65 results about "Tail Suspension" patented technology

The invention discloses a tail-suspended rat fixing device, which comprises a rat fixing box, a tail suspension device and an angle adjusting device. The invention also provides a tail-suspended rat vibration / motion training device, which comprises a motion track limit device, a vibration training device, an active motion training device, a passive motion training device, a rat hind limb fixing device and a height adjusting device. The invention also provides a vibration / motion control device, which comprises a display screen, a key, a direct-current motor speed adjusting knob, a power supply adapter, a switch, a USB interface and an internal circuit, wherein the direct-current motor speed adjusting knob is used for adjusting the rotating speed of a direct-current motor during passive motion training; the power supply adapter and the switch are used for supplying power for the whole device; the USB interface is used for carrying out function expansion later; and the internal circuit is used for controlling and quantifying rat vibration / motion training and supplying power. The device can keep the same tail-suspended height, can carry out equal-length and equal-tension motion by combining vibration and motion training, and simultaneously achieves training quantification and control.

The invention provides a tail-suspended rat fixing device which comprises a tail suspension device, a rat fixing box for storing the head and body of a rat, a body fixing device for fixing the body of a rat, an angle control device for controlling the included angle between the rat fixing box and a pedestal of the tail-suspended rat fixing device. The invention also provides a tail-suspended rat active / passive motion training device which comprises a rat hind limb motion device for training active / passive motion of the hind limb of a rat and further comprises a motion orbit control device for limiting the motion range of the hind limb of a rat, an active motion training device for training the active motion of the hind limb of a rat, and a passive motion training device for training the passive motion of the hind limb of a rat. The invention realizes the motion training and simultaneously keeps the tail suspension angle unchanged, that is, keeps the rat in a simulated weightlessness state.

The invention discloses a multi-functional device for simulating a space environment foundation. The multi-functional device comprises a base. A magnetic control system is fixed on the base, a sample table penetrates through the magnetic control system, a microgravity simulation device and / or a sample bottle are / is arranged on the table, a constant temperature constant humidity lighting box is covered on the upper portion of the base, the magnetic control system, the microgravity simulation device and / or the sample bottle are sealed in the constant temperature constant humidity lighting box, and an irradiation system is arranged outside the constant temperature constant humidity lighting box. The magnetic control system is composed of three groups of helmholtz coils, and the three groups of helmholtz coils are perpendicular to each other and sleeved with each other. The microgravity simulation device adopts a tail suspension device. A temperature control humidity control system and a fluorescent lamp are arranged inside the constant temperature constant humidity lighting box. The multi-functional device simulates space radiation, microgravity, flux weakening, circadian rhythms and air particle recombination action on the ground and has a simulation effect on a radiation biological effect of different energy and different kinds of particles and a synergy effect of various space environment factors such as particles and microgravity and a magnetic effect.

The invention discloses a Chinese medicinal composition for treating tristimania, which is prepared into certain formulations by taking curcuma longa, St John's wort and ginseng as raw materials, and extracting and separating the raw materials by using 0-75 percent ethanol. An animal toxicity test result shows that 284 times of an adult dosage of the medicinal composition for lavaging a mouse causes no acute toxicity reactions; a pharmacodynamic study shows that the medicinal composition can significantly perform antagonism on acinesia and hypothermia, induced by reserpoid, of a tristimania model mouse, and can increase the number of autonomic activities and the dead time for tail suspension and swimming, induced by the tail suspension and forced swimming, of a desperate animal model. A clinical research result shows that by adopting a Hamilton rating scale for depression (HAMD) to evaluate the depression severity which serves as the primary therapeutic effect index, a treatment group obtains a significant curative effect, the effective rate is 92.3 percent, and compared with a control group, the medicinal composition has significant differences but has no toxic and side effects. The medicinal composition can be prepared into medically acceptable oral preparations, such as tablets, capsules (soft capsules or hard capsules), granules and the like; and the clinical curative effect and the pharmacodynamic study prove that the medicinal composition has the functions of smoothing the liver to alleviate mental depression and relieving mental stresses, and is an effective special medicament for treating the tristimania.

