Application of tea extract composition to relief and treatment of diabetes

A technology of tea extracts and compositions, applied in the field of biopharmaceuticals, to improve sensitivity, lower blood sugar levels, and improve cell inflammation

Inactive Publication Date: 2018-06-08
TEA RES INST GUANGDONG ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no information about the tea extract composition EGCG and CrCl

Method used

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  • Application of tea extract composition to relief and treatment of diabetes
  • Application of tea extract composition to relief and treatment of diabetes
  • Application of tea extract composition to relief and treatment of diabetes

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0021] The following embodiments are some examples of the present invention, and should not be regarded as limiting the protection scope of the present invention. Unless otherwise specified, the reagents mentioned below are all commercially available.

[0022] 1. Study on the hypoglycemic effect of tea extract composition on type 2 diabetes

[0023] 1. Build an animal model of type 2 diabetes

[0024] Use high-sugar and high-fat feed (high-sugar and high-fat feed contains 16.46% protein, 45.65% fat and 37.89% carbohydrates) to feed 4-week-old ICR male mice for 1 month, and 1 month later with streptozotocin ( STZ, 60mg / kg) was intraperitoneally injected into mice, and 4 days after injection, blood glucose level ≥ 20.0mmol / L was a successful type 2 diabetes animal model (type 2 diabetes model).

[0025] 2. Animal grouping and administration

[0026] Take 10 8-week-old normal ICR male mice as the normal control group (Control group), 40 successfully modeled type 2 diabetic ICR mice were ...

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Abstract

The invention belongs to the field of biopharmaceutics, and particularly relates to application of a tea extract composition to relief and treatment of diabetes. Compared with the prior art, the invention provides a novel method and a novel research theory for treating and relieving the diabetes. Studies and experiments show that a composition of EGCG extracted from tea leaves and Cr<3+> has a very good diabetes relieving effect, can effectively reduce the fasting blood glucose level of a type-2 diabetic mouse, can activate an NO signaling pathway of an NIT-1 cell, significantly improve inflammation of the NIT-1 cell and increase the insulin secretion level thereof in the cellular level, and can increase the sugar utilization rate, improve the glycogen synthesis efficiency and improve thesensitivity of an L6 cell to insulin stress by activating an AMPK pathway of the L6 cell. The tea extract composition significantly improves the hypoglycemic effect of the EGCG, which has a guiding significance and a guiding value for efficacy improvement and application of the tea extract EGCG.

Description

Technical field [0001] The invention belongs to the field of biopharmaceuticals, and specifically relates to the application of a tea extract composition in relieving and treating diabetes. Background technique [0002] In recent years, China has become one of the regions with a rapid increase in the incidence of diabetes worldwide. At present, the most common types are type 1 diabetes and type 2 diabetes, and more than 90% of diabetic patients belong to type 2 diabetes. Type 2 diabetes is also known as non-insulin-dependent diabetes, which is characterized by relatively insufficient insulin. Although the artificial synthetic drugs currently used in clinical treatment have significant therapeutic effects on type 2 diabetes, the toxic and side effects are also obvious. [0003] EGCG, a natural functional substance in tea, has been proved to have the effect of treating and relieving type 2 diabetes. Studies have shown that EGCG can protect islet cells by inhibiting related inflamma...

Claims

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Application Information

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IPC IPC(8): A61K36/82A61K31/353A61K33/24A61P3/10
CPCA61K31/353A61K33/24A61K36/82A61K2300/00
Inventor 赖幸菲孙世利向丽敏黎秋华孙伶俐
Owner TEA RES INST GUANGDONG ACAD OF AGRI SCI
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