43results about How to "Oral dose is small" patented technology

The invention discloses a preparation for resisting altitude sickness and an application of the preparation and relates to the field of medicinal preparations. The preparation for resisting the altitude sickness comprises 0.05-0.2 g of acetazolamide, 10-20 mg of coenzyme Q10, 500-1,000 mg of tyrosine and 1-2 mg of selenium, wherein selenium can be selenium salt and selenium yeast. The preparation is used for preventing altitude sickness symptoms such as headache, insomnia, dyspnea and the like. According to the application, the altitude sickness symptoms can be prevented in multiple drug-delivery ways including subcutaneous injection or intramuscular injection, intravenous injection or intravenous drip, oral administration including pills, capsules, tablets and the like and a nasal drug delivery system such as nasal spray and the like. The preparation has the benefits that the preparation can prevent altitude sickness symptoms such as headache, insomnia, dyspnea and the like, can effectively prevent altitude sickness and can overcome side effects of acetazolamide when the use quantity of the preparations is smaller than a conventional dosage of acetazolamide.

The invention discloses a medicinal capsule for treating urinary system disease and preparation method, wherein the preparation comprises longspur epimedium 7.5-70%, prepared rehmannia root 6-50%, drynaria 5-65%, astragalus root 5-40%, radix salvia miltiorrhiza 5-60%, edible black fungus 3-20%, and cucumber seeds 5-30%.

The present invention relates to one kind of Chinese medicine composition for stopping itching and its preparation process. The Chinese medicine composition is prepared with 13 kinds of Chinese medicinal materials, including schizonepeta herb, flavescent sophora root, angelica, rehmannia root, gypsum, etc. The preparation process is advanced and sufficient in effective component extraction, and the Chinese medicine composition has reliable curative effect, no irritative smell and other advantages.

The invention relates to a self-microemulsifying nanocombination comprising lucid ganoderma total triterpene and jobstears seed oil and a preparation method and application thereof. The lucid ganoderma total triterpene and the jobstears seed oil are adopted as medicinal materials, the jobstears seed oil doubles as the oil phase, the mixture of surfactant and cosurfactant is adopted as medicine carrier, and the parts by weight are as follows: 15 parts of lucid ganoderma total triterpene, 45 to 150 parts of jobstears seed oil, 45 to 200 parts of surfactant and 20 to 100 parts of cosurfactant. The invention also discloses the preparation method and application of the self-microemulsifying nanocombination. The invention prepares the self-microemulsifying nanocombination with the water-insoluble medicinal lucid ganoderma total triterpene and the jobstears seed oil, wherein the jobstears seed oil has the effects of both medicine and adjuvant, so that the dosage of preparation adjuvant, and moreover, the jobstears seed oil and the lucid ganoderma total triterpene which are compatible have a synergistic antitumor effect. Meanwhile, the self-microemulsifying nanocombination can promote the absorption of medicines, so that the antitumor effect can be enhanced.

The invention provides a traditional Chinese medicine extract and a preparation method thereof. The compound traditional Chinese medicine extract is prepared from the following raw medicinal materials in parts by weight: 30-60 parts of astragalus membranaceus, 9-15 parts of glossy privet fruit, 9-30 parts of herba leonuri, 3-10 parts of fructus mume, 2-9 parts of coptis chinensis, 1-5 parts of cinnamon and 3-9 parts of butterflybush flower. The preparation method comprises the following steps: extracting volatile oil from cinnamon, and including the volatile oil by beta-cyclodextrin; extracting the cinnamon residue, astragalus membranaceus, glossy privet fruit, butterflybush flower and fructus mume by an ethanol solution I, and refining by means of macroporous adsorption resin to prepare dried extract powder 1; extracting the coptis chinensis and herba leonuri by an ethanol solution III, and refining by ion-exchange resin to prepare dried extract powder 2; and uniformly mixing the dried extract powder 1, the dried extract powder 2 and the volatile oil inclusion compound to obtain the compound traditional Chinese medicine extract. The preparation method is capable of remarkably improving the bioactive substance content and the pharmacologic action of the compound traditional Chinese medicine extract.

The invention relates to a process for extracting active ingredients of American eleutherine rhizome. The process includes the steps of crushing, extraction, concentration, extraction, separation and the like and is characterized in that a pyricularia oryzae active screen model is combined for determining the best extraction portion of the active ingredients, and active compounds are separated by means of silica gel column chromatography, medium and low pressure column chromatography, high performance liquid chromatography and the like. The separation and purification process for the effective portion is applicable to a certain scale of production and stable in qualities. The process for extracting the active ingredients of the American eleutherine rhizome is high in efficiency, high in treatment purity of the obtained active ingredients and strong in drug action.

