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37 results about "Hydrophilic Interactions" patented technology
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Hydrophilic ("water loving) interactions are possible with polar chemical group. Water is polar because oxygen is far more electronegative than hydrogen and thus the electrons involved in an oxygen-hydrogen bond spend more time in proximity to the oxygen atom.
Method of formation of shape-retentive aggregates of gel particles and their uses
The present invention relates to a method of forming shape-retentive aggregates of gel particles in which the aggregates are held together by non-covalent bond physical forces such as, without limitation, hydrophobic-hydrophilic interactions and hydrogen bonds. The method comprises introducing a suspension of gel particles in a polar liquid at a selected concentration, wherein the gel particles have an absolute zeta potential, into a medium in which the absolute zeta potential of the gel particles is decreased, resulting in the gel particles coalescing into the claimed shape-retentive aggregate. This invention also relates to uses of the method of formation of the shape-retentive aggregates of gel particles.
Owner:ULURU INC
Mixed-Modal Anion-Exchanged Type Separation Material
ActiveUS20080164211A1Improve performanceImprove productivityIon-exchanger regenerationChromatographic anion exchangersHybrid typeBinding site
The present invention relates to mixed-modal anion-exchange materials composed of a support on which a ligand is immobilized. The ligand combines at least one basic domain based on cyclic monobasic derivatives with two or more rings as anion-exchange domain and at least one non-ionic binding domain. The basic domain is ionized under the conditions of use and may contain secondary, tertiary, or quaternary nitrogen forming a weakly (WAX) or strongly (SAX) basic anionic exchange domains. The non-ionic binding domain allows adjustment of the overall hydrophobicity / hydrophilicity of the material and represents a second binding site for the solute to be separated. Binding to this second binding site is based on reversed phase (RP), hydrophobic interaction (HIC) or hydrophilic interaction (HILIC). Linker sites, which can be represented by a chemical bond or by hydrophobic moieties like alkyl(ene) chains or hydrophilic moieties like amide structures connect the support to the binding domains and the binding domains to each other.
Owner:MERCK PATENT GMBH
Forming active channel regions using enhanced drop-cast printing
ActiveUS20100155710A1Improve solubilityImprove electrical performanceMaterial nanotechnologyElectroluminescent light sourcesOrganic field-effect transistorDisplay device
An active region or channel for printed, organic or plastic electronics or polymer semiconductors, such as organic field-effect transistors (OFETs), is obtained by using an enhanced inkjet drop-cast printing technique. A two-liquid system is employed to achieve the direct growth of well-oriented organic crystals at the active region of channel. High-performance electrical properties exhibiting high carrier mobility and low threshold voltage are obtained due to the proper orientation of molecules in the grown crystal in a highest mobility direction, due to the absence of grain boundaries, and due to low trap densities. The hydrophobic-hydrophilic interactions between the liquids utilized, which results in the fabrication of low-cost and mass-producible printable electronic devices for applications in flexible displays, electronic signages, photovoltaic panels, membrane keyboards, radio frequency identification tags (RFIDs), electronic sensors, and integrated electronic circuits.
Owner:SEOUL NAT UNIV R&DB FOUND
Materials for hydrophilic interaction chromatography and processes for preparation and use thereof for analysis of glycoproteins and glycopeptides
ActiveUS20150204824A1High resolutionDesirable retentivityComponent separationSurface/boundary effectMaterial DesignGlycan
The invention relates to poly-amide bonded hydrophilic interaction chromatography (HILIC) stationary phases and novel HILIC methods for use in the characterization of large biological molecules modified with polar groups, known to those skilled in the art as glycans. The invention particularly provides novel, poly-amide bonded materials designed for efficient separation of large biomolecules, e.g. materials having a large percentage of larger pores (i.e. wide pores). Furthermore, the invention advantageously provides novel HILIC methods that can be used in combination with the stationary phase materials described herein to effectively separate protein and peptide glycoforms by eliminating previously unsolved problems, such as on-column aggregation of protein samples, low sensitivity of chromatographic detection of the glycan moieties, and low resolution of peaks due to restricted pore diffusion and long intra / inter-particle diffusion distances.
