299results about How to "Improve quality controllability" patented technology

The invention relates to the field of blood products, in particular to a process method for preparing three kinds of blood products from cryoprecitation, and aims to provide a complete separation and purification process for respectively and sequentially preparing the three kinds of blood products, i.e. a coagulation factor VIII, fibrinogen and fibronectin, from the cryoprecitation. The process method is implemented by the following technical scheme that the process method comprises the preparation steps of cryoprecitation dissolution, gel adsorption, precipitation of the fibrinogen and the fibronectin, two-step ion exchange chromatography and glycin/sodium chloride precipitation and inactivation of virus. The process method has the beneficial effects that the three kinds of useful blood products, i.e. the coagulation factor VIII, the fibrinogen and the fibronectin, can be separated and extracted from the cryoprecitation sequentially; and the utilization rate of blood plasma is greatly improved.

A preparation method of peony seed oil comprises the following process flow: 1, preprocessing; 2, squeezing and filtering; 3, precipitating; 4, deacidifying; 5, degumming; 6, drying and decoloring; 7, carrying out vacuum deodorization; 8, carrying out quality inspection, and filling; and 9, carrying out lamp inspection, sealing a case after the products are qualified, and carrying out storage warehousing. The preparation method has the advantages of simplicity, low requirements on a process apparatus, small investment, and easy scale production; and the peony seed oil obtained through the method has a good quality controllability.

The invention discloses a biguanide anti-diabetes medicine, in particular to a metformin hydrochloride enteric-coated medicine compound. The medicine compound is provided with a. a hollow pill core; b. a biguanide anti-diabetes medicine active component layer which is covered outside the hollow pill core; c. an enteric-coated layer which is covered outside the biguanide anti-diabetes medicine active component layer. The invention also discloses a method of preparing the medicine compound.

The invention provides a derivate of low molecular weight fucosylated glycosaminoglycan (dLFG) and a medical composition containing the dLFG or pharmaceutically acceptable salt and application of the dLFG and the medical composition for preparing medicines for treating thrombotic diseases.

The invention relates to medical polyvinyl alcohol gel for filling, repairing, application and radiation protection. A preparing method is characterized by including the steps that a cross-linking system is jointly constructed through boric acid in a certain proportion and boraxin a certain proportion, the boric acid and the boraxin are fully dissolved, polyvinyl alcohol is added, the mixture is mixed to be even to be subjected to heating and heat preservation, and the gel is constructed in one or more physical modes. On the basis, 0.9% of sodium chloride is used for reducing the toxicity of the cross-linking system, and blended or copolymerized atactic polyvinyl alcohol, intermittent polyvinyl alcohol and block polyvinyl alcohol are used; monomer alcohol, alkane and aldehyde are added; glycerol is added; the mode that rare earth elements and natural polymers are added is used for adjusting the performance of a gel system and allowing the gel system to meet the requirements of prospective applications of different medical apparatus and instruments. By means of the medical polyvinyl alcohol and the preparing method, the better cross-linking effect, the lower and more controllable toxicity of a cross-linking agent, the better cold accumulation performance and the better radiation protection performance can be provided, biocompatibility is excellent, and the boric acid-boraxin cross-linkage polyvinyl alcohol gel system is can be easily improved in the following process.

The invention discloses a medicinal capsule for treating urinary system disease and preparation method, wherein the preparation comprises longspur epimedium 7.5-70%, prepared rehmannia root 6-50%, drynaria 5-65%, astragalus root 5-40%, radix salvia miltiorrhiza 5-60%, edible black fungus 3-20%, and cucumber seeds 5-30%.

The invention discloses active tea cream high in extraction rate and complete in beneficial component preservation and a preparation method thereof, and belongs to the technical field of tea leaf deep processing. The active tea cream comprises the following components by weight: 30 to 50 % of tea polyphenol, 20 to 30 % of tea polysaccharide, 6 to 10 % of free amino acid and 3 to 4 % of caffeine, and the sum of the weight percentage of the components is not larger than 100 %. The preparation method comprises processes of stocking, extracting, dirt-removing, condensing and forming: placing pulverized tea leaves in an extracting jar, adding an extractive at the temperature of 40 to 60 DEG C according to the feed-liquid ratio of 1: (10 to 15), extracting once or twice, extracting for 10 to 20 min every time, and collecting low temperature extract liquid; adding an extractive at the temperature of 60 to 80 DEG C according to the feed-liquid ratio of 1: (5 to 10), extracting once or twice, extracting for 10 to 20 min every time, and collecting high temperature extract liquid, mixing the extract liquid gained after double extraction according to certain proportion to gain total extract liquid, and gaining the active tea cream after dirt-removing, condensing and drying. The preparation method is high in extraction rate, complete in beneficial component preservation and simple in manufacturing technology; the prepared active tea cream is rich in nutrition, strong in fragrance and mellow in taste, and has a good market popularizing value.

