2 results about "Biopharmaceutics" patented technology

The present application belongs to the field of biopharmaceutics, and relates to a three-branched hydrophilic linker and a protein-drug conjugate thereof, and in particular, to a three-branched hydrophilic linker, a linker-payload thereof or a protein-drug conjugate thereof, preparation methods therefor, and pharmaceutical use thereof.

Systems, methods, and devices predict pharmacokinetic parameters following administration of a formulation, such as a medium-chain triglyceride (MCT). The method includes generating training data indicating human metabolism outcomes of the formulation. The training data includes stomach emptying parameters, a digestion rate, an absorption constant, or a conversion rate with a training target variable being ketone concentration or plasma free fatty acid concentration. The method also includes training a physiologically based biopharmaceutics (PBB) model with the training data and using the PBB model to predict, using the patient data, at least one of a target plasma free fatty acid concentration or a target ketone concentration. Furthermore, as part of a parameter sensitivity analysis of the PBB model, the method varies input parameters of the training data against a simulated mean plasma free fatty acid profile or a simulated mean ketone plasma profile.