145 results about "Nanoparticle Complex" patented technology

The invention discloses a large-scale preparation method of a transparent super-hydrophobic / super-amphiphobic coating. The method comprises the steps of ultrasonically dispersing nano particles into an alcohol-water mixed system and carrying out hydrolysis and condensation reaction on the nano particles and fluoride-free or fluorine-containing organosilane under the acid or alkali catalysis action to prepare a transparent suspension liquid of a fluoride-free or fluorine-containing organosilane polymer-nano particle compound; and applying the transparent suspension liquid of the compound on the surface of a substrate material through spraying or dip-coating to obtain the transparent super-hydrophobic / super-amphiphobic coating with good performance. Preparation of the transparent super-hydrophobic / super-amphiphobic coating of 10-100m<2> can be completed within an hour; large-scale preparation of the large-area transparent super-hydrophobic / super-amphiphobic coating is achieved for the first time; the preparation method is low in cost and simple in process; and the prepared coating has excellent super-hydrophobic or super-amphiphobic property, relatively good mechanical stability, chemical stability and environment stability, and has a wide application prospect.

The invention discloses a preparation method of a water-based super-hydrophobic or super-amphiphobic coating. Nano-particles are ultrasonically dispersed into water, the pH of the solution is adjusted to obtain a nano-particle dispersion; The silane coupling agent is hydrolyzed under stirring to obtain an organosilane polymer / nanoparticle composite suspension; and then applied to the surface of the base material by spraying or dipping to obtain a water-based superhydrophobic / superamphiphobic coating. The present invention successfully prepares a water-based super-hydrophobic or super-amphiphobic coating with excellent performance without using any additives (organic solvent, surfactant and water-based solvent), and has many advantages such as water-based environmental protection, low price and excellent performance. , It has broader application prospects in the fields of self-cleaning surface, anti-corrosion coating, oil pollution prevention and oil transportation.

It is provided a Near Infrared Sensitive (NIR-sensitive) nanoparticle complex comprising a NIR-sensitive nanoparticle and surfactant(s) adsorbed on the nanoparticle, wherein the surfactant is at least one surfactant selected from: wherein X=1-9; Y=0-9; n=0-9; Z=1-9; W=0-9; m=0-9; each of R1, R2, R3 and R4, if present, is H, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 aryl, HS, COOH, NH2 or OH; R5 is COOH, NH2 or OH; with the proviso that n+m is <10; (b) an amino acid having the structure in (a), wherein X=1; Y=2; Z=1; W=1; R1, R2 and R4 are not present; R3 is NH2; and R5 is COOH; or (c) a peptide, wherein the peptide comprise at least one amino acid (b). Further, it is provided a NIR-sensitive nanoparticle complex(es) having biomolecule(s), for example drug(s), loaded on the surfactant(s).

The present invention relates to coatings that possess a dynamic contact angle hysteresis in water, measured by means of a Wilhelmy balance according to DIN EN 14370, of at most 15°, and are can be manufactured from star-shaped prepolymers and / or star-shaped prepolymer-nanoparticle complexes that are cross-linkable with one another and with the surface of the substrate to be coated, the star-shaped prepolymers and / or star-shaped prepolymer-nanoparticle complexes possessing, before being cross-linked, at least three hydrophilic polymer arms that, considered of themselves, are soluble in water, and that carry on all or on some of their free ends R1 silyl terminal groups of the following general formula (I): R1 is —CRa2—Si(ORb)r(Rc)3-r, where Ra denotes hydrogen or a linear or branched alkyl group having 1 to 6 carbon atoms, ORb denotes a hydrolyzable group, Rc denotes a linear or branched alkyl group having 1 to 6 carbon atoms, and r denotes a number from 1 to 3, and that carry, on the optionally present ends not carrying silyl terminal groups, reactive groups that are reactive with respect to themselves, the substrate to be coated, entities optionally introduced into the coating, and / or with the silyl terminal groups. The present invention furthermore relates to a method for manufacturing such coatings, and to star-shaped prepolymers that are used in the coatings. The invention moreover relates to use of the star-shaped prepolymers as additives to various agents for temporary or permanent anti-soiling finishing of surfaces.