The invention discloses a drug for treating depression. The drug is prepared by evenly mixing 0.3-99.7 parts by weight of industrial hemp seed extract and 99.7-0.3 parts by weight of industrial cannabinoid. It is proved through experiments that the drug can significantly shorten the tail suspension immobilization time of mice of a behavioral despair depression model and significantly shorten immobility time of forced swimming, has an obvious anti-depressant effect on a mouse depression model caused by reserpine and can significantly increase the frequency of spontaneous activities of the mice, and the effects are all superior to those of cannabidiol. The drug can be used for preparing drugs for treating various depression symptoms including endogenous depression, reactive depression, masked depression, secondary depression caused by drugs, climacteric or postnatal depression, depression caused by cerebral trauma or cerebral apoplexy, diabetes combined depression and depressive neurosis and used for preparing drugs for treating symptoms such as secondary learning memory decline and anhedonia caused by depression.

The invention discloses a Chinese medicinal composition for treating depression. The medicine adopts lilies, semen ziziphi apinosae, curcuma longa, hypericum perforatum L., perilla, ginseng, and radix bupleuri as raw materials, which are then separate and extracted by 0-75% ethanol so as to be prepared into certain preparation form. The above six drugs used together can soothe liver and relieve depression, reconcile and activate qi, tranquilize the mind and calm the nerves, and can be used for mild and moderate depression and patients belonging to stagnation of qi due to depression of liver, as well as heart-spleen deficiency. Pharmacodynamic research indicates that: the medicinal composition has substantial antagonistic effects on reserpine induced depression models, mouse akinesia and hypothermia, and can increase the spontaneous movements of tail suspension and forced swimming induced despair animal models, as well as the immobility time of tail suspension and swimming. Clinical research results show that a HAMD (Hamilton depression scale) used for evaluating depression severity and Chinese medicinal syndromes before and after treatment are taken as main curative effect indexes, which show that the Chinese medicinal composition in the invention has substantial curative effects. The composition provided in the invention can be prepared into medically acceptable oral preparations, such as tablets, capsules (soft capsules and hard capsules), granules, and other preparation forms. Clinical effects and pharmacodynamic research prove that the Chinese medicinal composition of the invention has the functions of liver soothing and depression relieving, mind tranquilizing as well as nerve calming, and is an effective medicine special for depression treatment.

The invention relates to the novel use of pharmaceutical preparations in the field of pharmacy, more specifically the use of barrenwort flavones and barrenwort glycosides monomers as active components in preparing medicament for preventing and treating suppression. Pharmaceutical test shows that, the barrenwort flavones and barrenwort glycosides monomer can appreciably shorten rat's tail suspension time and forced swimming standby time, reverse the decrease of mouse sucrose consumption caused by CMS, suppress animal brain monoamines oxidation enzyme an and B, thus achieving the purpose of suppression resistance.

The invention discloses an application of Akkermansia Muciniphila in the preparation of drugs for preventing depression or health products. In vivo pharmacodynamic studies are performed on the effectsof Akkermansia Muciniphila bacteria in depression and anti-depression; results show that the Akkermansia Muciniphila abundance in the intestinal tracts of depression patients is obviously reduced; and animal experiment results show that the Akkermansia Muciniphila abundance in the intestinal tracts of mice is obviously reduced. The Akkermansia Muciniphila bacteria are transplanted to a depressionmouse model, and experiments show that the transplantation of the Akkermansia Muciniphila bacteria can increase the movement distances of the mice and reduce the dead time of tail suspension tests and forced swimming tests, and the depression states of the mice can be significantly alleviated, so that the Akkermansia Muciniphila bacteria show good anti-depression curative effects and has no side-effects yet.

The invention provides new application of sea-buckthorn seed oil extracted from sea-buckthorn seeds, i.e., application of the sea-buckthorn seed oil to preparation of a medicament or a health-care food for preventing and / or treating depression, and application of the sea-buckthorn seed oil serving as a raw material to preparation of the medicament or the health-care food for preventing and / or treating the depression. Test results prove that the immobility time in forced swimming tests of mice and tail suspension tests of the mice can be obviously reduced by the sea-buckthorn seed oil and the sea-buckthorn seed oil has an obvious depression suppression effect. The sea-buckthorn seed oil is a natural anti-depression effective substance which has the advantages of easiness and convenience in preparation, obvious effect, safety, reliability and easiness for industrial production. The sea-buckthorn seed oil can be prepared into formulations such as soft capsules, dropping pills and emulsion for anti-depression medicaments or health care foods.

