Transdermal patch for preventing and treating lumbar disc herniation and preparation method thereof

The technology of lumbar intervertebral disc herniation and transdermal patch is applied in the field of transdermal patch for preventing and treating lumbar intervertebral disc herniation and its preparation, and can solve the problems of easy occurrence of lumbar intervertebral disc herniation, low bioavailability, loss of bone calcium, and the like, Achieve the effect of preventing and treating lumbar intervertebral disc herniation, fast transdermal absorption, and good lumbar intervertebral disc herniation

Inactive Publication Date: 2015-08-05
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, it is also clinically manifested as radiating pain in the lower limbs, numbness in the limbs, muscle paralysis and other symptoms, which seriously affect people's lives.
[0003] With the growth of age, people lose calcium in their bones, coupled with improper sitting posture, lumbar intervertebral discs are prone to lumbar disc herniation and other diseases, which seriously affect people's life and work. For lumbar disc herniation, surgery is generally used for treatment. Disadvantages such as pain and high cost, Chinese medicine has a unique advantage in preventing and treating lumbar disc herniation, but most of the traditional Chinese medicines currently used to treat lumbar disc herniation are mainly oral, have first-pass effects and damage to the gastrointestinal tract, and have low bioavailability And other issues

Method used

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  • Transdermal patch for preventing and treating lumbar disc herniation and preparation method thereof
  • Transdermal patch for preventing and treating lumbar disc herniation and preparation method thereof
  • Transdermal patch for preventing and treating lumbar disc herniation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The preparation method of the transdermal patch for preventing and treating lumbar intervertebral disc herniation according to the present invention comprises the following steps:

[0039] (1) Take 40 parts of Angelica sinensis, 30 parts of Codonopsis pilosula, 20 parts of safflower, 30 parts of Salvia miltiorrhiza, 25 parts of Chuanxiong, 20 parts of drynaria, 10 parts of dog ridge, 16 parts of Guanzhong, 20 parts of Eucommia, 35 parts of Dipsacus, 20 parts of Corydalis Corydalis, 40 parts of Dried Ginger, 16 parts of Duhuo, 16 parts of Chuanduan, 30 parts of Achyranthes bidentata, 25 parts of Radix Paeoniae Alba, 18 parts of Qingfengteng, 40 parts of Astragalus, 20 parts of Cuscuta, 30 parts of Miltonia, deer A traditional Chinese medicine composition composed of 10 parts of Herbs, 20 parts of Grass Sinensis and 6 parts of Scorpion; add 12 times the total weight of the Chinese medicine composition and decoct for 3 times, and collect the volatile oil parts with a volati...

Embodiment 2

[0045] A transdermal patch for preventing and treating lumbar intervertebral disc herniation, comprising a backing layer, a drug-containing matrix layer and an anti-adhesive layer, the preparation method of which comprises the following steps:

[0046] (1) Take (1) take 40 parts of Angelica sinensis, 30 parts of Codonopsis pilosula, 30 parts of safflower, 30 parts of Salvia miltiorrhiza, 30 parts of Chuanxiong, 25 parts of drynaria, 20 parts of dog ridge, 24 parts of rhizome, 30 parts of Eucommia, continued 40 parts of Duan Hu Suo, 40 parts of Corydalis Corydalis, 40 parts of Dried Ginger, 30 parts of Duhuo, 20 parts of Chuan Duan, 40 parts of Achyranthes bidentata, 25 parts of Radix Paeoniae Alba, 24 parts of Qingfengteng, 40 parts of Astragalus, 20 parts of Cuscuta, and Millet Spatholobus 40 parts, 25 parts of Luniancao, 45 parts of Shenjincao and 10 parts of Scorpion; add 10 times the total weight of the Chinese medicine composition and decoct twice, and collect the volatile...

Embodiment 3

[0052] A transdermal patch for preventing and treating lumbar intervertebral disc herniation, comprising a backing layer, a drug-containing matrix layer and an anti-adhesive layer, the preparation method of which comprises the following steps:

[0053] (1) Take 20 parts of Angelica sinensis, 15 parts of Codonopsis pilosula, 15 parts of safflower, 15 parts of Salvia miltiorrhiza, 15 parts of Chuanxiong, 10 parts of drynaria, 10 parts of dog ridge, 6 parts of Guanzhong, 10 parts of Eucommia, 10 parts of Dipsacus, 10 parts of Corydalis Corydalis, 20 parts of Dried Ginger, 10 parts of Duhuo, 10 parts of Chuanduan, 10 parts of Achyranthes bidentata, 5 parts of Radix Paeoniae Alba, 6 parts of Qingfengteng, 20 parts of Astragalus, 10 parts of Cuscuta, 20 parts of Miltonia, deer A traditional Chinese medicine composition consisting of 10 parts of Herbs, 15 parts of Grass and 5 parts of Scorpion; adding 8 times the total weight of the Chinese medicine composition and decocting for 3 tim...

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Abstract

The invention discloses a transdermal patch for preventing and treating lumbar disc herniation and a preparation method thereof. The transdermal patch includes a back lining layer, a drug-containing substrate layer fixed on the back lining layer and an anti-sticking layer covering the drug-containing substrate layer. The drug-containing substrate layer includes 15-45 parts of a hydrogel substrate, 15-45 parts of a volatile oil part, 30-90 parts of an ethanol refined extract and 8-24 parts of a transdermal penetration enhancer. The traditional Chinese medicines of the transdermal patch are matched scientifically and reasonably and the transdermal patch has a large carrying capacity. A test result proves that the hydrogel transdermal patch has significant effects of inflammation resistance, blood activation and pain relieving, has an excellent effect of treating the lumbar disc herniation, has a long-action slow-releasing effect of slowly releasing active drug components durably, is convenient to use, and is free of stimulation and allergy on skin.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine composition and an external hydrogel patch, in particular to a transdermal patch capable of preventing and treating lumbar intervertebral disc herniation and a preparation method thereof. Background technique [0002] Lumbar intervertebral disc herniation refers to a series of symptoms caused by the herniation of the lumbar intervertebral disc's nucleus pulposus and its surrounding nerve tissue. Clinical statistics show that lumbar disc herniation (prolapse) is one of the most common diseases in orthopedic outpatient clinics, and it is also the most common cause of low back pain. Clinically, persistent low back pain is the most common, and it can be relieved by lying down. , standing is exacerbated, under normal circumstances can be tolerated, and to allow moderate activities of the waist and slow walking, mainly caused by mechanical compression. The duration is as little as 2 weeks, and the eld...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K36/9068A61P19/08A61K35/646
Inventor 陶永梅马艳春徐丹杨书彬
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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