The invention belongs to the technical field of medicaments and provides active ingredients of Chinese herbal medicine camptosorus sibiricus and an extraction method and use of the same. The extraction method comprises a water extraction method, an alcohol extraction method, a macroporous resin purification method and a solvent extraction method. The main active ingredients of an extract obtained by the method are total flavonoids, total momordica saponins and total organic acids, wherein the content of the total flavonoids is 1 to 35 percent, the content of the total momordica saponins is 1 to 25 percent and the content of the total organic acids is 1 to 3 percent. The invention also provides a method for preparing the camptosorus sibiricus into a proper formulation directly or by mixing with solid or liquid commonly used for preparations of the type in pharmaceutics. The active ingredients of the camptosorus sibiricus and the preparation thereof have functions of treating thromboangiitis obliterans, nephritis, traumatism and bleeding, metrorrhagia, neurodermitis, hemiplegia caused by cerebral embolism and diabetes-related complications. The extraction method is simple, easy to implement and low in cost. And the extract obtained is free from toxic and side effects.

The invention relates to an injectable implant and a preparation method thereof. The implant is amnion microparticles mixed in a sodium chloride phosphate physiological solution with a pH of 7.0-7.5. The preparation method comprises the following steps of disinfection processing, decellularization processing, modification processing, and amnion microparticle preparation, and in particular, comprises: taking amnion microparticles as a component A and a sodium chloride phosphate physiological solution as a component B, performing vibration and well mixing according to a mass volume ratio of 20:1-100:1 to prepare an amnion microparticle suspension with a concentration of 20-100 mg/mL by high-speed microjet equipment, wherein the particle size of the amnion microparticles is 50-200 microns. The injectable implant of the invention maintains the natural three dimensional stereo structure and a lot of natural active components of human amnion, reduces immunological rejection reaction caused by raw material source after clinical application of cosmetic injection products, is suitable for injection into deep subcutaneous dermal layer to subcutaneous superficial layer to repair moderate to severe wrinkles or folds, and has good cosmetic repair effect.

The invention discloses a folic acid enteric preparation composition and a preparation method thereof. The composition is mainly prepared from folic acid raw material medicine and proper accessories.The folic acid enteric preparation composition provided by the invention is effective and safe for the improvement of a folic acid preparation, and has the advantages of little stimulation to the stomach so as to reduce the side reaction and the like compared with folic acid stomach tablets. The folic acid enteric preparation composition is particularly applied to pregnant women and patients withstomach upset diseases. The invention provides a new dosage form which is safer and has identical treatment effect; and the preparation process has quality controllability and good stability.

The invention discloses a PVC hole-pipe gravel pile and a soft foundation processing method of the PVC hole-pipe gravel pile, and relates to the technical field of soft foundation processing. According to the structure of the PVC hole-pipe gravel pile, a concrete pile tip (60) and a novel pipe rock pile are connected with each other. The novel pipe rock pile comprises a PVC hole pipe (20) and a gravel pile body (10) arranged in the PVC hole pipe (20), wherein a novel cushion layer is arranged on the top of the novel pipe rock pile in a connected mode, and is connected with a first steel-plastic geogrid (31), a first gravel layer (41), a second steel-plastic geogrid (32), a second gravel layer (42) and a surface soil layer (50) in sequence, and a drainage system (70) is communicated with the novel cushion layer. According to the PVC hole-pipe gravel pile and the soft foundation processing method of the PVC hole-pipe gravel pile, construction is easy and convenient, cost is low, the controllable degree of quality is high, and the PVC hole-pipe gravel pile and the soft foundation processing method of the PVC hole-pipe gravel pile are applicable to a soft foundation processing project which is large in area, and has high requirements for the bearing capacity and differential settlement control.

The invention relates to a doxofylline-containing liquid injection used for treating bronchiectasis, and provides the doxofylline with higher concentration. The injection comprises doxofylline, a water solvent, and a pH value regulating agent. The injection comprises the following components by weight percentage: 1 to 4 percent of the doxofylline, and 0.01 to 5 percent of the pH value regulating agent. The injection enriches specifications of the prior doxofylline injection, and brings convenience to the clinical application. The invention also provides a preparation method and a quality control method for the doxofylline liquid injection. Relevant materials in the doxofylline injection can be determined by an HPLC method to improve the product controllability.

