Applications of Akkermansia Muciniphila in preparation of antidepressants or health products

A technology of health care products and drugs, applied in the field of probiotics, to achieve the same effect of live bacteria and dead bacteria, effective of live bacteria and dead bacteria, and antidepressant effect

Inactive Publication Date: 2019-09-13
JIANGSU PROVINCIAL HOSPITAL OF TCM
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Applications of Akkermansia Muciniphila in preparation of antidepressants or health products
  • Applications of Akkermansia Muciniphila in preparation of antidepressants or health products
  • Applications of Akkermansia Muciniphila in preparation of antidepressants or health products

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Embodiment 1

[0025] 1. The preparation method of Akkermansia Muciniphila bacterial liquid:

[0026] Take 1ml of Akkermansia Muciniphila bacteria solution, add it into 10ml of brain heart extract broth, incubate at 37°C for 72 hours under anaerobic environment, centrifuge the bacteria solution (6000rpm) for 20 minutes, separate the supernatant, and dissolve it with sterile PBS solution. The bacterial solution was adjusted to OD600=1 to obtain the Akkermansia Muciniphila bacterial solution (abbreviated as AKK bacterial solution).

[0027] 2. Clinical stool sample preparation method:

[0028] Select 5 samples of feces collected from healthy and depressed volunteers, and mix the feces samples of each group. Dissolve the mixed feces in sterile PBS, centrifuge the bacteria solution (1000rpm) for 10 minutes, and take out the supernatant spare.

[0029] 3. Intestinal flora knockout model

[0030] 6-8 week old C57BL / 6 male mice were given routine daily drinking of broad-spectrum antibiotics for ...

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Abstract

The invention discloses an application of Akkermansia Muciniphila in the preparation of drugs for preventing depression or health products. In vivo pharmacodynamic studies are performed on the effectsof Akkermansia Muciniphila bacteria in depression and anti-depression; results show that the Akkermansia Muciniphila abundance in the intestinal tracts of depression patients is obviously reduced; and animal experiment results show that the Akkermansia Muciniphila abundance in the intestinal tracts of mice is obviously reduced. The Akkermansia Muciniphila bacteria are transplanted to a depressionmouse model, and experiments show that the transplantation of the Akkermansia Muciniphila bacteria can increase the movement distances of the mice and reduce the dead time of tail suspension tests and forced swimming tests, and the depression states of the mice can be significantly alleviated, so that the Akkermansia Muciniphila bacteria show good anti-depression curative effects and has no side-effects yet.

Description

technical field [0001] The invention relates to a probiotic, in particular to the new use of Akkermansia Muciniphila in antidepressant drugs or health products, and belongs to the technical field of medicine. Background technique [0002] Depression is a mental illness characterized by persistent and significant low mood. It is often accompanied by low mood, low self-esteem and depression, and even suicide attempts or behaviors, and most patients have a tendency to relapse. Therefore, depression is a disease with a high disabling rate. According to the World Health Organization (WHO), 15 out of every 100 people in the general population suffer from depression. The cost of treating depression accounts for 12.3% of the total medical expenditure every year. In China, it is estimated that there are 20-50 million depression patients, and the prevalence is increasing year by year. Currently, there is no safe and effective antidepressant biological agent in the market. [0003]...

Claims

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Application Information

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IPC IPC(8): A61K35/741A61P25/24A61P1/00A61P35/00A61P3/10A61P3/04A61P25/08A23L33/135
CPCA23V2002/00A61K35/741A23L33/135A61P1/00A61P3/04A61P3/10A61P25/08A61P25/24A61P35/00A23V2200/322A23V2200/32A23V2200/308
Inventor 陈玉根陈拓袁晓敏王琼施国平
Owner JIANGSU PROVINCIAL HOSPITAL OF TCM
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