68results about How to "Active ingredient clear" patented technology

The present invention relates to the new use of narigenin and similar compounds in preparing medicines for treating cardiac and cerebral vascular diseases. These compounds include narigenin and its derivative, hesperidene and its derivative, isosakuranetin and its derivative, eriodictyol and its derivative, etc. These compounds may be used in preventing, diagnosing and treating cerebral infarction, myocardial infarction, cerebral ischemia-reperfusion injury, myocardial ischemia-reperfusion injury and other cardiac and cerebral vascular diseases as well as Alzheimer disease and its relevant diseases. These compounds have high pharmacological action, low toxicity, wide material source, low cost and other advantages.

The invention provides a dendrobium officinale extract. In the extract, the content of dendrobium officinale polysaccharides is 70.0-90.0%, and the content of general flavones is 0.5-1.0%. The dendrobium officinale extract is capable of being used for preparing medicines or health products for preventing and treating embolic cardiovascular and cerebrovascular diseases and renal diabetes. The invention further provides a preparation method of the extract. The preparation method specifically comprises the four steps of organic solvent degreasing, flash extraction after ethanol solution soaking, Sevage reagent deproteinization and active carbon decolouration. The preparation method is capable of protecting the dendrobium officinale effective ingredient not to be thermally broken and furthest effectively extracting the dendrobium officinale polysaccharides and the flavones simultaneously, low in solvent dosage, short in extraction time, and capable of improving product quality and reducing production cost.

The invention discloses an active site composition of isatis roots, as well as a preparation method and the application thereof. The active site composition of isatis roots is prepared from a general phenylpropanoid part of isatis roots, a total alkaloid part, a total organic acid part and a total polysaccharide part. The active site composition obtained by the invention has high effective component contents and accurate active components. Proved by experimental results, the active site composition of isatis roots has obvious antiviral activity and favorable antibacterial and antipyretic activities. After being combined, the effective components reach favorable synergy, exert the antiviral, antibacterial and antipyretic activities at a plurality of targets spots through multiple paths, can be used for treating a viral disease with the bacterial inflammation of a febrile disease and have a wider clinical application range. Moreover, the invention optimizes and designs the extracting and refining process according to the physicochemical properties of the effective components, the active parts obtained through preparation has high effective component contents, and the preparation method has strong maneuverability and can realize industrialized mass production.

The invention relates to a traditional Chinese medicine for treating insulin resistance of type 2 diabetes, and is used for solving the problem that the safe and efficient drugs for treating insulin resistance of type 2 diabetes are not available at present. The traditional Chinese medicine for treating insulin resistance of type 2 diabetes is prepared from the following components in parts by weight: 10-20 parts of American ginseng, 20-40 parts of coix seed and 10-20 parts of alisma. The traditional Chinese medicine has mild drug property and low toxic and side effect, and is used for treating insulin resistance of type 2 diabetes with the main characteristics, such as deficiency of spleen qi and interior accumulation of dampness and turbid. Compared with the similar traditional Chinese medicines, the traditional Chinese medicine has clear main active ingredients and definite disease treatment effect, and can obviously improve insulin resistance of type 2 diabetes.

The invention relates to a medicine treating carcinoma of colon and the method for preparing the same, which in detail is aglycone extract from root of Patrinia scabra Bge and the preparation method. The effective component is iridoid glycosides aglycone, the content is above 40%. The invention also provides the medicine agent and preparation. It is proved by pharmacologia test that the medicine is characterized by safe utilization, function of preventing the weight of tumor in transplanted carcinoma of colon. The extract can be produced into preparations of tablet, capsule, drop pill, granular or oral.

The invention discloses a Chinese medicine compound effective part with an effect of treating arthritis. The effective part is prepared via the steps as follows: 10-50 parts of frankincense and 10-50 parts of myrrh are abstracted via water or alcohol, impurities are removed via alcohol deposition, and the frankincense and the myrrh are placed on a macropore adsorption resin column, and eluted and purified with alcohol gradient with optimized concentrate. The effective part is refined and prepared via modern analytical apparatuses and pharmacological experiments section and according to Chinese medicine theories, the pathogenesis of rheumatic and rheumatoid arthritis. Shown by the experiment result, the Chinese medicine compound effective part provided by the invention has the good effects of antiphlogosis, pain easing, immunization regulation and the like, can be used for treating rheumatic and rheumatoid arthritis, proliferative arthritis, and inflammation pain diseases, is clear in ingredient, low in clinical dosage and lower in adverse reaction, and possibly can be developed as a new generation of medicine for treating the arthritis.

