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Method of formation of shape-retentive aggregates of gel particles and their uses

a gel particle and aggregate technology, applied in the field of shape-retentive aggregate formation of gel particles, can solve the problems of difficult control of particle dissemination to, inability to localize at, and inability to control the diffusion of particles to, currently available particulate gels, and achieve the effects of reducing the risk of fracture, and improving the stability of the gel particl

Inactive Publication Date: 2008-03-13
ULURU INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This method enables the formation of shape-retentive aggregates that conform to the application site, enhancing the controlled release of substances and improving the efficacy of biomedical applications by providing a stable, shape-retentive matrix for drug delivery and tissue repair.

Problems solved by technology

However, particulate gels have their problems.
For instance, it is difficult to control the dissemination of the particles to, and localization at, a selected target site.
Furthermore, while bulk hydrogels can be rendered shape-retentive, making them useful as biomaterials in a variety of medical applications, currently available particulate gels, cannot.

Method used

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  • Method of formation of shape-retentive aggregates of gel particles and their uses
  • Method of formation of shape-retentive aggregates of gel particles and their uses
  • Method of formation of shape-retentive aggregates of gel particles and their uses

Examples

Experimental program
Comparison scheme
Effect test

example 1

Hydrogel Particle Preparation using Tween 80 Surfactant

[0215] A stock solution of Tween 80 in Milli-Q H2O was prepared by dissolving 27 g of Tween (80) with 100 g of Milli-Q H2O. A stock solution of potassium persulfate was prepared by dissolving 2 g in 30 mL of Milli-Q H2O. A 1 L media bottle was equipped with a stir bar and charged with 1.74 g HEMA containing 3.6 mg ethylene glycol dimethacrylate, 1.07 g of the Tween 80 stock solution, 571 mL of N2 purged Milli-Q H2O, and 0.952 mL of the potassium persulfate stock solution. The solution was stirred until all of the solids dissolved. The bottle was covered with foil and immersed in a 65° C. bath for 16 hours. The resulting suspension of hydrogel particles had a milky-white to opaque blue opalescence and the particles were found to have an average diameter of 466 nm by dynamic light scattering. The suspension was concentrated and purified by tangential flow filtration and was found to be stable against flocculation at a wet weight ...

example 2

Hydrogel Particle Preparation Using Dioctyl Sodium Succinate Surfactant

[0216] A 500 mL media bottle equipped with a stir bar was charged with 4.25 g HEMA monomer containing 8.8 mg ethylene glycol dimethacrylate, 290.18 mg dioctyl sodium succinate (DSS), 135 mg potassium persulfate, and 500 mL of N2-purged Milli-Q H2O. The bottle was capped and the solution was stirred for 3 hrs at room temperature. The bottle was transferred to a 50° C. water bath and incubated for 12 hrs. The resulting suspension of hydrogel particles had an opalescent blue color. The particles were analyzed by dynamic light scattering and found to have an average diameter of 241 nm. The suspension of particles contained 25 mg of hydrated polymer per mL of solution. The suspension was concentrated and purified using tangential flow filtration and was found to be stable against flocculation at a wet weight concentration approaching 150 mg / mL.

example 3

Hydrogel Particle Preparation Using Sodium Dodecyl Sulfate Surfactant

[0217] A 100 mL media bottle equipped with a stir bar was charged with 4.25 g HEMA monomer containing 8.8 mg ethylene glycol dimethacrylate, 267.91 mg sodium dodecyl sulfate (SDS), 135 mg potassium persulfate, and 500 mL of N2-purged Milli-Q H2O. The bottle was capped and the solution was stirred for 3 hrs at room temperature. The bottle was transferred to a 50° C. water bath and incubated for 12 hrs. The resulting suspension of hydrogel particles had an opalescent blue color. The particles were analyzed by dynamic light scattering and found to have an average diameter of 110 nm. The suspension of particles contained 78 mg of hydrated polymer per mL of solution. The suspension was concentrated and purified using tangential flow filtration and was found to be stable against flocculation at a wet weight concentration approaching 200 mg / mL.

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Abstract

The present invention relates to a method of forming shape-retentive aggregates of gel particles in which the aggregates are held together by non-covalent bond physical forces such as, without limitation, hydrophobic-hydrophilic interactions and hydrogen bonds. The method comprises introducing a suspension of gel particles in a polar liquid at a selected concentration, wherein the gel particles have an absolute zeta potential, into a medium in which the absolute zeta potential of the gel particles is decreased, resulting in the gel particles coalescing into the claimed shape-retentive aggregate. This invention also relates to uses of the method of formation of the shape-retentive aggregates of gel particles.

Description

[0001] This application is a continuation-in-part of U.S. patent application Ser. No. 10 / 289,756, filed Nov. 6, 2002, which is incorporated by reference, including all drawings, as if fully set forth herein.FIELD OF THE INVENTION [0002] This invention relates to the fields of organic chemistry, physical chemistry, polymer chemistry, pharmaceutical chemistry, medicine and material science. BACKGROUND OF THE INVENTION [0003] The discussion that follows is provided as background to aid the reader in understanding the present invention and is not intended, nor is it to be construed, as being prior art to the invention. [0004] A gel is a three-dimensional polymeric network that has absorbed a liquid to form a stable, usually soft and pliable, composition having a non-zero shear modulus. When the liquid absorbed by a gel is water, the gel is called a hydrogel. Water may comprise a significant weight percent of a hydrogel. This, plus the fact that many hydrogel-forming polymers are biologi...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/14A61K47/00A61K9/51A61K47/10A61K47/14A61K47/32A61L27/52A61L27/54C08L33/14C08L71/00
CPCA61K9/0024A61K9/1635C08L2312/00A61K9/5138A61K9/5192A61L27/52A61L27/54A61L27/58A61L2300/252A61L2300/406A61L2300/414A61L2300/416A61L2300/442A61L2300/602C08L33/14C08L71/00C08L2666/16A61P11/00A61P27/02A61P31/00A61P35/00A61P9/00A61K9/14A61K47/14A61K47/32
Inventor MORO, DANIEL G.ST. JOHN, JOHN V.SHANNON, KEVIN F.PONDER, BILL C.
Owner ULURU INC
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