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Chinese traditional medicine composition for relieving side effects of hormones

A composition and pharmaceutical technology, applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems of susceptibility, deficiency, acute adrenal cortex insufficiency, etc., and achieve the effect of intervening in the positive effect of hormone immunosuppression and reducing the side effects of hormones

Inactive Publication Date: 2006-02-15
SHANGHAI CENT OF RES & DEV OF NEW DRUGS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The second category is metabolic disorders caused by excessive hormones, such as osteoporosis, hyperglycemia, hyperlipidemia, hypertension, peptic ulcer and even bleeding, suppression of immune function, and susceptibility to infection;
[0006] The third category is disuse atrophy caused by the suppression of the adrenal cortex after long-term use of hormones. These patients are often dependent on hormones and are not easy to withdraw, and may occur at any time when encountering major stress, such as surgery or severe infection. life-threatening acute adrenal insufficiency crisis
[0009] Foreign countries have done a lot of work in the above three aspects and achieved certain results, but they have not yet achieved the effect of not affecting their main functions of anti-inflammation and suppressing humoral immunity, but also comprehensively correcting their side effects and complications, and making their own Unsuppressed adrenals and facilitates hormone withdrawal
[0010] There is also a lack of an ideal solution to this difficult problem of clinical treatment in China

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Extract total flavonoids from Epimedium

[0067] (1) Crushing the aerial parts of Epimedium koreanum Nakai into coarse powder;

[0068] (2) Take a portion (1 kg) of coarse powder, add 15 times of water each time, decoct in water three times, each time for 1 hour, to obtain a boiled extract, and then concentrate the extract under reduced pressure to 2 times the weight of the raw material;

[0069] (3) filter to remove insoluble matter, the D101 macroporous adsorbent resin that has been processed on the filtrate, the ratio of loading sample amount (equivalent to crude drug amount) and resin consumption is 1: 2 (W / V), use 10 times column bed volume Elution with deionized water;

[0070] (4) Elution with 20% ethanol of 15 times column bed volume;

[0071] (5) Elution with 60% ethanol of 10 times the volume of the column bed, collect the 60% ethanol eluate, concentrate and evaporate to dryness to obtain the total flavonoids extract of Epimedium.

[0072] After testing, th...

Embodiment 2

[0074] extract total timosaponin

[0075] (1) Pulverize Anemarrhena asphodeloides Bge into coarse powder;

[0076] (2) Take a portion (1 kg) of coarse powder, add 6 times of 75% ethanol and heat and reflux three times, each time for 1 hour, to obtain the extract, then concentrate the extract under reduced pressure to recover ethanol, filter the aqueous solution to remove insoluble matter, and dilute with water Up to 4 times the weight of medicinal materials;

[0077] (3) The D101 macroporous adsorbent resin that has been processed on the diluent, the ratio of the sample amount (equivalent to the amount of crude drug) to the amount of resin is 1: 2 (W / V), with 1% NaOH solution of 5 times the column bed volume Elution;

[0078] (4) Elution with 20% ethanol of 10 times column bed volume;

[0079] (5) Elution with 75% ethanol of 10 times the volume of the column bed, collect the 75% ethanol eluate, concentrate and evaporate to dryness to obtain the total saponins extract of Ane...

Embodiment 3

[0082] extract glycyrrhetinic acid

[0083] (1) Glycyrrhiza uralensis Fisch is crushed into coarse powder;

[0084] (2) Take a portion (1 kg) of coarse powder, add 10 times of 10% ethanol solution containing 0.5% ammonia each time, heat and extract at 85°C for three times, each time for 2 hours, to obtain the extract, and then decompress the extract Concentrate to one-third of the original volume;

[0085] (3) under stirring, add concentrated H2SO4 dropwise to acidify until no more precipitates are precipitated, leave for 6 hours, collect the precipitates by filtration, and obtain crude glycyrrhizic acid;

[0086] (4) the crude product is treated with conventional KOH solvent, and the pure product of glycyrrhizic acid monopotassium salt is obtained through multi-step purification;

[0087] (5) after 5% H 2 SO 4 After heat treatment and purification, the pure product of glycyrrhetinic acid is obtained.

[0088] After testing, the purity of glycyrrhetinic acid is >98%.

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Abstract

The invention discloses a Chinese traditional medicine composition for relieving side effects of hormones, wherein the composition comprises barren wort flavones extract, anemarrhena rhizome saponins extract and glycyrrhetinic acid. The invention also discloses the process for preparing medicament for reducing side effect of hormones.

Description

technical field [0001] The invention relates to a composition for alleviating the side effects of hormones, in particular to a traditional Chinese medicine composition for alleviating the side effects of glucocorticoids. Background technique [0002] Glucocorticoid (Glucocorticoid; GC) is a group of steroid drugs, also known as corticosteroids (referred to as hormones), it is an important drug in modern medicine. In 1949, Hench and others successfully applied corticosteroids for the first time in the treatment of rheumatoid arthritis. Corticosteroids have significant curative effect, and are mostly used for anti-inflammation and immune suppression, especially for humoral immunity. [0003] However, its clinical application is limited due to serious side effects of corticosteroids. Complications and side effects caused by corticosteroids can be divided into three categories: [0004] The first category is the external manifestations of hypercortisolism caused by excessive ...

Claims

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Application Information

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IPC IPC(8): A61K36/8964A61P43/00
Inventor 沈自尹吴志军傅大煦
Owner SHANGHAI CENT OF RES & DEV OF NEW DRUGS
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