The invention discloses a negative-pressure comprehensive therapeutic device for wound surfaces. The negative-pressure comprehensive therapeutic device comprises medical dressing, a medical transparent adhesion film, a drainage sucker, a negative-pressure drainage system, a nutrition providing system, an oxygen supply system, an ozone system and a main circuit board. The medical dressing can cover the tissue of the wound surfaces of human bodies, the medical transparent adhesion film covers the medical dressing and is used for closing wound surface regions, the drainage sucker is arranged at an opening in the upper surface of the medical transparent adhesion film, the negative-pressure drainage system is connected with the liquid outlet of the drainage sucker by a drainage tube, the nutrition providing system, the oxygen supply system and the ozone system are respectively connected with the joint input port of the drainage sucker by a joint delivery tube with a four-way connector, and the main circuit board is used for regulating and controlling the operations of the negative-pressure drainage system, the nutrition providing system and the oxygen supply system. The negative-pressure comprehensive therapeutic device is applicable to negative-pressure drainage therapy, oxygen therapy, ozone therapy and local nutritional therapy, capable of accelerating the healing of the wound surfaces, controlling infection, reducing complications, promoting function recovery, shortening therapy time and lowering therapy cost, easy to operate and convenient to use.