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Rhodiola crenulata extract and preparation method thereof

The technology of Rhodiola rosea and its extracts is applied in the directions of pharmaceutical formulations, plant raw materials, and medical preparations containing active ingredients, which can solve the problems of restricting the development of Rhodiola rosea medicinal materials, and achieve good medicinal effects, The effect of reducing environmental pollution

Inactive Publication Date: 2011-07-27
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Those skilled in the art know that not all rhodiola medicinal materials contain Rosavin, and the content of rosavin is limited, which limits the development of the source material of rhodiola medicinal materials; The quality of day herbs or extracts

Method used

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  • Rhodiola crenulata extract and preparation method thereof
  • Rhodiola crenulata extract and preparation method thereof
  • Rhodiola crenulata extract and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 The preparation method of Rhodiola rosea extract of the present invention

[0026] Take an appropriate amount of Rhodiola rosea coarse powder, use 70% ethanol as the extraction solvent, 10 times the amount, and reflux extraction twice, each time reflux extraction for 1 hour. HPD 826 Purification of salidroside by macroporous adsorption resin, the crude drug concentration of the sample solution is 0.1g / ml (the concentration of salidroside is about 1.28mg / ml), the diameter-to-height ratio is 1.5 / 10, and the sample volume is 1.0g per gram of resin Crude drug, adsorption rate is 2ml / min, after adsorption balance, with distilled water 0.5BV, 30% ethanol 6BV successively elution, elution rate is 2ml / min, reclaims ethanol, dry, obtains the Rhodiola rosea of ​​the present invention extract.

Embodiment 2

[0027] Example 2 Determination of the active ingredient content of the Rhodiola rosea extract of the present invention

[0028] Salidroside in the extract of Rhodiola rosea is its main functional component. In addition, the content of polysaccharides and polyphenols in Rhodiola rosea is relatively high, and it has definite pharmacological effects. Phenol is used as an index component for content determination in order to better control the quality of Rhodiola rosea extract. The following test samples are all prepared in Example 1.

[0029] Determination of salidroside content

[0030] ① Chromatographic conditions Chromatographic column: HypersiL ODS (4.6mm×200mm, 5μm); mobile phase: acetonitrile-water (8:92); flow rate: 1.0ml / min; detection wavelength: 275nm; column temperature: 30°C.

[0031] ②Preparation of the test solution Take about 50mg of the powder of this product, accurately weigh it, put it in a 10ml volumetric flask, add 70% ethanol to dissolve it and make it cons...

Embodiment 3

[0113] Example 3 Screening of the preparation method of Rhodiola rosea extract of the present invention

[0114] 1 Selection of extraction medium

[0115] The salidroside contained in Rhodiola daflora is relatively polar and has good solubility in hydrophilic solvents such as water and ethanol. In this experiment, the content of salidroside and extracts were used as the evaluation index, and the extraction efficiency of salidroside by water and 30%, 50%, 70%, and 95% ethanol was investigated, and the best method for screening Rhodiola grandiflora medicinal materials was investigated. The solvent is extracted by weighing 50g of Rhodiola rosea coarse powder, placing it in a 1000ml flask, adding 10 times the amount of 70% ethanol to reflux and extracting once, the extraction time is 1h, filtering, taking 2ml of the filtrate in a 10ml volumetric flask, Dilute to the mark with distilled water, shake well, and pass through a 0.45um microporous membrane for measurement. The results...

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Abstract

The invention provides a rhodiola crenulata extract which is characterized in that: in the extract, the weight percentage of rhodioloside is not less than 10%, the weight percentage of rhodiola polysaccharide is not less than 30%, and the weight percentage of rhodiola polyphenol is not less than 34.0%; and the content of rosavin is 0%. The invention also provides a preparation method of the extract. The rhodiola crenulata provided by the invention has the advantages of exact drug effect, stable quality and strong controllability.

Description

technical field [0001] The invention relates to a rhodiola rosea extract and a preparation method thereof. Background technique [0002] Rhodiola rosea (Rhodio Larosea) is the root and rhizome of Crassu Laceae (Crassu Laceae) Sedum genus (Rhodio La) plants. my country is the distribution center of Rhodiola, and more than 70 of the more than 90 species of Rhodiola in the world are distributed in my country. Southwest regions such as Sichuan, Tibet, and Yunnan are the main producing areas of Rhodio Lacrenuata (Hook.f.et Thomx.) H.Ohba, and Tibet has the largest output. Rhodiola grandiflorum, also known as Rhodiola wide petals and Rhodiola scallopedum, grows in hillside grasslands, shrubs, and rock crevices at an altitude of 2,800 to 5,600 meters. Rhodiola daflora is rich in plant resources, distributed in Sichuan, Yunnan, Tibet, Qinghai and other vast western regions, and has a large amount of reserves. Xiong Xianrong, He Junsheng, etc. only made research statistics on the r...

Claims

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Application Information

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IPC IPC(8): A61K36/41
Inventor 刘友平黎代余陈鸿平向楚兵施学骄
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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