6results about How to "Simple synthesis path" patented technology

The invention relates to a synthesis method and application of a double-layer thermochromic deformation hydrogel, according to the double-layer thermochromic deformation hydrogel, CMC is adopted to perform mechanical enhancement on original PNIPAm, LAP is adopted to perform photo-initiation on a monomer, and the price of CMC and LAP is far lower than that of functionalized silicon dioxide nanoparticles and AIBA in the prior art under the same usage amount. Meanwhile, drugs used in the process are free of volatility and corrosivity, and the safety degree is higher than that of acrylic monomers used in the prior art. Besides, the use temperature of a hydrogel device in the prior art is 60 DEG C and is high, while the double-layer temperature-sensitive hydrogel in the invention can be curled only at 40 DEG C, so that the hydrogel has more advantages in temperature. By adding CMC, the volume change of the hydrogel in the heating process is remarkably reduced, meanwhile, the mechanical property of the hydrogel is greatly improved, the mechanical property of the hydrogel is further improved through impregnation of zirconium ions, and the hydrogel has a wider application scene.

The invention relates to a high-strength antibacterial spandex fabric and a preparation method thereof, and belongs to the technical field of functional textile materials. The spandex fiber comprises a spandex fiber matrix and a functional polymer layer grafted on the surface of the matrix through a covalent bond, and the functional polymer layer is a polymer of an unsaturated derivative of natural phenolic acid and is prepared by introducing carbon-carbon unsaturated bond groups such as acryloyloxy and the like into the natural phenolic acid through esterification or etherification. During preparation, the spandex fiber is subjected to plasma pretreatment, and then the spandex fiber and the natural phenolic acid-containing unsaturated derivative monomer are subjected to thermal initiation or photo-initiation graft polymerization to form the functional layer. The lasting and stable antibacterial function is achieved through covalent bond grafting, the natural phenolic acid derivative endows the fiber with the environment-friendly and non-dissolution type antibacterial property, the functional layer can improve the modulus and breaking strength of the fiber, the intrinsic elasticity of spandex is considered, the comfortable fitting characteristic of the composite fabric is reserved, and the composite fabric is endowed with the high strength and the antibacterial function.

This invention provides an endoplasmic reticulum-targeted single-chain cyclic poly(β-amino ester), its preparation method, and its applications. The structural formula of the endoplasmic reticulum-targeted single-chain cyclic poly(β-amino ester) is as follows. The endoplasmic reticulum-targeted single-chain cyclic poly(β-amino ester) exhibits excellent affinity for DNA, and the complex nanoparticles formed with DNA are uniformly distributed, stable, biodegradable, and biocompatible. The endoplasmic reticulum-targeted single-chain cyclic poly(β-amino ester) and DNA can be efficiently taken up by cells, exhibiting excellent endoplasmic reticulum targeting performance. It can overcome the limitations of gene retention in lysosomes and nuclear internalization of the complex nanoparticles, enabling efficient delivery of DNA and mRNA.

The present application relates to the technical field of synthetic biology, in particular to a novel taxane acetyl hydrolase, nucleic acid molecule, biological material and application thereof. The acetyl hydrolase comprises at least one of the following sequences: the amino acid sequence of the enzyme shown in SEQ ID NO. 1, SEQ ID NO. 9, SEQ ID NO. 16, SEQ ID NO. 19, SEQ ID NO. 21, SEQ ID NO. 24 or a protein with the same function obtained by substitution and / or deletion and / or addition. The above-mentioned biological enzyme has stronger site selectivity and more controllable product spectrum, has clear regional selectivity for taxane acetyl hydrolysis, can reduce excessive hydrolysis and by-products caused by chemical hydrolysis or non-specific esterase, and has important value for green manufacturing application of taxane.

This invention provides a method for preparing a three-dimensional textured macroporous carbon composite with adjustable carbon shell morphology, comprising the following steps: S1, dispersing a phenolic prepolymer in a solvent to prepare a phenolic prepolymer slurry; S2, adding graphene oxide to the prepared phenolic prepolymer slurry, mixing well, and preparing a carbon precursor spraying liquid; S3, spraying the prepared carbon precursor spraying liquid onto a planar fiber carrier to obtain a carbon precursor carrier composite; S4, heat-treating the carbon precursor carrier composite to obtain three-dimensional hollow porous carbon. This invention uses planar fiber materials as the reaction site, eliminating the need for other templates, and uses graphene oxide as the key component of the carbon precursor. Combining the advantages of continuous operation technology such as ultrasonic dispersion and atomized spraying, the carbon precursor is composited on the surface and interior of the carrier. After heat treatment, three-dimensional hollow porous carbon is prepared. The morphology of the carbon shell composited on the three-dimensional textured macroporous carbon framework can be controlled simply by adjusting the content of the key components in the carbon precursor.

The invention provides a nano-composite with a function of recovering HMGB1 stimulating activity by removing active oxygen and a preparation method and application of the nano-composite, and the nano-composite can recover the stimulating activity of high mobility protein 1 (HMGB1) and maintain the function of T cells by removing excessive active oxygen after cold-heat composite ablation operation, so that the preparation method and application of the nano-composite can be used for preparing the high mobility protein 1 (HMGB1). The nano drug-loading platform for promoting smooth proceeding of immune death of tumor cells is prepared by wrapping an immunologic adjuvant with a drug-loading molecule R1P or R1PR2 through a nano coprecipitation method, and the R1PR2 drug-loading molecule has a fluorescence imaging function at the same time. The invention provides a method for preparing the drug-loading molecule and the nano drug-loading platform, and an application of the drug-loading molecule and the nano drug-loading platform in tumor treatment. The polythioether group in the drug-loading molecule can relieve the oxidative stress environment of the microenvironment, can change the configuration at a fixed point in the presence of active oxygen, and has the active oxygen response capability.