Owner:WATERS TECH CORP
Materials for hydrophilic interaction chromatography and processes for preparation and use thereof for analysis of glycoproteins and glycopeptides
The invention relates to poly-amide bonded hydrophilic interaction chromatography (HILIC) stationary phases and novel HILIC methods for use in the characterization of large biological molecules modified with polar groups, known to those skilled in the art as glycans. The invention particularly provides novel, poly-amide bonded materials designed for efficient separation of large biomolecules, e.g. materials having a large percentage of larger pores (i.e. wide pores). Furthermore, the invention advantageously provides novel HILIC methods that can be used in combination with the stationary phase materials described herein to effectively separate protein and peptide glycoforms by eliminating previously unsolved problems, such as on-column aggregation of protein samples, low sensitivity of chromatographic detection of the glycan moieties, and low resolution of peaks due to restricted pore diffusion and long intra / inter-particle diffusion distances.
Owner:WATERS TECH CORP
Chromatographic separation material
ActiveUS20140021136A1HILIC separation performanceControl levelIon-exchange process apparatusIon-exchanger regenerationChromatographic separationCross-link
The chromatographic separation material is a cyclofructan or a derivative of cyclofructan covalently bonded to a cross-linked, organic polymer. The separation material works well in hydrophilic interaction liquid chromatography.
Owner:AZYP +1
Packing Material For Hydrophilic Interaction Chromatography
InactiveUS20110100915A1Easy to separateSufficient retention timeIon-exchanger regenerationGlass/slag layered productsHalogenFilling materials
The object of the present invention is to provide a packing material and a separation method that manifest excellent hydrophilic interactions.The present invention provides a packing material for hydrophilic interaction chromatography consisting of a modified support treated with the surface modifier represented by the following formula (6) or (7).(In this formula, m denotes 2-6 and n denotes 1-4. X1, X2, and X3, independent of each other, denote a methoxy group, ethoxy group, or halogen. Up to two of X1, X2, and X3 can be any of the following groups: a methyl group, ethyl group, propyl group, isopropyl group, butyl group, or isobutyl group.)
Owner:SHISEIDO CO LTD
Phenylboronic acid functionalized magnetic metal organic skeleton microsphere and its synthesis method and use
InactiveCN108636359AHydrophilicBoronicMaterial nanotechnologyOther chemical processesPhenylboronic acidSynthesis methods
The invention discloses a phenylboronic acid functionalized magnetic metal organic skeleton microsphere and its synthesis method and use for enriching glycoprotein. The microsphere orderly comprises amagnetic core, a connecting layer, a metal organic skeleton layer and a phenylboronic acid outer layer from inside to outside, has a large specific surface area and good hydrophilicity, contains a large number of functional groups of boric acid and can specifically enrich glycoprotein through hydrophilic interaction and boric acid affinity.
Owner:XIANGTAN UNIV
Ionic liquid functionalized organic polymerized monolithic column and preparation method thereof
InactiveCN105771318AQuick responseMass transfer speedOther chemical processesSolid sorbent liquid separationIon exchangeIonic liquid
Owner:FUZHOU UNIV
Ultrathin lamellar functionalized molybdenum disulfide nanocomposite material and its application in glycopeptide enrichment
ActiveCN107727480AHigh specific surface areaThe synthesis method is simplePreparing sample for investigationChemical reactionBoronic acid
The invention discloses an ultrathin lamellar functionalized molybdenum disulfide nanocomposite material and its application in glycopeptide enrichment. A glycopeptide enrichment material utilizes anultrathin two-dimensional lamellar structure molybdenum disulfide nano-material as a matrix. After surface modification with nano-gold, through a simple and stable Au-S bond chemical reaction, a mercapto-containing glycopeptide enrichment functional group is loaded. An experimental result shows that the functionalized molybdenum disulfide-nano-noble metal composite material and glycopeptides produce hydrophobic interaction or through a reversible reaction of the boronic acid group supported on the surface of the material and the sugar chain of the glycopeptides, the functional material realizes the highly selective enrichment of glycopeptides. The functionalized molybdenum disulfide-nano-noble metal composite material is prepared through simple processes under mild reaction conditions.