Provided are a charge trap memory device including a substrate and a gate structure including a charge trapping layer formed of a composite of nanoparticles, and a method of manufacturing the charge trap memory device.

The invention discloses a nano particle compound and a preparation process thereof. The nano particle compound which is provided by the invention is formed by aquogel microsphere and inorganic nano particles, wherein the inorganic nano particles are jogged in the aquogel microsphere, the aquogel microsphere is isopropyl acrylamide and acroleic acid copolymer aquogel microsphere. The preparation process of nano particle compound comprises following steps that firstly preparing isopropyl acrylamide and acroleic acid copolymer aquogel microsphere, and dispersing aquogel microsphere into water, and dispersing inorganic nano particles into water, secondly mixing two kinds water solution which are obtained in first step, wherein the mass ratio of isopropyl acrylamide and acroleic acid copolymer aquogel microsphere and inorganic nano particle in mixing solution is 1:10-1:20, stirring mixing solution for 5-10 minutes under the conditions of temperature is 25-35 DEG C, and pH is 5-7, thereby obtaining nano particle compound.

The present invention relates to a graphene-nanoparticle composite having a structure in which nanoparticles are crystallized at a high density in a carbon-based material, for example, graphene, and, more particularly, to a graphene-nanoparticle composite capable of remarkably improving physical properties such as contact characteristics between basal planes of graphene and conductivity since nanoparticles are included as a large amount of 20 to 50% by weight, based on 100% by weight of graphene, and a method of preparing the same.

The present invention relates to a nitrogen-doped graphene-iron-based nanoparticle composite catalyst and a preparation method thereof, wherein the catalyst is a complex of nitrogen-doped graphene and iron-based nanoparticles (including metal iron and iron nitride). The main preparation process comprises: carrying out a reaction of a graphene oxide aqueous solution and a reducing agent (hydrazine hydrate or sodium borohydride) for 1 h under an oil bath to obtain reduced graphene oxide; mixing the reduced graphene oxide aqueous solution and an iron salt, completely stirring, and carrying out freezing drying to obtain a reduced graphene oxide-iron salt aerogel precursor; and carrying out a high temperature heat treatment under a mixed atmosphere of ammonia gas and an inert gas to obtain the nitrogen-doped graphene and iron-based nanoparticle complex. Compared with the commercial platinum-carbon catalyst, the composite non-precious metal catalyst of the present invention has advantages of simple preparation process, low cost, high oxygen reduction catalysis activity, good methanol tolerance and the like, and can be used for fuel cells, lithium-air batteries and other oxygen reduction catalysis reaction systems.

The present invention relates to a graphene-nanoparticle composite having a structure in which nanoparticles are crystallized in a carbon-based material, for example, graphene, at a high density, and, more particularly, to a graphene-nanoparticle composite capable of remarkably improving physical properties such as contact characteristics between basal planes of graphene and conductivity, wherein nanoparticles are included as a large amount of 30% by weight or more, based on 100% by weight of graphene, and crystallized nanoparticles have an average particle diameter of 200 nm or more, and a method of preparing the same.

The invention provides a protein-based carbon / magnetic Fe Co nanoparticle composite wave-absorbing agent and a preparation method and application thereof, and belongs to the technical field of wave-absorbing materials. The preparation method of the protein-based carbon / magnetic Fe Co nanoparticle composite wave-absorbing agent comprises the following steps: 1) mixing water, ferric chloride hexahydrate, ferrous chloride tetrahydrate and cobalt chloride hexahydrate, and reacting for 1-2 h at the temperature of 70-100 DEG C to prepare magnetic nanoparticles; 2) mixing the magnetic nanoparticles with egg white liquid, and curing to obtain a protein-magnetic nanoparticle compound; 3) carbonizing the protein-magnetic nanoparticle compound obtained in the step 2) to obtain the protein-based carbon / magnetic Fe Co nanoparticle composite wave-absorbing agent. The material prepared by using the composite wave-absorbing agent has strong wave-absorbing performance, meanwhile has the characteristicsof wide wave-absorbing frequency band, small matching thickness of an absorber and the like, and has a large application prospect in the field of wave-absorbing materials.

