917 results about "Amide bonds" patented technology

The invention belongs to the technical field of flame retardants, and particularly relates to a high-thermal-stability polyphosphate flame retardant and a preparation method thereof. The DOPO is modified through the polyethylene glycol acrylate, methyl methacrylate and dicumyl peroxide composite solution, double bonds of the polyethylene glycol acrylate and P-H bonds of the DOPO can be subjected to nucleophilic addition to form stable C-P bonds, and thermal migration of the DOPO is hindered; dOPO has polymerization double bonds of methyl methacrylate and long carbon chains of polyethylene glycol acrylate, so that the compatibility of the polyphosphate flame retardant and a polymer substrate is improved, and phase separation is avoided; maleic anhydride grafted silicone oil is connected to the surface of an amino modified gamma-cyclodextrin-modified DOPO inclusion compound, so that the polyphosphate flame retardant has high thermal stability and high compatibility after long-chain alkyl modification; amino groups in the modified gamma-cyclodextrin react with maleic anhydride grafted silicone oil to generate an amido bond cross-linked network, so that the thermal migration of DOPO is reduced together, and the high thermal stability of the polyphosphate flame retardant is improved.

The invention relates to the technical field of electronic devices, in particular to a monomolecular electric memristor based on dipole control and a preparation method thereof.The monomolecular electric memristor comprises a molecular heterojunction, and the molecular heterojunction is formed by connecting dipole molecules and graphene point electrodes through amido bonds; the dipole molecule comprises an amide structure based on a carbazole nitrogen-containing heterocyclic ring unit, under the action of an external electric field, a side chain chemical bond of the dipole molecule can rapidly rotate, the size and direction of an intramolecular dipole moment can be changed, the molecule can be rapidly and stably switched among different resistance states, and the read-write speed of the memristor is remarkably improved; the storage state is stably kept under the power-off condition, and the long-term stability and reliability of the memristor function are ensured. The preparation method comprises the processes of introducing dipole molecules and forming amido bonds between the dipole molecules and the graphene point electrode, and the preparation method is simple and convenient to operate, mild in condition and beneficial to large-scale production.

The invention relates to the technical field of fabrics, and discloses a preparation method of a high-elastic anti-wrinkle blended fabric, which comprises the following steps: adding sodium carbonate, an organosilicon quaternary ammonium salt triazine finishing agent and a cotton / spandex blended fabric into water, soaking, then soaking and rolling twice, washing, and then pre-drying and baking to obtain the high-elastic anti-wrinkle blended fabric. The finishing agent contains cyanuric chloride groups, active chlorine atoms of the cyanuric chloride groups can react with hydroxyl groups of the cotton fabric, so that the finishing agent is connected to the surface of the blended fabric through stable chemical bonds, meanwhile, the finishing agent contains a large number of amido bonds, and the amido bonds and carbamate groups of spandex fabric form hydrogen bond interaction, so that the finishing agent can be used for finishing the cotton fabric. The finishing agent can be firmly attached to the surface of the blended fabric and has good washing resistance, the finishing agent is not prone to falling off after multiple times of washing, and the fabric still has high wrinkle recovery angle, moisture regain and good hand feeling and keeps good wrinkle resistance, hydrophilic performance and soft and elastic hand feeling.

The invention belongs to the technical field of antibacterial peptides, and particularly relates to an antibacterial peptide and application thereof. The amino acid sequence of the antibacterial peptide is shown as SEQ ID NO: 1, the number of amino acids is small, the synthesis cost is low, the antibacterial peptide has high antibacterial activity on gram-negative bacteria and gram-positive bacteria, the minimum inhibitory concentration of the antibacterial peptide on acinetobacter baumannii, escherichia coli, pseudomonas aeruginosa and staphylococcus aureus is 4.68-37.5 mu g / mL, and the antibacterial peptide has the advantages of broad-spectrum antibacterial property, good stability and good application prospect. No obvious cytotoxicity and hemolysis effect exist; moreover, end-to-end amido bond cyclization is carried out, so that the antibacterial activity is further enhanced, the antibacterial effect on acinetobacter baumannii, escherichia coli, pseudomonas aeruginosa and staphylococcus aureus is enhanced by 2-4 times, and the minimum inhibitory concentration is reduced to 2.34-9.38 mu g / mL; after the end-to-end amido bonds are cyclized, the plasma stability and safety of the antibacterial peptide are further improved, and the cytotoxicity and hemolysis are reduced.