The present invention discloses application of bilobalide as a synergist in preparation of a drug or a heath product for preventing cranial nerve injury diseases. An inventor discovers that compounds of bilobalides, particularly bilobalide, bilobalide extracts, and hydroxyl derivatives of bilobalides, particularly glucoside derivatives, ester derivatives and ether derivatives can well promote drug molecules with a treating or health care function on cranial nerve injury diseases to enter brain tissues, wherein the drug molecules comprise ginsenoside, stibene glucoside, resveratrol, levodopa, edaravone, vinpocetine, nicergoline, citicoline, oxiracetam and the like; under the conditions of not increasing drug concentration in blood, the concentration of bilobalide can be increased to a large extent in the brain tissues, so that the efficacy of the drug can be improved, and side effects and adverse reactions of the drug can be reduced.

The invention relates to a Chinese wampee fruit extract and application thereof in preparation of a medicine for preventing and treating an alzheimer disease. The prepared Chinese wampee fruit extract disclosed by the invention can be applied to the medicine for preventing and treating the alzheimer disease as a new method for preventing and treating the alzheimer disease. The medicine disclosed by the invention has the effects of resisting oxidation, inhibiting generation of Abeta, reducing activation of astrocyte cells, and protecting nerve cells, so that the cognitive disorder caused by the disease can be effectively relieved; and the Chinese wampee fruit extract has a relatively good effect on prevention and treatment of the alzheimer disease.

The invention discloses a use of a bufadienolide compound in preparing medicines for treating oral mucosal malignant tumors. Anti-cancer experiments of human tongue squamous cancer cells are carried out in vitro through a bufadienolide extract and monomeric compounds, namely gamabufalin, arenobufagin, telocinobufagin, bufotaline, cinobufagin, desacetylcinobufotalin, heloniogenin, resibufogenin, and cinobufotalin, and experimental results show that the bufadienolide compound has strong inhibition effect on tongue squamous cancer cells and compared with the bufadienolide extract and eight monomeric compounds, namely gamabufalin, arenobufagin, telocinobufagin, bufotaline, desacetylcinobufotalin, heloniogenin, resibufogenin, and cinobufotalin, cinobufagin has a stronger anti-tumor cell activity. The bufadienolide compound provided by the invention has clear components, controllable quality, strong anti-tumor activity and little adverse reaction and is expected to be developed into a novel anti oral mucosal malignant tumor medicine.

The invention relates to a maca extract with sexual dysfunction improving function and a preparation method and application thereof. The maca extract is an effective part which is extracted from maca, and mainly consists of maca amide active ingredients, such as N-benzyl linenamide, N-benzyl linoleamide, and N-benzyl hexadecanamide. In the maca extract of effective part, the content of maca amide is 30% to 100%. The invention also provides a preparation method of the maca extract, an active ingredient content measuring method and application. The maca extract has the advantages that the function of improving sexual dysfunction, improving fertility and resisting fatigue is good, and the effect is better than the effect of the maca raw material. The preparation method of the maca extract has the advantages that the preparation method is normal and standard, the technology is simple, and the industrialized production is easy; the content of effective component in maca extract is higher, and the medicine effect is clear.

The invention discloses a Chinese traditional medicine composition for relieving side effects of hormones, wherein the composition comprises barren wort flavones extract, anemarrhena rhizome saponins extract and glycyrrhetinic acid. The invention also discloses the process for preparing medicament for reducing side effect of hormones.

An anti-tumor Chinese medicine product comprises medicine, reagent, food and drink and is characterized in that the effective component of the Chinese medicine product is a betulic acid liposome containing betulic acid. The entrapment rate of the betulic acid liposome reaches over 90 percent and particle diameter is 100 to 1000 nanometers. Firstly, the betulic acid plastid is obtained by membrane process; and then the single betulic acid liposome or the betulic acid liposome as well as other chemical substances comprising a pharmaceutically acceptable carrier, the food, a natural product, synthetic chemicals or medicine composition for human are made into the medicine, the food or the drink by general process.

The invention discloses a medicine composition for treating depression. The medicine composition consists of the following four components: geniposide, naringin, neohesperidin and magnolol; the medicine composition comprises the following components in parts by weight: 5-20 weight parts of geniposide, 5-20 weight parts of naringin, 5-20 weight parts of neohesperidin and 0.5-2 weight parts of magnolol; and preferably, the medicine composition comprises the following components in parts by weight: 10 weight parts of geniposide, 10 weight parts of naringin, 10 weight parts of neohesperidin and 1 weight part of magnolol. The composition disclosed by the invention can be used for preparing medicines for treating depression, and has the advantages of accurate composition, significant medicine effect, safety and reliability.

