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479results about How to "Improve medicinal effect" patented technology

Chirality 7-(piperazine-substituted pyrazol aldehyde condensation isoniazide) fluoroquinolone carboxylic acid derivative as well as preparation method and application thereof

The invention discloses a chirality 7-(piperazine-substituted pyrazol aldehyde condensation isoniazide) fluoroquinolone carboxylic acid derivative as well as a preparation method and application thereof. The chirality 7-(piperazine-substituted pyrazol aldehyde condensation isoniazide) fluoroquinolone carboxylic acid derivative is a compound with the general structural formula (I), wherein R1 is H, methyl or ethyl, and R2 is H or methyl. According to the chirality 7-(piperazine-substituted pyrazol aldehyde condensation isoniazide) fluoroquinolone carboxylic acid derivative provided by the invention, fluoroquinolone, isoniazide and pyrazole aldehyde hydrazone are effectively combined to form a compound with a new structure; superposition and cooperation of activity are achieved; superposition of the three pharmacophores of fluoroquinolone, isoniazide and pyrazole aldehyde hydrazone is realized, the antituberculosis activity is improved, the toxic and side effects of fluoroquinolone and isoniazide to normal cells are decreased, and meanwhile, the probability that mycobacterium tuberculosis resists such drugs can be lowered; the chirality 7-(piperazine-substituted pyrazol aldehyde condensation isoniazide) fluoroquinolone carboxylic acid derivative can serve as an antituberculous active substance used for development of an antituberculous drug with a new structure.
Owner:HENAN UNIVERSITY +1

A kind of brewing method of kudzu root wine

ActiveCN102268344AAntibacterialSolving the Difficulty of Poor Importability in Making LiquorAlcoholic beverage preparationBiotechnologyNutrition
The invention discloses a brewing method of kudzuvine root wine. The brewing method is characterized by comprising the following steps: saccharifying rhizomes of leaguminosae plant kudzuvine used as a main raw material and indica rice used as an auxiliary material in different vats by using Chinese yeast and rice wine koji; and mixing mashes and distilling, and cellaring and ageing, and then blending so as to obtain the kudzuvine root wine. By using the method, the difficulty that distilled spirit prepared from kudzuvine root by a production plant in the past few years has poor mouth feel is solved; and the kudzuvine root wine prepared by the method provided by the invention has pure taste, and also completely maintains the nutrient and medical efficiencies of the kudzuvine root, such as blood circulation invigorating and sterilizing function on a human body and the function of improving the immunity of a human body. In the method provided by the invention, the kudzuvine root is used as the raw material, and raw materials such as cavings and the like in the traditional brewing are replaced by the kudzuvine root because the kudzuvine root has high fiber contents. The white spirit brewed by the method is mellow and unique, is rich in wine quality and is sweet and delightful. According to the invention, the processing technology is simple, has high operability and high economic and social benefits.
Owner:刘海燕

Extraction method of morindea officinalis polysaccharide

The invention provides an extraction method of morindea officinalis polysaccharide, belonging to the technical field of traditional Chinese medicines and solving the problems that in the existing morindea officinalis polysaccharide extraction method, the extraction method has complicated process steps and a poor protein removal effect, and the yield and purity of the obtained morindea officinalispolysaccharide are low. The extraction method of morindea officinalis polysaccharide in the invention comprises the following steps of: drying morindea officinalis rhizome and then smashing to 40-80 meshes; adding a chloroform/methanol mixed solvent in morindea officinalis powder for carrying out reflux extraction; carrying out alcohol extraction on a filter cake obtained by filtration and then adding water for lixiviation; subsequently, filtering and concentrating a filtrate, carrying out alcohol precipitation on a concentrated liquid and then filtering so as to obtain the crude morindea officinalis polysaccharide; adding the crude morindea officinalis polysaccharide into a n-butanol/trichloroacetic acid mixed solvent for processing, and entering a chromatographic column for elution; andcarrying out concentration, alcohol precipitation, filtration and drying on an effluent liquid so as to obtain the morindea officinalis polysaccharide. The extraction method of the morindea officinalis polysaccharide in the invention has a simple process and a good protein removal effect, and the extracted morindea officinalis polysaccharide has less impurities and high yield and purity.
Owner:朱孟勇