The invention relates to the technical field of coating surface preparation, in particular to an anticoagulant coating based on novel tick-derived anticoagulant protein Qinghaenin and a preparation method of the anticoagulant coating. The functional layer of the anticoagulant coating comprises the following components: anticoagulant protein Qinghaenin or a functional peptide fragment Qinghaenin 167-192 of the anticoagulant protein Qinghaenin, wherein the amino acid sequence of the functional peptide fragment is as shown in SEQ ID NO. 2. The preparation method of the anticoagulant coating comprises the following steps: by using a polydopamine coating as a substrate layer, covalently grafting through an amido bond, immobilizing anticoagulant protein Qinghaenin capable of inhibiting FXII factor activation or a functional peptide fragment Qinghaenin 167-192 thereof on the surface of a medical polymer material, and successfully constructing a novel anticoagulant coating. Compared with an unmodified medical polymer material, the modified coating can significantly enhance the hydrophilic performance of the material and inhibit platelet adhesion and activation, finally effectively prolongs the in-vitro blood coagulation time, and shows excellent anticoagulation performance.

The invention relates to the technical field of fibers, and discloses a graphene modified polyamide fiber preparation method, which comprises: mixing 0.05-0.5 part by weight of graphene oxide, 1-4 parts by weight of carboxyl-terminated hyperbranched polyesteramide and nylon 6, and carrying out melt blending spinning, drafting and cooling setting in a spinning machine to obtain the graphene modified polyamide fiber. The hyperbranched polyesteramide has good compatibility with nylon 6, plays a good toughening role, improves the interfacial compatibility of graphene oxide and nylon 6, and improves the breaking strength and elongation at break of the fiber. The end group of the hyperbranched polyesteramide contains a large amount of hydrophilic carboxyl, and the main chain contains hydrophilic amido bonds, so that the moisture regain of the polyamide fiber can be improved, and the hydrophilic moisture absorption performance can be improved.

The present invention relates to a composite sulfide electrolyte, and a preparation method therefor and a use thereof. The composite sulfide electrolyte has a three-dimensional crosslinked structure formed by connecting a sulfide electrolyte and a dynamic bond-containing crosslinked polymer by means of chemical bonds. The polymer contains a sulfur element and exhibits relatively higher stability when interacting with the sulfide electrolyte, the chemical crosslinking between the sulfide electrolyte and the dynamic bond-containing crosslinked polymer is formed by means of multiple chemical bonds, such as a disulfide bond and an amido bond, and a strong binding force and self-healing function are provided, in order to simultaneously solve the problems of interfacial delamination and cracking caused by mechanical stress inside the sulfide electrolyte. When applied in an all-solid-state battery, the composite sulfide electrolyte can improve the limiting current density and cycle stability of the all-solid-state battery.

The invention provides a cyclic peptide as well as a preparation method and application thereof. The cyclic peptide has an amino acid sequence # imgabs0 # represented by formula (1) (wherein X is a Lys residue modified with a fatty acid molecule, and a line connecting Arg and Lys represents an amide bond. The cyclic peptide prepared by the invention has wide antifungal activity and antibacterial activity on drug-resistant bacteria; meanwhile, the biotoxicity and the protease degradation resistance are high, and the in-vivo antibacterial effect of the cyclopeptide can be prolonged. The cyclic peptide can be applied to preparation of anti-bacterial and anti-fungal infection drugs, and can be used as an excellent substitute drug or an auxiliary drug of existing antibiotics. The method for preparing the cyclic peptide is simple, raw materials are easy to obtain, and industrial production can be achieved.

