34 results about "Tetramethylurea" patented technology

The invention discloses a preparation method and application of a compound with a cold sensing regulation effect, which comprises the following steps: dissolving tryptophan in methanol, adding concentrated sulfuric acid, esterifying the acid to protect carboxyl so as to obtain tryptophan methyl ester, dissolving the obtained tryptophan methyl ester and aromatic carboxylic acid substances in N, N-dimethylformamide, and reacting to obtain the compound with the cold sensing regulation effect. The method comprises the following steps: catalyzing 2-(7-azabenzotriazole)-N, N, N ', N'-tetramethylurea hexafluorophosphate and N, N-diisopropylethylamine, dissolving a catalyzed product in ethanol (98%), adding into a NaOH solution, stirring, carrying out rotary evaporation treatment, slowly dropwise adding a 0.5 mol / L hydrochloric acid solution, adjusting the pH value of a reaction system to 3-4, and finally obtaining the tryptophan derivative compound with the yield of 70%. The invention provides a potential medicine for improving the working ability and cold injury in the cold environment for people living and working in the cold environment, and is developed into a medicine for effectively improving neuropathic pain diseases in the cold environment.

The invention discloses a method for synthesizing dipeptide Fmoc-Leu-Aib-OH, and belongs to the field of polypeptide synthesis, the specific preparation method comprises the following steps: under the action of organic alkali and an activating reagent, Fmoc-Leu-OH and H-Aib-OH react to obtain the dipeptide Fmoc-Leu-Aib-OH; the activating reagent comprises at least one of N, N, N ', N'-tetramethyl chloroformamidine hexafluorophosphate, 2-(7-azabenzotriazole)-N, N, N ', N'-tetramethyl urea hexafluorophosphate and benzotriazole-1-yl-oxytripyrrolidinyl phosphorus hexafluorophosphate, and the organic base comprises at least one of N-methylimidazole, N, N-diisopropylethylamine and pyridine. The dipeptide Fmoc-Leu-Aib-OH prepared by the preparation method disclosed by the invention is high in yield, high in purity and high in raw material conversion rate.

The invention discloses a production method of a hexafluorophosphate product, the hexafluorophosphate product is 2-(inner-5-norbornene-2, 3-dicarboximide)-1, 1, 3, 3-tetramethylurea hexafluorophosphate, the first-step reaction of the invention comprises the following steps: preparing an intermediate from norbornene dianhydride as a raw material and a hydroxylamine compound under the action of organic alkali; in the second-step reaction, the intermediate and TCFH are subjected to a nucleophilic substitution reaction under the action of an alkaline metal catalyst to obtain a crude product, and the crude product is purified to obtain a target product; the synthesis route used in the invention is simple, special high temperature or high pressure is not needed in the reaction process, and the used catalyst is a conventional raw material which is low in price and easy to obtain; according to the method, the purity of the product can be increased to 99.8% or above, the total yield is stabilized to be 85% or above, in addition, the reaction route greatly reduces side reactions, and by-products in the product are few in variety and low in content.

The invention discloses a preparation method of dipeptide Fmoc-Leu-Aib-OH, and belongs to the field of polypeptide synthesis, the specific preparation method comprises the following steps: under the action of organic alkali and an activating reagent, Fmoc-Leu-OH and H-Aib-OH react to obtain the dipeptide Fmoc-Leu-Aib-OH; the activating reagent comprises at least one of N, N, N ', N'-tetramethyl chloroformamidine hexafluorophosphate, 2-(7-azabenzotriazole)-N, N, N ', N'-tetramethyl urea hexafluorophosphate and benzotriazole-1-yl-oxytripyrrolidinyl phosphorus hexafluorophosphate, and the organic base comprises at least one of N-methylimidazole, N, N-diisopropylethylamine and pyridine. The dipeptide Fmoc-Leu-Aib-OH prepared by the preparation method disclosed by the invention is high in yield, high in purity and high in raw material conversion rate.