A fibronectin type III (FN3) domain-nanoparticle or direct conjugate complex containing a polynucleotide molecule, a toxin, polynucleotide molecule or other pharmaceutically active payload is obtained by panning an FN3 domain library with a protein or nucleotide of interest, recovering the FN3 domain and conjugating the FN3 domain with a toxin or nanoparticle containing an active polynucleotide, such as an ASO or siRNA molecule. A fibronectin type III (FN3) domain-nucleic acid conjugate is obtained by panning an FN3 domain library with a protein or nucleotide of interest, recovering the FN3 domain and conjugating the FN3 domain to a nucleic acid (e.g., ASO or siRNA). The nanoparticle complex, nucleic acid conjugate or FN3 domain toxin conjugate may be used in the treatment of diseases and conditions, for example, oncology or auto-immune indications.

The invention discloses a method for detecting oxytetracycline (OTC) in food by virtue of a functional magnetic bead separation-enzyme linked aptamer. The method is characterized by comprising the following steps: with a nucleic acid aptamer-magnetic nanoparticle composite probe, binding an OTC aptamer on the surface of a magnetic bead through direct competition between HRP-OTC and OTC in a sample, and detecting the change of a light absorption value through substrate chromogenic assay so as to quantitatively analyze the content of OTC in a sample. Compared with conventional enzyme-linked immuno sorbent assay (ELISA) and enzyme linked aptamer (ELAA), the method disclosed by the invention achieves the full combination of the rapid separation and enrichment effects of magnetic nano material, the high specificity of a nucleic acid aptamer and the high-throughput screening characteristic of an ELISA plate, so as to greatly shorten detection time, improve detection sensitivity and specificity and reduce detection cost.

It is provided a Near Infrared Sensitive (NIR-sensitive) nanoparticle complex comprising a NIR-sensitive nanoparticle and surfactant(s) adsorbed on the nanoparticle, wherein the surfactant is at least one surfactant selected from:wherein X=1-9; Y=0-9; n=0-9; Z=1-9; W=0-9; m=0-9; each of R1, R2, R3 and R4, if present, is H, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 aryl, HS, COOH, NH2 or OH; R5 is COOH, NH2 or OH; with the proviso that n+m is <10;(b) an amino acid having the structure in (a), wherein X=1; Y=2; Z=1; W=1; R1, R2 and R4 are not present; R3 is NH2; and R5 is COOH; or (c) a peptide, wherein the peptide comprise at least one amino acid (b). Further, it is provided a NIR-sensitive nanoparticle complex(es) having biomolecule(s), for example drug(s), loaded on the surfactant(s).

The invention discloses a preparation method of a tirapazamine-gold nanoparticle compound and an application of the tirapazamine-gold nanoparticle compound. The tirapazamine-gold nanoparticle compound is mainly characterized by being formed by connecting tirapazamine on an outer layer and kernel gold nanoparticles through a connecting part; the preparation method of the tirapazamine-gold nanoparticle compound comprises the following three steps: (1) condensing the tirapazamine and carboxylic acid containing sulfydryl or a disulfide bond into a tirapazamine-connecting part under the action of a condensing agent; and (2) preparing the gold nanoparticles; and (3) dissolving the tirapazamine-connecting part into a solvent, adding the mixture to water-soluble gold nanoparticles, and preparing the tirapazamine-gold nanoparticle compound through ligands interchange reaction. The preparation method has the advantages that the tirapazamine-gold nanoparticle compound is capable of enhancing the yield of free radicals under the irradiation of an X ray; the biggest enhancement coefficient can reach 4 times; radiation injuries to hepatoma carcinoma cells caused by the X ray are enhanced by the tirapazamine-gold nanoparticle compound; and the enhancement of the X ray in hepatoma carcinoma cell lethal effect can reach 20%.