The invention relates to an oral insulin medicament for treating type II diabetes, which contains insulin, primary bile acid, lecithin, cholesterol and bilirubin. The oral insulin medicament comprises the following components by weight: 1 weight portion of insulin, 30 to 100 weight portions of primary bile acid, 100 to 300 weight portions of lecithin, 1 to 3 weight portions of cholesterol, 0.08 to 0.8 weight portion of bilirubin, and 50 weight portions of bile acid. The invention prepares the insulin medicament which satisfies physiological characteristics of organisms according to the bionics, and proves the administration of the insulin medicament through an oral way has exact therapeutic effect on the type II diabetes through animal experiments and clinical trials. The medicament satisfies the physiological characteristics of the organisms, can ensure that blood sugar keeps relatively steady within 24 hours without hypoglycemic reaction, can also ensure that the lecithin in bodies of type II diabetic patients is reduced and the metabolic disturbance of the bile acid is gradually corrected when the blood sugar is reduced, and has preventing and treating effect on complicating diseases caused by the type II diabetes.

The invention discloses a hazel leaf flavone extract and a medicinal composition thereof. The method for preparing the hazel leaf flavone extract comprises the following steps: 1) pulverizing dried hazel leaf into fine powder; 2) mixing the fine powder and helicase in a weight ratio of 1500:1 or so to obtain an extraction material; 3) filling the extraction material into an extraction kettle, carrying out supercritical carbon dioxide extraction to obtain a mixture, wherein the extraction conditions are as follows: the extraction pressure is 35MPa, the extraction temperature is 48-52 DEG C, the supercritical carbon dioxide flow rate is 37-40kg/h, and the extraction time is 2.0-2.5 hours; and 4) carrying out two-stage separation on the extraction mixture in the step 3 through a reduced pressure separation kettle, thereby obtaining the hazel leaf flavone extract, wherein the primary pressure separation is carried out under the pressure of 7.5MPa or so at the temperature of 45-50 DEG C, and the secondary reduced pressure separation is carried out under the pressure of 5.5MPa at the temperature of 45 DEG C. The invention has the advantages of high extraction yield and high composition dissolution rate.

The invention relates to an extraction technology of active component from red onions. The extraction technology comprises main steps of pulverizing, extracting, condensing, extracting, and separating; and is characterized in that a pyricularia oryzae activity screening mode is used to assist the extraction technology so as to determine the optimal extraction part for active component extraction, and the active components are separated by silica gel column chromatography, medium-low pressure column chromatography, high performance liquid chromatography (HPLC), and the like. The provided extraction technology can be applied to massive production of active components with a stable quality from effective parts of red onions. The extraction technology has a high efficiency, and the obtained active component has the advantages of high purity and strong pharmaceutical effect.

The invention discloses a chicken gallbladder extractum dispersible tablet and its preparation process, wherein the raw materials for preparing the chicken gallbladder extractum dispersible tablet comprises chenodeoxycholanic acid, coating agent, diluent, crumbling agent, binding agent, lubricating agent, flavoring agent.

A purpose of the present invention is to provide a purification process for a traditional Chinese medicine allium macrostemon or an effective fraction, wherein the purification process has characteristics of stable quality and simple route, and is suitable for large-scale production. According to the present invention, the natural medicinal chemistry and molecular pharmacology combined method is adopted to study the diabetes treatment effect of the traditional Chinese medicine allium macrostemon and the effective substance basis in the field of cardiovascular protection, and determine the structure, the characteristic and the activity of the macrostemonoside compound and the like, and the new active components can be produced through compatibility of different proportions of monomers; and the extraction process has characteristics of simpleness, easily available raw materials, low cost and high extraction rate, and is suitable for large-scale industrial production, and advantages of easy drug quality control, low oral dose, high patient compliance and the like are provided.

