The invention relates to a method for producing high-safety caramel color through twice catalytic reaction. The method comprises the following steps of: a, rice pulverization; b, spraying liquefaction; c, diastatic enzyme addition into liquefied rice for saccharification; d, filtering; e, concentration; f, primary catalytic reaction: through being metered by the mass percentage content of dry basis, catalysts accounting for 40 percent of the catalyst consumption are adopted and added in the primary catalytic reaction, then, through the pressurization and temperature rise reaction, the reaction pressure is controlled to a value being smaller than or equal to 0.1 MPa, the temperature is smaller than or equal to 110 DEG C, and the primary catalytic reaction is stopped when the reaction is carried out to reach 60 percent of the total required color rate; g, secondary catalytic reaction: the secondary catalytic reaction is stopped when the reaction is carried out to reach the required color rate; h, cooling; and i, finished product blending. Through the twice catalytic reaction, the reaction temperature and the reaction pressure are reduced, the reaction conditions are milder, the single consumption of steam is reduced, the reaction process and the control are easier and more stable, each ton of products can save 100kg of steam, and the method is favorable for improving the market competitiveness of products.