Medicine composition with function of lowering blood sugar level as well as preparation method and application thereof
A composition and blood sugar-lowering technology, applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems that do not involve the extraction and preparation of α-glucosidase inhibitors, do not involve joint use, and do not involve Combined use of alkaloids and amino acids to achieve a clear mechanism of action and definite curative effect
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Embodiment 1
[0034] Weigh 2.50 kg of Cortex Mori, cut into shreds, add 37.5 L, 25 L, and 12.5 L of water respectively, extract dynamically at 80°C three times, filter, and discard the dregs. Combine the filtrates three times, concentrate to a certain volume, and centrifuge at high speed, adjust the pH value of the liquid to 4.0 with 1.0mol / L hydrochloric acid solution, then centrifuge at high speed, put the supernatant on a 001×7 cation exchange resin column, and wash with water to remove the non-adsorbed Impurities were then eluted with 1.0 mol / L ammonia solution, and the positive fractions in the alkaloid identification reaction and amino acid identification reaction were collected. The collected solution was concentrated under reduced pressure to remove ammonia water; the concentrated solution was vacuum-dried to obtain 26.40 g of extract, which contained 7.30 g of total alkaloids and 10.60 g of total amino acids, see Table 1 for details. Take 26.40g of extract, add 2.64g of crospovidon...
Embodiment 2
[0036] Weigh 2.50kg of Cortex Mori, crush it into a coarse powder, add 0.01mol / L hydrochloric acid solution at room temperature and dynamically extract twice, 25L each time, filter, and discard the dregs. Combine the two filtrates, concentrate to a certain volume, and centrifuge at high speed. The centrifugal supernatant is directly applied to the Amberlite IR120 cation exchange resin column, and the non-adsorbed impurities are washed with water first, and then eluted with 1.0mol / L ammonia solution to collect the alkaloid identification reaction. And amino acid identification reaction positive part. The collected solution was concentrated under reduced pressure to remove ammonia water; the concentrated solution was freeze-dried to obtain 31.35 g of extract, which contained 13.35 g of total alkaloids and 10.50 g of total amino acids, see Table 1 for details. Take 31.35g of extract, add 10.95g of crospovidone, 24.09g of microcrystalline cellulose, and 6.57g of silicon dioxide, m...
Embodiment 3
[0038] Weigh 2.50 kg of mulberry branches, slice them, add 25 L, 20 L, and 15 L of methanol respectively, heat and reflux for extraction three times, filter, and discard the medicinal residues. Combine the three filtrates, concentrate to dryness, add 12.5 L of deionized water, stir to dissolve it fully, let it stand for 30 minutes, and centrifuge at high speed, adjust the pH value of the centrifugal supernatant to 5.0 with 0.1mol / L sulfuric acid solution, filter under reduced pressure, and the filtrate Put it on the D001 cation exchange resin column, wash the non-adsorbed impurities with water first, and then elute with 0.2mol / L ammonia solution to collect the positive part of the alkaloid identification reaction and amino acid identification reaction. The collected solution was concentrated under reduced pressure to remove ammonia water; the concentrated solution was vacuum-dried to obtain 24.30 g of extract, which contained 5.05 g of total alkaloids and 7.25 g of total amino ...
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