To provide a photosensitive resin composition containing an organic solvent other than NMP and exhibiting excellent photosensitivity.SOLUTION: A photosensitive resin composition contains: a polyimide precursor having a polymerizable unsaturated bond; a photopolymerization initiator; and a solvent. The solvent contains at least one selected from the group consisting of N-ethyl-2-pyrrolidone, 1,3-dimethyl-2-imidazolidinone, and tetramethylurea.SELECTED DRAWING: None

The invention provides fluorescein and a purification and synthesis method thereof, and relates to the field of compound preparation. The method comprises the following steps: carrying out first mixing and first reaction on 4-(aminomethyl) benzoic acid, triethylamine, a first organic solvent and trifluoroacetate to obtain a first intermediate; performing second mixing on the first intermediate, a second organic solvent, triethylamine and 2-succinimido-1, 1, 3, 3-tetramethylurea tetrafluoroborate, and performing second reaction to obtain a second intermediate; and carrying out third mixing on the second intermediate, amino FAM, a third organic solvent and triethylamine, and carrying out third reaction to obtain fluorescein. The synthesis and purification method is efficient, and fluorescein can be rapidly obtained without column chromatography; chemical raw materials used in the synthesis method are simple and easy to obtain, the cost is low, reaction conditions are mild, amplified production is easy, the purification method is simple and convenient to operate, and the obtained intermediate is high in stability.

The invention belongs to the technical field of biochemistry, and relates to a ratio type probe compound, a preparation method thereof, a Cu (I) response photoacoustic probe composition and application. The preparation method of the ratiometric probe compound comprises the following steps: (1) reacting a compound (I), a compound (II), acetic acid and piperidine to obtain a compound (III); (2) reacting the compound (III) with trifluoroacetic acid to obtain a compound (IV); (3) carrying out a reaction on the compound (IV), the compound (V), 2-(7-azabenzotriazole)-N, N, N ', N'-tetramethylurea hexafluorophosphate and 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, so as to obtain a compound (VI); and (4) reacting the compound (VI), the compound (VII), acetic acid and piperidine to obtain the compound. The photoacoustic probe provided by the invention has excellent selectivity and high sensitivity.

The invention belongs to the photovoltaic field, and particularly relates to a perovskite precursor solution, a perovskite thin film and a solar cell. A solvent of the perovskite precursor solution comprises a main solvent and an auxiliary solvent, the main solvent is N, N-diethyl formamide, the auxiliary solvent is selected from one or more of dimethyl propenyl urea, tetramethylurea, N, N-dimethylacetamide and N-methylacetamide, and the mass ratio of the main solvent to the auxiliary solvent is (1: 1)-(10: 1). The solvent of the perovskite precursor solution is green and low in toxicity, and controllable crystallization of the perovskite thin film can be realized by changing the perovskite nucleation and growth process so as to obtain the high-quality perovskite thin film. The use of a high-toxicity solvent is avoided, and the safety of the industrial environment is improved.

The application belongs to the technical field of biochemistry, and relates to a ratio type probe compound, a preparation method thereof, a Cu(I) response photoacoustic probe composition and application. The preparation method of the ratio type probe compound comprises the following steps: (1) reacting compound (I), compound (II), acetic acid and piperidine to obtain compound (III); (2) reacting compound (III) and trifluoroacetic acid to obtain compound (IV); (3) reacting compound (IV), compound (V), 2-(7-azabenzotriazole)-N,N,N',N'-tetramethyluronium hexafluorophosphate and 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride to obtain compound (VI); and (4) reacting compound (VI), compound (VII), acetic acid and piperidine to obtain the compound. The photoacoustic probe provided by the application has excellent selectivity and high sensitivity.

The invention discloses a fluorescent probe for detecting the viscosity of a cell membrane as well as a preparation method and application of the fluorescent probe, and belongs to the technical field of small molecule probes. The structural formula of the fluorescent probe is shown in the specification. The preparation method specifically comprises the following steps: (1) reacting 4-diethylaminoketonic acid and cyclohexanone in concentrated sulfuric acid, pouring into crushed ice, stirring, adding perchloric acid, stirring, standing and filtering; (2) dissolving 4-diethylaminobenzaldehyde in absolute ethyl alcohol, heating and refluxing, removing the solvent, and carrying out chromatography; and (3) dissolving benzotriazole-N, N, N ', N'-tetramethylurea hexafluorophosphate and N, N-diisopropylethylamine in N, N-dimethylformamide, stirring at normal temperature, adding a compound 43-(tetradecyl amino) propane-1-sulfonate, continuously stirring, removing the solvent, and carrying out chromatography to obtain the compound 43-(tetradecyl amino) propane-1-sulfonate. The fluorescent probe has excellent anchoring and imaging capabilities and viscosity-triggered near-infrared (NIR) fluorescence response characteristics, can be used for fluorescence imaging of cell membrane viscosity, and can also be used for viscosity imaging analysis of breast cancer mice.