Medicament for treating gynaecologic urinary system infection contamination and preparation method thereof

ActiveCN101314004AFormula features are obviousGood curative effectUrinary disorderCapsule deliveryDiseaseRhizome
The invention relates to a medicine for treating gynaecological urinary system infection. The medicine is prepared by the following raw materials by weight portion: 1.30 to 1.70 portions of phellodendron, 2.80 to 3.20 portions of folium pyrrosiae, 1.80 to 3.20 portions of cogongrass rhizome, 1 grams of atractylis ovata, 1.30 to 1.70 portions of poria cocos, 1.00 to 1.40 portions of alisma orientale, 1.00 to 1.40 portions of teasel roots, 1.00 to 1.40 portions of Chinese wolfberry fruit, 0.80 to 1.20 portions of tree peony root barks, 1.30 to 1.70 grams of dandelion, 1.00 to 1.40 portions of sanguisorba, 1.60 to 2.00 portions of talcum powder and 0.10 to 0.50 portion of liquorice. The invention also discloses a method for producing the medicine for treating the gynaecological urinary system infection. The medicine reduces fever and promotes urination, and invigorates the spleen and strengthens the kidney, and is used for diseases such as urgent micturition, frequent micturition, urination fever, odynuria, lumbago, hypogastric pain and so on caused by damp heat retention. Compared with the prior art, the healing effect is more obvious, and the functions of the medicine are obviously superior to those of Sanjin tablets.
Owner:北京羚锐伟业科技有限公司

General flavone extract of seeds of nigella damascena l., nigella sativa l. or nigella glandulifera freyn et sint., and preparation method and use thereof

InactiveCN103316096AAnti-tumorEasy to prepareAntipyreticAnalgesicsNigella glanduliferaAnti platelet
The invention discloses a general flavone extract of seeds of nigella damascena l., nigella sativa l. or nigella glandulifera freyn et sint., and a preparation method and a use thereof. The extract is extracted from the seeds of nigella damascena l., nigella sativa l. or nigella glandulifera freyn et sint., and the mass percentage of general flavones is 50%-90% of that of the extract. The preparation of the extract comprises: extracting the seeds by water, alcohol or alcohol-water solution, then degreasing by an ether solvent, leaching by an organic solvent, carrying out adsorption and desorption by a macroporous resin column, concentrating, and drying to obtain the extract. The extract provided by the invention has anti-malignant tumor, anti-platelet aggregation and anti-inflammatory activities, is expected to develop into an anti-malignant tumor drug or an anti-platelet aggregation drug or an anti-inflammatory drug, and has significantly medicinal effect; in addition, the preparation method of the general flavone extract of the seeds of nigella damascena l., nigella sativa l. or nigella glandulifera freyn et sint. is simple, has high practicality, and is suitable for industrialized production requirements.
Owner:SHANGHAI UNIV OF T C M

Planting method for dendrobium officinale

InactiveCN105409744AImprove food safetyEnhance disease resistance, insecticide and antibacterial effectBiocideBio-organic fraction processingFecesInsect pest
The invention relates to the technical field of agricultural planting, particularly a planting method for dendrobium officinale. The method comprises the steps of: preparing a seedbed; preparing a cultivation matrix; preparing flower pots; performing fixed planting; performing watering; performing fertilization; performing pest control; controlling temperature and humidity and the like. The planting method provided by the invention has the beneficial effects that the survival rate of transplanted tissue culture seedlings reaches over 99%; by virtue of spraying biogas slurry, particular biogas slurry produced in a soft biogas pool, performing special treatment on a cultivation matrix, fermenting silkworm feces as top dressing and self-making a natural plant bactericide to prevent and treat plant diseases and insect pests, the produced dendrobium officinale is fleshy in leaf and stem, high in various nutritional components, quick to grow, high in yield and higher than wild dendrobium officinale in effective medicinal component content, and the occurrence rate of plant diseases and insect pests is obviously reduced, so that the cost is lowered, and the food safety of dendrobium officinale is improved. By adopting the method to plant dendrobium officinale, harvest within 12-14 months can be realized.
Owner:GUANGXI NANYIZAI SCI & TECH CO LTD