Owner:ACADEMY OF MILITARY MEDICAL SCI
Separation of Charged Solutes by Electrostatic Repulsion-Hydrophilic Interaction Chromatography
InactiveUS20080220532A1Component separationSolid sorbent liquid separationStationary phaseOrganic solvent
In one aspect, a method of performing electrostatic repulsion-hydrophilic interaction chromatography on a protein, peptide, or amino acid includes providing a column having an anion-exchange material at a pH of less than about 4, and eluting the compound using a mobile phase comprising an amount of organic solvent sufficient to substantially balance the electrostatic repulsion of the stationary phase with hydrophilic interaction. In another aspect, a method of performing electrostatic repulsion-hydrophilic interaction chromatography on a nucleic acid or nucleotide comprises providing a column having a cation-exchange material at a pH of less than about 3.4, and eluting the compound using a mobile phase comprising organic solvent sufficient to substantially balance the electrostatic repulsion of the stationary phase with hydrophilic interaction.
Owner:POLYLC
Online hydrophilic interaction chromatography/reversed phase chromatography serial interface device and application thereof
ActiveCN104076113AEasy to operateAchieve removal of HILICComponent separationReversed-Phase Liquid ChromatographyNitrogen
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Sol-Gel Polymeric Stationary Phases for High-Performance Liquid Chromatography and Solid Phase Extraction: Their Method of Making
ActiveUS20170291158A1Other chemical processesSolid sorbent liquid separationSorbentSolid phase extraction
A sol-gel sorbent or chromatography stationary phase is a particulate metal oxide gel containing polymeric segments uniformly distributed throughout the metal oxide gel. The metal oxide gel is an oxide from silicone or other metal oxide that can have one of the valence bonds attached to an organic group and the remainder occupied by oxygens that can be provided as an oxide or an alkoxide or aryl oxide of the polymeric segments. The particles are used for an SPE sorbent or as a packing for a reversed phase high-performance liquid chromatography (RP-HPLC), a normal phase high-performance liquid chromatography (NP-HPLC) column or a hydrophilic interaction liquid chromatography (HILIC) column.
Owner:FLORIDA INTERNATIONAL UNIVERSITY
Preparation and application of hydrogel@silicon dioxide liquid chromatography filler
ActiveCN113522256ASimple synthesis pathEasy to operateOther chemical processesComponent separationBenzoic acidChromatographic separation
The invention provides a preparation method of a hydrogel@silicon dioxide liquid chromatography filler, wherein the preparation method comprises the steps: firstly, coating the surface of mesoporous silicon dioxide with a layer of hydrogel formed by N,N-dimethylacrylamide, and then coating the surface of a viscous coating layer with a hydrogel layer formed by N,N-dimethylacrylamide and n-octadecene to obtain the hydrogel@silicon dioxide liquid chromatography filler. The hydrogel@silicon dioxide liquid chromatography filler is prepared on the surfaces of silica gel beads through a preparation technology combining physical coating and chemical coating and a post-treatment technology of a solvent evaporation method, the synthesis path is simple and easy to operate, and due to the existence of amido bonds and octadecyl in hydrogel, and the chromatography filler has quite good chromatographic separation performance; and particularly, in a hydrophilic interaction mode, the chromatography filler has relatively good separation selectivity on polar analytes such as nucleoside bases, benzoic acid compounds, sulfonamides, amino acids and carbohydrates.