The invention provides a preparation method of N-(4-(tert-butyl) thiazole-2-yl)-3-fluorobenzamide, which comprises the following steps: mixing a compound as shown in a formula I, N, N-diisopropylethylamine and 2-succinimido-1, 1, 3, 3-tetramethylurea tetrafluoroborate for reaction, then adding a compound as shown in a formula II for amidation reaction, and finally obtaining the N-(4-(tert-butyl) thiazole-2-yl)-3-fluorobenzamide. And reacting the N-(4-(tert-butyl) thiazole-2-yl)-3-fluorobenzamide to obtain the N-(4-(tert-butyl) thiazole-2-yl)-3- According to the preparation method provided by the invention, by innovatively changing the reaction sequence, firstly activating the raw materials and then carrying out amidation reaction, the polarity of by-products is successfully changed, the polarity of main by-products is obviously smaller than that of target products, the products are easy to separate, the column chromatography separation efficiency is greatly improved, the yield is increased, and the post-treatment time is shortened.

The invention belongs to the technical field of magnesium ion batteries, and discloses a water-based magnesium ion battery electrolyte and a preparation method and application thereof, and the mixed electrolyte for the water-based magnesium ion battery is composed of magnesium salt, an organic solvent and deionized water; wherein the organic solvent is tetramethylurea (TMU), the tetramethylurea and the deionized water jointly form a mixed solvent of the mixed electrolyte, the volume percent of the tetramethylurea in the mixed solvent is 10%-50%, and the volume percent of the deionized water in the mixed solvent is 90%-50%; the magnesium salt is dissolved in the mixed solvent. The components of the electrolyte are improved, the TMU is taken as the mixed electrolyte of the cosolvent, and the volume fraction of the TMU is accurately regulated and controlled, so that the problem of short cycle life caused by narrow electrochemical stability window (ESW) and serious interface side reaction of the water-based magnesium ion battery is solved, and the electrolyte has the advantages of simplicity in preparation, environment friendliness and low cost, and is suitable for industrial production. A new way is provided for improving the energy density and the cycle life of the water-based magnesium ion battery.

This invention relates to a coating solution for composite lithium-ion battery separators, a composite lithium-ion battery separator, and a method for preparing the same. The coating solution for composite lithium-ion battery separators comprises: (A) poly(p-phenylene terephthalamide); (B) an organic solvent, which is at least one selected from hexamethylphosphoramide and tetramethylurea; (C) a co-solubilizing salt, which is at least one selected from lithium chloride and calcium chloride; and (D) an additive, which is at least one selected from ceramic powder and polymer binder. The coating solution for composite lithium-ion battery separators exhibits good stability. The composite lithium-ion battery separator possesses good air permeability, heat resistance, and good compatibility with the electrolyte, making it suitable for lithium-ion batteries. The preparation methods for both the coating solution and the composite lithium-ion battery separator are simple, convenient, and have low production costs.

Solvent blends useful for the formulation and application of polyamide-imide resins are described. A solvent blend may include a primary solvent and a co-solvent, wherein the primary solvent is provided at a higher concentration than the co-solvent. The primary solvent may include one or more first materials, wherein the first materials include at least one of 1,3- Dimethyl-2-imidazolidinone, N-Cyclohexyl-2-pyrrolidone, or N,N'-Dimethyl propyleneurea. The co-solvent may include one or more second materials different than the one or more first materials, wherein the second materials include at least one of N,N-Diethylacetamide, N,NDimethylpropionamide, gamma-butyrolactone, N-butylpyrrolidinone, N-Methylmorpholine, 2,5,7,10-Tetraoxaundecane, 3-Methoxy-N,N-dimethyl propenamide, Anisole, Cyrene, 1,1,3,3- Tetramethylurea, Diethylene Glycol Diethyl Ether, 1,3-Dimethyl-2-imidazolidinone, NCyclohexyl- 2-pyrrolidone, or N,N'-Dimethyl propyleneurea.

