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Preparation for resisting altitude sickness and application of preparation

A technology for altitude sickness and altitude sickness, applied in the direction of anti-toxic agents, medical preparations containing active ingredients, active ingredients of sulfur/selenium/tellurium, etc., can solve problems such as no reports in the literature, and achieve prevention of insomnia, prevention of altitude sickness, and overcoming side effects

Inactive Publication Date: 2015-12-30
CHANGZHOU ADAM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are currently no reports in the literature

Method used

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  • Preparation for resisting altitude sickness and application of preparation
  • Preparation for resisting altitude sickness and application of preparation
  • Preparation for resisting altitude sickness and application of preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Acetazolamide 50mg, Coenzyme Q 10 10mg, tyrosine 500mg and selenium 1mg. Each component is weighed and mixed, then calcium silicate, maltodextrin, silicon dioxide and magnesium stearate are added, mixed, packed into starchy capsules to obtain capsules.

Embodiment 2

[0016] Acetazolamide 200mg, Coenzyme Q10 20mg, Tyrosine 1000mg and Selenium 2mg. Each component is weighed and mixed, then calcium silicate, maltodextrin, silicon dioxide and magnesium stearate are added, mixed, packed into starchy capsules to obtain capsules.

Embodiment 3

[0018] The sedative effect of the preparation of embodiment 1: Adopt spontaneous activity experiment, take mouse as test animal, get 50 mice, male and female half and half, body weight is 18-22g, is divided into 5 groups at random: high-dose group, middle-dose group , low-dose group, acetazolamide control group, and normal group, with 10 rats in each group. The normal group was administrated with normal saline at a dose of 0.2ml / 10g; the acetazolamide control group was administrated with 40mg / kg acetazolamide tablets; medicine for 4 days. 50 minutes after the last administration, the mice were sequentially put into the SD-5G multi-purpose instrument for pharmacological and physiological experiments. After adapting to the environment, the number of autonomous activities of the mice within 5 minutes was recorded.

[0019] Results: See Table 1. The high, medium and low doses of the preparation of Example 1 can significantly reduce the number of spontaneous activities of the mic...

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Abstract

The invention discloses a preparation for resisting altitude sickness and an application of the preparation and relates to the field of medicinal preparations. The preparation for resisting the altitude sickness comprises 0.05-0.2 g of acetazolamide, 10-20 mg of coenzyme Q10, 500-1,000 mg of tyrosine and 1-2 mg of selenium, wherein selenium can be selenium salt and selenium yeast. The preparation is used for preventing altitude sickness symptoms such as headache, insomnia, dyspnea and the like. According to the application, the altitude sickness symptoms can be prevented in multiple drug-delivery ways including subcutaneous injection or intramuscular injection, intravenous injection or intravenous drip, oral administration including pills, capsules, tablets and the like and a nasal drug delivery system such as nasal spray and the like. The preparation has the benefits that the preparation can prevent altitude sickness symptoms such as headache, insomnia, dyspnea and the like, can effectively prevent altitude sickness and can overcome side effects of acetazolamide when the use quantity of the preparations is smaller than a conventional dosage of acetazolamide.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to the field of anti-altitude sickness preparations. technical background [0002] Altitude sickness is a variety of pathological reactions after the human body is exposed to a low-pressure hypoxic environment. It is a common disease unique to plateau areas. Common symptoms include headache, insomnia, loss of appetite, tiredness, and difficulty breathing. In severe cases, there may be insensitivity, emotional restlessness, hyperactivity, decreased thinking ability and memory, abnormal hearing, vision, smell, taste, hallucinations, etc., and edema, shock or convulsions may also occur. [0003] Acetazolamide is a weak diuretic used primarily in the treatment of glaucoma to temporarily lower intraocular pressure. But in fact, acetazolamide is recommended by the International Mountaineering Association as an anti-altitude sickness drug. DIAMOX produced in Germany is the tra...

Claims

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Application Information

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IPC IPC(8): A61K33/04A61P39/00A61K31/433A61K31/122A61K31/198
Inventor 叶亚东叶季峨
Owner CHANGZHOU ADAM BIOTECH
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