The invention relates to the field of preparation of polyurethane damping materials, in particular to a preparation method of a repairable polyurethane damping material based on multiple hydrogen bonds and metal coordination. Compared with a traditional damping material, the damping material has a higher damping temperature range and has a good damping effect at the temperature of-20 DEG C to 60 DEG C. Multiple reversible hydrogen bonds are introduced through diamine containing amido bonds, the material is endowed with self-repairing and high mechanical strength, and damping and self-repairing performance is further enhanced through pyridine nitrogen atom metal coordination. Starting from molecular structure design, multiple hydrogen bonds and metal-ligand coordination bonds constructed on a polyurethane molecular main chain play a role in synergistic enhancement, energy can be effectively dissipated through dissociation and recombination of the multiple hydrogen bonds and fracture and association of the metal coordination bonds, and the energy consumption is reduced. The polyurethane material is endowed with excellent damping performance and self-healing capability by the dual dynamic action.

The invention discloses a tough full-bio-based polylactic acid / polyamide composite material and a preparation method thereof, and belongs to the technical field of polymer composite material preparation. The tough polylactic acid / polyamide composite material comprises polylactic acid, bio-based polyamide, a core-shell amide modified material, a hydrolysis stabilizer, an antioxidant and a chain extender. The core-shell amide modified material is prepared by filling a functional elastomer copolymer with amino nanoparticles. The core-shell amide modified material formed on the basis of the amino nanoparticle reactive filling functional elastomer copolymer has a micro core-shell structure formed in situ and a large number of amido bonds, so that the number of hydrogen bonds between molecular chains of a blend system is increased, and entanglement and intermolecular acting force between micro molecular chains of the blend material are improved; therefore, the system compatibility is improved, the absorption of the material on external stress and energy is enhanced, more obvious plastic deformation is generated when the material is stressed and deformed, and the material is endowed with better mechanical properties.

The invention provides a low-temperature-impact-resistant food packaging material and a preparation method and application thereof.The low-temperature-impact-resistant food packaging material is prepared from, by mass, 100 parts of polylactic acid, 1-10 parts of modified layered double hydroxide and 5-40 parts of hyperbranched polyester; wherein the modified layered double hydroxide is obtained by treating layered double hydroxide with a composite anionic surfactant and then treating the treated layered double hydroxide with an organic cationic compound with a long alkyl chain; the composite anionic surfactant comprises a first anionic surfactant and a second anionic surfactant; wherein the first anionic surfactant comprises sodium dodecyl sulfate; the second anionic surfactant comprises a sulfonate anionic surfactant containing an amido bond and a catechol structure. Through the formula design, the impact toughness of the material at low temperature can be improved while the mechanical property of polylactic acid is maintained, and the material can be suitable for the field of food packaging.

An object of the present invention is to provide a polyurethane urea elastic fiber whose physical properties do not change much over time and which retains its initial mechanical properties, and a method for obtaining this fiber by modifying the molecular chain and ends of the polyurethane urea polymer. Another object of the present invention is to provide a polyurethane urea elastic fiber whose use can improve inventory management and fiber processing condition management, and which can be used to obtain a fabric with stable physical properties and qualities, and to provide a method for producing this fiber. The present invention is a polyurethane urea elastic fiber comprising: polyurethane urea polymer A having a molecular chain using a polymer diol, a diisocyanate, and an organic amine as starting materials, and having a primary or secondary amino group on at least one end; and polyurethane urea polymer B using a polymer diol, a diisocyanate, an organic amine, and an organic carboxylic acid as starting materials, and containing an amide bond, wherein the polyurethane urea elastic fiber contains primary or secondary amino end groups in the range of 0.1 meq or more and 20 meq or less per kilogram of polyurethane urea elastic fiber.