The invention discloses a method for preparing diphenyl carbonate through transesterification, which adopts an efficient solvent diphenyl ether, ensures the reaction through a high boiling point, realizes efficient crystallization of DPC (Diphenyl Carbonate) by utilizing low solubility at 50-60 DEG C, and simultaneously meets the requirements of high-temperature safety and green chemistry. Through the synergistic catalysis of 4-dimethylaminopyridine, nano cerium oxide and tetramethylurea, DMAP serves as a strong nucleophilic catalyst to activate phenol, after nano CeO2 (5-10 nm) is modified with acetylacetone, surface Lewis acid sites are highly dispersed, carbonyl of dimethyl carbonate (DMC) and carbonyl of tetramethylurea are remarkably activated, carbonyl of DMC is activated, and DMC reaction is accelerated. And according to the mass ratio of 4-dimethylaminopyridine to nano cerium oxide to tetramethylurea being 122: (40.7-73.2): (227-366), the catalytic effect is optimal, so that the breakthrough of the DMC yield is greater than 99%, which is far higher than the level of 70-75% in the traditional transesterification method. The strategy of temperature-controlled dropwise adding and inert gas (N2) purging is creatively adopted, and the method conforms to the development direction of green chemical engineering.

The present invention provides a method for synthesizing 4-bromo-N-(2,6-dioxopiperidin-3-yl)-2-fluorobenzamide, which relates to the field of organic chemical synthesis technology and includes a one-step reaction. Specifically, it involves using 4-bromo-2-fluorobenzoic acid and 3-aminopiperidin-2,6-dione hydrochloride as raw materials, N,N-dimethylformamide as solvent, and adding triethylamine and 2-(7-azabenzotriazole)-N,N,N',N'-tetramethylurea hexafluorophosphate to obtain the target product 4-bromo-N-(2,6-dioxopiperidin-3-yl)-2-fluorobenzamide. The synthesis method of the present invention has a short process route, inexpensive and readily available raw materials and excipients, high reactivity, simple operation, easy control, and a high yield of the target product, which is convenient for industrial scale-up.

The present invention relates to a high-voltage electrolyte and a preparation method and application thereof, belonging to the technical field of sodium ion batteries; the high-voltage electrolyte includes the following preparation raw materials: sodium salt, organic solvent, 3-(((guanidino-4-thiazolyl)methyl)thio)propylimidate and benzotriazole-N,N,N',N'-tetramethyluronium hexafluorophosphate; wherein the mass fraction of 3-(((guanidino-4-thiazolyl)methyl)thio)propylimidate in the high-voltage electrolyte is 0.5% to 2.5%; the mass fraction of benzotriazole-N,N,N',N'-tetramethyluronium hexafluorophosphate in the high-voltage electrolyte is 0.5% to 2%; the sodium salt includes sodium tetrafluoroborate and sodium difluorooxalatoborate; the organic solvent is composed of carbonate and carboxylate. The present invention can make the sodium ion battery have good cycle performance, fast charging performance and low temperature performance at high voltage through the synergistic effect of each component of the electrolyte.

The present invention provides a polyimide precursor composition for producing an aromatic polyimide film in which light transmittance and / or heat resistance is improved. The polyimide precursor composition comprises: a polyimide precursor having a repeating unit represented by formula (I); a solvent A selected from among 1,3-dimethyl-2-imidazolidinone, 3-methoxy-N,N-dimethylpropanamide, 1-butyl-2-pyrrolidone, N,N-diphenylformamide, N,N-diethylbenzamide, benzanilide, and 1-phenyl-2-pyrrolidone; and a solvent B selected from among N,N-dimethylpropionamide, N,N-diethylformamide, N,N-diethylacetamide N,N-dimethylisobutylamide, N,N-diethylpropionamide, and tetramethyl urea. (In the formula, R1 and R2 are each a hydrogen atom or the like, and not less than 50 mol% of X1 is an aromatic group and / or not less than 50 mol% of Y1 is an aromatic group.)