A composite medicine for treating depression is prepared from pachyman (3.5-14 g) and ginger oil (0.2-3.5g) through proportioning, including ginger oil by beta-cyclodextrin, and mixing. Its advantages are sure curative effect and high safety.

The invention discloses a myrrh target area for treatment of gynecological tumors and a preparation method and application thereof. The preparation method comprises the following steps: extracting with alcohol for myrrh and other solvents through supercritical fluid extraction, impregnation or reflux extraction to obtain alcohol extract; concentrating, suspending the concentrate with water, extracting with ether, petroleum ether, n-hexane or other low-polar solvents to obtain low-polar solvents extract; and concentrating, thereby obtaining the myrrh target area with 0-5 weight percent of diterpene and 0-30 weight percent of diterpenoid resin acid components. The invention combines the modern extraction and separation and the pharmacological activity screening to determine the optimal target area, the active ingredients of the prepared target area are clearer, the contents of the active ingredients are high and the results of in vitro anti-tumor experiments show that the myrrh target area provided by the invention has the function of inhibiting and killing multiple kinds of gynecological tumors with low dosage, and is expected to be developed as the novel traditional Chinese medicine with significant treatment effect and fewer low adverse reactions.

The invention discloses a transdermal patch for preventing and treating lumbar disc herniation and a preparation method thereof. The transdermal patch includes a back lining layer, a drug-containing substrate layer fixed on the back lining layer and an anti-sticking layer covering the drug-containing substrate layer. The drug-containing substrate layer includes 15-45 parts of a hydrogel substrate, 15-45 parts of a volatile oil part, 30-90 parts of an ethanol refined extract and 8-24 parts of a transdermal penetration enhancer. The traditional Chinese medicines of the transdermal patch are matched scientifically and reasonably and the transdermal patch has a large carrying capacity. A test result proves that the hydrogel transdermal patch has significant effects of inflammation resistance, blood activation and pain relieving, has an excellent effect of treating the lumbar disc herniation, has a long-action slow-releasing effect of slowly releasing active drug components durably, is convenient to use, and is free of stimulation and allergy on skin.

The invention provides preparation for anti-tumor compound medicine active ingredients. The compound comprises the following medicines: sculellaria barbata, Chinese lobelia, oldenlandia diffusa and windpipe trachea. The preparation for compound medicine active ingredients comprises the following steps: first, all the medicinal materials of the compound are crushed; second, extraction is carried out with medicinal ethanol for 3 times, filtration is carried out and the extraction solutions are mixed, ethanol is recycled and a dry extract is obtained; third, the dry exact is subjected to ultrasonic dissolution with water, a suspension is obtained, extraction is carried out for 3-5 times by utilization of isopyknic ethyl acetate, the extraction solutions are mixed, heating decolouring is carried out with active carbon, ethyl acetate is recycled and a solid is obtained; fourth, the solid is dissolved through squeezing with petroleum ether, filtration is carried out, insoluble substances are obtained, namely the active ingredients are obtained. The anti-tumor effects are stable, the active components are clear, the quality is controllable, the technology is simple, the preparation method is suitable for industrial production and the officinal prospect is wide.

The invention discloses effervescent tablets and a preparing method and application thereof. The effervescent tablets comprise active components and auxiliary materials, wherein the active componentscomprise, by mass, 5-30 parts of an extract 1, 10-30 parts of an extract 2, 10-20 parts of an extract 3, 5-20 parts of an extract 4 and 15 parts of an extract 5. The extract 1 is prepared from 30 or 35 parts of fruits of actinidia arguta, 20-40 parts of abelmoschus esculentus and 10-40 parts of Chinese yam; the extract 2 is prepared from 30 or 40 parts of mulberry fruits, 20-50 parts of black currants and 10-40 parts of blueberries; the extract 3 is prepared from 5 parts of radix codcnopsitis pilosulas, 5-10 parts of rhizome chuanxiong, 20-30 parts of herba taraxaci, 20-30 parts of roasted malt, 5-10 parts of fructus evodiae and 10-30 parts of fructus ziziphi jujubae. The extract 4 is prepared from black rice bran; the extract 5 is prepared from honey. The effervescent tablets are appliedto preparing products with the function of alleviating and restoring gastric ulcers, at least one activity function of resisting oxidation, resisting fatigue, resisting tumors and reducing blood sugarand the effect of protecting the liver.