The invention discloses a traditional Chinese medicine multicomponent micro-emulsion composition having a function of resisting lung cancer, a preparation method and application thereof in preparation of an orally-taking lung cancer resistant medicine. The application comprises the following steps of: adding ganoderma lucidum total triterpenes, coixenolide, ganoderan and semen coicis polysaccharide used as raw material medicines into a nano-medicine composition which consists of surfactants and cosurfactant, wherein the traditional Chinese medicine multicomponent micro-emulsion composition comprises the following components in parts by weight: 5-30 parts of ganoderma lucidum total triterpenes, 45-150 parts of coixenolide, 5-50 parts of ganoderan and 10-90 parts of semen coicis polysaccharide, 45-200 parts of surfactants, 20-100 parts of cosurfactant and 300-900 parts of distilled water. The invention also discloses a preparation method of the composition. The ganoderma lucidum total triterpenes and the coixenolide are carried into a non-water phase, and the lucid ganoderma and the semen coicis polysaccharide are carried into a water phase, so that the coixendide can be used as medicines and also can be used as an auxiliary; the polysaccharide can enhance the immunization and the stability of a micro-emulsion system; and by the micro-emulsion, the absorption of the ganoderma lucidum total triterpenes and coixenolide used as the lipid solubility components can be increased, and the matching of four components have a synergy anti-tumor effect so as to increase the anti-tumor effect.

The invention discloses an aloe haw ball and a preparation method thereof. The aloe haw ball includes, by weight, 2-4 parts of hawthorn fruit, 0.5-1.5 parts of aloe powder, 2-4 parts of honey and 0.05-0.15 part of senna leaf extract. By means of the combination of the aloe and the senna leaf extract, the two raw materials which are originally irritating substances become relatively moderate underthe harmony of the hawthorn fruit and the honey, and the irritation to the body is greatly reduced. The efficacy of the two raw materials is synergistic and can achieve a better effect under the low content to reduce the oral doses. Therefore, the beneficial technical advantages can be achieved, and the problems in the prior art of poor effects and strong gastrointestinal dependence due to low effective substance content of the senna leaf are solved.

The present invention relates to pyrazolopyrimidinone derivatives of formula (1), their preparation method and pharmaceutical compositions containing the said derivatives. The compounds have efficacy on the treatment of impotence, one of male sexual dysfunctions with the side effects reduced.

The invention discloses an ahypnia headache medicine and a preparation method of the medicine, and relates to a medicine for treating an ahypnia headache and a preparation method of the medicine. Themedicine solves the technical problems that the existing method for treating the post-ahypnia headache has a non-ideal medication effect, and especially, a western medicine has side effects of hypersomnia, dizziness and digestive disorders after long-term administration. The medicine comprises radix rehmanniae recen, Chinese angelica, spina date seeds, semen platycladi, polygala roots, rhizoma acori graminei, ligusticum wallichii and radix paeoniae alba. The preparation method comprises the steps of mixing the ligusticum wallichii, the spina date seeds, the Chinese angelica, the rhizoma acorigraminei, the semen platycladi and water for distillation and extraction, preparing a beta cyclodextrin inclusion compound, mixing and decocting decoction dreg after distillation with the radix rehmanniae recen, the radix paeoniae alba and the polygala roots, mixing a residual aqueous solution after the distillation with filtrate, performing pressure reduction concentration, standing, cooling to aroom temperature, adding ethanol, performing uniform mixing, refrigeration, filtration, pressure reduction, drying and grinding, and adding the beta cyclodextrin inclusion compound. The medicine hasan effective rate of 94.30% for treating the post-ahypnia headache, the hypersomnia, the dizziness and the digestive disorders do not occur, and a recurrence rate is less than 26%.

The invention discloses a preparation method of a medicine capable of moistening dryness and relieving itching. The raw materials of the medicine consist of traditional Chinese medicine materials of 50-300 parts of prepared polygonum multiflorum root tubers, 80-350 parts of polygonum multiflorum root tubers, 300-500 parts of unprepared rehmannia glutinosa root tubers, 80-350 parts of sophora flavescens roots, 80-350 parts of morus alba leaves and 50-200 parts of laportea bulbifera herbs. The preparation method comprises the steps of (1) taking the polygonum multiflorum root tubers, the prepared polygonum multiflorum root tubers and beta-CD, enabling the polygonum multiflorum root tubers, the prepared polygonum multiflorum root tubers and the beta-CD to dissolve in water, performing soaking, performing reflux extraction, performing concentrating to obtain an extracting solution, and performing spray drying to obtain spray dried powder 1 for standby application; and (2) adding water to the remaining four medicinal materials of the unprepared rehmannia glutinosa root tubers, the morus alba leaves and the like, performing soaking, performing decoction, performing filtration, performingconcentrating to obtain an extracting solution, performing spray drying to obtain spray dried powder 2, uniformly mixing the spray dried powder 2 with the spray dried powder 1 obtained through extraction and concentration of the polygonum multiflorum root tubers and the prepared polygonum multiflorum root tubers, and performing loading into capsules so as to obtain the medicine.