Owner:LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Surface polymerized ionic liquid modified magnetic nanometer material as well as preparation method and application thereof
ActiveCN106975467AThe synthesis method is simpleSynthetic method cleaningIon-exchange process apparatusOther chemical processesMagnetite NanoparticlesDouble bond
The invention discloses a surface polymerized ionic liquid modified magnetic nanometer material as well as a preparation method and application thereof. The surface polymerized ionic liquid modified magnetic nanometer material is prepared from magnetic nanoparticles, a silicon dioxide layer cladding the surfaces of the magnetic nanoparticles and a hydrophilic ionic liquid layer which is polymerized on the surface of the silicon dioxide layer through a mode of modifying a silane coupling agent with carbon-carbon double bonds at terminal on the surface of the silicon dioxide layer for precipitation polymerization. With adoption of the surface polymerized ionic liquid modified magnetic nanometer material, through a mode of precipitation polymerization, the ionic liquid is polymerized on the surfaces of the magnetic nanoparticles; a material synthetic method is simple, clean and rapid; through the hydrophilic interaction and electrostatic interaction of the polymerized ionic liquid and glycopeptide, efficient selective enrichment of the glycopeptide is realized; the glycopeptide enrichment effect is good, and glycopeptide enrichment detection in human serum albumin (such as IgG) with low concentration can be realized.
Owner:ACADEMY OF MILITARY MEDICAL SCI
Forming active channel regions using enhanced drop-cast printing
ActiveUS8860008B2Improve electrical performanceMaterial nanotechnologyElectroluminescent light sourcesOrganic field-effect transistorDisplay device
An active region or channel for printed, organic or plastic electronics or polymer semiconductors, such as organic field-effect transistors (OFETs), is obtained by using an enhanced inkjet drop-cast printing technique. A two-liquid system is employed to achieve the direct growth of well-oriented organic crystals at the active region of channel. High-performance electrical properties exhibiting high carrier mobility and low threshold voltage are obtained due to the proper orientation of molecules in the grown crystal in a highest mobility direction, due to the absence of grain boundaries, and due to low trap densities. The hydrophobic-hydrophilic interactions between the liquids utilized, which results in the fabrication of low-cost and mass-producible printable electronic devices for applications in flexible displays, electronic signages, photovoltaic panels, membrane keyboards, radio frequency identification tags (RFIDs), electronic sensors, and integrated electronic circuits.
Owner:SEOUL NAT UNIV R&DB FOUND
Stationary phase of HILLIC (hydrophilic interaction chromatography) and preparation method of stationary phase
InactiveCN107262076AEfficient separationGood reproducibilityIon-exchange process apparatusOther chemical processesElectrochromatographySilica gel
The invention discloses a stationary phase of HILLIC (hydrophilic interaction chromatography) and a preparation method of the stationary phase. The stationary phase of the HILLIC refers to a monolithic silica column with polyvinyl pyrrolidone bonded on the surface of porous silica gel or a monolithic capillary column with polyvinyl pyrrolidone directly bonded on the inner wall of a capillary; the monolithic capillary column comprises a capillary liquid chromatography monolithic column and a monolithic electrochromatography monolithic column. Experiments prove that the stationary phase of the HILLIC has a typical retention mechanism of hydrophilic interaction chromatography, effective separation of a series of polar compounds can be realized, efficient separation of the polar compounds can be realized without a buffer salt mobile phase, reproducibility is good, and electrochromatography column efficiency can be up to 200000 plates / m. Besides, preparation conditions of the stationary phase of the HILLIC are easy to control, raw materials are cheap and available, a preparation process is simple, and industrialization is easy to realize.