The invention relates to a method for low-temperature copperizing of the surface of titanium or a titanium alloy. The method comprises the steps that surface ultrasonic rolling treatment is conductedon a titanium or titanium alloy workpiece under the condition of ultralow temperature to enable the surface of the titanium or titanium alloy workpiece to plastically deform and sequentially form a gradient nano-structure layer including equiaxial nano-crystals, lamellar nano-crystals and macro-crystals from the most superficial layer to a core part; the workpiece subjected to ultrasonic rolling treatment is subjected to degreasing, oil removal and acid cleaning activation treatment; then the workpiece is plated with copper, cleaned and blow-dried; and finally the treated workpiece is placed into a vacuum annealing furnace to be subjected to copperizing treatment and then taken out for air cooling, a copper-plated layer is stripped, and cleaning and blow drying are carried out. According to the method, the copperizing temperature of the surface of the titanium or titanium alloy can be greatly decreased, the copperizing time is shortened, the copperizing thickness is increased, qualitycontrollability of an obtained copperized layer is strong, the copperized layer is uniform, flat and good in finish degree and has the good antibacterial property and biocompatibility, and the methodcan meet the clinical demand for human body hard tissue implants.

The invention relates to a deformation controlling method for machining a double-side multi-rib structural part. The method comprises the following steps of: 1) clamping a part blank by adopting a tool; 2) milling a single side reference till a new metal inner layer appears; 3) turning over the part, and clamping the part by using vacuum adsorption and an external tool; 4) machining a web plate and a lateral surface on the front side, and reserving low allowance or directly machining in place, wherein ribs are not machined in height; 5) removing the vacuum adsorption and the external tool, and removing the deformation of the upper surface part in a natural state; 6) turning over and then clamping the part by using the vacuum adsorption and the external tool again, and performing rough machining and finish machining on the reverse side sequentially till the size of the part is achieved; and 7) turning over again, clamping the part by using the vacuum adsorption and the external tool, milling the ribs on the front side until the height is appropriate, and performing finish machining till the size of the part is achieved. According to the method, the deformation of the part is controlled by adopting an internal stress counteraction method in the part machining process, so that the machining period is shortened, and the quality of the part is improved.

The invention discloses a preparation method of desulfurized building gypsum for powder gypsum mortar, which particularly comprises the following steps: 1) selecting flue gas desulfurized gypsum with a water content of below 10%; 2) allowing the flue gas desulfurized gypsum to enter a steam rotary kiln by a desulfurized gypsum charging / conveying system for drying and calcination; detecting the material temperature, and performing cloth-bag dusting; 3) performing cooling and homogenization in a cooling rotary kiln; 4) grinding in a grinding machine to obtain the desulfurized building gypsum, performing product detection, and keeping in reserve after qualification. The desulfurized building gypsum prepared by the invention has the characteristics of high purity, low content of the two aqueous phases, low coagulation time, high absolute dry strength, and the like; when the desulfurized building gypsum is used to prepare powder gypsum mortar, the retarder mixing amount is decreased and the aggregate mixing amount is increased, and the material cost is greatly reduced. Meanwhile, the mortar prepared by the desulfurized building gypsum has quite stable performance, and thus facilitates large-area construction, popularization and application. A good approach for the comprehensive resource utilization of desulfurized gypsum is provided.

The invention belongs to the field of processes for extracting plant effective components and discloses a method for extracting and separating ceramide in konjac flying powder. According to the invention, an ultrasonic technology is utilized to carry out primary processing, so as to separate the ceramide from raw material cells in short time, extraction time is short, damage to effective ingredients, which is caused by high temperature heating, is avoided, and an extraction rate is improved for extraction and separation in the next step; then the characteristic of selective dissolving capacity of carbon dioxide in a super-critical state is utilized to carry out secondary extraction, refining and separation on different polar materials. The method has the advantages of low operating temperature, good selectivity, no damage to effective ingredient structures, capability of perfectly storing active ingredients of natural plants and the like, and enables the ceramide in the konjac flying powder to be efficiently extracted and separated out; compared with the prior art, content of the ceramide is higher and the konjac flying powder is more pure.

A method for determining content of triamcinolone acetonide acetate and micronazole nitrate in qumixing emulsifiable paste utilizes high efficiency liquid plase external standard method to determine simultaneously out content of triamcinolone acetonide acetate and miconazole nitrate in qumixing emulsifiable paste.

