97 results about "Triazole antifungals" patented technology

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

A coating composition used for coating of a steel material and/or aluminum material comprises a corrosion inhibitor, a base resin and a curing agent. The corrosion inhibitor may be selected from cerium compounds, lanthanum compounds, molybdate salt compounds, gluconic acid derivative salts, porous base materials, triazole compounds, thiazole compounds, tetracyclines, and metal phosphate salt compounds of ascorbic acid. The base resin may include a xylene-formaldehyde-resin-modified amino-containing epoxy resins obtained by reacting an epoxy resin having an epoxy equivalent of from 180 to 2500 with a xylene formaldehyde resin and an amino-containing compound. The curing agent may be a blocked polyisocyanate compound obtained by blocking an isocyanate group of a polyisocyanate compound with a blocking agent.

There is provided an etching solution comprised of a cupric chloride solution and a high-concentration triazole type compound added to the cupric chloride solution and capable of forming an etching-inhibiting coating. In a process of forming a circuit pattern by etching with the etching solution, an etching-inhibiting coating is selected formed on parts of a copper foil laid under the edge of an etching resist to effectively inhibit horizontal side-etching of the copper foil from the edge of the etching resist. Also, nonuniform irregularities formed on the side wall of the circuit pattern by the etching improves the adhesion between the circuit pattern and an insulating resin layer covering the circuit pattern.

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

The present invention generally relates to gas generant compositions for inflators of occupant restraint systems, for example. An extrudable pyrotechnic composition includes polyvinylazoles for use within an airbag gas generator. The fuel may be selected from exemplary polyvinylazoles including 5-amino-1-vinyltetrazole, poly(5-vinyltetrazole), poly(2-methyl-5-vinyl) tetrazole, poly(1-vinyl) tetrazole, poly(3-vinyl) 1,2,5 oxadiazole, and poly(3-vinyl) 1,2,4-triazole. An oxidizer is combined with the fuel and preferably contains phase stabilized ammonium nitrate. A novel method of forming the compositions is also presented wherein the various constituents are wetted and/or dissolved, and then cured within the polyvinylazole matrix thereby forming a more intimate combination within the gas generant composition. A vehicle occupant protection system 180, and other gas generating systems, incorporate the compositions of the present invention.

Use of macrolide and ketolide antibiotics for the treatment of acute exposure and diseases caused by biodefense pathogens is described.

A process for the preparation of 4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furanyl]methoxy]phenyl]-1-piperazinyl]phenyl]-2-[(1S,2S)-1-ethyl-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one compound of formula-1, its intermediates and polymorphs thereof. (I)

The invention discloses a pesticide composite containing pyraclostrobin. The pesticide composite contains active ingredients, namely pyraclostrobin and one of triazole compounds: flusilazole, epoxiconazole, tetraconazole, tricyclazole and propiconazole. The ratio of the parts of the two active ingredients by weight is 60 to 1-1 to 60. The pesticide composite at least contains one type of surfactant, thus being beneficial to the dispersion of the active ingredients in water. The pesticide composite integrates protection activity, treatment activity with eradication activity. The pesticide composite can be used for various crop plants such as wheat, paddy rice, vegetables, fruit trees and the like; and the pesticide composite can prevent and treat diseases such as downy mildew, phytophthora disease, rust disease, powdery mildew, alternaria mali roberts, leaf spot, scab disease, rice blast and the like.

Polymers, polymer precursors, and other materials are described, having at least one heterocycle and being useful for fabrication of proton-exchange membranes (PEMs). In representative examples, the heterocycle is a fluorinated imidazole ring. The heterocycle can be chosen to have a low value of pKa, and may be a triazole ring, other nitrogen-containing heterocycle, or derivative thereof. Polymers and composites were prepared having excellent proton conductivity. Applications of these materials include fuel cells and other ion-conducting applications.

Carboxylic acids or the salts thereof are suitable for use in cooling systems where low electrical conductivity is required. The compositions are of particular use in fuel cell stacks. The preferred salts are those of amines. The salts can be used with a liquid alcohol freezing point depressant such as monoethylene glycol. Thiazoles and/or triazoles may be included, as well as other corrosion inhibitors known in the art.

The invention relates to a bacteriocidal composition and an application thereof. The bacteriocidal composition is characterized by comprising Boscalid (A) and at least one (B) selected from the following active components of a triazole bactericide: difenoconazole, propiconazole, tebuconazole, hexaconazole, flutriafol, epoxiconazole, tetraconazole, flusilazole, myclobutanil, cyproconazole, triazolone and diniconazole, wherein the mass ratio of A to B is (1:50)-(50:1). The composition can be applied to preventing and treating diseases of crops such as cereal crops, melons, fruits, vegetables and the like.

The invention relates to compositions suitable as additive packages for lubricants and other functional fluids, the composition comprising sulfur-containing extreme pressure components, phosphorus-containing anti-wear additives, a triazole-containing species. A preferred use is in industrial gear oils. In embodiments, enhance protection in the areas of bearing wear and micropitting are obtained.