The invention discloses a nanofiber functional dressing for wound healing of burns and scalds, and belongs to the technical field of wound repairing dressings. The dressing is prepared through double-layer electrostatic spinning and comprises a hydrophilic nanofiber layer and a hydrophobic nanofiber layer. The hydrophobic nanofiber layer is prepared by electrostatic spinning of an antibacterial composite modified material and isocyanate-terminated oligomeric lactic acid, and the antibacterial composite modified material is prepared by acylating chlorination of (9I)-2, 4, 8, 10-tetraoxaspiro [5.5] undecane-3, 9-dipropionic acid, reaction of the acylating chlorination product and N, N-bis (2-benzimidazole methyl) amine, and quaternization of benzyl chloride. The tetrooxaspiro rigid structure improves the thermal stability and inhibits the molecular chain from absorbing water and expanding; the quaternized benzimidazole group destroys cell membranes through positive charges, and can efficiently resist bacteria. An amido bond in the hydrophilic layer and a urea bond formed by the antibacterial material and an isocyanate group remarkably improve the liquid absorption capacity; the hydrophobic layer provides mechanical support and ductility; two layers of interfaces are fused through heat treatment, the overall tearing strength is improved, and the joint movement requirement is met.

The invention relates to the technical field of antibacterial polyamide fiber preparation, and discloses a polyamide fiber with antibacterial performance and a preparation method thereof.The polyamide fiber is prepared from, by weight, 100 parts of PA6 slices, 10-15 parts of graphene oxide, 1-5 parts of surface amination mesoporous catechin-silver-loaded zirconium phosphate and related auxiliaries, after surface amination mesoporous catechin-silver-loaded zirconium phosphate and graphene oxide are subjected to amide linkage, the surface amination mesoporous catechin-silver-loaded zirconium phosphate and amide groups of polyamide fibers form a hydrogen bond network, the surface amination mesoporous catechin-silver-loaded zirconium phosphate and the amide groups of the polyamide fibers are mutually combined to play a synergistic effect, the interface binding energy is increased, and antibacterial components can stably exist in the polyamide fibers; meanwhile, the mesoporous structure provides multi-channel support, induces cracks to expand along the edge of a pore and increases the length of a fracture path, so that the stress transfer efficiency is obviously improved, and the problem of internal stress concentration caused by the addition of large-particle high-content rigid particles is avoided.

The invention relates to the technical field of polymer separation and purification, in particular to a preparation method of a molecularly imprinted polymer for separating asiaticoside, and the method comprises the following steps: S1, under an anaerobic condition, sequentially adding asiaticoside and a functional monomer containing unsaturated double bonds and amido bonds into a reactor, and carrying out a reaction for 2-4 hours; carrying out self-assembly reaction on the asiaticoside and the functional monomer to obtain a prepolymer containing an asiaticoside structure and unsaturated double bonds; s2, continuing to add a cross-linking agent and an initiator into the reactor, so that the prepolymer is subjected to a polymerization reaction, and a mixed solution is obtained; s3, separating and filtering to obtain a precipitate, and washing to remove template molecules; and S4, collecting the asiaticoside molecularly imprinted polymer, and carrying out vacuum drying to obtain the asiaticoside-containing molecularly imprinted polymer. According to the present invention, with the molecular imprinting technology, the asiaticoside is specifically recognized by using the functional group so as to embody the specificity and the high selectivity of the method;

Filtration apparatus comprising Graphene Oxide (GO) membranes modified by incorporation of polymeric components are described herein. The GO membranes include graphene oxide sheets covalently coupled to one or more polymeric components. Incorporation of polymeric components may increase d-spacing of the graphene oxide sheets resulting in improved filtration apparatus performance with respect to prior art membranes (e.g., high flux and rejection rate). In some embodiments the polymeric components may comprise branched polymers with primary amine functionalities which can act as efficient handles for covalent attachment to graphene oxide, resulting in the formation of new, robust amide bonds. The filtration apparatus described herein can exhibit improved performance in applications such as pulp and paper processing, which facilitates achieving permeate quality targets.

