3results about How to "Significant antidepressant effect" patented technology

The application belongs to the technical field of medicines, and specifically discloses an anti-depression m-hydroxybenzoic acid compound and a preparation method and application thereof; the m-hydroxybenzoic acid compound Hyperioxides A-F provided by the application has not been reported; the six compounds have good anti-depression effects, and further research shows that the compounds Hyperioxide A, Hyperioxide D, Hyperioxide E and Hyperioxide F have significant protective effects on SH-SY5Y cells induced by corticosterone, and are superior to positive drugs fluoxetine and Luoyoutei, and can be used for developing drugs for treating depression.

The application discloses a method for extracting antidepression active Euphausia superba oil by adopting subcritical combination solvent, and belongs to the technical field of deep processing of Euphausia superba. The method is a three-stage gradient extraction method of "subcritical butane-acetone-ethanol", and realizes differential separation and enrichment of lipid components by using solvent polarity difference. The first-stage subcritical butane extraction is carried out under low temperature, closed and oxygen isolation conditions, and high-efficiency desolventizing is realized by using reduced pressure gasification, so that the heat-sensitive active ingredients are effectively reserved, and meanwhile, oxidation and metamorphosis of raw materials are avoided, thereby laying a foundation for preparation of subsequent high-quality extracts. The method successfully prepares three Euphausia superba oil products with significant component differences, and especially, the third-stage extract and the enzymatic modification product thereof exhibit excellent antidepression activity. The application realizes functional separation of Euphausia superba lipid components, and provides strong support for development of personalized and diversified antidepression products.

The application discloses a use of an aporphine alkaloid shown in formula III in preparation of an antidepressant, wherein R1 and R2 are independently selected from alkoxy and methylenedioxy, R3 and R4 are independently selected from H, OH, alkoxy and methylenedioxy, but R3 and R4 cannot be H at the same time or R1 and R2 are both selected from methoxy, and R3 cannot be OH and R4 cannot be H. Pharmacological experiments show that the aporphine alkaloid shown in formula III has better antidepressant effect, higher response rate and faster effect than fluoxetine.