88results about How to "Overcome side effects" patented technology

The present invention provides an oral delivery system for creatine. The creatine delivery system may additionally contain other bioactive ingredients such as nutraceuticals, botanicals, and vitamins. The delivery system comprises an ingestible matrix within which a creatine formulation and optionally one or more bioactives are substantially uniformly and completely dispersed and in which degradation of the creatine and other bioactives is minimised or eliminated. The invention also provides methods of preparing and using the delivery system.

The invention provides sustained release formulations of basic drugs, stereoisomers of basic drugs, pharmaceutically acceptable salts of basic drugs, and pharmaceutically acceptable salts of stereoisomers of basic drugs. The basic drugs may be anti-dementia drugs, such as cholinesterase inhibitors or memantine. In one embodiment, the cholinesterase inhibitor is donepezil.

The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and / or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.

The present invention relates to a cytoplasmic transduction peptide (CTP) showing transduction potential, as well as cytoplasmic remaining potential and various uses thereof. The CTP of this invention exhibits a transduction potential identical or higher than the conventional protein transduction, PTD, and a strong tendency to remain in the cytoplasm, so that it is very useful in inducing cytotoxic T lymphocytes (CTL) and a drug delivery system (DDS) targeting cytoplasm.

The invention discloses a preparation for resisting altitude sickness and an application of the preparation and relates to the field of medicinal preparations. The preparation for resisting the altitude sickness comprises 0.05-0.2 g of acetazolamide, 10-20 mg of coenzyme Q10, 500-1,000 mg of tyrosine and 1-2 mg of selenium, wherein selenium can be selenium salt and selenium yeast. The preparation is used for preventing altitude sickness symptoms such as headache, insomnia, dyspnea and the like. According to the application, the altitude sickness symptoms can be prevented in multiple drug-delivery ways including subcutaneous injection or intramuscular injection, intravenous injection or intravenous drip, oral administration including pills, capsules, tablets and the like and a nasal drug delivery system such as nasal spray and the like. The preparation has the benefits that the preparation can prevent altitude sickness symptoms such as headache, insomnia, dyspnea and the like, can effectively prevent altitude sickness and can overcome side effects of acetazolamide when the use quantity of the preparations is smaller than a conventional dosage of acetazolamide.

The present invention relates to a cytoplasmic transduction peptide (CTP) showing transduction potential, as well as cytoplasmic remaining potential and various uses thereof. The CTP of this invention exhibits a transduction potential identical or higher than the conventional protein transduction, PTD, and a strong tendency to remain in the cytoplasm, so that it is very useful in inducing cytotoxic T lymphocytes (CTL) and a drug delivery system (DDS) targeting cytoplasm.

The invention relates to pharmaceutical compositions, as well as health functional food compositions and quasi-drug compositions, for preventing, treating, or improving rheumatoid arthritis, comprising a monoacetyldiacylglycerol compound as an active ingredient. The monoacetyldiacylglycerol of the invention is effective in inhibiting the phosphorylation of STAT-3 known to be a therapeutic target for rheumatoid arthritis. As the monoacetyldiacylglycerol is an effective therapeutic agent without toxicity, the monoacetyldiacylglycerol can overcome the side effects of the medicines currently used in the treatment of rheumatoid arthritis. Thus, the monoacetyldiacylglycerol can be used for preventing, treating or improving rheumatoid arthritis.

The invention relates to a method for preparing a phosphate series lithium ion battery anode material, comprising the following steps: preparing one or more of divalent manganese source compound, ferrum source compound, nickel source compound or cobalt source compound into a mixed solution; adding oxalic acid or oxalate, acid and urea, and slowly hydrolyzing the urea by controlling the reaction temperature and time; causing the pH value of the system to rise to reach the condition of homogeneous precipitation; after the reaction, filtering, washing and drying to obtain a precursor; evenly mixing and carrying out ball milling on the precursor, a lithium source and a phosphorous source; and calcining the mixture under the non-oxidability atmosphere to prepare the unitary or multielement phosphate series lithium ion battery anode material. The precursor prepared with the method has the advantages of stable ingredient proportion, even granularity distribution, good consistency and simple synthetic technology, does not need to consider the influence of flow rate and agitation and is suitable for industrial production. The synthesized battery anode material is the phosphate compound with an olivine structure, the average grain size of the primary particle is 100-500nm, and the battery anode material has good electrochemistry property.

The present invention relates the application of nano copper powder in preparation of immunity-enhancing medicine. It adopts the commercial nano copper powder whose grain size is 0.1-1000 nm as raw material, the weight ratio of raw material nano copper powder required for preparing medicine and preparation is 0.002-0.04:1. Said nano copper powder has the enhancement for specific immunity and non-specific immunity of body, and said medicine can be used for curing various diseases due to infective microbe and its toxin, tumor, dead cell or mutant cell.