The invention discloses a hydrogel for gastric perforation repair, which belongs to the field of bioadhesives. The technical scheme is as follows: a hydrogel for gastric perforation repair is generated by chemical reaction of compound A and compound B; compound A is a polyethylene glycol derivative A with a terminal active group α; the terminal active group α is succinimidyl succinate; compound B is a polyethylene glycol derivative B with a terminal active group β; the terminal active group β is an amino group; when compound A reacts with compound B, the terminal active group α and the terminal active group β chemically react to form an amide bond. The beneficial effects of the invention are as follows: the hydrogel for gastric perforation repair provided by the invention has a fast gelation speed, can be gelled in situ, is easy to use, has strong adhesion to gastric tissue, has a low swelling rate in simulated gastric fluid and PBS solution, has a strong ability to resist simulated gastric fluid corrosion, has good compression resistance and anti-peristalsis performance, has good biocompatibility, and can be safely degraded.

The invention belongs to the technical field of antibacterial peptides, and particularly relates to an LL-37 derived antibacterial peptide and application thereof. According to the invention, 17-29aa of the LL-37 antibacterial peptide is used as a core fragment and is connected with an amino acid sequence shown as SEQ ID NO: 1 or SEQ ID NO: 2 through an amido bond, the antibacterial activity of the obtained antibacterial peptide is obviously higher than that of the LL-37 antibacterial peptide, and the antibacterial peptide shows an obvious bactericidal effect on clinical drug-resistant bacteria such as acinetobacter baumannii, pseudomonas aeruginosa, escherichia coli, staphylococcus aureus, klebsiella pneumoniae and the like; meanwhile, the cytotoxicity and hemolytic activity are weak, drug resistance is not prone to being generated, bacteria can be rapidly killed in vivo through multiple mechanisms, no obvious cytotoxicity exists, the bacterium load in tissue is remarkably reduced, and the lifetime of a bacterium-infected mouse is prolonged.

The invention discloses a high-barrier material based on a PET aminolysis monomer and a preparation method of the high-barrier material, and belongs to the technical field of high polymer materials. The preparation method comprises the following steps: carrying out aminolysis reaction on polyethylene glycol terephthalate (PET) to prepare a dihydric alcohol monomer containing an amido bond, and carrying out polymerization reaction on the dihydric alcohol monomer and aliphatic dibasic acid to prepare a polyesteramide (PEA) material. The prepared PEA material has excellent oxygen barrier property and toughness, the oxygen barrier property of the PEA material is obviously superior to that of a PET material, and the barrier property and mechanical property of the PEA material can be regulated and controlled by changing the length of a methylene chain segment of the aliphatic dibasic acid monomer. The aliphatic dibasic acid monomer can be derived from biomass resources, the reaction condition is mild, the process is simple, and the method is suitable for industrial large-scale production.

The invention discloses a long-time strong-adhesion tissue repair patch and a preparation method thereof, and the preparation method comprises the following steps: adding an adhesion component, an anti-swelling component and alpha-ketoglutaric acid into a colloidal aqueous solution of a patch matrix material to obtain a precursor solution; and pouring the precursor solution into a patch mold, carrying out ultraviolet curing, and drying the obtained gel to obtain the patch. From the selection of materials and chemical bonds, physical and chemical bonds such as amido bonds, disulfide bonds and catechol groups are combined, so that the adhesion strength is improved, the adhesion duration is prolonged, and the adhesive has excellent anti-swelling performance and mechanical performance, can effectively isolate external saliva, food residues and the like when being applied to the oral cavity, reduces infection of ulcer wounds, and has a good application prospect. The dental ulcer healing is accelerated, and the method also has a relatively good application prospect in the field of tissue repair.

