9results about How to "Significant antidepressant effect" patented technology

The application belongs to the technical field of medicines, and specifically discloses an anti-depression m-hydroxybenzoic acid compound and a preparation method and application thereof; the m-hydroxybenzoic acid compound Hyperioxides A-F provided by the application has not been reported; the six compounds have good anti-depression effects, and further research shows that the compounds Hyperioxide A, Hyperioxide D, Hyperioxide E and Hyperioxide F have significant protective effects on SH-SY5Y cells induced by corticosterone, and are superior to positive drugs fluoxetine and Luoyoutei, and can be used for developing drugs for treating depression.

The invention provides a compound cannabidiol essential oil composition for resisting depression, soothing nerves and helping sleep and a preparation method thereof, and belongs to the technical field of depression resistance. The mosquito-repellent incense is prepared from the following raw materials in parts by weight: 5-7 parts of lavender, 3-5 parts of clove, 1-2 parts of folium artemisiae argyi, 4-6 parts of chamomile, 5-7 parts of bergamot, 3-5 parts of verbena blue, 2-4 parts of valeriana affinis, 0.01-0.02 part of a penetration enhancer and 0.05-0.1 part of cannabidiol. The prepared composite cannabidiol essential oil composition for resisting depression, soothing nerves and helping sleep is safe to use, is extracted from flowers and plants, and has very good effects on relieving human mood, relieving pressure and improving insomnia and has very good effects on depression and insomnia.

The invention provides an application of aryl olefine acid schisandra chinensis phenolic ester (O-dihydroxyphenyl) hernandezine and a derivative thereof in preparation of a medicine for treating depression and an anti-depression medicine prepared from the O-dihydroxyphenyl hernandezine and the derivative of the O-dihydroxyphenyl hernandezine and the derivative of the O-dihydroxyphenyl hernandezine. The application dosage is 0.01-30 mg of aryl olefine acid schisandra phenolic ester or the derivative thereof per kilogram of body weight, and the anti-depression effect can be achieved within 60 minutes after administration. After the medicine is administrated for 5 days, a remarkable anti-depression effect can be generated at a high dosage. A research result shows that in a mammal mouse tail suspension experiment, the aryl olefine acid schisandra phenolic ester or the derivative thereof has a rapid anti-depression effect and is more effective than a conventional anti-depression drug fluoxetine. According to the invention, a forced swimming experiment and a mouse tail suspension experiment are adopted as drug screening experiments, and meanwhile, an open field test is carried out on the mouse, so that the autonomous activity of the mouse is detected, and the interference of central excitation drugs is avoided. The anti-depression drug has the advantages of being remarkable in anti-depression effect, quick in effect taking, small in dosage, small in side effect and the like, and is expected to become a new anti-depression drug which is quick, efficient and novel in mechanism.

The application discloses a kind of pharmaceutical composition and its purposes in preparation for treating major depressive disorder of drug. The pharmaceutical composition includes esketamine and yohimbine. The yohimbine in the pharmaceutical composition provided by the application can effectively promote the antidepressant effect of esketamine, significantly reduce the dosage of esketamine when it plays the antidepressant effect, prolong the duration of antidepressant effect, and a certain dosage of yohimbine can promote the antidepressant effect of less dosage of esketamine.

The invention discloses application of a composition as a synergist of a drug for treating depression, the composition is prepared from pyrola, loranthus parasiticus, pyrrosia lingua, oldenlandia diffusa and achyranthes bidentata, and the drug for treating depression is prepared from astragalus membranaceus, bighead atractylodes rhizome, poria cocos, codonopsis pilosula, radix aconiti lateralis preparata (black prepared common monkshood daughter root), dogwood, salvia miltiorrhiza and motherwort. A drug combination prepared from the composition and a depression treatment drug can significantly improve depression-like behaviors of depression mice, relieve interest deficiency symptoms and increase neurotransmitter content in brains of the depression mice. Further clinical tests find that the medicine combination has remarkable clinical effects on depression of various traditional Chinese medicine syndromes such as liver depression and qi stagnation, liver depression transforming into fire, liver depression and spleen deficiency, phlegm and qi stagnation, heart and spleen deficiency, kidney deficiency and liver depression and the like, shows a good anti-depression effect and has a wide application prospect.

