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Pharmaceutical composition, liquid crystal gel prepared from pharmaceutical composition, and preparation method and applications of pharmaceutical composition

A technology of gel preparation and composition, applied in the field of pharmaceutical preparations, can solve problems such as large viscosity, and achieve the effects of moderate viscosity, favorable for skin penetration, and good therapeutic effect

Inactive Publication Date: 2018-12-04
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the conventional lyotropic liquid crystal systems have relatively high viscosity, which has certain limitations in the field of drug carriers and needs further optimization

Method used

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  • Pharmaceutical composition, liquid crystal gel prepared from pharmaceutical composition, and preparation method and applications of pharmaceutical composition
  • Pharmaceutical composition, liquid crystal gel prepared from pharmaceutical composition, and preparation method and applications of pharmaceutical composition
  • Pharmaceutical composition, liquid crystal gel prepared from pharmaceutical composition, and preparation method and applications of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0061] Secondly, the present invention provides a preparation method of the above pharmaceutical composition, which includes the step of mixing gentamicin, ciprofloxacin, solvent, gel material and lyotropic liquid crystal material.

[0062] Thirdly, the present invention provides a liquid crystal gel preparation prepared from the above pharmaceutical composition.

[0063] Again, the present invention provides the preparation method of above-mentioned liquid crystal gel preparation, and it comprises the following steps: 1) gentamicin, ciprofloxacin, solvent that comprise in the pharmaceutical composition are mixed, then mix with gel material again , obtain the drug-loaded gel after swelling; 2) mix the lyotropic liquid crystal material with the drug-loaded gel obtained in step 1), and obtain the liquid crystal gel preparation after standing.

[0064] In a preferred embodiment, the above-mentioned preparation method comprises the following steps: 1) mixing gentamicin, ciprofloxa...

experiment example 1

[0071] Experimental example 1: In vitro inhibitory effect of gentamicin / ciprofloxacin on common pathogenic bacteria in seawater.

[0072] The main pathogenic bacteria in seawater are Vibrio alginolyticus, Vibrio vulnificus, Acinetobacter baumannii, Pseudomonas aeruginosa, etc. In this example, the test tube culture method was used to investigate the effects of gentamicin and / or ciprosa. The in vitro inhibitory effect of star on the above bacteria.

[0073] 1 Instruments and reagents:

[0074] 1.1 Instruments:

[0075] High pressure steam sterilizer (SANYO company, Japan)

[0076] THZ-D desktop constant temperature oscillator (Taicang Experimental Equipment Factory)

[0077] Electric constant temperature incubator (Tianjin Zhonghuan Experimental Electric Furnace Co., Ltd.)

[0078] Biological safety cabinet (NUAIRE company, USA)

[0079] New class MS type one hundred thousandth balance (METTLER-TOLEDO company, Switzerland)

[0080] 1.2 Materials and reagents:

[0081] Vi...

experiment example 2

[0119] Experimental Example 2: Preparation and Characterization of Gentamicin / Ciprofloxacin Liquid Crystal Gel Preparation.

[0120] In this embodiment, water (deionized water) is used as a solvent, poloxamer is used as a gel material, and glycerol monooleate / ethanol is used as a lyotropic liquid crystal material to prepare a liquid crystal containing gentamicin / ciproxa Star's liquid crystal gel preparation, and use polarizing microscope and small angle X-ray scattering instrument to characterize the prepared liquid crystal gel preparation.

[0121] 1 Instruments and reagents:

[0122] 1.1 Instruments:

[0123] Vortex mixer (Haimen Qilinbeier Instrument Manufacturing Co., Ltd.)

[0124] Axio Imager Ai polarizing microscope (Zeiss, Germany)

[0125] SAXSess small-angle X-ray scattering instrument (Anton Paar, Austria)

[0126] 1.2 Materials and reagents:

[0127] Glyceryl monooleate (abbreviated as GMO, Denmark company, U.S.)

[0128] Ethanol (Sinopharm Chemical Reagent C...

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Abstract

The invention belongs to the field of medicinal preparation, and relates to a pharmaceutical composition, a liquid crystal gel preparation prepared from the pharmaceutical composition, and a preparation method and applications of the pharmaceutical composition. The pharmaceutical composition comprises gentamycin, ciprofloxacin, a solvent, a gel material, and a lyotropic liquid crystal material. The liquid crystal gel preparation prepared from the pharmaceutical composition is white, is uniform, is moderate in viscosity, and is convenient for smearing, and a novel approach is provided for antibiotic medicine liquid crystal gel preparation development. Compared with commercially available medicines of the same kind, after treatment of wounds infected with seawater pathogenic bacteria with the liquid crystal gel preparation, healing situations are excellent. After preparation of the two active antibacterial components into the liquid crystal gel, better skin permeability is achieved, so that the treatment effect on bacterium infection after immersion in seawater is better.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a pharmaceutical composition comprising gentamicin and ciprofloxacin, a liquid crystal gel preparation prepared therefrom, a preparation method thereof, and its preparation for preventing and / or treating seawater Use in medicine for soaking wounds. Background technique [0002] There are many pathogenic bacteria in seawater, including more than 20 kinds of pathogenic bacteria dominated by Acinetobacter, Pseudomonas and Vibrio bacteria, such as Vibrio alginolyticus (V.alginolyticus), Vibrio vulnificus (V.vulnificus), Acinetobacter baumannii (A.baumannii), Pseudomonas aeruginosa (P.aeruginosa), etc. The above-mentioned bacteria can not only survive in seawater, but also in human tissues, and they are especially easy to multiply in wound tissues. When the wounded are soaked in seawater after being injured, the seawater with high sodium, high chloride and partial alkalinity...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7036A61K31/496A61K9/06A61K9/127A61K47/02A61K47/10A61K47/14A61K47/36A61P31/04
CPCA61K47/02A61K47/10A61K47/14A61K47/36A61P31/04A61K9/06A61K9/1274A61K31/496A61K31/7036A61K2300/00
Inventor 杜丽娜孙云波金义光
Owner ACADEMY OF MILITARY MEDICAL SCI
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