The invention discloses a multidimensional sense man-machine interaction system and a multidimensional sense man-machine interaction method, which are based on combine interaction modes of head posture control, voice control, keyboard and mouse operation, etc. The system is composed of the following 8 modules: a user information collecting module, a user information identifying and analyzing module, a head posture control functional module, a voice control functional module, a storage module, an interface interaction module, a self-customizing module and a program control module. The method is realized by the following four processes: collecting user information, identifying and analyzing the user information, realizing head posture control or voice control and outputting a user interface. The system and the method disclosed by the invention have the advantages of large application range, good maintainability, good expandability and the like. In addition, the system provides a novel man-machine interaction process method for a computer user, so that the operation efficiency of a common user can be improved, and great help on neck fitness and learning of old people on computers can be realized.