32results about How to "Strong antifungal effect" patented technology

The invention relates to the technical field of medicines. Present antifungal medicines which have problems of large side effect, narrow antimicrobial spectrum, easy generation of the drug resistance and the like cannot satisfy clinical treatment needs. The invention provides novel triazole alcohol antifungal compounds with high efficiency, low toxicity and wide spectrum and pharmaceutically acceptable salts thereof. The compounds are 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-(nitrogen-containing side chain substituted)-2-propanol compounds, and the general structure of the compounds is shown in the specification. The invention also provides a preparation method of the compounds and an application of the compounds in the preparation of antifungal medicines.

The invention relates to the medical technical field, in particular to a new triazole alcohols antifungal compound and salts thereof with the following chemical structure formula and a preparation method and the application thereof; R1 is selected from n-propyl, isopropyl or butyl; R2 is selected from alkyl or halogen; the salts include hydrochloride, hydrobromide and methane sulphonate. The compound has strong antifungal activity on various fungi in shallow parts and deep parts. Compared with the antifungal medicines used in the existing clinical applications, the compound has the advantages of high efficiency, low toxicity, broad antifungal spectrum, and the like, and can be used for preparing new antifungal medicines.

The invention relates to the technical field of medicines and particularly relates to pseudolarix acid derivatives with the structure shown in a formula (1) (the detailed definitions of all groups are shown in the specification). The compounds have favorable activity for various tumor cells such as human lung cancer, colon cancer, breast cancer and the like; besides, the compounds show better antifungal activity. The invention also discloses a composition and preparation method of the pseudolarix acid derivatives as well as the application of the seudolarix acid derivatives in preparation of antitumor medicaments, antifungal medicaments or anti-angiogenesis medicaments.

The invention relates to a substituted triazolone benzyl amine triazole antifungal compound, i.e. 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[N-methyl-N-(2-substituted-2H-1,2,4-triazol-3-one-4-yl) benzylaminoformyl]-2-propanols compounds, their salts and their preparation process. The compounds has very strong antimycotic effect.

The invention relates to the field of hygienic products, and provides a uterus warming sanitary towel. The uterus warming sanitary towel comprises a surface layer, a uterus warming layer, an absorption layer and a leakage-proof bottom layer which are sequentially laminated from top to bottom, wherein the uterus warming layer comprises a sealing bag formed by hot pressing of two layers of polypropylene non-woven fabrics, and a heating composition and a plant extract microcapsule which are filled in the sealing bag, the plant extract microcapsule and the heating composition are separated by a PEbreathable film, the heating composition is pressed into a sheet shape and comprises the following raw materials in parts by weight: 60-80 parts of iron powder, 5-15 parts of activated carbon, 3-5 parts of potassium nitrate, 10-20 parts of water, 2-4 parts of vermiculite, 0.5-1.5 parts of sodium alginate, 1.5-3 parts of starch, 1-2 parts of polyvinylpyrrolidone and 0.4-0.8 part of sodium bicarbonate, and the plant extract microcapsule is prepared by taking a chitosan quaternary ammonium salt and sodium alginate as wall materials and taking a plant extract as a core material. The uterus warming sanitary towel solves the problems that sanitary towels in the prior art are relatively single in function and cannot meet various requirements of female users for sanitary towels.

The invention relates to technical field of medicine, in particular to novel azole antifungal compound and salt thereof and the application, wherein, X presents hydroxyl or straight-chain ester group or branch-chain ester group with 1-6 carbon atoms and the ester group with easily-leaving group; Y presents substituent group on aromatic ring; M presents propargyl group or cyanomethyl; P presents various substituent groups on benzene ring, the substituent positions can be different positions on aromatic ring, mono substitution, or polysubstitution combined by the substituent groups; Z presents C or N atom; if Z presents Z atom, the position can be different positions on ring, and can be mono substitution, or polysubstitution; n is equal to 0-5; the salt comprises hydrochloride, nitrate, hydrobromide or methane sulfonate. The advantages of the invention are as follows: the compound provided by the invention has strong antifungal activity, low toxicity, and wide antifungal spectrum, and can be used for preparing novel antifungal drugs.

The invention relates to a compound of the general formula (1): 13, 13'-O-isopropylidene substrate Jungermanniaceae D. The invention also relates to a method of extracting and separating the compound and uses of the compound in preparation of antifungal drug. The compound exploits a new road to develop and apply the new generation antifungal drug derived from nature.