The invention discloses a compound traditional Chinese medicine for treating depression. The compound traditional Chinese medicine taking Chinese herbaceous peony, radix bupleurim, turmeric, hyperforin perforatum, purple perilla, rhizoma anemarrhenae and long pepper as raw materials is extracted and separated by 0-75% ethanol and prepared as medically acceptable oral preparations such as troches, capsules (soft or hard capsules) and particles. The drafted major functions of the compound traditional Chinese medicine are soothing liver-qi stagnation and dispersing blood stasis and dredging collateral, and the compound traditional Chinese medicine is used for treating mild-to-moderate depression. The pharmacological researches show that the pharmaceutical composition can remarkably enhance open field activity of chronic stress depression mode mice and increase the consumption of sweet water; antagonizes akinesia and hypothermia of chronic stress depression mode mice induced by reserpine, so that the number of autonomic activities of despair animal mode induced by tail suspension and forced swimming and tail suspension and swimming immobility time are increased. The compound traditional Chinese medicine disclosed by the invention with the functions of soothing liver-qi stagnation is an effective special medicine for treating depression.

The present invention discloses a medicine compound for curing melancholia and associated functional dyspepsia made from the raw materials including ginseng, morinda root and largehead atractylode. The present invention also discloses a preparation method of the medicine compound. The experiment proves that the medicine compound provided by the present invention can obviously reduce the immobility time in tail suspension of tested small mice and the accumulative immobility time in forced swimming of tested large mice, and promote the gastrointestinal power of tested large mice, thus inferring that the medicine compound provided by the present invention has the efficacy of resisting experimental melancholia and curing dyspepsia.

The present invention discloses a medicine made from paeoniflorin for curing depression and the dosage thereof. The present invention has the following main technical characteristics: the effective dosage of the paeoniflorin is 80 to 400mg / day; the optimal dosage is 150 to 300mg / day; the best dosage is 220mg / day. The present invention also discloses the preparation method of the medicine. The experiment proves that the medicine provided by the present invention can obviously reduce tail suspension fixed time and reserpine-induced temperature dropping of tested mice, thus concluding that the medicine provided by the present invention has the efficacy of experimental depression resistance.

The present invention discloses a new medical use of hypericum sampsonii hance xanthone compounds. Pharmacodynamics researches show that xanthone compounds such as 1-hydroxy-7-methoxy xanthone and 1,3,5-trihydroxy xanthone in the hypericum sampsonii hance can significantly shorten immobility times in tail suspension and immobility times in forced swimming of mice, and have good antidepressant activity, such that the xanthone compounds can be used for preparing antidepressant drugs or food. With the present invention, a new source is provided for seeking antidepressant drugs or food.

The invention discloses application of a Xinnaoxin capsule in preparation of an antidepressant. According to experimental studies, the Xinnaoxin capsule can substantially reduce dead time during tail suspension and forced swimming of behavioral despair model mice; according to open field experiments, spontaneous activities of the mice are not influenced while dead time is substantially decreased, which prompts that the Xinnaoxin capsule has a certain anti-depression effect. Meanwhile, the Xinnaoxin capsule can substantially inhibit activity of monoamine oxidase and increase the content of a monoamine neurotransmitter in a synaptic cleft, which proves that the Xinnaoxin capsule has the anti-depression effect. Moreover, the Xinnaoxin capsule can substantially antagonize decrease of body temperature of the mice caused by reserpine and apomorphine and increase exogenous toxicity given to NE, which reveals that the capsule has the anti-depression effect. The anti-depression effect of the capsule is realized through improvement of the level of the monoamine neurotransmitter in the synaptic cleft.