The invention relates to the technical field of tea bags and particularly relates to a tea bag containing moringa tree leaves and a preparing method thereof. A formula of the tea bag comprises 1-2.8 parts by mass of cyclocarya paliurus leaves, 0.1-1.0 part by mass of the moringa tree leaves and 0.1-0.5 part of Liubao tea leaves. The preparing method of the tea bag is also provided. The preparing method includes smashing, mixing, granulating, packing into a bag, and the like. The tea bag can effectively reduce blood sugar for human bodies and regulate overall functions of a human body. The tea bag is ideal in quality, flavor, taste, color and fragrance and is suitable for diabetic patients.

The invention provides application of protocatechuic acid as a feed additive in livestock breeding, the protocatechuic acid is used for promoting the growth and development of animals, improving the feed conversion rate, improving ketone body quality and meat quality, comprehensively enhancing animal immunization function and capacity of preventing disease; the toxic and side effect of chemically synthesized organic acid and food potential risk are overcome, the disadvantages that the Chinese herbal medicine additives are complex in component, the use is inconvenient, and the quality standard is hard to control are avoided, the research and development prospect is positive, and the clinical application is wide.

The present invention relates to a preparation method of quilt core. Said quilt core has several health-care functions of killing bacteria, relieving inflammation and removing toxic material, and is made up by using 7 Chinese medicinal materials of lonicera flower, isatis leaf, isatis root, coptis root, rhubarb, scutellaria root and phellondron bark as raw material, adding essence, alum and organic silicon as auxiliary material and making them undergo the processes of preparing pulp, sizing, drying and dewatering so as to obtain the invented bulk and soft material. Said bulk and soft material can be made into the invented health-care quilt core.

An interior-applied Chinese medicine for treating acute nasosinusitis is prepared from more than 9 Chinese-medicinal materials including xanthium fruit, magnolia flower, mint, liquorice root, etc through decocting.

The invention discloses a composition for improving memory and brain health conditions of patients with Alzheimer disease, which is invented for treating Alzheimer disease. The composition is prepared from DHA alga oil composite powder, glutamine, asparagine, soyabean lecithin, taurine, panaxoside, gingko leaf extract, arachidonate grease composite powder, tea polyphenol, raw ginger, selenium-enriched yeast and starch. The prescription is used for supplying the cerebral neuron main structure caused by senescence or various changes by extremely targeted enhancement and adjustment for nutrition metabolism of cerebral neuron, starting with improving the nutrition state and activity of cerebral neuron and improving the metabolism system for cerebral blood and nutrition transmission, from the view of nutriology according to the physiological characteristics of the human brain. According to the composition, toxic and side effects and possible adverse results generated by certain chemical drugs and certain traditional Chinese medicinal materials can be overcome, the defect of poor medical non-nutritional rehabilitation durability can be avoided, and the frequency of relapse can be reduced.

An interior-applied Chinese medicine for treating herpes zoster is prepared from more than 11 Chinese-medicinal materials including borneol, rhubarb, coptis root, scutellaria root, etc. Its preparing process is also disclosed.

The present invention relates the application of nano copper powder in preparation of immunity-enhancing medicine. It adopts the commercial nano copper powder whose grain size is 0.1-1000 nm as raw material, the weight ratio of raw material nano copper powder required for preparing medicine and preparation is 0.002-0.04:1. Said nano copper powder has the enhancement for specific immunity and non-specific immunity of body, and said medicine can be used for curing various diseases due to infective microbe and its toxin, tumor, dead cell or mutant cell.

The invention discloses a preparation method of a nano simple-substance bismuth diagnosis and treatment agent for CT (computed tomography) / PAT (pericardial adipose tissue) imaging. The method comprises the following steps: carrying out reaction on a hydrophobic reducing organic solvent and Bi(NO3)3 to generate a hydrophobic-molecule-coated nano simple-substance bismuth crystal, and carrying out reaction on the hydrophobic-molecule-coated nano simple-substance bismuth crystal and an amphiphilic polymer in a hydrophobic organic solvent-water mixed solution. The nano simple-substance bismuth diagnosis and treatment agent has the functions of CT imaging reinforcement and PAT imaging reinforcement, has favorable photothermal effects, can simultaneously implement the integrated diagnosis and treatment process composed of tumor preoperative diagnosis, intraoperative tracking, post-operative evaluation and the like, and thus, has favorable development potential.

