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Use of naringenin and derivative in preparation of product for resisting cardiovascular and cerebrovascular disease

A technology for cardiovascular and cerebrovascular diseases and naringenin, which is applied in the fields of food and beverages and medicine, and can solve problems such as the influence of liver function and transaminase index, the growth of sales is not as good, and market development is restricted.

Inactive Publication Date: 2006-11-22
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0052] Tetrahydroaminoacridine was the first cholinesterase inhibitor to pass FDA and clinically treat Alzheimer's disease, but regulations still need to be improved
[0059] The disadvantage of tacrine is that it has a great impact on liver function and transaminase index, which restricts the development of the market, and its sales growth is far behind other AD drugs
[0108] However, through literature search, so far, no report on the application of naringenin and its derivatives as anti-cardiocerebral disease products has been found; that is, so far, no naringenin and its derivatives have been used for Preparation of products against cerebral infarction and myocardial infarction, products against cerebral ischemia-reperfusion injury, myocardial ischemia-reperfusion injury, products against sequelae of stroke and vascular dementia and reports on products used in the preparation of anti-Alzheimer's disease

Method used

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  • Use of naringenin and derivative in preparation of product for resisting cardiovascular and cerebrovascular disease
  • Use of naringenin and derivative in preparation of product for resisting cardiovascular and cerebrovascular disease
  • Use of naringenin and derivative in preparation of product for resisting cardiovascular and cerebrovascular disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0188] Embodiment 1, the impact of naringenin and its derivatives on acute cerebral ischemia in mice

[0189] grouping:

[0190] ①Blank control group: given the same volume of normal saline as the drug group;

[0191] ② Positive control drug group: Administer breviscapine tablets (Shanghai Leiyunshang Pharmaceutical Co., Ltd., product batch number 031111), with a dose of 200 mg / kg;

[0192] ③Test drug group: given the test drug, the dose is 200mg / kg;

[0193] method:

[0194] Each group was intragastrically administered once a day for 7 days. One hour after the last administration, the anesthetized mice were fixed in the supine position on the surgical closure, the skin of the neck was cut open, the common carotid arteries on both sides were separated, the left and right common carotid arteries with the vagus nerve were ligated with No. 4 surgical thread, and the death of the mice was recorded. time.

[0195] group

dosage

Average survival time of mice (mi...

Embodiment 2

[0198] Example 2. Protective effect of naringenin and its derivatives on focal cerebral ischemia-reperfusion injury in rats

[0199] Group:

[0200] ①Blank control group: given the same volume of normal saline as the drug group;

[0201] ② Positive control drug group: the drug breviscapine tablets (Shanghai Leiyunshang Pharmaceutical Co., Ltd., product batch number 031111) was administered at a dose of 50 mg / kg;

[0202] ③Test drug group: given the test drug, the dose is 50mg / kg;

[0203] method:

[0204] The SD rats, 280-300g, were anesthetized with 10% chloral hydrate 3ml / kg intraperitoneally, and the neck was cut in the middle, and the proximal end of the right common carotid artery, external carotid artery and its branch arteries were separated and ligated. The right internal carotid artery was separated, the pterygognathic artery was separated downward along the internal carotid artery, and the root of the branch was ligated. Prepare the thread at the proximal end of ...

Embodiment 3

[0212] Example 3, Effects of Naringenin and Its Derivatives on Learning and Memory in Vascular Dementia Rats

[0213] Group:

[0214] ①Blank control group: given the same volume of normal saline as the drug group;

[0215] ② Positive control drug group: the drug breviscapine tablets (Shanghai Leiyunshang Pharmaceutical Co., Ltd., product batch number 031111) was administered at a dose of 100 mg / kg;

[0216] ③Test drug group: given the test drug, the dose is 100mg / kg;

[0217] method:

[0218] The SD rats, 280-300g, were anesthetized with 10% chloral hydrate 3ml / kg intraperitoneally, and the neck was cut in the middle, and the proximal end of the right common carotid artery, external carotid artery and its branch arteries were separated and ligated. The right internal carotid artery was separated, the pterygognathic artery was separated downward along the internal carotid artery, and the root of the branch was ligated. Prepare the thread at the proximal end of the external ...

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Abstract

The present invention relates to the new use of narigenin and similar compounds in preparing medicines for treating cardiac and cerebral vascular diseases. These compounds include narigenin and its derivative, hesperidene and its derivative, isosakuranetin and its derivative, eriodictyol and its derivative, etc. These compounds may be used in preventing, diagnosing and treating cerebral infarction, myocardial infarction, cerebral ischemia-reperfusion injury, myocardial ischemia-reperfusion injury and other cardiac and cerebral vascular diseases as well as Alzheimer disease and its relevant diseases. These compounds have high pharmacological action, low toxicity, wide material source, low cost and other advantages.

Description

technical field [0001] The present invention relates to the technical fields of medicine, food and beverages, in particular to the use of naringenin and its derivatives, and more specifically to the use of naringenin and its derivatives in the preparation of anti-cardiocerebral disease products use. Background technique [0002] (1) Research progress of naringenin and its derivatives [0003] 1. Overview [0004] The plant sources of naringenin are the flower buds of Prunus yedoensis Mats. of Rosaceae plants, the flower buds of plum P.mumeSieb.etZucc., etc. The English name of naringenin is naringenin, and its molecular formula and molecular weight are C 15 h 12 o 5 , 272.25, the structural formula is shown on the right. [0005] [0006] Naringenin is a white needle-like crystal (methanol), with a melting point of 260°C. Naringenin is soluble in ethanol, ether and benzene, and almost insoluble in water. [0007] A considerable part of naringenin and its derivatives...

Claims

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Application Information

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IPC IPC(8): A61K31/352A23L2/52A23L33/105A61K31/7048A61P9/00A61P9/10A61P25/28G01N33/48
Inventor 李铁军陆波邱彦毛俊琴陈强徐江平芮耀诚
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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