The present invention relates a method for preparing gongyanping tablet and controlling quality. The gongyanping tablet is prepared from five Chinese traditional medicines including diren, shinyleaf pricklyash root, angelica, chuanposhi (tuomu), wuzhimaotao. The method comprises identifying and content determinating which takes octadecylsilane chemically bonded silica as filling agent; acetonitrile -0.05% phosphoric acid (3:97) as flowing phase; detecting wavelength 272nm; detecting the amount of gallic acid contained in manufactured goods each unit.

The invention discloses a Chinese medicinal extract with anti-allergic effect as well as a preparation method and an application thereof. The Chinese medicinal extract liquid is made from the following raw materials in parts by weight: 50 to 100 of Poria cocos, 10 to 50 of Fructus Macrocarpii, 10 to 50 of Ganoderma lucidum, and 10 to 35 of Fructus Viticis; and 1 to 20 of Salvia miltiorrhiza and 1 to 15 of Hibiscus sabdariffa can serve as adjuvant to be added in the raw materials for extraction. The Chinese medicinal extract is prepared by use of a ZLUPD high differential pressure continuous low-temperature high-efficiency extractor. The raw materials and solvents are mixed thoroughly by low-temperature differential pressure extraction technique, and then, under the powerful mechanical force generated due to high differential pressure in instantaneous vacuum-pressurization-vacuum cyclic variation, the tissue cells of the raw materials are broken and the effective components dissolve directly, resulting in a high transfer rate up to more than 90%. The extract liquid is filtered by a microporous membrane to produce a golden yellow transparent liquid which is added to anti-allergic cosmetics and is characterized in having stable properties, being absorbed rapidly by skin cells and having good anti-allergic and anti-inflammatory effects.

The invention discloses a flexible mineral insulated pre-branch fireproof cable. The fireproof cable comprises a trunk cable. The trunk cable is connected to a branch line cable through a branch connection head. The branch connection head comprises a branch shell. The branch shell comprises an aluminum-alloy upper shell and an aluminum-alloy lower shell. One end of the branch shell is provided with an inlet corresponding to the trunk cable. The other end of the branch shell is provided with an outlet corresponding to the branch line cable. An aluminum sleeve connecting device is arranged in the branch shell. The aluminum sleeve connecting device comprises a copper pressing plate. The copper pressing plate fixes the trunk cable to a U-shaped copper die casting. The U-shaped copper die casting is provided with a branch cable hole corresponding to the branch line cable. And the U-shaped copper die casting is also provided with an insulation puncture device corresponding to the trunk cable and the branch line cable. The branch shell is provided with an insulation glue pouring hole. And the insulation glue pouring hole is provided with a thread sealing port.

The invention relates to a spiral soil squeezing recompaction cast-in-place concrete pile, a pile forming drill bit and a construction method. According to the adopted technical scheme, the spiral soil squeezing recompaction cast-in-place concrete pile comprises a primary soil squeezing pile section and a plurality of recompaction sections, the primary soil squeezing pile section is a concrete pile I, concrete piles II arranged inside the recompaction sections, the outer diameter of the concrete piles II is larger than that of the concrete pile I, the concrete piles II are wrapped by a recompaction layer formed by mixing rock soil and concrete, and the concrete pile I and the concrete piles II are of an integrated structure. The spiral soil squeezing recompaction cast-in-place concrete pile can carry out strengthened compaction on a rock soil layer with the large compressibility in the pile depth range, the pile bearing capacity is further improved, and energy conservation and emissionreduction are achieved.

The invention discloses a blood leucocyte separating medium and application thereof, a preparation method of the blood leucocyte separating medium, and a blood leucocyte separating vacuum blood collection tube with the blood leucocyte separating medium and application thereof. The blood leucocyte separating medium comprises glucan T500, hydroxyethyl starch, meglumine diatrizoate, water, sodium citrate, NaN3, poly(diallyldimethylammonium chloride) and polyvinyl pyrrolidone, the proportion of parts by weight of which is 18.5-21.5:1.5-2.5:2-3:69:3.8:0.1:0.05-0.15:2-3. The invention has the advantages that clinical blood collection and anticoagulant leucocyte seperation can be completed at a time, the sodium citrate in the blood leucocyte separating medium and calcium ions in blood are chelate and anticoagulant, the technical problem of damaging the liquid level layer of the separating medium does not exit, a supernatant liquor is sucked up without needing centrifugation after natural precipitation, a complex cell seperation technology is transformed into a simple blood collection seperation process, the processes are easily united, the repeatability of test results is good, and the quality controllability is strong.