The invention relates to a new use of 20(S)-protopanoxadiol derivatives and 20(S)-protopanaxatriol derivatives, and mainly relates to a use in the preparation of medicines for treating or preventing depressive mental diseases. 20(S)-protopanoxadiol and 20(S)-protopanaxatriol are used as raw materials, and undergo oxidative cyclization to prepare dammara-20S-24(R)-epoxy-3beta,12beta,25-triol, dammara-20S-24(S)-epoxy-3beta,12beta,25-triol, dammara-20S-24(S)-epoxy-3beta,6beta,12beta,25-tetrol or dammara-20S-24(R)-epoxy-3beta,6beta,12beta,25-tetrol. Researches of pharmacological experiments show that dammara-20S-24(R / S)-epoxy-3beta,12beta,25-triol and dammara-20S-24(R / S)-epoxy-3beta,6beta,12beta,25-tetrol can obviously shorten the tail immobility time of mice in mouse tail suspension tests of a classic depression model, and can obviously shorten the swimming immobility time of the mice in mouse forced swimming model tests, so dammara-20S-24(R / S)-epoxy-3beta,12beta,25-triol and dammara-20S-24(R / S)-epoxy-3beta,6beta,12beta,25-tetraol have potential development values in the preparation of medicines for treating or preventing depressive mental diseases.

The invention discloses a device for testing activity of animals under the tail suspension state. The device comprises an uncovered testing box body, a sealed collecting and transmitting box and a computer operation system which are connected in turn, wherein the inner part of the testing box body is divided into eight testing lattices capable of partitioning small animals by partition plates; a beam is arranged above the testing box body by a supporting rod which is fixed on the testing box body; eight sensors are fixed on both sides of the beam by sensor fixing rods and correspond to the positions of the testing lattices below; and a plurality of hooks are connected below the sensors. The device provided by the invention for testing activity of the animals under the tail suspension state is reasonable in design and compact in structure, and meets the needs of each animal suspension test.

The invention discloses a medicine composition for treating depression, which is prepared from panaxoside Rg1, Rb1 and glycyrrhizic acid (glycyrrhetinic acid), and a preparation method of the medicine composition. Proven by a test, the medicine composition can obviously reduce the tail suspension and immobility time during forced swimming, can rapidly arouse the CAMP-PKA access of a hippocampus and improves the expressions of CREB and BDNF. Accordingly, the medicine composition can be used for treating depression acted on the body.

The invention belongs to the technical field of biopharmaceutics and provides an application of saikosaponin B2 in preparation of an antidepressant drug. A structural formula of saikosaponin B2 is asshown in the specification, and saikosaponin B2 is a unique active ingredient in the antidepressant drug. In-vitro activity tests prove that saikosaponin B2 has better protection activity for PC12 injured by corticosterone, and in-vivo test results show that saikosaponin B2 can significantly shorten immobile time of mice in forced swimming and tail suspension tests. Test results show that saikosaponin B2 has a significant antidepressant effect and can be used for preparing a drug for preventing and treating depression.

The invention provides the application of a saffron crocus pigment composition to the preparation of a medicine for treating or improving depressive disorder, and relates to the field of depressive disorder medicines. Through research findings, the saffron crocus pigment composition can obviously antagonize ptosis of upper eyelid of a mouse caused by reserpine, obviously improve the akinesis condition, obviously reduce the tail suspension immobility time and increase sweet water preference coefficient, so that the saffron crocus pigment composition has a good anti-depression effect, can improve various symptoms of the depressive disorder, serves as an anti-depression medicine and provides a new scheme for research and treatment on the depressive disorder.

The invention relates to applications of a compound cinnamyl-(6'-O-alpha-L-arabopyranose)-O-beta-D-glucopyranoside in pharmaceutical field. The compound can effectively resist blepharoptosis caused by reserpine or akinesia, resist small mouse thrill caused by L-5-HT, resist small mouse tail suspension or acquired desperation depression by a forced swinging method, strengthen L-dopa behavioural effect, and has no exciting or inhibiting effect to nerve centres. The action mechanism thereof may be related to breaking reuptake of NA, DA transmittances so as to increase concentration of the two transmittances in synaptic spaces. The compound has no toxic reactions in acute toxicity experiences on mice so that the compound with experience dosage has relatively high security and good anti-depression effect and can be used to treat depression.