An oligomer-contained nanoparticle complex is provided. The oligomer-contained nanoparticle complex of the invention comprises (a) a nanoparticle, (b) a polymer with high molecule weigh, (c) a target molecule, (d) an oligomer, wherein the oligomer is crosslinked with the polymer by the intermolecular hydrogen bonds or electron bonds, and e) a space for active substances, wherein the space for active substances is encapsulated by the nanoparticle. The oligomer-contained nanoparticle complex of the invention has the high stability and fast drug release rate, and would not be largely accumulated in normal tissues. The invention also provides a method for preparing the oligomer-contained nanoparticle complex and the method for releasing drug.

The invention discloses a black phosphorus-gold nanoparticle compound photo-thermal quantitative immunochromatography test strip for detecting small-molecule substances and a preparation method thereof. The method comprises the following steps: 1) reducing chloroauric acid to gold nanoparticles on the surface of black phosphorus; 2) adsorbing an antibody of a substance to be tested on the surfaceof the black phosphorus-gold nanoparticle compound to prepare a photothermal probe;3) pasting a sample pad, a combination pad, a nitrocellulose membrane and a water absorbent pad on a PVC back plate in sequence; 4)coating detection lines formed by an antigen of the substance to be tested and quality control lines formed by goat anti-rabbit or rat antibodies on the nitrocellulose membrane; 5)mixingthe photothermal probe and a sample to be tested and then, dropping the mixture onto the sample pad, and through the capillary action, conducting chromatography on the water absorbent pad, the antigen of the substance to be tested and the substance to be tested competitively combining the photothermal probe; and 6) carrying out laser radiation with 808 nm laser and capturing temperature with an infrared thermometer. The test strip has the advantages of high specificity, good sensitivity and simple operation and can realize quantitative detection.

Nanoparticle composites comprised of a metal oxide and ions of a metallic element included within a crystal lattice of said metal oxide are disclosed. Process of preparing the nanoparticle composites per se and incorporated in or on a substrate are also disclosed. Uses of the nanoparticle composites and of substrates incorporating same, particularly for reducing a formation of a load of a microorganism or of a biofilm, are also disclosed.

The disclosure provides a nanodelivery system and related process having complex, multilayered nanoparticles for sophisticated drug / gene delivery systems to intracellular portions of a cell. Outermost layers can include cell targeting and cell-entry facilitating molecules. The next layer can include intracellular targeting molecules for precise delivery of the nanoparticle complex inside the cell of interest. Molecular biosensors can be used to confirm the presence of expected molecules as a surrogate molecule for signs of infection, for activation in radiation damage, or other criteria, prior to delivery of counter-measure molecules such as drugs or gene therapy. The biosensors can also be used as a feedback control mechanism to control the proper amount of drug / gene delivery for each cell. Further, the nanodelivery system can be used to restrict any cells from encountering the drug unless that cell is specifically targeted. Successful targeting can be verified by 3D multispectral confocal microscopy.

The invention discloses a nucleic acid aptamer probe-based rapid, super sensitive on-site one-step method non-mark type bisphenol-A colorimetric detection method. The detection method comprises the following steps of: (1) determining the optimal salt concentration of a detection system; (2) combining gold nano particles with a nucleic acid aptamer probe, and preparing a nucleic acid aptamer-gold nano particle composite probe; and (3) detecting the bisphenol-A. The detection method can be used for on-site, rapid and super sensitive detection without other auxiliary instruments or equipment. The detection can be accomplished within 10-15 minutes, and a qualitative and quantitative detection result can be obtained; corresponding detection of other target objects can be realized by only changing and replacing the sequence of the nucleic acid aptamer probe of the gold nano particle; and the method further has the advantages of high specificity, good stability, wide application range, low cost and the like, and therefore the method is easy to be popularized and applied to normal use.

