Application of a kind of 4-hydroxyl-2-pyridone alkaloid in the preparation of anti-tumor products

A technology of pyridone and alkaloids, which is applied in the field of medicine, can solve the problems such as the lack of biological activity of Sambutoxin, and achieve the effect of strong pharmacological effect, significant activation activity and safe use

Active Publication Date: 2020-05-12
SHANDONG UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0006] It was originally isolated from the fermentation broth of the rotten potato endophyte Fusarium sambucinum, but the existing technology only studies the synthesis of Sambutoxin, and there is no relevant report on the biological activity of Sambutoxin

Method used

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  • Application of a kind of 4-hydroxyl-2-pyridone alkaloid in the preparation of anti-tumor products
  • Application of a kind of 4-hydroxyl-2-pyridone alkaloid in the preparation of anti-tumor products
  • Application of a kind of 4-hydroxyl-2-pyridone alkaloid in the preparation of anti-tumor products

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Embodiment Construction

[0025] It should be pointed out that the following detailed description is exemplary and is intended to provide further explanation to the present application. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

[0026] It should be noted that the terminology used here is only for describing specific implementations, and is not intended to limit the exemplary implementations according to the present application. As used herein, unless the context clearly dictates otherwise, the singular is intended to include the plural, and it should also be understood that when the terms "comprising" and / or "comprising" are used in this specification, they mean There are features, steps, operations, means, components and / or combinations thereof.

[0027] The organic solvent described in this application is a kind of solvent with organic medium as the medi...

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Abstract

The invention discloses application of 4-hydroxyl-2-pyridone alkaloid in preparing an antitumor product. The 4-hydroxyl-2-pyridone alkaloid is Sambutoxin, and a chemical structure of the 4-hydroxyl-2-pyridone alkaloid is shown in the description. Through researches of animal experiments, cell experiments and the like, the compound is shown to have very strong antitumor activity on varieties of tumor cells including lung cancer, cervical cancer, colon cancer and breast cancer; the compound has the advantages of obvious effects, safety, low toxin, convenience in use and rich and cheap raw material sources; a preparation technology has the advantages of simpleness, high yield, stable characters, convenience in quality control, lower production cost and convenience in application production; anovel medicine source and a safe raw material are provided for treating and researching antitumor and direct related diseases of the antitumor.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of a 4-hydroxy-2-pyridone alkaloid in the preparation of antitumor products. Background technique [0002] Tumor is a frequently-occurring and common disease that seriously endangers human health and life. As early as 2000-3000 years ago, there were records about tumors in Egypt and my country. In many countries including China, especially in moderately developed countries, the death caused by cancer occupies the first or second place among all the causes of death, and the incidence rate is still on the rise worldwide. Tumor is an abnormal lesion formed by the body under the action of various carcinogenic factors when a certain cell in a local tissue loses its normal regulation of its growth at the gene level, resulting in its clonal abnormal proliferation. Generally divided into benign and malignant two categories. All malignant tumors are collectively called ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4433A61P35/00C07D405/04A23L33/00A23L31/00
Inventor 郭秀丽李璐宁张新科程艳娜王磊
Owner SHANDONG UNIV
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