Flexible conductive antibacterial material and preparation method thereof

Abstract

The invention discloses a flexible conductive antibacterial material and a preparation method thereof and belongs to the field of flexible biological electronic materials. The flexible conductive antibacterial material is used for solving the problems in the prior art that a whole wound is difficult to stimulate by using a hard electrode, and ES therapy lacks the capacity of controlling infection. According to the invention, polyaniline-sulfonic acid hyaluronic acid (SHA) hydrogel is prepared. Under a weakly alkaline physiological condition, SHA in a hydrogel network can be doped with polyaniline in situ and maintain the conductivity of the polyaniline, and the doped PANI has positive charges and has relatively high antibacterial activity on gram-positive bacteria. In addition, exogenous ES can be used for enhancing the antibacterial activity of the hydrogel. The hydrogel prepared by the invention can be used for completely covering the wound and has conductivity similar to that of human tissue, good biocompatibility and antibacterial property, and can be used for preparing products such as flexible conductive dressings.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a flexible conductive antibacterial material and a preparation method thereof. Background technique [0002] Wounds that do not heal within 3 months may deteriorate into chronic wounds, seriously threatening human health. Chronic wounds include diabetic foot ulcers, venous leg ulcers, and pressure ulcers. With an aging population, weight gain, and increasing complications secondary to diabetes, venous insufficiency, and other diseases, the number of chronic wound patients has increased significantly. It is estimated that about 1% of people will develop a leg ulcer during their lifetime. In the United States alone, there are 3 to 6 million chronic wound patients every year, and the cost of treating these wounds is nearly 5 to 10 billion US dollars. In China, according to the results of epidemiological studies, the rate of chronic wounds in surgical inpatients is ...

AI Technical Summary

Problems solved by technology

[0007] Aiming at the problems in the prior art that it is difficult to stimulate the whole wound with hard electrodes, and ES therapy lacks the ability to control infection, the present invention provides a flexible conductive antibacterial material and Its preparation method, its purpose is to:

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