The present invention relates to the technical field of specific molecular targeted diagnostic reagents. Provided are a near-infrared fluorescent probe for active targeting detection of an epidermal growth factor receptor, and a preparation method therefor and the use thereof. The preparation method comprises: mixing N-(3-chloro-2-fluorophenyl)-7-methoxy-6-(piperidin-4-yloxy)quinazolin-4-amine and X in the presence of 2-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, a base and a polar solvent; adding the product dropwise to water; extracting the suspension with an organic solvent, followed by drying and concentration; removing the protecting group from the concentrate, followed by column chromatography to obtain an intermediate compound; and adding the intermediate compound to 2-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, a base, Y and a polar solvent, followed by purification to obtain the near-infrared fluorescent probe. The prepared near-infrared fluorescent probe can achieve the effect of in-vivo diagnosis.

The invention discloses a lysosome targeted copper ion fluorescent probe with an AIE (aggregation-induced emission) effect, which is obtained by taking 7-(diphenylamino)-2-oxo-2H-benzopyran-3-carboxylic acid (I) and 8-aminoquinoline (II) as raw materials and reacting and synthesizing under the action of 2-(7-azabenzotriazole)-N, N, N ', N'-tetramethylurea hexafluorophosphate and triethylamine. The chemical structural formula of the fluorescent probe is shown as a formula (III), and the fluorescent probe has an AIE effect, has the advantages of high selectivity and high sensitivity on Cu < 2 + > recognition and the like, and can be used for effectively detecting Cu < 2 + > in an environmental water sample; besides, the probe has good biocompatibility, can be positioned in a lysosome, and is applied to real-time fluorescence imaging monitoring of Cu < 2 + > concentration change in an autophagy process caused by starvation or a chemical inducer in living cells and zebra fish bodies; the invention provides a copper ion detection tool with excellent performance, which has huge potential in the fields of environmental monitoring and life science research.

The invention discloses a method for improving the production capacity of II type full-length collagen of pichia pastoris. The method comprises the following steps: in a methanol-induced pichia pastoris fermentation production system, adding three stabilizers, namely dimethyl sulfoxide (DMSO), 4-phenylbutyric acid (4-PBA) and tetramethylurea (TMU), into a fermentation culture medium in a combined manner. According to the method, the yield of the complete recombinant human II type full-length collagen is remarkably improved, and compared with the sum of target protein yield improvement effects of independently using the three stabilizers, the combined use of the three stabilizers achieves a synergistic target protein yield improvement effect. The method also has the advantages of simple process, low cost, no need of gene modification and easiness in large-scale production.

The present invention provides a method for synthesizing 4-bromo-N-(2,6-dioxopiperidin-3-yl)-2-fluorobenzamide, which relates to the field of organic chemical synthesis technology and includes a one-step reaction. Specifically, it involves using 4-bromo-2-fluorobenzoic acid and 3-aminopiperidin-2,6-dione hydrochloride as raw materials, N,N-dimethylformamide as solvent, and adding triethylamine and 2-(7-azabenzotriazole)-N,N,N',N'-tetramethylurea hexafluorophosphate to obtain the target product 4-bromo-N-(2,6-dioxopiperidin-3-yl)-2-fluorobenzamide. The synthesis method of the present invention has a short process route, inexpensive and readily available raw materials and excipients, high reactivity, simple operation, easy control, and a high yield of the target product, which is convenient for industrial scale-up.

The invention discloses a method for in-situ labeling and synchronous promotion of extracellular vesicle secretion, and a preparation method of a glucose modified photosensitizer comprises the following steps: carrying out an amidation reaction on glucosamine, a photosensitizer, benzotriazole-N, N, N ', N'-tetramethylurea hexafluorophosphate, 4-(dimethylamino) pyridine and N, N-diisopropylethylamine in a solvent, cooling to room temperature, filtering, washing, and drying to obtain the glucose modified photosensitizer. According to the glucose-modified photosensitizer and the preparation method thereof disclosed by the invention, the glucose is modified by the photosensitizer to be loaded into the EV by utilizing the metabolic process of the glucose, so that the drug loading rate of a disease treatment drug can be improved while the integrity of an EV membrane is maintained; and negative side effects of physical or chemical intervention are avoided, so that the functional EV with higher purity is obtained.