The invention relates to an active targeting nano ball for photo-thermally treating tumor and a preparation method and an appliance thereof, which effectively solve the problems that existing tumor treatment drugs are large in side effect and poor in treatment effect. The method for preparing the active targeting nano ball for photo-thermally treating the tumor comprises steps: copper chloride (CuCl2) is dissolved in povidone solution, sodium sulphide (Na2S) is dissolved in ultrapure water, the CuCl2 solution and the Na2S solution are combined to react, and are subsided and dried to be copper sulfide nano-particles, and the copper sulfide nano-particles are dissolved into acetate solution containing chitosan, thereby forming polyvinyl pyrrolidone- Cu2-xS (PVP-Cu2-xS) solution. Docetaxel is dissolved into methyl alcohol, and is added into the PVP-Cu2-xS solution, and then sodium tripolyphosphate is added, and is subsided to be a passive targeting nano ball. folic acid is added into the passive targeting nano ball, then 1-ethyl-(3- dimethylaminopropyl) carbodiimide hydrochloride is added, and liquid supernatant is removed by centrifuging, thereby obtaining an active targeting nano ball. The method for preparing the active targeting nano ball for photo-thermally treating the tumor is steady and reliable, is steady in product performance, convenient to use, excellent in effect, easy to operate, rich in source of raw materials, low in cost and small in side effect, and can effectively restrain tumor cells from breeding.

The invention provides lycium barbarum polysaccharide modified nanoparticle preparation and anti-tumor activity research, and particularly relates to low-toxicity composite nanoparticles (LBP / 5-ASA / Pt) prepared by takinglycium barbarbarum polysaccharide as a main chain and conducting covalent bonding on 5-aminosalicylic acid and a platinum complex, and the anti-cancer effect of drugs is improved.By determining the semi-lethal number of cells (IC50),it is shown that the composite nanoparticles havevery strong lethalityand inhibitionon lung cancer cells, wherein the semi-lethal number reaches 40 microgram / mL, but the composite nanoparticleshave little toxicity to normal live cells of the human body. Accordingly, the lycium barbarum polysaccharide is utilized as the main body to modify bonded molecules, and a new idea is provided for modification and application of highly-toxic anticancer drugs.

The anticancer analgetic preparation has lappaconitine and vincristine as main active anticancer components. Lappaconitine has the effect of increasing the sensitivity of vincristine in killing cancer cell, so that the preparation of the present invention can reverse the drug resistance of tumor. The present invention has obvious functions of resisting liver cancer, lung cancer, cancer of uterus and breast cancer, stopping pain, etc. and has the feature of less recovery of the blood supply to embolized tumor artery. Compared with similar medicines, the present invention has the advantages of less side effect, high tumor cell killing effect, high stability, low cost, etc.

The invention discloses wettable powder for preventing and treating fusarium wilt of cucumber. The wettable powder is prepared by the following formula components in parts by weight: 5-10 parts of a wetter, 3-10 parts of a dispersant, 25-35 parts of kieselguhr, 15-35 parts of water, and 5-15 parts of trichoderma harziamum fermentation liquor freeze-dried powder. The wettable powder disclosed by the invention overcomes the problems of environmental toxic and side effects and pesticide residue brought by chemical agents, has the characteristics of being efficient, non-toxic, safe and free of residual, and is an environment-friendly solid microbial inoculum for preventing and treating fusarium wilt of cucumber.

The invention provides a special composite biological agent for ginseng and a preparation method, and belongs to the technical field of biological agents. The special composite biological agent for ginseng comprises three composite effective microbial communities including a bacterium A, a bacterium B and a bacterium C, a strain is cultured by a seed solution, is fermented and cultured and then ismixed to obtain the biological agent. By the biological agent, development of a root system of a plant can be promoted, the plant grows with luxuriant foliage, the plant is protected against being infringed by harmful bacteria through the antibacterial property and the disease resistance of beneficial microorganisms, stress resistance of the plant is enhanced, and pest and disease damage is relieved. Therefore, use and residues of chemical fertilizers and pesticide can be relieved, an environment can be repaired effectively, soil is improved, the yield is increased, and the quality is improved.

The invention relates to a polypropylene composition showing a high melt flow rate and simultaneously high stiffness and a process for the production thereof. The invention further relates to a material comprising the inventive polypropylene.

