROPORT ORTHOPEDICS
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