Targeted drug delivery device for anti-tumor magnetic nanometer particle drug

Abstract

The invention belongs to the technical field of drug delivery device products, and particularly relates to a targeted drug delivery device for an anti-tumor magnetic nanometer particle drug. The device comprises a liquid conveying container, a drug liquid conveying device and a control unit, wherein a magnetic field generation device and a biological electric sensor are arranged on the body surface of a tumor area, the magnetic field generator is connected with a magnetic field control device, the drug liquid conveying device is connected with a flow rate controller, and the control unit is respectively connected with the biological electric sensor, the magnetic field control device and the flow rate controller. The targeted drug delivery device can reduce the flowing of the magnetic nanometer particle anti-tumor drug, and the drug can be well centralized into the tumor area, so the concentration of the drug in the tumor area is higher, and the medical effect is good; meanwhile, the strength of a magnetic field and the flow rate of drug liquid can be controlled according to the feedback of the biological electric signals of the tissues of the tumor area, the therapy safety of the magnetic nanometer particle drug is improved, the restoration of the body of a tumor patient is facilitated, and the unnecessary injury to other organs of the body by the drug is also reduced.

Description

technical field [0001] The invention belongs to the technical field of drug delivery device products, and in particular relates to a targeted drug delivery device for anti-tumor magnetic nanoparticle drugs. Background technique [0002] Nanoparticles refer to particles with a particle size between 1 and 100nm (nanoparticles are also called ultrafine particles). It belongs to the category of colloidal particle size. They are in the transition zone between atomic clusters and macroscopic objects, between microscopic systems and macroscopic systems, and are groups composed of a small number of atoms or molecules, so they are neither typical microscopic systems nor typical macroscopic systems. It can be predicted that nanoparticles should have some novel physical and chemical properties. Nanoparticles differ from macroscopic object structures in that their surface area accounts for a large proportion, and surface atoms have neither long-program nor short-program amorphous laye...

AI Technical Summary

Problems solved by technology

That is, drugs are carried on the surface of proteins coated with magnetic nanoparticles, such as figure 1 As shown, the antitumor drug 20 is carried on the surface of the magnetic nanoparticle 10, such as Pingyangmycin, which is combined into a magnetic nanoparticle antitumor drug 30 through physical or covalent bonding, and then the magnetic nanoparticle antitumor drug 20 is Entering human diseased tissue through intravascular injection or tumor cavity injection can reduce the side effects of drugs on the liver, spleen, kidney, etc. , especially for lesions with rich blood supply, such as angiosarcoma, malignant melanoma, arterial malformation (mangiform hemangioma) and large venous malformation, the blood flow in the lesion area is fast, and the residence time of the drug in the lesion area tissue is short after entering. The concentration is low, and the medicinal effect is poor, which affects the curative effect of tumor patients. In addition, the drug entering the blood circulation increases the damage of human tissues and organs. Therefore, it is necessary to develop a kind of anti-tumor magnetic nanoparticle drug that can be concentrated and controlled in the tumor area. The targeted device is imminent

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