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128results about How to "Reduce chance of drug resistance" patented technology

Chirality 7-(piperazine-substituted pyrazol aldehyde condensation isoniazide) fluoroquinolone carboxylic acid derivative as well as preparation method and application thereof

The invention discloses a chirality 7-(piperazine-substituted pyrazol aldehyde condensation isoniazide) fluoroquinolone carboxylic acid derivative as well as a preparation method and application thereof. The chirality 7-(piperazine-substituted pyrazol aldehyde condensation isoniazide) fluoroquinolone carboxylic acid derivative is a compound with the general structural formula (I), wherein R1 is H, methyl or ethyl, and R2 is H or methyl. According to the chirality 7-(piperazine-substituted pyrazol aldehyde condensation isoniazide) fluoroquinolone carboxylic acid derivative provided by the invention, fluoroquinolone, isoniazide and pyrazole aldehyde hydrazone are effectively combined to form a compound with a new structure; superposition and cooperation of activity are achieved; superposition of the three pharmacophores of fluoroquinolone, isoniazide and pyrazole aldehyde hydrazone is realized, the antituberculosis activity is improved, the toxic and side effects of fluoroquinolone and isoniazide to normal cells are decreased, and meanwhile, the probability that mycobacterium tuberculosis resists such drugs can be lowered; the chirality 7-(piperazine-substituted pyrazol aldehyde condensation isoniazide) fluoroquinolone carboxylic acid derivative can serve as an antituberculous active substance used for development of an antituberculous drug with a new structure.
Owner:HENAN UNIVERSITY +1

Compound colistin sulfate soluble powder for treating lamb dysentery and preparation method thereof

The invention discloses compound colistin sulfate soluble powder for treating lamb dysentery and a preparation method thereof and aims to provide the compound colistin sulfate soluble powder which hasa quick therapeutic effect on lamb dysentery, has efficacy in secondary infection bacteria and is convenient to use, and the preparation method which has a simple process and is easy to implement. The powder comprises the following components in percentage by weight: 2 to 10 percent of colistin sulfate, 5 to 20 percent of sulfathiazole sodium, 0.05 to 0.5 percent of atropine sulfate, 0.2 percentof vitamin K, and the balance of anhydrous dextrose. The soluble powder is a compound preparation of the combination of four medicaments, wherein the colistin sulfate and the sulfathiazole sodium areantibacterial for killing pathogens, the atropine sulfate controls diarrhea, reduces water loss and accelerates the treatment speed, and the vitamin K prevents and treats intestinal tract bleeding; and the four medicaments are mixed together reasonably so that the powder has a quick response, treats both symptoms and root causes, and can reduce the losses of raisers. The compound colistin sulfatesoluble powder is soluble powder, is soluble in milk, is used for feeding lambs through the milk and is more convenient to use.
Owner:TIANJIN SHENGJI GRP CO LTD
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