8results about How to "Expanded indications" patented technology

The invention relates to the field of biological medicine, in particular to application of demethyleneberberine in preparation of medicine for preventing or treating gout. In-vitro experiments show that the demethyleneberberine hydrochloride can inhibit RAW264.7 cell inflammation caused by monosodium urate crystals; in-vitro experiments show that the traditional Chinese medicine composition can relieve rat gout-like symptoms induced by MSU and relieve hyperuricemia induced by oteracil potassium combined with hypoxanthine. The result shows that the demethyleneberberine hydrochloride (DMB) can inhibit gout induced by monosodium urate crystals in the aspects of resisting inflammation and regulating uric acid metabolism, and the application range of the demethyleneberberine hydrochloride is widened.

According to the open endoscope, the design scheme that the main body and the endoscope body are of the bent connecting structure is provided, so that a good and wide visual field is provided for a doctor in a pipeline of a working sleeve, and meanwhile, the occupied hand operation space is effectively reduced; therefore, the purposes of improving operation flexibility, reducing work intensity of doctors and improving operation efficiency are achieved. The open endoscope comprises an endoscope body and a main body which are connected with each other, internal pipelines of the endoscope body and the main body are communicated, and an included angle of 80-100 degrees is formed at the joint of the endoscope body and the main body.

The invention discloses a brand-new synthesis method of a pyrrolidine structural unit compound, high-yield and high-selectivity synthesis is realized by utilizing an efficient cross-coupling reaction of a Ni catalyst and a 1, 6-diene compound, the method takes the diene compound as a raw material, and through a simple cyclization reaction, the pyrrolidine structural unit compound is obtained. The pyrrolidine structural unit compound can be obtained in one step under mild conditions. Compared with a traditional synthesis method, the method has the advantages of simple steps, high yield, cheap and easily available raw materials, environmental friendliness and the like; by adjusting the structural formula of the diene compound, multiple pyrrolidine structural unit compounds with different substituent groups can be synthesized, and the compounds have wide application potential in multiple fields of drug research and development, pesticide manufacturing, material science and the like; the synthesis method provided by the invention not only simplifies tedious steps of a traditional synthesis method, but also greatly reduces the production cost, provides powerful support for large-scale production of pyrrolidine compounds, and provides an important raw material source for development of heterocyclic drug molecules.

The application discloses a new application of SCH772984 in treating SPSB1 high-expression tumors. It is found for the first time that SCH772984 can be used as an SPSB1 inhibitor and has a therapeutic effect on SPSB1 high-expression diseases such as tumors and infectious diseases, and has a wide clinical application prospect.

The utility model provides an aorta covered stent for implementing in-situ fenestration in an intracavitary repair process, which comprises a stent and a covering membrane, the stent comprises a plurality of wave rings, the plurality of wave rings are arranged at intervals along the length direction of the stent, and the covering membrane is arranged at intervals along the length direction of the stent. The device is divided into a bare section, a reinforcing section, a membrane rupturing section and a supporting section from the near end to the far end, and the density of the membrane rupturing section, the density of the supporting section and the density of the reinforcing section are gradually increased. The membrane comprises a membrane body and a marker which are connected, the membrane body wraps the reinforcing section, the membrane breaking section and the supporting section in the circumferential direction of the stent, the marker is arranged between the membrane breaking section and the reinforcing section, the marker is arranged between the membrane breaking section and the supporting section, the membrane is easy to break, in-situ windowing is achieved, and meanwhile after the membrane is broken, the other parts are stable in structure.

The present application relates to the technical field of bioengineering, and particularly relates to a fermented liquid of Gomphrena yatschekii, a fermentation method and application thereof.The present application provides a fermentation method of Gomphrena yatschekii, comprising the following steps: (1) mixing Gomphrena yatschekii with mixed enzymes for enzymolysis, and sterilizing to obtain an enzymolysis liquid of Gomphrena yatschekii; (2) mixing the enzymolysis liquid of Gomphrena yatschekii with a compound microbial agent for fermentation, and filtering and sterilizing after fermentation to obtain a fermented liquid of Gomphrena yatschekii; the compound microbial agent is Lactobacillus plantarum LZU-J-TSL6 and Lactobacillus plantarum LZU-J-QA25.After fermentation by the method, the effective components in Gomphrena yatschekii are fully dissolved, the drug activity is improved and increased, the body can rapidly absorb the drug, inflammation and oxidative stress can be regulated, and gastric ulcer can be resisted.

The present invention discloses an adaptive transcranial electrical stimulation method and system, and relates to the technical field of transcranial electrical stimulation equipment. The method and system acquire the EEG data of the subject and transmit it to a brain activity analysis module to calculate the real-time EEG index and judge whether the EEG is abnormal, and record the abnormal target, the number N of abnormal frequency segments and the abnormal frequency segment; in the target selection module, the stimulation target is adaptively determined based on the abnormal target and the number N of abnormal frequency segments; in the stimulation waveform generation module, an adaptive stimulation waveform is generated based on the abnormal target, the number N of abnormal frequency segments and the abnormal frequency segment; in the stimulation generation device, continuous electrical stimulation is achieved based on the stimulation target and the stimulation waveform until the abnormality disappears. The transcranial electrical stimulation method and system can automatically select a suitable stimulation target in real time according to the brain activity state, and at the same time, can modify the stimulation waveform, frequency, duration, amplitude and other parameters in real time according to the brain activity state to adapt to various different diseases.

The utility model discloses a snore preventing belt which comprises a main body, a nostril penetrating hole is formed in the main body, symmetrical side pockets are arranged on the two sides of the nostril penetrating hole, a hard handle rod and a hard handle spoon are inserted into the side pockets in a sleeved mode, the hard handle rod and the hard handle spoon are connected through rotating shafts, and the rotating shafts on the two sides are connected through an inter-shaft belt. A chin strap inclining towards the middle is arranged on the lower side of the side pocket, symmetrical top straps inclining outwards are arranged at the two ends of the upper side of the body, and the head is wound through the two top straps. Symmetrical necklace bodies are arranged at the two ends of the lower side of the main body in an outwards inclined mode, and the neck is surrounded through the necklace bodies on the two sides. The utility model provides an externally-applied snore-preventing belt which is characterized in that the tongue body and the tongue root are driven to move forwards by pushing the lower jawbone forwards, so that the posterior lingual space is increased, the blockage of the lingual pharynx plane and part of the palatopharynx plane is improved, and the treatment purpose of OSA is finally achieved. The utility model provides an important method for treating simple snoring and tongue pharynx plane obstruction, and is parallel to the treatment of surgical treatment, breathing machine wearing and the like.