The invention discloses a molecular imprinting electrochemical sensor for detecting vanillin. The molecular imprinting electrochemical sensor makes the surface of a glass carbon electrode covered with a prepared graphene oxide / carbon nanometer tube / ion liquid / gold nanometer particle composite through an electrode surface decoration technology so that the aims of enhancing electric signals and improving the detection sensitivity of the sensor can be achieved. Through the electrochemical polymerization mode, the surface of the electrode is decorated with molecularly imprinted polymers with pyrrole as functional monomers and vanillin as template molecules, and the molecular imprinting electrochemical sensor is formed after the template molecules are washed away. After the template molecules are washed away, holes are formed in the surface of the sensor, and specificity matching between the holes and the structure of vanillin can be achieved. The prepared electrochemical sensor is connected to an electrochemical working station as a working electrode, current changes are produced through the specific binding of the template molecules on the surface of the electrode and the holes, and vanillin can be detected through the current changes. The prepared molecular imprinting electrochemical sensor is high in selectivity and sensitivity, easy and rapid to operate and suitable for detecting vanillin in food.

The invention discloses a carbon nanotube-thionine / gold nanoparticle composite material and a preparation method thereof. According to the carbon nanotube-thionine / gold nanoparticle composite material, acidified cut short carbon nanotubes and thionine are used as raw materials, and a carbon nanotube-thionine composite with high loading of thionine electrical signal molecules is prepared; and a ternary nanocomposite is prepared by using the carbon nanotube-thionine composite as a support matrix and micro-gold nanoparticles reduced by Au-N and Au-S bonding. The composite material has high conductivity, small gold particle size, uniform dispersion, large specific surface area and high adhesion ability on a substrate. The preparation method of the carbon nanotube-thionine / gold nanoparticle composite material is simple, convenient and easy to operate. The composite material can be used as sensitive electrical signal probes for immunosensors and DNA sensors.

The invention relates to polymers / gold nanoparticles complex medium for DNA sequencing with capillary electrophoresis and its preparation method, and belongs to the biotechnological field of DNA sequencing and separation. The concentration of the buffer solution of polymers / gold nanoparticles complex medium used for DNA sequencing is 2.0%-3.0%. The invention comprises the steps of: (1) synthesis of quasi-interpenetrating polymer networks with self-spreading ability, (2) preparation of Au nanoparticles, and (3) synthesis of complex medium of quasi-interpenetrating polymer networks / gold nanoparticles. The complex medium with reduced viscosity at proper concentration is easy to be pumped into and run out of the capillaries, and can prevent the production of electroosmotic flow because of the existence of complex with self spreading ability, which saves the step of spreading inner wall of the capillary, simplifies the preparation process of column, reduces the application cost of capillary, elongates the service time of capillary. The invention is mainly used for separating DNA with capillary electrophoresis and DNA sequencing.

The invention discloses a method for simultaneously detecting zearalenone (ZEN) and fumonisin B1 (FB1), and also discloses an aptamer sensor for simultaneously detecting the zearalenone and the fumonisin. The aptamer sensor is prepared by the following method: (1) covering a glassy carbon electrode with reducing molybdenum disulfide and a gold nanoparticle composite (rMoS2-Au) nanomaterial, and drying; (2) subsequently dripping a mixed solution of a zearalenone nucleic acid aptamer (AP1) and a fumonisin B1 nucleic acid aptamer (AP2) onto the electrode, incubating for 1-10h at 1-10 mu mol / L, v / v, 1 / 1, and blocking the same with 1 mg / mL QBSA; and (3) finally, dripping a mixed solution of a self-developed ZEN nucleic acid aptamer partial complementary sequence (CP1-Au-Thi) solution of 5'-endmodified gold nanoparticles and thionine and a FB1 nucleic acid aptamer partial complementary sequence (CP2-Au-FC6S) solution of 5'-end modified gold nanoparticles and ferrocenyl hexanethiol, and incubating for 1-10h at 1-10 mu mol / L, v / v, 1 / 1 to obtain the required aptamer sensor. The method provided by the invention is suitable for the rapid and simultaneous detection of QEN and FB1 in agricultural products such as corn and feed, thereby effectively preventing the agricultural products with over-standard QEN and FB1 from flowing into the market, and the diet safety of people is guaranteed asa result.

