Combinaton of medication for treating depression and preparation method

A composition and technology for depression, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as difficulty in formulating quality control standards, insufficient drug efficacy, complex components, etc., to reduce absolute Immobility time, remarkable drug effect, and reasonable formula effect

Inactive Publication Date: 2004-10-27
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The above-mentioned traditional Chinese medicine compound has slow onset of action, relatively complex components, and insufficient efficacy, making it difficult to formulate and implement strict quality control standards

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1. The pharmaceutical composition for the treatment of depression

[0026] A pharmaceutical composition for treating depression, which is composed of 3.5-14g of pachyphyllin and 0.2-3.5g of ginger oil;

Embodiment 2

[0027] The preparation method of embodiment 2 pharmaceutical compositions, its steps are:

[0028] (1) Take the dried Poria cocos sclerotia, extract three times with 10 times the volume of water, combine the extracts, add 95% ethanol after concentration until the ethanol concentration is 80%, and the resulting precipitate is Poria cocos polysaccharide, with a yield of 80.1%;

[0029] (2) Take dried ginger and extract it three times with conventional steam, the yield is 1.0%.

[0030] (3) Take 10 g of Poria cocos polysaccharide and 1 g of ginger oil, add ginger oil with β-cyclodextrin, and mix to obtain the composition PG. An appropriate amount of starch is added to the composition PG to make a tablet.

Embodiment 3

[0031] Example 3 Effect of Composition on Behavior of Desperate Model Mice

[0032] Animal models: mouse forced swimming test and mouse tail suspension swimming test

[0033] Animals: Male Kunming mice, weighing 28±2g, were randomly divided into groups.

[0034] After 15 days of intragastric administration, a behavioral experiment was carried out to measure the absolute immobility time in the forced swimming and tail suspension experiments of mice;

[0035] See Table 1 for the results of the composition components on the mice forced swimming test and tail suspension test. A major symptom of depression is a decrease in motivated behavior, struggling in the forced swim test and tail suspension test is the animal's motivated behavior, and absolute immobility reflects the negative amotivated state of the animal in the experiment. Most antidepressants increase motivated behavior and decrease absolute immobility time in the forced swim test and the tail suspension test. Both high...

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PUM

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Abstract

A composite medicine for treating depression is prepared from pachyman (3.5-14 g) and ginger oil (0.2-3.5g) through proportioning, including ginger oil by beta-cyclodextrin, and mixing. Its advantages are sure curative effect and high safety.

Description

[0001] The patent application for the present invention is a divisional application of the invention titled "antidepressant composition and preparation method thereof" (application number 02138217.4) filed on September 5, 2002. 1. Technical field: [0002] The invention relates to a composition of natural plant active ingredients, a preparation method and a medicinal application thereof, in particular to preparation of the composition of pachyphyllum polysaccharide and ginger oil as a medicine for treating depression. 2. Background technology: [0003] Depression refers to an affective disorder syndrome characterized by low mood. The main clinical manifestations are depressed mood, fatigue, anhedonia, thinking and movement retardation, accompanied by anxiety, sleep disturbance, loss of appetite, despair and suicidal delusions. Depression is a common and frequently-occurring disease that endangers the physical and mental health of all human beings. According to the World Hea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P25/24
Inventor 孔令东王业民
Owner NANJING UNIV
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