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Preparation and application of hydrogel@silicon dioxide liquid chromatography filler

A technology of liquid chromatography and silica, which is applied in the field of preparation of hydrogel@silica liquid chromatography filler, to achieve good chromatographic separation performance, simple synthesis route, and good separation selectivity

Active Publication Date: 2021-10-22
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, so far, there has been no research report on the use of hydrogel as a liquid chromatography stationary phase for the highly selective separation of polar analytes.

Method used

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  • Preparation and application of hydrogel@silicon dioxide liquid chromatography filler
  • Preparation and application of hydrogel@silicon dioxide liquid chromatography filler
  • Preparation and application of hydrogel@silicon dioxide liquid chromatography filler

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Embodiment Construction

[0019] The preparation method and application of the hydrogel@silica liquid chromatography filler of the present invention will be further described below through specific implementation methods.

[0020] The preparation method of hydrogel@silica liquid chromatography filler, comprises the following steps:

[0021] (1) Dissolve N, N-dimethylacrylamide (0.2g) and N, N-methylenebisacrylamide (0.05g) in anhydrous methanol (70ml), then add spherical mesoporous silica gel (4.0 g), the mixture was left to stand for 8h. Spherical mesoporous silica gel was purchased from Suzhou Nanomicro Technology Co., Ltd., with a particle size of 5 microns and a pore size of 10 nm.

[0022] (2) After the above mixture was shaken by hand, it was added to a three-necked flask, and then AIBN (0.05 g) was added. Continuous pass N 2 Remove the dissolved air in the mixture by bubbling, and react under magnetic stirring in an oil bath at 75°C for 5 hours; heat to evaporate the methanol solvent, and cen...

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Abstract

The invention provides a preparation method of a hydrogel@silicon dioxide liquid chromatography filler, wherein the preparation method comprises the steps: firstly, coating the surface of mesoporous silicon dioxide with a layer of hydrogel formed by N,N-dimethylacrylamide, and then coating the surface of a viscous coating layer with a hydrogel layer formed by N,N-dimethylacrylamide and n-octadecene to obtain the hydrogel@silicon dioxide liquid chromatography filler. The hydrogel@silicon dioxide liquid chromatography filler is prepared on the surfaces of silica gel beads through a preparation technology combining physical coating and chemical coating and a post-treatment technology of a solvent evaporation method, the synthesis path is simple and easy to operate, and due to the existence of amido bonds and octadecyl in hydrogel, and the chromatography filler has quite good chromatographic separation performance; and particularly, in a hydrophilic interaction mode, the chromatography filler has relatively good separation selectivity on polar analytes such as nucleoside bases, benzoic acid compounds, sulfonamides, amino acids and carbohydrates.

Description

technical field [0001] The invention relates to a hydrogel liquid chromatography filler, in particular to a preparation method of a hydrogel@silica liquid chromatography filler, the liquid chromatography filler is mainly used for nucleoside bases, benzoic acid compounds, Separation of sulfa drugs, amino acids, and sugar compounds. Background technique [0002] N, N-Dimethacrylamide is a substance that is both hydrophilic and lipophilic. It is easy to undergo copolymerization with other monomers and the formed cross-linked polymer has strong hydrolysis resistance. It can be used to prepare excellent performance Hydrogel material. Polymers (including hydrogels) or adducts prepared from N,N-dimethylacrylamide have excellent hygroscopicity, antistatic properties, dispersibility, compatibility, protection stability, adhesiveness, etc. However, this hydrogel@silica HPLC packing prepared by coating pure N,N-dimethylacrylamide hydrogel has limited retention capacity. From this qu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/291B01J20/30B01D15/20G01N30/56
CPCB01J20/291B01D15/20G01N30/56G01N2030/562
Inventor 郭勇樊芳斌梁晓静王立成卢晓峰王帅
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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