Chicken gallbladder extractum dispersible tablet and its preparation process

A technology of dispersible tablets and extracts, which is applied in the field of medicine, can solve the problems of affecting appearance and use compliance, complex preparation process, difficult quality control, etc., and achieves the effects of easy control, simple preparation method, and convenient transportation

Inactive Publication Date: 2005-06-22
吉林省七星山药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But also find its deficiency in its preparation and clinical use: one oral dose is big (10ml-20ml) or more, mouthfeel is not good, especially its corrective agent is honey and sucrose, sticky and uncomfortable, the bitter taste of bile stays in Oral cavity, if not used for a long time, patients, especially diabetic patients and children are difficult to accept; the preparation process is complicated, the stability is not good, the quality is difficult to control, and there will be precipitation after long-term storage. Although it does not affect the curative effect, it will affect the appearance and compliance of use; liquid Glass bottle packaging, inconvenient to transport, inconvenient to carry, inconvenient to take, poor compliance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Calculate by preparing 1000 pieces of chicken gall extract dispersible tablets, get chicken gall extract in terms of chenodeoxycholic acid 3g, β-cyclodextrin 30g, starch 5g, microcrystalline cellulose 20g, sodium carboxymethyl starch 20g, Stevioside 2g, polyvinylpyrrolidone-K30 5g, micronized silica gel 3g, talcum powder 2g, magnesium stearate 1g.

[0024] Preparation Process

[0025] (1) Take chicken gallbladder extract and β-cyclodextrin according to the prescription, mix them well, put them in a colloid mill and grind them fully until they become a sticky paste, dry them at 30-40°C, crush them through a 100-mesh sieve to get chicken gallbladder Extract inclusion powder.

[0026] (2) Take starch, microcrystalline cellulose, and sodium carboxymethyl starch according to the prescription, dry them at 80°C for 4 hours, and then crush them through a 100-mesh sieve.

[0027] (3) Take the dried auxiliary material from (2) and chicken bile extract inclusion powder, mix thor...

Embodiment 2

[0040] Calculate by preparing 1000 pieces of chicken gall extract dispersible tablets, get chicken gall extract in terms of chenodeoxycholic acid 8g, β-cyclodextrin 80g, starch 10g, microcrystalline cellulose 30g, sodium carboxymethyl starch 20g, Low-substituted hydroxypropyl cellulose 15g, stevioside 3g, polyvinylpyrrolidone-K30 8g, micronized silica gel 5g, talcum powder 2g, magnesium stearate 1g.

[0041] Preparation process, dispersion inspection, content determination are the same as [embodiment one]

Embodiment 3

[0043] According to the calculation of preparing 1000 pieces of chicken gall extract dispersible tablets, take chicken gall extract 11g in terms of chenodeoxycholic acid, β-cyclodextrin 110g, starch 20g, microcrystalline cellulose 40g, low-substituted hydroxypropyl cellulose 12g, sodium carboxymethyl starch 20g, cross-linked polyvinylpyrrolidone 8g, aspartame 2g, fruit essence 1ml, polyvinylpyrrolidone-K30 10g, micropowder silica gel 5g, talcum powder 4g, magnesium stearate 1.5g.

[0044] The preparation process is the same as [Example 1] except that the adhesive uses polyvinylpyrrolidone-K30 with 80% ethanol solution, and the dispersion inspection and content determination are the same as [Example 1]

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PUM

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Abstract

The invention discloses a chicken gallbladder extractum dispersible tablet and its preparation process, wherein the raw materials for preparing the chicken gallbladder extractum dispersible tablet comprises chenodeoxycholanic acid, coating agent, diluent, crumbling agent, binding agent, lubricating agent, flavoring agent.

Description

[technical field] [0001] The invention relates to the field of medicine, in particular to chicken bile extract dispersible tablets and a preparation method thereof. [Background technique] [0002] The medicinal use of chicken gall to treat whooping cough has existed in ancient times. Modern medical research has confirmed that the main component of chicken bile is chenodeoxycholic acid (CDCA), followed by cholic acid (CA), wherein chenodeoxycholic acid accounts for 80% of the total cholic acid. Chenodeoxycholic acid has strong anti-inflammatory, cough-relieving, expectorant, and anti-asthma activities, and its anti-cough, anti-asthma, and anti-inflammatory activities rank first among all animal bile. Gu Xueqiu editor-in-chief's 1981 edition of pharmaceutical preparation notes mentioned that in terms of the effect of treating pertussis and chronic bronchitis, compared with cattle, sheep, pigs, and chicken bile, chicken bile is the best. After removing the roughness and extra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K35/413A61P11/00A61P31/04
Inventor 张德桐向鲁湘刘伟王强张松玲李宇
Owner 吉林省七星山药业有限公司
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