The invention belongs to the technical field of research and development of anti-cancer drugs, and particularly relates to a Pt (II) complex with photodynamic tri-negative breast cancer resisting activity and a preparation method and application thereof. According to the invention, iodo-BODIPY with excellent photosensitive activity is used as a photosensitive group, DPA (dimethylamine pyridine) is used as a Pt (II) coordination group, and the Pt (II) complex with photodynamic activity is creatively designed and synthesized. The Pt (II) complex belongs to a novel compound, shows excellent in-vitro tri-negative breast cancer resisting activity, has potential medicinal value and is expected to be used for preparing various tri-negative breast cancer resisting drugs. The structural formula of the Pt (II) complex is as shown in the specification.

The invention relates to platinum drugphotosensitizer-loaded protein nanoparticles and a preparation method and application thereof. The platinum drugphotosensitizer-loaded protein nanoparticles comprise platinum drugphotosensitizer complexes and proteins wrapping the platinum drugphotosensitizer complexes. Chemical therapy and photodynamic therapy are combined through an albumin nano-drug delivery system so that a synergistic anti-cancer effect is achieved, and the toxicity-reducing and efficacy-improving treatment effect is achieved. The nanoparticles prepared by the method are small in particle size, uniform in dispersion and round in shape; good chemical stability and illumination stability are realized; under the irradiation of near-infrared light, the nanoparticles have relatively high active oxygen generation capability; in addition, in cell experiments and animal experiments, it is verified that the nanoparticle has strong cytotoxicity and good in-vivo tumor targeting to tumorcells, plays a synergistic effect, reduces toxic and side effects, realizes combined treatment of tumors by chemotherapy and photodynamic therapy, and inhibits tumor metastasis.

The invention discloses a process of extracting, fractionating and purifying bioactive molecules from an associated mangrove plant, methods of screening for pharmacological activities of crude extract, its fractions and purified compounds and use of methyl palmitate obtained from the crude extract as a muscurine antagonist.

The present invention relates to a Chinese materia medica foot bath preserving health essence which is prepared from raw materials by weight part as follows: saffron crocus 0.5-1 parts, chuan chinese flowering quince 15-25 parts, lopseed 15-25 parts, yam 10-15 parts, dried rehmannia root 10-15 parts, saussurea involucrata 5-15 parts, american ginseng 5-15 parts, earth poria cocos wolf 15-20 parts,areca-nut 5-15 parts, broom cypress fruit 15-25 parts, Chinese angelica 5-15 parts, and extractum glycyrrhizae liquidum 5-10 parts. The essence has advantages of reasonable prescription, safe use andsimple preparing method which can preserve health and strengthen body. The essence has functions of cleaning deodorizing, stretching muscle and activating collateral, elimination foot fatigue, also has effects of tonifying kidney and boosting liver, benefiting qi and nourishing yin, clearing heat and antitoxic, bactericidal and relieving itching; has obvious assistant treating effect to insomniashort memory, constipated, deficiency body and deficient kidney, waist soreness leg pain, wind dampness bone disease, fungal athlete's foot wet poisonous and menoxenia. The essence integrates treating, preserving and health caring into a whole without fillip and side-effect to human body, and is suitable for general household.

Disclosed is a quick-effective vagina contraction agent and its preparation method, wherein the agent is prepared from the following raw materials (by weight ratio): purslane 55-65, Chinese dittany bark 55-65, dragon's bone 12-18, oyster 20-32, donkey-hide gelatin 20-32, Chinese angelica root 20-32, deglued antler powder 32-48, bletilla tuber 20-32, herba Gentianae loureiri 7-9, cnidium fruit 20-32, Chinese yam 30-40, gorgon euryale seed 30-40, gingko leaf 20-28, licorice root 12-18, Chinese mugwort leaf 30-50, wolfberry fruit 30-40, dipsacus root 30-40 and spatholobus stem 12-18.

The invention relates to a weight-losing capsule based on a biodegradable stent material. The weight-losing capsule is prepared by coating the biodegradable stent material in a capsule housing. The invention further provides a preparation method and application of the weight-losing capsule. The advantage of the weight-losing capsule is expressed as follows: spinning a biodegradable material by using the electrostatic spinning, performing brittle failure by liquid nitrogen, grinding to be a thread, dispersing, forming by thermal induction, and improving the thermal induction forming ability thereof by using gelatin; exchanging solvents, and preparing the biodegradable stent material after freeze-drying; and extruding the material to be a minimum volume, and coating in the capsule housing toprepare the weight-losing capsule. After the weight-losing capsule is administered, the capsule housing is corroded and broken in the stomach, the internal biodegradable stent material is rapidly expanded after absorbing water, and a partial space in the stomach is occupied, thereby the food acceptable daily intake is reduced, and the effect of dieting and losing weight is achieved.

The invention relates to a polypropylene composition showing a high melt flow rate and simultaneously high stiffness and a process for the production thereof. The invention further relates to a material comprising the inventive polypropylene.