The application provides a coumarin derivative and a preparation method thereof, which comprises the following steps: dissolving coumarin, N,N-diisopropylethylamine and O-benzotriazole-tetramethyl urea hexafluorophosphate in N,N-dimethylformamide to react, then adding amino-functionalized polyethylene glycol, after reaction, separating by column chromatography to obtain an intermediate product; mixing the intermediate product with DL-pyroglutamic acid, adding N,N-diisopropylethylamine and O-benzotriazole-tetramethyl urea hexafluorophosphate to react, and separating by column chromatography to obtain the coumarin derivative. The application also provides an application for preparing an anti-prostate cancer drug or an endothelin receptor A antagonistic drug. The coumarin derivative of the application can significantly inhibit the proliferation of prostate cancer cells LNCaP, can significantly inhibit the expression of endothelin receptor A in tumor tissues under a dosing amount of 20 mg / kg, and can obviously reduce the expression level of prostate specific antigen in serum when combined with docetaxel, so as to play an anti-tumor proliferation role.

The application discloses a preparation method of a bile acid-norfloxacin compound, which comprises the following steps: reacting bile acid and norfloxacin in the presence of 2-(7-azobenzotriazole)-N,N,N',N'-tetramethyluronium hexafluorophosphate and diisopropylethylamine in THF solvent at 10-30 DEG C for 12-30 h, and then carrying out post-treatment to obtain the bile acid-norfloxacin compound. The bile acid-norfloxacin compound is obtained by condensation reaction between the carboxyl group of the bile acid and the piperazine group of the norfloxacin, and the compound structure is combined with the bile acid and the norfloxacin. The antibacterial activity of the norfloxacin is obviously improved, the norfloxacin has better inhibition effect on Escherichia coli, Helicobacter pylori and the like, and also has better inhibition effect on Pseudomonas aeruginosa, Staphylococcus aureus and Pneumococcus, and meanwhile, the preparation operation process is simple.

The invention provides a safety starting working system in a tetramethylurea production process, which comprises the following steps that: after a cloud platform receives safety transmission information sent by an rfid card reader, the cloud platform sends a user code to an intelligent mobile handheld terminal; after the cloud platform obtains the secure transmission information, the method for obtaining the user code according to the secure transmission information comprises the following steps: S31, converting the received secure transmission information into a decimal numerical value; s32, converting the decimal cloud platform security transmission information into security transmission information with the same system as the security transmission information; s33, converting the secure transmission information of the cloud platform into a two-dimensional code image; sequentially extracting numerical values from left to right and from top to bottom according to the color of each grid in the two-dimensional code image to obtain a 0-1 character string; s34, converting the 0-1 character string into a d ''system character string; and S35, sending the user code to the intelligent mobile handheld terminal.

The application belongs to the technical field of organic synthesis, and specifically provides a 2-(4,6-dimethoxy-1,3,5-triazin-2-yl)-1,1,3,3-tetramethylurea hexafluorophosphate, a preparation method and a condensation reagent. The preparation method of the 2-(4,6-dimethoxy-1,3,5-triazin-2-yl)-1,1,3,3-tetramethylurea hexafluorophosphate comprises: making 2-chloro-4,6-dimethoxy-1,3,5-triazine and tetramethylurea undergo a nucleophilic substitution reaction to generate an intermediate; and making the intermediate and potassium hexafluorophosphate undergo an ion exchange reaction to generate the 2-(4,6-dimethoxy-1,3,5-triazin-2-yl)-1,1,3,3-tetramethylurea hexafluorophosphate. The 2-(4,6-dimethoxy-1,3,5-triazin-2-yl)-1,1,3,3-tetramethylurea hexafluorophosphate according to the embodiment of the application can be used as a condensation reagent for forming an amide bond, and compared with condensation reagents such as HBTU and HATU which have two high-energy heteroatomic bonds of N-N and N-O, the thermal hazard of the 2-(4,6-dimethoxy-1,3,5-triazin-2-yl)-1,1,3,3-tetramethylurea hexafluorophosphate is smaller, and the 2-(4,6-dimethoxy-1,3,5-triazin-2-yl)-1,1,3,3-tetramethylurea hexafluorophosphate is suitable for industrial production. In addition, the preparation method according to the embodiment of the application has mild reaction, fewer reaction steps and low operation risk coefficient.

