Material for flexible biological electronic device, and preparation method thereof

An electronic device and biological technology, applied in the field of flexible bioelectronic device materials and its preparation, can solve problems such as applications that are not suitable for long-term contact with the human body, complex chemical reactions, expensive raw materials, etc., to achieve enhanced mechanical properties, enhanced antibacterial properties, The effect of high elongation

Active Publication Date: 2020-09-15
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some progress has been made in the development of such materials, but major limitations include complex chemical reactions and expensive raw materials
Great challenges remain to create robust, conductive, self-healing antimicrobial hydrogels with deformation and temperature sensitivity using conventional polymers
In addition, flexible bioelectronic devices often need long-term contact with the human body, so they need to have long-term antibacterial properties, but in order to obtain the antibacterial properties of materials, it is usually used to incorporate Ag + , while Ag + Cytotoxic and not suitable for applications involving long-term human exposure

Method used

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  • Material for flexible biological electronic device, and preparation method thereof
  • Material for flexible biological electronic device, and preparation method thereof
  • Material for flexible biological electronic device, and preparation method thereof

Examples

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Embodiment 1

[0048] A preferred embodiment of the present invention provides a method for preparing a Zn-CS antibacterial complex, the specific steps are as follows:

[0049] Dissolve CS in aqueous acetic acid solution and dissolve ZnSO 4 Added CS to acetic acid solution at a Zn:CS ratio of 0.25; after adjusting the pH to 7.0 with ammonium hydroxide solution, the mixture was vigorously stirred at 80 °C for 3 h, then poured into acetone to precipitate Zn-CS Antibacterial complex.

Embodiment 2

[0051] A preferred embodiment of the present invention provides a method for preparing a Zn-CS antibacterial complex, the specific steps are as follows:

[0052] Dissolve CS in aqueous acetic acid solution and dissolve ZnSO 4 Added CS to an acetic acid solution at a ratio of Zn:CS of 0.5; after adjusting the pH to 7.0 with ammonium hydroxide solution, the mixture was vigorously stirred at 80 °C for 3 hours, and then poured into acetone to precipitate Zn-CS Antibacterial complex.

Embodiment 3

[0054] A preferred embodiment of the present invention provides a method for preparing a Zn-CS antibacterial complex, the specific steps are as follows:

[0055] Dissolve CS in aqueous acetic acid solution and dissolve ZnSO 4 According to the Zn:CS ratio of 0.75, CS was added to the acetic acid solution; after adjusting the pH value to 7.0 with ammonium hydroxide solution, the mixture was vigorously stirred at 80 °C for 3 hours, and then poured into acetone to precipitate Zn-CS Antibacterial complex.

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Abstract

The invention discloses a material for a flexible biological electronic device, and a preparation method thereof, and belongs to the field of flexible bioelectronic materials. A conductive polymer isintroduced into a chitosan main chain through a covalent bond to enhance the conductivity, Zn<2+> is connected to chitosan through a coordination bond to enhance the antibacterial property, and then functionalized chitosan and polyvinyl alcohol are subjected to dynamic multiple physical and chemical actions to form the material. These multiple dynamic interactions impart high stretchability and autonomous self-healing capability to the material, and the conductivity provided by the conductive polymer functionalized chitosan can provide a variety of sensing functions against strain and temperature. The prepared flexible temperature and stress sensor has flexible and autonomous self-repairing functions. The conductive dressing prepared by the invention not only can effectively promote chronic wound healing, but also can solve the problem that an antibacterial dressing needs to use Ag<+> with higher toxicity.

Description

technical field [0001] The invention belongs to the field of flexible bioelectronic materials, in particular to a material for flexible bioelectronic devices and a preparation method thereof. Background technique [0002] In recent years, flexible and wearable bioelectronic devices have developed rapidly, but few studies have been translated into commercial products. The main obstacle is that most of the currently developed flexible wearable bioelectronic devices cannot tolerate various mechanical shocks including high strain and are easily damaged. Traditional electronic materials, such as silicon and metal, are rigid and brittle, and have low deformation resistance. Electronic devices made of these hard materials are usually difficult to integrate with soft organisms, resulting in low signal-to-noise ratio and limited resistance to mechanical strain. The weak resistance severely limits their application in flexible bioelectronic devices. To build flexible bioelectronic d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L29/04C08L5/08C08L79/04C08K3/38A61L15/28A61L15/26A61L15/24A61L15/08A61L15/42A61L15/46A61L15/44G01D5/16
CPCA61L15/08A61L15/24A61L15/26A61L15/28A61L15/42A61L15/44A61L15/46A61L2300/102A61L2300/404C08K2003/387C08L29/04C08L2205/025C08L2205/035C08L2312/00G01D5/16C08L5/08C08L79/04C08K3/38
Inventor 张婕妤胡雪丰王云兵
Owner SICHUAN UNIV
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