The invention discloses a use of a Qing'e prescription extract in preparation of an antidepressant and anxiolytic composition. With oral administration of the Qing'e prescription extract, the experimental animal mine field movement total distance can be increased, the tail suspension immobility time is reduced, the elevated plus maze open-arm time is increased, the forced swimming immobility time is reduced, and relatively good antidepressant and anxiolytic effects are shown. The Qing'e prescription extract can increase the contents of hippocampal area 5-hydroxytryptamine (5-HT), norepinephrine (NE) and gamma-aminobutyric acid (gamma-GABA), and reduces the content of glutamate (Glu). On one hand, the gamma-GABA increasing role and the Glu reduction role of the Qing'e prescription extract indicate that the Qing'e prescription extract has a role in adjusting metabolism of central nervous system neurotransmitters Glu and gamma-GABA, reduces the Glu / gamma-GABA ratio, reduces transmission of GABAergic neurotransmitters, regulates the reactivity of a catecholamine acceptor, thereby playing antidepressant and anxiolytic roles. On the other hand, the Qing'e prescription extract increases the central nervous system 5-HT level and plays the antidepressant and anxiolytic roles by inhibiting the activity of monoamine oxidase.

This invention relates to the field of traditional Chinese medicine, particularly to the application of traditional Chinese medicine composition. The invention provides the application of a traditional Chinese medicine composition comprising Sichuan lovage rhizome and tall gastrodia tuber in the traditional Chinese medicine preparation for increasing the content of serotonin, norepinephrine and dopamine in the brain. This invention also provides the application of the traditional Chinese medicine composition comprising Sichuan lovage rhizome and tall gastrodia tuber in the manufacture of a medicament for the treatment and / or prophylaxis of depression. The experimental results of the invention show that the provided composition can significantly reduce the immobility time in the mice forcing swimming and the tail suspension experiment, and increase the amount of serotonin (5-HT), norepinephrine (NE), Dopamine (DA), whose effect is similar to the positive control drug paroxetine, suggesting that the compositions provided by the present invention will play an important role in the treatment or prevention of depression.

The invention discloses a compound beverage containing lycium ruthenicum and herba cistanches, and a manufacturing method thereof. The lycium ruthenicum is subjected to ultrasonic low-temperature extraction under pressure so as to obtain a normal lycium ruthenicum juice; herba cistanche decoction pieces are crushed and extracted so as to obtain a herba cistanche leaching solution; the herba cistanche leaching solution is uniformly mixed with the normal lycium ruthenicum juice; and the obtained mixture is subjected to blending, homogenization, rough filtration, filling, and sterilization so as to obtain the compound beverage containing the lycium ruthenicum and the herba cistanches. The compound beverage has a uniform and brightly purple color, a moderate sweet taste, a moderate sour taste, an aroma specific to the lycium ruthenicum, a soft and delicate mouth feel, uniform quality, and no deposition. A functional test indicates that for a mouse forced swimming and tail suspension model, the prepared compound beverage can significantly shorten the still time of the mouse forced swimming and tail suspension; and an open field test indicates that the compound beverage has no obvious influence on the autonomic activities of mice. Therefore, the compound beverage has an anti-depression effect on a mice depression model, and extensive practicability and exploitation value.

The invention discloses a traditional Chinese medicine combined extract with an anti-depression effect as well as a preparation method and application thereof and belongs to the technical field of traditional Chinese medicinal preparations. The traditional Chinese medicine combined extract with the anti-depression effect is prepared from salviae miltiorrhizae, ligusticum wallichii, kudzuvine root and earthworm in certain parts by weight. The traditional Chinese medicine combined extract is scientific in compatibility and reasonable in preparation; experiments show that the traditional Chinese medicine combined extract or traditional Chinese medicine tablets thereof can obviously reduce the dead time of mouse tail suspension and forced swimming of a behavioural despair model, and open-field test results show that the autonomic activity of a mouse is not influenced while the dead time is reduced; and meanwhile, the traditional Chinese medicine combined extract also can obviously resist mouse body temperature decrease caused by reserpine and obviously improve the mouse head shaking frequency induced by 5-hydroxytryptophane, so that the traditional Chinese medicine combined extract has the anti-depression effect, plays a role by changing the monoaminergic level in the brain, and has an application prospect of being developed into an anti-depression drug.