The invention discloses a preparation method and application of sesamin targeted carrying nanoparticles, and the preparation method comprises the following steps: reacting ketal thiol TK, 2-succinimido-1, 1, 3, 3-tetramethylurea tetrafluoroborate, N, N-diisopropylethylamine and iramitide SS-31 peptide to prepare an SS31 peptide-TK compound, then reacting with chitosan, and simultaneously preparing a sodium alginate-lactobionic acid compound, so as to obtain the sesamin targeted carrying nanoparticles. Finally, mixing the two solutions to obtain a covalent complex; the method comprises the following steps: baking pork slices, extracting with ethanol, filtering, carrying out rotary evaporation, extracting, dialyzing and purifying, and freeze-drying; and mixing the products of the first two steps, dissolving in ethanol, adding sesamin, and carrying out electrostatic self-assembly and freeze drying to obtain the visual sesamin targeted nanoparticles. According to the invention, specific positioning of liver mitochondria, ROS stimulation response intelligent drug release and real-time visualization of food-borne fluorescence labeling are realized, and the application prospect in prevention and treatment of liver diseases is wide.

The application belongs to the technical field of magnesium ion batteries, and discloses a kind of aqueous magnesium ion battery electrolyte and its preparation method and application, the mixed electrolyte for aqueous magnesium ion battery is composed of magnesium salt, organic solvent and deionized water;Wherein, the organic solvent is tetramethyl urea (TMU), and tetramethyl urea and deionized water jointly constitute the mixed solvent of the mixed electrolyte, and the volume percentage of tetramethyl urea in the mixed solvent is 10%~50%, and the volume percentage of deionized water is 90%~50%;Magnesium salt is dissolved in the mixed solvent.The application improves the components of electrolyte, the mixed electrolyte with TMU as cosolvent and accurate control of TMU volume fraction, solves the problem of narrow electrochemical stability window (ESW) of aqueous magnesium ion battery, serious interface side reaction leads to the poor cycle life, and the electrolyte has the advantages of simple preparation, environmental friendliness and low cost, which provides a new way for improving the energy density and cycle life of aqueous magnesium ion battery.

The invention belongs to the technical field of organic synthesis, and particularly provides 2-(4, 6-dimethoxy-1, 3, 5-triazine-2-yl)-1, 1, 3, 3-tetramethylurea hexafluorophosphate, a preparation method and a condensation reagent. The preparation method of the 2-(4, 6-dimethoxy-1, 3, 5-triazine-2-yl)-1, 1, 3, 3-tetramethylurea hexafluorophosphate comprises the following steps: carrying out nucleophilic substitution reaction on 2-chloro-4, 6-dimethoxy-1, 3, 5-triazine and tetramethylurea to generate an intermediate; and carrying out ion exchange reaction on the intermediate and potassium hexafluorophosphate to generate 2-(4, 6-dimethoxy-1, 3, 5-triazine-2-yl)-1, 1, 3, 3-tetramethylurea hexafluorophosphate. The 2-(4, 6-dimethoxy-1, 3, 5-triazine-2-yl)-1, 1, 3, 3-tetramethylurea hexafluorophosphate provided by the embodiment of the invention can be used as a condensation reagent for forming an amido bond, and compared with condensation reagents with two high-energy heteroatom bonds of N-N and N-O, such as HBTU and HATU, the 2-(4, 6-dimethoxy-1, 3, 5-triazine-2-yl)-1, 1, 3, 3-tetramethylurea hexafluorophosphate is smaller in heat hazard and suitable for industrial production. In addition, according to the preparation method of the embodiment of the invention, the reaction is mild, the reaction steps are few, and the operation danger coefficient is low.