Hazel leaf flavonoid extract and its pharmaceutical composition

A technology of flavonoids and extracts from hazel leaves, which is applied in the field of flavones extracts from hazel leaves and their pharmaceutical compositions, and can solve the problems of restricting the application of hazel flavones and the lack of reports on the extraction methods of hazel flavones

Inactive Publication Date: 2011-11-30
HEILONGJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Hazel flavone is a biologically active substance rich in hazel. It is composed of a variety of flavonoids characterized by quercetin, kaempferol and its glycosides. They have a variety of physiological functions and can effectively prevent cancer. Antioxidant, blood lipid lowering, preventive eff

Method used

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  • Hazel leaf flavonoid extract and its pharmaceutical composition
  • Hazel leaf flavonoid extract and its pharmaceutical composition
  • Hazel leaf flavonoid extract and its pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1. Composition and preparation of the flavonoid extract pharmaceutical composition (soft capsule or hard capsule) of the present invention Prescription composition:

[0061]

[0062] Preparation method (prepared in the amount of 1000 grains):

[0063] Mix the caprylic / capric glyceride, transcutol, polyethylene glycol 400, polyoxyethylene hydrogenated castor oil (RH-40) and polyvinylpyrrolidone described above to obtain a mixed solution, and add the above-mentioned The flavonoids extract of flavones described above is obtained to obtain the pharmaceutical composition of the present invention, and then the obtained pharmaceutical composition is divided into soft capsules or hard capsules to obtain the soft capsule or hard capsule preparation containing the self-microemulsion of the present invention.

Embodiment 2

[0064] Embodiment 2. Composition and preparation of the pharmaceutical composition (soft capsule or hard capsule preparation) of hazel leaf flavone extract of the present invention

[0065]

[0066] Preparation method (prepared in the amount of 1000 grains):

[0067] Mix the above-mentioned caprylic / capric glycerides, isopropanol, poloxamer (F108) and polyvinylpyrrolidone evenly to obtain a mixed solution, and add the above-mentioned hazel leaf flavone extract to the mixed solution, The pharmaceutical composition of the present invention is obtained, and then the obtained pharmaceutical composition is divided into soft capsules or hard capsules to obtain the soft capsule or hard capsule preparation containing the self-microemulsion of the present invention.

Embodiment 3

[0068] Embodiment 3. Composition and preparation of the pharmaceutical composition (soft capsule or hard capsule preparation) of hazel leaf flavonoid extract of the present invention

[0069]

[0070] Preparation method (prepared in the amount of 1000 grains):

[0071] Mix caprylic acid / capric glyceride, oleic acid, polyethylene glycol 400, polyoxyethylene hydrogenated castor oil (RH-40) and hypromellose evenly to obtain a mixed solution, and pour it into the mixed solution Add the above-mentioned flavonoid extract of hazel leaves to obtain the pharmaceutical composition of the present invention, and then divide the obtained pharmaceutical composition into soft capsules or hard capsules to obtain the soft capsule or hard capsule preparation containing the self-microemulsion of the present invention.

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Abstract

The invention discloses a hazel leaf flavone extract and a medicinal composition thereof. The method for preparing the hazel leaf flavone extract comprises the following steps: 1) pulverizing dried hazel leaf into fine powder; 2) mixing the fine powder and helicase in a weight ratio of 1500:1 or so to obtain an extraction material; 3) filling the extraction material into an extraction kettle, carrying out supercritical carbon dioxide extraction to obtain a mixture, wherein the extraction conditions are as follows: the extraction pressure is 35MPa, the extraction temperature is 48-52 DEG C, the supercritical carbon dioxide flow rate is 37-40kg/h, and the extraction time is 2.0-2.5 hours; and 4) carrying out two-stage separation on the extraction mixture in the step 3 through a reduced pressure separation kettle, thereby obtaining the hazel leaf flavone extract, wherein the primary pressure separation is carried out under the pressure of 7.5MPa or so at the temperature of 45-50 DEG C, and the secondary reduced pressure separation is carried out under the pressure of 5.5MPa at the temperature of 45 DEG C. The invention has the advantages of high extraction yield and high composition dissolution rate.

Description

technical field [0001] The invention relates to a hazel leaf flavonoid extract and a pharmaceutical composition thereof. Background technique [0002] The active ingredients in plant materials exist in cells surrounded by cell walls and protoplasts. The outer walls are composed of cellulose, hemicellulose, pectin, lignin and other substances. There are also proteins, lipid compounds, Sugars and other substances form obstacles to the extraction and purification of natural compounds such as flavonoids. In recent years, researchers have successively adopted liquid-phase enzymes (such as aqueous phase enzymes) to degrade cell walls, intercellular junctions and some components that interfere with extraction, which can not only shorten the extraction time, but also increase the yield of active components. In recent years, based on the research and development of aqueous enzyme catalysis, a new and distinctive non-aqueous medium, namely supercritical fluid, has been discovered. I...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P35/00A61P39/06A61P3/06A61K127/00
Inventor 金涛刘利群邹积宏
Owner HEILONGJIANG UNIV
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