The application discloses a method for extracting antidepression active Euphausia superba oil by adopting subcritical combination solvent, and belongs to the technical field of deep processing of Euphausia superba. The method is a three-stage gradient extraction method of "subcritical butane-acetone-ethanol", and realizes differential separation and enrichment of lipid components by using solvent polarity difference. The first-stage subcritical butane extraction is carried out under low temperature, closed and oxygen isolation conditions, and high-efficiency desolventizing is realized by using reduced pressure gasification, so that the heat-sensitive active ingredients are effectively reserved, and meanwhile, oxidation and metamorphosis of raw materials are avoided, thereby laying a foundation for preparation of subsequent high-quality extracts. The method successfully prepares three Euphausia superba oil products with significant component differences, and especially, the third-stage extract and the enzymatic modification product thereof exhibit excellent antidepression activity. The application realizes functional separation of Euphausia superba lipid components, and provides strong support for development of personalized and diversified antidepression products.

The invention discloses a traditional Chinese medicine composition with effects of improving sleep and resisting depression, and application, a preparation and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition with the sleep improving and depression resisting effects is prepared from the following raw materials in parts by weight: 5 to 100 parts of semen ziziphi spinosae, 5 to 100 parts of semen persicae, 5 to 100 parts of fructus gardeniae, 5 to 100 parts of semen sojae praeparatum, 10 to 200 parts of concha ostreae, 1 to 20 parts of arillus longan and 1 to 10 parts of gamma-aminobutyric acid. The traditional Chinese medicine composition with the effects of improving sleep and resisting depression, which is provided by the technical scheme of the invention, can be used for remarkably shortening the sleep time of rats with insomnia and improving the content of 5-hydroxytryptamine, dopamine and melatonin in brain tissues, and is used for improving the symptoms such as difficulty in falling asleep, insomnia, easy waking, dreaminess and anxiety; the traditional Chinese medicine composition helps patients to improve sleep quality and accompanying depressive symptoms, and is small in side effect and stable in curative effect.

The application discloses a use of an aporphine alkaloid shown in formula III in preparation of an antidepressant, wherein R1 and R2 are independently selected from alkoxy and methylenedioxy, R3 and R4 are independently selected from H, OH, alkoxy and methylenedioxy, but R3 and R4 cannot be H at the same time or R1 and R2 are both selected from methoxy, and R3 cannot be OH and R4 cannot be H. Pharmacological experiments show that the aporphine alkaloid shown in formula III has better antidepressant effect, higher response rate and faster effect than fluoxetine.

The invention discloses a folium cortex eucommiae pharmaceutical composition for improving depression as well as a preparation method and application thereof, and relates to the technical field of medicines. The preparation method comprises the following steps: performing liquid nitrogen low-temperature crushing on eucommia ulmoides leaves, performing enzymolysis fermentation on cellulase and pectinase, performing secondary enzymolysis on beta-glucosidase, performing ultrasonic ethanol extraction on filter residues obtained by enzymolysis, performing acetic fermentation, combining secondary enzymolysis liquid and acetic fermentation liquid, and concentrating to obtain eucommia ulmoides leaf extracting liquid; the extracting solution has the effects of improving depression, resisting inflammation and inhibiting HPA axis excitation, can be used as a pharmaceutical composition or a conventional additive for preparing medicines for preparing the medicines for improving depression, resisting inflammation and inhibiting HPA axis excitation, can be prepared into various dosage forms, including but not limited to tablets, capsules, pills, oral solutions, injections and the like, and can be used for preparing medicines for improving depression, resisting inflammation and inhibiting HPA axis excitation. The application value is realized in efficient utilization of the folium cortex eucommiae and depression improvement treatment.