Ganoderma-lucidum medicinal mycoplasm, pharmaceutical preparation, pharmaceutical composition and food composition

A technology of medicinal bacteria and pharmaceutical preparations, applied in the field of bioengineering, can solve the problem of only containing active ingredients of ginseng, achieve good health care and medicinal effects, enhance physical fitness, and regulate immunity

Active Publication Date: 2010-09-15
陈心智 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current ginseng processed products, such as red ginseng, white ginseng, active ginseng, ginseng tea, ginseng carbonated drinks, etc.,

Method used

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  • Ganoderma-lucidum medicinal mycoplasm, pharmaceutical preparation, pharmaceutical composition and food composition
  • Ganoderma-lucidum medicinal mycoplasm, pharmaceutical preparation, pharmaceutical composition and food composition
  • Ganoderma-lucidum medicinal mycoplasm, pharmaceutical preparation, pharmaceutical composition and food composition

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0064] Example 1

[0065] Inoculate the Ganoderma lucidum strains preserved in the Institute of Medicinal Fungi of Changchun University of Traditional Chinese Medicine on PDA slant medium, cultivate at 27℃±1℃, cultivate for 7 days to obtain mycelium for use;

[0066] Production containing 2wt% glucose, 0.5wt% peptone, 0.1wt% yeast powder, 0.15wt% KH 2 PO 4 , And 0.1wt% MgSO 4 The strain culture medium. Take 100mL strain culture solution into 250mL Erlenmeyer flask, and sterilize at 0.1MPa and 121℃ for 30min. Cut 4 pieces of 0.5cm×0.5cm mycelium in a sterile room and put them into the culture medium of the culture medium of the Erlenmeyer flask, and after shaking culture for 5 days under the conditions of 28℃ and 150r / min, the seed liquid containing the mycelium ball is obtained;

[0067] Take 50g of raw sun-dried ginseng free from insects and mildew, crush it through a 60-mesh sieve, add 50g of water to moisten for 12h, put the obtained ginseng into a 500mL Erlenmeyer flask, sterili...

Example Embodiment

[0072] Example 2

[0073] Ginseng medicinal fungal substance toxicity test

[0074] 2.1 Experimental animals and groups

[0075] The 40 Kunming mice provided by the Changchun High-tech Medical Animal Experimental Research Center are half male and half male, weighing 18g-22g.

[0076] 2.2 Experimental equipment and reagents

[0077] Electronic scale, mouse cage and 1mL gastric applicator;

[0078] Take 100g of Ganoderma lucidum and ginseng medicinal fungal powder prepared in Example 1, and after blending with 0.2g Tween 80, add 400g of distilled water to prepare a test drug solution with a mass concentration of 25%;

[0079] 0.2g Tween 80 and 400g distilled water were used as a control solution.

[0080] 2.3 Pre-experiment

[0081] Take 20 mice, half male and half, fasted for 16 hours without water, and divided into sample group and control group;

[0082] The mice in the sample group were given the test drug solution of 7.5g / kg body weight by gavage every day for 7 consecutive days. It was f...

Example Embodiment

[0095] Example 3

[0096] Ginseng medicinal fungal substance has the effect of improving sleep

[0097] 3.1 Experimental animals

[0098] Male ICR mice, weighing 18g~26g, provided by the Experimental Animal Center of Jilin University.

[0099] 3.2 Reagents

[0100] Take the Ganoderma ginseng medicinal fungal substance powder prepared in Example 1 and add distilled water to prepare a test drug solution with a mass concentration of 25%;

[0101] Mix the Ganoderma lucidum powder provided by Jilin Jinyu Pharmaceutical Development Co., Ltd. and distilled water to prepare a 25% Ganoderma lucidum solution;

[0102] Mix ginseng powder provided by Jilin Jinyu Pharmaceutical Development Co., Ltd. and distilled water into a ginseng solution with a mass concentration of 25%;

[0103] Ganoderma lucidum and ginseng are ground together, and distilled water is added to prepare a mixture of ganoderma and ginseng with a mass concentration of 25%;

[0104] Sodium pentobarbital (AR), produced by China National...

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Abstract

The invention provides a ganoderma-lucidum medicinal mycoplasm, which is prepared by a method comprising the following steps: pulverizeing ginseng, adding water to moisten, and sterilizing to obtain the fermentation substrate; activating the ganoderma lucidum strain, and carrying out enlarged culture to obtain the fermentation strain; and inoculating the fermentation strain in the fermentation substrate, and carrying out bidirectional solid fermentation at 24-28 DEG C for 10-20 days under a lucifugal condition. The invention provides a pharmaceutical preparation which comprises the ganoderma-lucidum medicinal mycoplasm and a medicinal carrier. The invention provides a pharmaceutical composition which comprises the ganoderma-lucidum medicinal mycoplasm, pharmacological active substances and a medicinal carrier. The invention also provides a food composition which comprises the ganoderma-lucidum medicinal mycoplasm and nutriologically acceptable food additives. The ganoderma-lucidum medicinal mycoplasm has the active constituents in both ginseng and ganoderma lucidum, and thus, has favorable effects of health care and medicinal function.

Description

technical field [0001] The invention relates to the technical field of bioengineering, in particular to a ganoderma ginseng medicinal fungus, a pharmaceutical preparation, a pharmaceutical composition and a food composition. Background technique [0002] Ginseng contains various active ingredients such as saponins, polysaccharides, and volatile oils. It has the functions of replenishing vitality, restoring pulse and solidifying, nourishing the spleen and lungs, promoting body fluid and calming the nerves. It is a typical medicinal and edible plant. However, the current ginseng processed products, such as red ginseng, white ginseng, active ginseng, ginseng tea, ginseng carbonated drinks, etc., are mostly processed with other edible or medicinal substances after soaking or grinding ginseng, and only contain Active ingredients of ginseng. [0003] Ganoderma lucidum is not only delicious, but also contains biologically active substances such as polysaccharides, amino acids, vit...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K36/06A61K36/232A61K36/484A61K36/62A61K36/69C12N1/14A23L1/30A61P1/14A61P25/20A61P37/04A23L33/10
Inventor 陈心智邱智东翁丽丽陈雪松
Owner 陈心智
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