The invention belongs to the field of biomedical materials, and discloses a hydrogel patch with piezoelectricity, conductivity and high adhesion and a preparation method and application of the hydrogel patch. Polyvinyl alcohol (PVA) and acrylic acid (AA) serve as polymer frameworks of the hydrogel patch; the invention relates to a nano-zinc oxide / poly (3, 4-ethylenedioxythiophene) / poly (styrenesulfonic acid) (PEDOT: PSS) composite conductive adhesive, which comprises nano-zinc oxide (ZnO) as a piezoelectric material, poly (3, 4-ethylenedioxythiophene)-poly (styrenesulfonic acid) (PEDOT: PSS) as a conductive material, and N-hydroxysuccinimide acrylate (NHS-AA) as an adhesive functional monomer. According to the invention, active ester groups in the N-hydroxysuccinimide acrylate are utilized, so that the patch can quickly form covalent amido bonds with amino groups on the surface of a tissue in a dry state, firm adhesion is realized, local nerve repair can be effectively promoted through a piezoelectric effect, a novel ideal material is provided for disease treatment, and the patch has wide application prospects. Wide clinical application prospects are realized in the field of biological medicines.

The present invention discloses a wear-resistant and tear-resistant polyamide elastomer composition and a preparation method and application thereof, and belongs to the technical field of modified materials. The wear-resistant and tear-resistant polyamide elastomer composition is prepared by weight from 87.1 to 95.9 parts of polyamide elastomer, 3 to 10 parts of wear-resistant agent, 0.2 to 1 part of cross-linking agent, 0.4 to 1 part of antioxidant, 0.1 to 0.6 parts of nucleating agent, 0.2 to 0.6 parts of dispersant, 0 to 2 parts of masterbatch, and 0 to 0.01 parts of fluorescent brightener. The present invention adopts polyamide elastomer as a substrate, and generates a cross-linking structure through a trifunctional cross-linking agent and an amide bond and / or an end group (amino, carboxyl, hydroxyl) in a polyamide elastomer molecular chain to improve the tear strength of the composition, and adds a polymer wear-resistant agent (PTFE and / or POM powder) to improve the wear resistance and resilience of the composition, so that the badminton racket line nails prepared by the composition of the present invention have playability and durability.

The invention provides heterocyclic tetrabasic acid as well as a preparation method and application thereof. The heterocyclic tetrabasic acid has a structure as shown in a formula I, # imgabs0 #, Y is selected from substituted or unsubstituted heterocyclic groups, and R1 and R2 are independently selected from C1-C10 straight chain or branched chain alkyl or substituted or unsubstituted aromatic rings. The heterocyclic tetrabasic acid has the advantages of good biocompatibility, low toxicity and the like due to the existence of amido bonds, and is suitable for synthesizing low-toxicity plasticizers.

The invention provides a preparation method for preparing hydrogel in a water phase and application of the hydrogel in tumor immune microenvironment evaluation ultrasonic detection, and relates to the technical field of organic synthesis. The preparation method comprises the following steps that chitosan is dissolved in water, a chitosan solution with a first preset concentration is prepared, and chitosan has carboxyl groups and amino groups; dissolving a condensing agent in water to prepare a reaction solution with a second preset concentration; mixing the chitosan solution with the reaction solution, adding glacial acetic acid, and reacting for preset time at preset temperature and preset pressure to obtain a mixed solution; carrying out dialysis treatment on the mixed solution to obtain hydrogel; wherein the ratio of the first preset concentration to the second preset concentration ranges from 10: 1 to 1: 1. According to the invention, the hydrogel with amido bonds is prepared in a water phase, and the hydrogel has the characteristics of low toxicity, good biocompatibility and good biodegradability.

The present invention relates to a polymer having a main chain, wherein the main chain comprises linear amide bonds and a heteromonocyclic moiety containing a nitrogen atom, wherein the main chain does not contain peptide bonds, or wherein, based on the total number of linear amide bonds in the main chain, the proportion of peptide bonds in the main chain is at most 30%, and wherein, based on the total weight of the polymer, the proportion of the heteromonocyclic moiety containing a nitrogen atom is from 5% by weight to 25% by weight. The present invention also relates to a product or article and the use of the polymer for manufacturing or producing the product or article.