The invention relates to a compound tea seed powder foot bath agent, made from tea seed powder, Alpinia japonica, bamboo leaf, mugwort, Radix Sophorae Flavescentis, Cortex Pseudolaricis, Cortex Dictamni, radish, garlic, pomelo peel and Xanthoxylum pepper; a preparation method comprises: taking the Alpinia japonica, mugwort, bamboo leaf, Radix Sophorae Flavescentis, Cortex Pseudolaricis, Cortex Dictamni, radish leaf, garlic, pomelo peel and Xanthoxylum pepper, crushing with a traditional Chinese medicine crusher to obtain powder less than 40-60 mesh, stirring well, adding parts by weight of the tea seed powder into a container, and hermetically storing at normal temperature. Eleven Chinese herbs are added and compounded in the formulation, the unique pharmacological actions of the Chinese herbs are used to provide the effects of removing damp and stopping itching, drying dampness and killing insects, cleaning skin, killing foot germs, removing foot odor, removing peeled skin and assisting in improving foot skin, the agent is natural and nonirritating, free of side effect and chemical residue, and suitable for long-term usage.

The present invention discloses one kind of antifungal medicine composition for treating superficial fungous diseases. The antifungal medicine composition contains cell synthesis factor inhibitor type immunological inhibitor; azepexole or allyl amine type antifungal agent; and pharmaceutically acceptable carrier. The immunological inhibitor and the antifungal agent account for 0.001-99.9 % of the total composition and has weight ratio of 0.01-100. The composition of the present invention may be used in treating tinea corporis, tinea capitis, tinea manuum and other superficial fungous diseases.

The invention relates to a Chinese herbal compound externally-applied preparation for resisting fungal infection of skin and belongs to the technical field of traditional Chinese medicines. The Chinese herbal compound externally-applied preparation is prepared by mixing the following effective components in parts by weight: 1-5 parts of resina draconis powder, 3-9 parts of pericarpium zanthoxyli,3-15 parts of aloe, 1-5 parts of scolopendra, 3-15 parts of radix phytolaccae and 1-5 parts of camphor powder. The Chinese herbal compound externally-applied preparation is prepared by the following steps of weighing the Chinese medicinal materials in parts by weight, heating the pericarpium zanthoxyli, the aloe, the scolopendra and the radix phytolaccae to 100-150 DEG C with the heating extraction time being 2-4h, removing residues after extraction, then adding 15-30 parts of beewax, adding the resina draconis powder and the camphor powder when a temperature is about 70 DEG C, and performinguniform mixing and cooling to prepare an ointment. The ointment or a tincture externally-applied preparation prepared by compounding the traditional Chinese medicines has very strong killing and inhibiting effects to various fungi infected by the skin, including porrigo, tinea corporis, tinea cruris, tinea pedis, tinea manuum, foot odour and tinea versicolor and the like.

The invention relates to a toilet article, in particular to a scented soap. A sea cucumber soap, the weight percentage of each component is: 80-90% of soap base, 5-10% of sea cucumber active extract, 2-4% of white sugar, 1-2% of dye solution, and 2-4% of natural plant essential oil. The present invention recycles and reuses the cooking waste liquid produced during the processing of fresh and live sea cucumbers, extracts soluble sea cucumber active substances such as sea cucumber collagen, sea cucumber polysaccharides, sea cucumber saponins and the like, and combines these active substances with traditional Soaps are combined to make the sea cucumber soap with certain beauty and health care effects. Not only the cooking waste liquid, which is a processing waste, is well reused, reducing waste and pollution, but also makes the soap have more beauty and health care functions such as maintenance, skin care, anti-aging, and anti-oxidation, so that sea cucumbers are no longer just for eating. Nutritional supplements.

An antifungus compound 1-(1H-1,2,4-triazole-1-yl)-2-(2,4- difluorophenyl)-3-[N-methyl-N-(4-substituted amino) benzylamino]-2-propanol and its salts, and its preparing process are disclosed. Its advantages are high curative effect, low poison and broad spectrum.

