7results about How to "Infection control" patented technology

The invention relates to the field of biological medicine, in particular to a recombinant herpes zoster vaccine composition and a preparation method thereof. The recombinant herpes zoster vaccine composition comprises gE protein and an adjuvant, the adjuvant is a squalene oil-in-water adjuvant, and the squalene oil-in-water adjuvant comprises the following components by concentration: 4-5wt% of squalene, 1-5wt% of gE protein, 1-5wt% of gE protein, 1-5wt% of gE protein, 1-5wt% of gE protein, and the balance of water. 0.2 to 0.8 wt% of Tween 80; and 0.2 to 0.8 wt% of Span 85. The vaccine composition disclosed by the invention can specifically enhance cellular immune response aiming at the varicella-zoster virus, can remarkably improve expression of cytokines such as INF-gamma and IL-2 of CD4 + T cells of mice, improves the immune response level of body fluid and cells at the same time, shows high immunocompetence for preventing clinical varicella-zoster virus infection, and has good clinical application prospects. And the components in the vaccine composition are cheap and easy to obtain, so that the vaccine yield is effectively improved, and the vaccine cost is reduced.

The invention discloses preparation and application of a space-time cascade wound dressing, relates to the technical field of biomedical materials, and solves the problems of limited depth and poor treatment effect when a diabetes infected wound is treated in the prior art. The space-time cascade wound dressing is composed of a hydrogel patch and a soluble microneedle array. The hydrogel patch comprises polyvinyl alcohol, sodium alginate, nano-enzyme, a color reagent for indicating pH and the like, has the functions of oxidation resistance and sterilization, and can monitor the state of the wound surface in real time according to the pH change indication of the wound surface; the soluble microneedle array comprises a soluble polymer and glucose oxidase, and has the functions of deep sterilization and local blood glucose reduction. According to the space-time cascade wound dressing provided by the invention, two treatment forms of the hydrogel patch and the soluble microneedle array are integrated, and a nano enzyme and a natural enzyme catalytic system capable of generating cascade catalytic reaction are respectively introduced into the hydrogel patch and the soluble microneedle array, so that a multifunctional treatment system with a space-time cascade catalytic effect is formed; and comprehensive treatment and real-time monitoring of multi-layer wound surfaces are realized.

The invention belongs to the field of medical instruments, and discloses a medical silica gel dressing fixing adhesive tape which comprises an adhesive tape body, and the adhesive tape body sequentially comprises a carrier layer, a silica gel adhesive layer and a stripping liner from outside to inside; the carrier layer is made of an elastic breathable material, and the silica gel adhesive layer is made of medical-grade organic silica gel; a plurality of first microcapsules are dispersed in the silica gel adhesive layer, the first microcapsules are drug-loaded microcapsules, and wall materials of the drug-loaded microcapsules are made of materials responding to the pH value, enzyme concentration or temperature change of a wound environment. Enzyme or ions are released after the second microcapsule is broken, the wall material of the first microcapsule is actively degraded, cascade response of'exudate increase-developing prompt-drug accelerated release 'is realized, a large amount of drugs are quickly released when the exudate appears, and infection or inflammation is effectively controlled.

The invention discloses application of morin, and relates to the technical field of bacterial quorum sensing inhibition. The invention discloses application of morin in preparation of a medicine for reducing enterotoxigenic escherichia coli quorum sensing. Quorum sensing of enterotoxigenic escherichia coli can be reduced by using 5.0 mg / mL of Morrin, so that secretion of virulence factors of the enterotoxigenic escherichia coli is reduced. In the Escherichia coli treated by the Morin, the Morin has no obvious inhibition effect on the growth of the Escherichia coli, and the abundance of an autoinducer 2 (AI-2) and a quorum sensing related gene is obviously reduced, so that the toxicity and the adhesion capability of the Escherichia coli are reduced. The method for reducing enterotoxigenic Escherichia coli quorum sensing provided by the invention is beneficial to replacing traditional antibiotic in-vivo treatment and assists in resisting bacterial infection.

The application discloses synthesis of a novel Schiff base gold (III) compound and antibacterial application thereof, and belongs to the technical field of medicine preparation; gold sodium aurothiomalate has significant antibacterial activity, but the Au-S bond thereof is easily broken by intracellular reducing thiol, and the gold sodium aurothiomalate is metabolized before reaching a target point to produce toxic side effects; based on the gold sodium aurothiomalate, developing a gold compound with stronger stability is one of strategies for overcoming drug-resistant bacteria; the Schiff base itself has antibacterial activity, and after being combined with gold (III) ions, the Schiff base can stabilize gold atoms and improve the activity of the gold atoms; in vitro antibacterial activity shows that Au6 and Au13 have significant antibacterial advantages on carbapenem and polymyxin-resistant Klebsiella pneumoniae, the minimum inhibitory concentration (MIC) is 10 micromoles, and the antibacterial activity is at least 16 times higher than that of the gold sodium aurothiomalate; in vivo antibacterial activity experiments prove that Au6 and Au13 can reduce mouse skin infection and promote wound healing, and can prolong the survival time of abdominal infection mice, and have important practical application value.

The embodiment of the present invention discloses a real-time fluorescent primer probe group and a detection kit and application of fetal Tritrichomonas fetus from cats. The primer probe group for detecting fetal Tritrichomonas fetus from cats is characterized in that it comprises a primer pair and a probe, wherein the primer pair is composed of a single-stranded DNA shown in SEQ ID No.1 and a single-stranded DNA shown in SEQ ID No.2; and the probe is a single-stranded DNA shown in SEQ ID No.3. The real-time fluorescent quantitative PCR detection kit for fetal Tritrichomonas fetus prepared by the primer probe group of the present invention has a simple and fast detection method, good repeatability, high sensitivity, strong specificity, and can realize the detection of large-throughput samples, and can perform rapid and highly sensitive real-time fluorescent quantitative PCR detection of fetal Tritrichomonas fetus from cats.