The invention discloses a remodelable polyguanidine urea material based on aromatic guanidyl amino acid as well as a preparation method and application thereof, and relates to the technical field of high polymer materials. The preparation method comprises the following steps: uniformly mixing a reaction system containing an aromatic guanidino amino acid monomer, a polyfunctional isocyanate compound and a solvent, firstly carrying out pre-reaction, removing the solvent, and then curing to obtain the remodelable polyguanidino urea material based on the aromatic guanidino amino acid. Aromatic guanidyl amino acid containing guanidyl and carboxyl functional groups reacts with polyfunctional isocyanate to form a guanidyl urea bond and an amido bond, so that the dynamic covalent polymer network structure material is formed, has excellent thermal stability and mechanical properties, is high in dynamic exchange speed, and can be applied to the field of chemical engineering. Rapid remodeling and reprocessing can be realized through a simple hot pressing method; meanwhile, the method has the characteristics of simple preparation method, no need of a catalyst through the action of multistage hydrogen bonds and non-covalent bonds in the structure, mild reaction conditions, strong operability, easiness in realization of industrial production and great application prospect.

The present disclosure discloses a medical hydrogel, formed by in-situ crosslinking an aldehyde-terminated multi-arm star polyethylene glycol and a polyamino compound, wherein the aldehyde group and the multi-arm star polyethylene glycol are linked by a chemical bond such as an ether bond, an amide bond, an ester bond, a urethane bond, an imine bond, or a urea bond, and the molar ratio of the amino in the polyamino compound to the aldehyde group in the aldehyde-terminated multi-arm star polyethylene glycol is 0.4-4.4:1. The polyamino compound is polylysine or a mixture of polylysine and polyethylenimine in a molar ratio of 2-30:3. The hydrogel of the present disclosure gels rapidly, has a long-term stability in an aqueous solution, and still has good swelling property and stability after a plurality of radiations, and thus can be used as a medical radiotherapy protection spacer for radiation protection.

The present invention belongs to the field of pharmacy. Provided are peptides, derivatives thereof, and the use of same. The peptides and the derivatives thereof are compounds as shown in formula 1 or pharmaceutically acceptable salts thereof, wherein aa represents natural or unnatural amino acids, the configurations thereof being D- or L-configuration; 4-7 represents that the peptides can be formed by amide bond condensation of four to seven amino acids; R is hydrogen, or glycosyl, or PEG chains having different lengths, or acetyl; in addition, the peptide sequences at least contain two to three basic natural or unnatural amino acids. The compounds have the effects of promoting post-stroke or post-traumatic neurofunction restoration and treating affective disorder diseases. Meanwhile, because of a unique action mechanism of the compounds, the compounds can also be used for preparing drugs for treating Alzheimer's disease and various neurodegenerative diseases. R-(aa)4-7-NH2 (formula 1).

The invention relates to the field of hydrophilic thermosensitive resin, in particular to hydrophilic thermosensitive resin as well as a preparation method and application thereof, and aims to solve the problems that an existing thermosensitive material is insufficient in hydrophilicity, an existing hydrophilic material is insufficient in thermosensitive performance, and a resin material cannot give consideration to both the hydrophilic material and the hydrophilic material at the same time. According to the resin, an imidazole structure is introduced into polyacrylamide and grafted into PNIPAM to form an amido bond, the hydrophilic performance of the PNIPAM is improved, ethyl cellulose is grafted onto amino-treated silicon dioxide to form an amido bond, and the hydrophilic performance of the resin is improved together with modified polyacrylamide blended PNIPAM; when the resin is applied to a specific medium or environment, the resin can show a corresponding response behavior on absorption or release of moisture according to the change of environment temperature, realizes effective regulation and control and induction on temperature and humidity, and can be applied to temperature-sensitive medical treatment, electronic packaging and other emerging technical fields.