The invention discloses a tail suspension mouse cage which comprises at least one mouse cage unit, mouse suspension cavities are limited in the mouse cage units, partition plates are slidably arrangedin the mouse suspension cavities, the mouse suspension cavities are divided into two mouse suspension spaces, the sizes of the two mouse suspension spaces can be adjusted by sliding the partition plates, suspension devices are mounted above the mouse suspension spaces and comprise sliding cross rods, suspension springs, suspension rings and tail tying mechanisms, the sliding cross rods are slidably arranged at the tops of the mouse suspension spaces, the suspension rings are arranged on the sliding cross rods in a sleeving manner, one end of each suspension spring is connected with the corresponding suspension ring, the other end of each suspension spring is connected with the corresponding tail tying mechanism, the tail of an experimental mouse can be suspended by the tail tying mechanism, the tail is firmly fixed, wound is omitted, mouse tail damage and mouse tail dividing injury or mouse tail avascular necrosis can be omitted, and the number of samples and accuracy of experimentalresults are ensured.

The present invention relates to a traditional Chinese medicine composition for treating depression and a preparation method thereof, and the traditional Chinese medicine composition comprises the following components: radix bupleuri, radix curcumae, hyperforin perforatum, fructus schisandrae, fried gardenia, morinda officinalis, dodder, ginseng and mint. Pharmacological experimental results show that the traditional Chinese medicine composition can significantly shorten, mouse tail suspension immobility time is significantly shortened, mouse forced swimming desperate time can be significantly shortened, mouse swimming speed and swimming distance can be increased, and the pharmacodynamical effect of treating of depression of the traditional Chinese medicine composition can be initially identified from the point of view of modern pharmacology.

The invention belongs to the technical field of traditional Chinese medicines and natural medicines, and particularly relates to traditional Chinese medicine composition volatile oil and a preparation method and application thereof. The traditional Chinese medicine composition volatile oil is characterized by comprising the following Chinese herbal medicines by weight: 15-60 parts of mangnolia officinalis and 10-40 parts of perilla leaf. The traditional Chinese medicine composition volatile oil can be prepared into an oral preparation, an inhalant or an externally used ointment by a conventional traditional Chinese medicine preparation method. The beneficial effects of the traditional Chinese medicine composition volatile oil are mainly reflected in that: the traditional Chinese medicine composition volatile oil drug can significantly shorten the forced swimming and tail suspension immobility time of behavioral despair model mice, significantly shorten immobility time in forced swimming test and tail suspension test of chronic stress depression model mice, and significantly increase syrup preference of the chronic stress depression model mice. The result of study shows that the traditional Chinese medicine composition volatile oil has the significant anti experimental depression effect in mice.

The invention discloses a group of pharmaceutical compositions for treating melancholia made from the raw materials including licorice and jujube. The invention further discloses the preparation method of the pharmaceutical compositions. Experiments proves that: the pharmaceutical composition of the invention can obviously reduce the tail suspension time and the reserpine induced temperature of the tested mice, which proves that it achieves anti-melancholia function.

The invention discloses an automatic analysis system and method of a rodent tail suspension experiment based on deep learning. The automatic analysis system and method are used for solving the problems that in the tail suspension experiment, due to a series of influences of the inertia effect, mouse physical strength and other influences on an experiment result, the false negative or false positive probability of related drug effect evaluation is high, the experiment cost is high, and the experiment time is long. The automatic analysis system comprises a tail suspension experiment module, a video analysis module and a data output module. According to the automatic analysis system and method, full-automatic tracking and fine behavior index extraction are realized through a deep learning technology without depending on other experimental hardware equipment, so that the experimental cost is greatly reduced, 14 body key points of rodents are analyzed, and full-automatic accurate tracking is realized; and compared with a traditional method for judging immobility and struggling time through changes of a trunk area and the gravity center of a mouse, cost is low, and time is short.

The invention provides an asiatic acid derivative compound represented by general formula (I), or a pharmaceutically acceptable salt or ester thereof, or any optical isomer of the asiatic acid derivative compound, or any of tautomer of the asiatic acid derivative compound. The invention also provides a preparation method of the asiatic acid derivative compound, wherein the asiatic acid derivative compound is obtained via structural modification of asiatic acid with microorganisms. The invention also provides applications of any of the compound above in preparation of antidepressant drugs. It is shown by mice forced swimming tests and mice tail suspension tests that the asiatic acid derivative compound possesses relatively high antidepressant activity.