Owner:SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
HILIC (hydrophilic interaction chromatography)-MRM (multiple-reaction monitoring) MS/MS (tandem mass spectrometry) detection method for basic constitutional units of low-molecular-weight heparin
ActiveCN106018597AHigh practical valueComponent separationBiological material analysisHydrophilic InteractionsHydrolysis
Owner:SHANDONG UNIV
Mixed-modal anion-exchanged type separation material
ActiveUS7648636B2High selectivityCation exchanger materialsIon-exchanger regenerationHybrid typeBinding site
Owner:MERCK PATENT GMBH
Analytical method for detecting sulfated oligosaccharides
The present invention describes an analytical method for detecting and quantitating poly-sulfated oligosaccharides, including Fondaparinux sodium, using hydrophilic interaction ultra-performance liquid chromatography (HILIC-UPLC) coupled with a charged aerosol detector (CAD) or a mass spectrometer (MS). This analytical method provides in-process control in a total synthesis of highly sulfated oligosaccharides by separation, quantification and mass identification. Systems and conditions utilizing such methods are also provided.
Owner:SCINOPHARM TAIWAN LTD
Sol-gel polymeric stationary phases for high-performance liquid chromatography and solid phase extraction: their method of making
ActiveUS9925518B2Other chemical processesSolid sorbent liquid separationSorbentSolid phase extraction
Owner:FLORIDA INTERNATIONAL UNIVERSITY
Packing Material For Hydrophilic Interaction Chromatography
InactiveUS20120205316A1Easy to separateSharp peakIon-exchange process apparatusIon-exchanger regenerationHalogenFilling materials
Owner:SHISEIDO CO LTD
Zwitterionic stationary phase for hydrophilic interaction liquid chromatography and preparation method thereof
ActiveUS9138721B2Simple manufacturing methodSimple and reliable procedureCation exchanger materialsOrganic anion exchangersStationary phaseSilanes
A type of liquid chromatographic stationary phase and preparation method thereof, the bonding terminal of the chromatographic stationary phase is zwitterionic functional group. The preparation method includes the following steps, alkenyl or alkynyl silane is bonded onto the surface of silica based on the horizontal polymerization approach to obtain alkenyl- or alkynyl-modified silica. Then the thiol click reaction with zwitterionic compound containing thiol group is performed to obtain the zwitterionic hydrophilic interaction chromatographic stationary phase. The present stationary phase possesses both zwitterionic characteristics and excellent hydrophilicity. It can be widely applied in the separation of variety of samples.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Separating agent
ActiveUS20160168302A1Raise the ratioOther chemical processesSolid sorbent liquid separationArylDouble bond
The problem addressed by the present invention is to provide a novel separating medium for hydrophilic interaction chromatography useful in separating hydrophilic compounds. The hydrophilic interaction chromatography separating medium, which is formed from a support and a ligand carried by the support, is a separating medium wherein the ligand is a (meth)acrylic polymer having a constituent unit derived from the compound indicated by formula (I).(In formula (I): there are one or two double bonds between atoms configuring a heterocycle; X1 is selected from the group consisting of S, SCH3+, O, NH, NCH3, CH2, CHR, and CR1R2; and X2, X3, and X4 are each selected from the group consisting of N, NH, NCH3, CH2, CHR, NCH3+, CH, CR, and CR1R2; R1 and R2 are each a substituted or unsubstituted alkyl having 1-18 carbon atoms, an aryl having 6-18 carbon atoms, an alkenyl having 2-18 carbon atoms, an alkynyl having 2-18 carbon atoms, an aralkyl having 7-18 carbon atoms, an acyl having 2-18 carbon atoms, a cycloalkyl having 3-18 carbon atoms, a carboxyl, an amino, an aryloxy having 6-18 carbon atoms, an alkoxy having 1-18 carbon atoms, a halo, a hydroxy, a nitro, or a cyano. R is a substituted or unsubstituted alkyl having 1-18 carbon atoms, an aryl having 6-18 carbon atoms, an alkenyl having 2-18 carbon atoms, an alkynyl having 2-18 carbon atoms, an aralkyl having 7-18 carbon atoms, an acyl having 2-18 carbon atoms, a cycloalkyl having 3-18 carbon atoms, a carboxyl, an amino, an aryloxy having 6-18 carbon atoms, an alkoxy having 1-18 carbon atoms, a halo, a hydroxy, a nitro, or a cyano. At least two of X1, X2, X3, and X4 are not CH2, CH, CR, or CR1R2, and R3 is H or CH3.)