The invention provides a gold nanoparticle complex with an effect of inhibiting nerve cell apoptosis and an application thereof. The gold nanoparticle complex is prepared by the following steps: modifying thiolated chitosan (TCTS) onto the surface of gold nanoparticles, performing electrostatic adsorption on pDNA interfering alpha-synuclein synthesis, finally grafting a nerve growth factor by adopting a photo-grafting method, thereby obtaining the complex. The successfully synthesized gold nanoparticle complex acts on nerve cells, the cell apoptosis can be obviously inhibited by the complex, and the complex has an effect of inhibiting apoptosis of an in-vitro cell model for Parkinson's disease, is a method and novel drug for treating the Parkinson's disease occurring after operative treatment and chemotherapy and has high guiding significance for treating and researching the disease.

The invention discloses a fluorescent aptamer probe based on Prussian blue nanoparticles as well as a preparation method and application of the fluorescent aptamer probe. The fluorescent aptamer probeis composed of Prussian blue nanoparticle complex modified FAM fluorophore aptamers. The preparation method comprises the following steps: incubating the Prussian blue nanoparticles and the aptamersmodified with the FAM fluorophore in an HEPEs buffer solution system in a dark place, and closing by adopting BSA, thereby obtaining the fluorescent aptamer probe. The fluorescent aptamer probe can beused for detecting various markers such as markers of tumor, breast cancer, blood glucose and Alzheimer's disease, has the advantages of strong signal, high specificity, high sensitivity, wide detection concentration range, good biological safety and the like, and is beneficial to popularization and application.

The present invention provides methods, compositions, systems, and kits comprising core-satellite nanocomposites useful for photothermal and / or MRI applications (e.g., tumor treatment and / or imaging). In certain embodiments, the core-satellite nanocomposites comprise: i) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core, and ii) at least one satellite component attached to, or absorbed to, the biocompatible coating. In some embodiments, the nanoparticle core and satellite component are composed of near-infrared photothermal agent material and / or MRI contrast agent material. In further embodiments, the satellite component is additionally or alternatively composed of near-infrared optical dye material.

Methods of characterizing nanoparticles, nanoparticle complexes, and their biomolecular interactions are provided. Concurrent excitation and emission wavelength scans are performed and the optimal fluorescence intensity for the intersect of these wavelengths is determined. The intersect is dependent upon the physical characteristics of the particle and can be used to verify, for example, attachment of biomolecules, amount of biomolecules present, and structure of the attached biomolecule.

The present invention relates to a method for preparing a nickel ferrite nanoparticle composite having an inverse spinel structure obtained using a polyol process, a nickel ferrite nanoparticle composite prepared by the method, and a method for selectively binding, separating or purifying a specific protein using the nickel ferrite nanoparticle composite. The method for preparing a magnetic nanoparticle composite according to the present invention includes a one-step hydrothermal synthesis process, and thereby the magnetic nanoparticle composite can be prepared in a simple and economic manner. Also, the nickel ferrite nanoparticles synthesized by the method of the present invention can be strongly magnetic, and also exist in the form of Ni2+ in which Ni binds to a specific protein, thereby preventing loss of separability caused by additional oxidation and repeated recycling of the nanoparticles.

The invention discloses a preparation method of fluorescent golden nanometer particle protected by stable organic monolayer. The preparation method is that: chloric acid water solution is mixed with sodium citrate, and then the mixture is subjected to reduction reaction with sodium borohydride to generate the hydrosol of the golden nanometer particle stabilized by citric acid; with the assistant of ethanol, N, N'dialkyl-dithio formic acid alkyl fluorene with fluorescent group moves the golden nanometer particle to organic phase so as to form the fluorescent golden nanometer particle compound protected by organic monocular. The preparation method is characterized by easy obtaining of the raw materials, simple technique, no need of heating, high efficiency and quickness, and high productivity, etc. The prepared golden nanometer particle compound has small particle diameter (4-30nm) and even distribution; through coordination adsorption of sulfur atoms in carbon-sulfur dual bonds on the surface of the golden nanometer particle, the golden nanometer particle can be steadily dispersed into a plurality of polarity and nonpolarity organic solvents; proved by experiment, the synthetical golden nanometer particle has very strong fluorescent property, thereby the golden nanometer particle has wide application prospect on the fields of nanometer electron, optoelectronic devices, optics, magnetism material, etc.