Preparation method of banana polysaccharide

The invention discloses a preparation method of banana polysaccharide, and the preparation method comprises the following processes in sequence: the banana is washed to be clean, cut to pieces and soaked and processed with acid solution, and then blanched with hot water for a few minutes, cooled, and beaten for stand-by, and then water is added to be extracted. The hydrolysis is performed with double enzyme, and then the enzyme inactivation is performed; the liquid is filtered, and the clear liquid is alcoholized and settled statically over night. The liquid is centrifuged and filtered, the deposit is taken and then washed for two times respectively with 95 percent of ethyl alcohol and acetone, and then dried with vacuum, and the banana polysaccharide crude product is obtained. The banana polysaccharide crude product is taken to be dissolved, centrifuged and filtered with water, and then adsorbed, separated and purified through a DEAE chromatography column on the filtrate, the object is collected and then ultrafilted with ultra filtration membrane, and trapped fluid is collected, alcoholized and settled statically over night. The fluid is centrifuged and filtered, the deposit is washed for two times respectively with 95 percent of ethyl alcohol and acetone, and then dried with vacuum, and the high-purity banana polysaccharide is obtained. The extraction method is simple and safe, no pollution is produced, the yield is high, the production cost is low, the purity of the obtained banana polysaccharide is high, and the preparation method is suitable for the large-scale industrialization production.
Owner:HAINAN STAND BIO TECH

Wild planting imitation method of dendrobii officmalis caulis

The invention provides a wild planting imitation method of dendrobii officmalis caulis. The wild planting imitation method comprises the following specific steps: (1) selecting planting places, namely selecting cliff walls which are positioned at the southern region of Yangtze River, faces to the shade side and has the characteristics that the altitude is 300-1700 meters, the average temperature is 15-21 DEG C all the year round, and rock bodies are sandy conglomerates; (2) selecting planting stocks, namely selecting plants which grow for 1-2 years, have light green colors and developed roots and do not have pest and disease damage as seed plants; (3) planting in January to March, during planting, upturning dendrobii officmalis caulis seed plants, arranging the dendrobii officmalis caulis seed plants by being close to the cliff walls, and tightly fixing the roots of the seed plants on the cliff walls which are smooth, cannot accumulate water and has the slopes being 80-90 degrees by using iron fixing buckles; (4) managing after planting, namely carrying out spray irrigation once every 5-10 days by mountain spring water in the arid season; and (5) harvesting. According to the method, the originally ecological wild planting imitation of dendrobii officmalis caulis can be realized, the harvested dendrobii officmalis caulis has high effective constituents and good quality, and is safe and reliable in quality, and the medicinal efficacy of dendrobii officmalis caulis prepared by the method is equivalent to that of wild dendrobii officmalis caulis.
Owner:TAINING BAXIANYA ECO AGRI DEV CO LTD

Targeted drug delivery device for anti-tumor magnetic nanometer particle drug

The invention belongs to the technical field of drug delivery device products, and particularly relates to a targeted drug delivery device for an anti-tumor magnetic nanometer particle drug. The device comprises a liquid conveying container, a drug liquid conveying device and a control unit, wherein a magnetic field generation device and a biological electric sensor are arranged on the body surface of a tumor area, the magnetic field generator is connected with a magnetic field control device, the drug liquid conveying device is connected with a flow rate controller, and the control unit is respectively connected with the biological electric sensor, the magnetic field control device and the flow rate controller. The targeted drug delivery device can reduce the flowing of the magnetic nanometer particle anti-tumor drug, and the drug can be well centralized into the tumor area, so the concentration of the drug in the tumor area is higher, and the medical effect is good; meanwhile, the strength of a magnetic field and the flow rate of drug liquid can be controlled according to the feedback of the biological electric signals of the tissues of the tumor area, the therapy safety of the magnetic nanometer particle drug is improved, the restoration of the body of a tumor patient is facilitated, and the unnecessary injury to other organs of the body by the drug is also reduced.
Owner:GUANGZHOU YIDAI PHARMA CO LTD
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