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Composition for preventing and treating diabetes

A composition and diabetes technology, applied in drug combination, food science, metabolic diseases, etc., can solve problems such as treatment and prevention of diabetes with spleen and kidney yang deficiency, low curative effect, cross allergy, etc.

Inactive Publication Date: 2012-10-17
SUZHOU NEUPHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the prevention and treatment of diabetes at home and abroad mainly use chemical drugs such as biguanides, sulfonylureas, insulin and other chemical drugs, but these drugs have the following problems: biguanides have low curative effect, large side effects, and long-term use can cause hyperlactic acidemia Long-term use of sulfonylureas damages the liver and kidneys, and cross-allergy occurs with sulfonamides; long-term use of insulin produces antibodies, the biological activity decreases, and the dose increases, resulting in hyperinsulinemia
[0008] None of the above patent applications involves the treatment and prevention of spleen and kidney yang deficiency diabetes

Method used

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  • Composition for preventing and treating diabetes
  • Composition for preventing and treating diabetes
  • Composition for preventing and treating diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1: Composition product of the present invention containing cinnamon, mulberry leaf, kudzu root, Poria cocos, Chinese yam and bitter gourd

[0058] dosage form

Capsule (mg)

tablet (mg)

Solid drink (mg)

Teabag (mg)

Cinnamon

200

110

1000

1000

Poria cocos

80

110

1200

1000

yam

60

60

800

1000

Mulberry leaves

40

30

400

1000

Pueraria

40

20

400

500

Momordica charantia

30

20

200

500

microcrystalline cellulose

---

64

---

---

Hydroxypropylmethylcellulose

---

50

---

---

Polyvinylpyrrolidone k30

---

25

---

---

Sodium carboxymethyl starch

---

10

---

---

Magnesium stearate

---

1

---

---

Maltodextrin

-...

Embodiment 2

[0063] Embodiment 2: Composition product of the present invention containing cinnamon, mulberry leaf, kudzu root, Poria cocos, Chinese yam and bitter gourd

[0064] dosage form

[0065] The preparation method is the same as in Example 1.

Embodiment 3

[0066] Embodiment 3 hypoglycemic effect on OLETF rats

[0067] The sample is selected from the contents of the capsules in Example 1.

[0068] 40 OLETF rats (purchased from Tokushima Research Institute of Otsuka Pharmaceutical Co., Ltd., 20 weeks old, half male and half female) were fed under specific pathogen-free (SPF grade) conditions, and fed with standard feed (purchased from Shanghai Xipuer- Bikai Laboratory Animal Co., Ltd.). After feeding for 32 weeks, they were randomly divided into 4 groups. Intragastric administration for 4 weeks, once a day, the dose is ① model group: normal saline, 3 mL / ; ② western medicine group: rosiglitazone, 1.5 mg / kg body weight; g / kg body weight; 4. Chinese medicine large dose group: composition of the present invention 1.2g / kg body weight. After the administration, the fasting blood glucose of each group was detected.

[0069] Table 1 Comparison of fasting blood glucose in each group

[0070]

[0071] Compared with the model group...

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PUM

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Abstract

The invention provides a composition for preventing and treating diabetes, which comprises the following ingredients by weight: 1-100 parts of cinnamon, 1-100 parts of mulberry leaf, 1-100 parts of root of kudzu vine, 1-100 parts of Poria cocos, 1-100 parts of Chinese yam and 1-100 parts of bitter gourd. The composition possesses good hypoglycemic effect, and is especially suitable for preventing and treating of spleen and kidney insufficiency type diabetes.

Description

technical field [0001] The present invention relates to compositions for preventing and treating diabetes. Specifically, it relates to a composition for preventing and treating diabetes prepared from cinnamon, mulberry leaves, kudzu root, poria cocos, yam and bitter melon as main raw materials. Background technique [0002] At present, there are 285 million diabetic patients in the world, about 92.4 million diabetic patients in my country, and 148 million pre-diabetic patients. Diabetes has become the fourth leading cause of global population death. In view of the great harm that diabetes has brought to human beings, the World Health Organization called it "the disaster of the 21st century". Diabetes has a long course of disease and expensive treatment. According to statistics from the Diabetes Society of the Chinese Medical Association, the direct medical expenditure of diabetes in China has reached 173.4 billion yuan, accounting for 13% of the country's total medical expe...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A23L2/38A23F3/34A61P3/10
Inventor 刘敬阁钱向平朱永亮史克勇申付文曹进国
Owner SUZHOU NEUPHARMA
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