This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with new aminium salts of 1,2,3-triazoles which can be used as prodrugs to improve the solubility or pharmaceutical properties of 1,2,3-triazole containing compounds. More particularly, the present disclosure relates to compounds containing N-aminium-1,2,3-triazoles that are useful as antiviral agents and specifically for the treatment of HIV and AIDS.

The invention discloses an azoxystrobin-containing pesticide composition. The pesticide composition comprises azoxystrobin and a triazole fungicide. The weight ratio of the azoxystrobin to the triazole fungicide is 1:60-60:1, and particularly the weight ratio of the azoxystrobin to the triazole fungicide is 1:1-3:2. The triazole fungicide is one of epoxiconazole, flutriafol, propiconazole, tebuconazole, hexaconazole, fluazinam or penconazole. The composition of the triazole fungicide and the azoxystrobin has significant synergistic effects, and can be used for disease control of fruit trees, cotton, rice, vegetables, and other crops, especially for disease control of rice blast, powdery mildew, gray mold and anthracnose.

The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.

The invention relates to a suspending agent type and water dispersible granule type sterilization compound which comprises the following raw materials in percentage by weight: 5-50% of triazole fungicide, 5-50 % of azoxystrobin and 3-15 % of accessory ingredient, wherein the triazole fungicide is one or the combination selected from Epoxiconazole, lutriafol, Cyproconazole and Penconazole, and theaccessory ingredient is composed of polycarboxylate dispersing agent and lignosulfonate wetting agent at the weight ratio of 0.15-6:1. The sterilization compound of the invention keeps good compound stability for two active ingredients in use; compared with the condition that single solvent is used for preventing and curing crop diseases, the sterilization compound enlarges disease prevention andcure range, delays the generation of resistance to drugs, obviously improves pesticide effect, reduces dosage and application times for each acre, preferably ensures the safe production of agriculture and protects ecological environment.

The invention provides a pesticide composite containing picoxystrobin and triazole compound, comprising an effective active ingredient A and an effective active ingredient B, wherein the effective active ingredient A is the picoxystrobin; the effective active ingredient B is selected from one of epoxiconazole, flusilazole, tetraconazole, triazole and propiconazole. The pesticide composite disclosed by the invention comprises the following ingredients in percentage by weight: 1-60wt% of effective active ingredient A- picoxystrobin, 1-50wt% of effective active ingredient B selected from one of epoxiconazole, flusilazole, tetraconazole, triazole and propiconazole and the balance of accessory ingredient and butyl stearate. The pesticide composite disclosed by the invention is used for preventing and curing various diseases, such as crop powdery mildew, Septoria nodorum, leaf blight, downy mildew, smut, leaf spot, banana freckle, epidemic diseases, rust diseases, leaf mold, rice blast, banded sclerotial blight and anthracnose of grape and has obvious synergy.

A process for making an ion-conducting polymer comprises cross-linking polymers having functional groups such as alkyne groups and azide groups. An example ion-conducting polymer has cross-links including nitrogen-containing heterocycles formed by the reaction between the functional groups, such as 1,2,3-triazole groups formed by a cycloaddition reaction between alkyne and azide groups. The ion-conducting polymer may be used in an ion-electrolyte membrane. Examples include a proton-electrolyte membrane useful for fuel cells.

The invention relates to a sterilizing compound of ethirimol and triazole, and the compound contains the ethirimol of synergic and effective amount, the triazole bactericide which is tebuconazole, difenoconazole, hexaconazole or myclobutanil, and diluent or carrier that is acceptable in pesticide, wherein the weight ratio of the ethirimol to the triazole bactericide which is tebuconazole, difenoconazole, hexaconazole or myclobutanil is 25:1 to 1:50. When being compounded with the triazole bactericide, the ethirimol has obvious synergy, and the amount of effective ingredients of the compound preparation is less than that when being used independently. The compound can be used for curing powdery mildew of fruit trees, melons, beans, solanaceous fruits, flowers, and the like.

A stable matrix emulsion concentrate of a biocide, e.g. 3-iodopropynyl-2-butyl carbamate (IPBC) and/or a triazole fungicide, and stable aqueous and/or organic solvent formulations thereof, i.e. dilutable in water and/or an organic solvent are provided, which are particularly useful for treating wood products to provide protection against microorganisms and insects.

at least one aurone or a natural or synthetic derivative of aurone, or an analogue of aurone, in which the independent phenyl ring can be substituted by a heterocycle of pyrrole, imidazole, triazole, pyridine, furan, or thiophene type, is disclosed as a cosmetic agent, or as an active substance, for the manufacture either of a cosmetic composition, or of a pharmaceutical composition, notably a dermatological composition, having a melanogenesis-inhibiting activity or a depigmenting activity, or an anti-tyrosinase activity.

The invention relates to a substituted triazolone benzyl amine triazole antifungal compound, i.e. 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[N-methyl-N-(2-substituted-2H-1,2,4-triazol-3-one-4-yl) benzylaminoformyl]-2-propanols compounds, their salts and their preparation process. The compounds has very strong antimycotic effect.

The present invention relates to substituted 1-(alkyl)-3-aniline-5-aryl triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I).

The invention particularly relates to potent positive allosteric modulators of nicotinic acetylcholine receptors which have the capability of increasing the efficacy of nicotinic receptor agonists.