Owner:NAT UNIV KYOTO INST OF TECH +1
Preparation method and application of polar bridging cyclodextrin chiral monolithic column
ActiveCN111812258AImprove Chiral Separation PerformanceImprove retentionOther chemical processesComponent separationElectrochromatographyCyclodextrin
The invention discloses a preparation method and application of a polar bridging cyclodextrin chiral monolithic column, and belongs to the field of analytical chemistry. The monolithic column is prepared by the following steps: dissolving cyclodextrin with N, N-(1, 2-dihydroxyethylene) diacrylamide DAA in deionized water, reacting under the condition of an initiator AIBA to generate polar bridgingcyclodextrin, adding urea and formaldehyde, and quickly preparing the polar bridging cyclodextrin chiral monolithic column within 30 minutes by virtue of a one-pot thermal polycondensation method. The preparation method is simple and rapid in reaction, a cyclodextrin bimolecular bridging structure is constructed by adopting a bridging agent with high polarity; the additional hydrophilic interaction can be provided, the chiral recognition ability of the stationary phase can be significantly enhanced, the excellent resolution ability on a variety of amino acids, RS-(+)-(4-methoxybenzene) ethylamine and other different types of drugs can be displayed in the electrochromatography, and the method can be used as the chromatographic chiral fixation so as to be correspondingly used in the field of drug chiral resolution.
Owner:FUZHOU UNIV
Materials for hydrophilic interaction chromatography and processes for preparation and use thereof for analysis of glycoproteins and glycopeptides
Owner:WATERS TECH CORP
Solid Phase Microextraction-High Performance Liquid Chromatography Online Detection Method of Oil Antioxidants
ActiveCN112526034BEfficient enrichment and extractionReduced enrichmentComponent separationOil and greaseFluid phase
The invention discloses a solid-phase microextraction-high performance liquid chromatography on-line combined detection method for oil antioxidants. In the present invention, a covalent organic framework functional solid phase microextraction monolithic column is firstly prepared, and then the monolithic column is used as a solid phase microextraction medium, combined with a solid phase microextraction-high performance liquid chromatography on-line combined system, to establish an oil antioxidant Solid-phase microextraction-high performance liquid chromatography online detection method. The invention utilizes the synergistic mechanism of the hydrophilic interaction between the urea-formaldehyde resin matrix of the monolithic column and the analysis object and the π-π stacking interaction between the covalent organic framework and the analysis object to realize the efficient extraction and enrichment of oil antioxidants , and eliminate the interference of impurities in the sample matrix on the analysis and detection. The method of the invention is simple, the technique is ingenious, the required instruments are widely used, and it is easy to popularize. It can realize the efficient extraction and enrichment of trace oil antioxidants in complex actual samples, and can meet the relevant high-sensitivity detection requirements.
Owner:FUZHOU UNIV
Chromatography-mass spectrometry detection method for electrophoresis hydrophilic interaction of sulodexide
PendingCN107991414AAchieve separationComprehensive detection and analysisComponent separationFine structureIon exchange
The invention provides a chromatography-mass spectrometry detection method for electrophoresis hydrophilic interaction of sulodexide and belongs to the technical field of detection of medicines, crudedrugs and raw materials. According to the method provided by the invention, the difference of electrophoretic mobility of each component in the sulodexide is utilized and the components are separatedthrough agarose gel electrophoresis; then the components are extracted by utilizing an ion exchange centrifugal column; then each component is enzymolyzed into a composition unit by utilizing the specificity of an enzyme; finally, each component of the sulodexide is detected through a chromatography-mass spectrometry method for the hydrophobic interaction, so that qualitative and relatively quantitative analysis is carried out on rapid mobile heparin (FMH), slow mobile heparin (SMH) and dermatan sulfate (DS) of the sulodexide, and a fine structure and a terminal structure of each component are identified and analyzed.
Owner:SHANDONG UNIV
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