Applications of Akkermansia Muciniphila in preparation of antidepressants or health products

A technology of health care products and drugs, applied in the field of probiotics, to achieve the same effect of live bacteria and dead bacteria, effective of live bacteria and dead bacteria, and antidepressant effect
CN110227085AInactive Publication Date: 2019-09-13JIANGSU PROVINCIAL HOSPITAL OF TCM
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Patent Information

Authority / Receiving Office
CN ยท China
Current Assignee / Owner
JIANGSU PROVINCIAL HOSPITAL OF TCM
Publication Date
2019-09-13
Estimated Expiration
Not applicable ยท inactive patent

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Abstract

The invention discloses an application of Akkermansia Muciniphila in the preparation of drugs for preventing depression or health products. In vivo pharmacodynamic studies are performed on the effectsof Akkermansia Muciniphila bacteria in depression and anti-depression; results show that the Akkermansia Muciniphila abundance in the intestinal tracts of depression patients is obviously reduced; and animal experiment results show that the Akkermansia Muciniphila abundance in the intestinal tracts of mice is obviously reduced. The Akkermansia Muciniphila bacteria are transplanted to a depressionmouse model, and experiments show that the transplantation of the Akkermansia Muciniphila bacteria can increase the movement distances of the mice and reduce the dead time of tail suspension tests and forced swimming tests, and the depression states of the mice can be significantly alleviated, so that the Akkermansia Muciniphila bacteria show good anti-depression curative effects and has no side-effects yet.
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Description

technical field

[0001] The invention relates to a probiotic, in particular to the new use of Akkermansia Muciniphila in antidepressant drugs or health products, and belongs to the technical field of medicine. Background technique

[0002] Depression is a mental illness characterized by persistent and significant low mood. It is often accompanied by low mood, low self-esteem and depression, and even suicide attempts or behaviors, and most patients have a tendency to relapse. Therefore, depression is a disease with a high disabling rate. According to the World Health Organization (WHO), 15 out of every 100 people in the general population suffer from depression. The cost of treating depression accounts for 12.3% of the total medical expenditure every year. In China, it is estimated that there are 20-50 million depression patients, and the prevalence is increasing year by year. Currently, there is no safe and effective antidepressant biological agent in the market.

[0003] ...

Claims

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