The invention relates to the technical field of medicine, and provides a class of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-((piperidine oxadiazole side chain substituted))-2-propanol compound, which comprises cis-trans-isomers of the compound and any mixture of these forms or medical salts thereof. The chemical structure of the compound is as shown in a formula (I) in the Specification. The invention further provides a preparation method of the compound, and an application in the preparation of an antifungal drug. Antifungal experiments show that the compound has excellent antifungal effect for various shallow and deep funguses; compared with an existing antifungal drug such as fluconazole in clinical application, the compound has the advantages of high efficiency, low toxicity and wide antifungal spectrum, and can be used for preparing new antifungal drugs.

The invention discloses a natural extract for repairing mechanical damage of fruits and vegetables and prolonging storage period. The natural extract is prepared from the following raw materials: garlic, wormwood, flat peach leaf, a cucumber extract, a eucommia extract, a tea extract, a burdock extract, a wolfberry extract, an elm extract, a schisandra fruit extract, a magnolia bark extract, a ruscus aculeatus extract, vegetable oil and a composite bacterial liquid. The natural extract can effectively prolong the shelf life of fruits and vegetables. After picking of fruits and vegetables, thenatural extract has the effect of reducing water loss of fruits and vegetables during transportation and storage, plays a role in sterilization and bacteriostasis, can also repair the mechanical damage of fruits and vegetables during picking and transportation, forms a water-retaining layer on fruits and vegetables, enhances the water-retaining capacity of fruits and vegetables, further prolongs the storage time of fruits and vegetables, reduces mildew rate and decay rate of fruits and vegetables, and can maintain the taste and luster of fruits and vegetables when fruits and vegetables are just picked.

The invention relates to a raw material formula which is prepared by artificially synthesizing endangered wild animal traditional Chinese medicinal materials and especially relates to an external-usedrug for treating skin superficial mycosis through an artificially-synthesized levo muscone and plant traditional Chinese medicinal material chemical extractive formula, an external-use preparation prepared from the composition and a preparation method of the external-use preparation. The external-use drug has obvious anti-inflammatory, sterilizing and itching reliving effects on the skin superficial mycosis, has a short treating cycle, can promote infiltration and absorption of infection focus patches and can accelerate damaged skin parts to gradually restore normal skin functions.

The invention relates to the technical field of medical materials, in particular to natamycin and silver loaded nano mesoporous carbon eye drops as well as a preparation method and application thereof. The preparation method comprises the following steps: loading silver on the nano mesoporous carbon, loading natamycin on the nano mesoporous carbon, and preparing the eye drops. Herein, the nano mesoporous carbon is used as a carrier to load natamycin and silver, the nano mesoporous carbon has the characteristics of high drug loading capacity and large specific surface area, the purpose of slowly releasing natamycin can be achieved, and the solubility and bioavailability of natamycin can be improved; therefore, the medication frequency of a fungal keratitis patient is reduced, the compliance of the patient is improved, and the treatment effect is improved; meanwhile, the nano mesoporous carbon can also adsorb inflammatory factors into an internal carbon structure, so that inflammatory response is effectively relieved; in addition, the silver elementary substance has a strong fungus killing effect, the antifungal time of the silver elementary substance can be prolonged by loading the silver elementary substance into the nano mesoporous carbon, meanwhile, the dosage of natamycin is reduced, and adverse reactions are relieved. The preparation method is simple, low in cost and easy to store.

The invention relates to the technical field of shoot killing agents, in particular to a high-effective low-toxicity shoot killing agent. The high-effective low-toxicity shoot killing agent is prepared from the following materials in parts by weight: 8 to 15 parts of ethephon, 10 to 20 parts of maleic hydrazide, 5 to 15 parts of Chinese herbal medicine ingredient, 20 to 30 parts of ethanol, 10 to 18 parts of tea saponin and 30 to 40 parts of water. The Chinese herbal medicine ingredient is prepared from the following materials in parts by weight: 20 to 30 parts of radix sophorae flavescentis, 15 to 25 parts of water chestnut peels, 20 to 30 parts of Sichuan pepper and 10 to 20 parts of guava peels. The effect of the high-effective low-toxicity shoot killing agent disclosed by the invention is good, the high-effective low-toxicity shoot killing agent is highly effective and nontoxic, the high-effective low-toxicity shoot killing agent is easily degraded after use, not easily remained, and favorable for environment protection, the high-effective low-toxicity shoot killing agent does not have adverse influence on mature branches, leaves and fruits, and also has pesticidal and sterilizing effects, and thereby the high-effective low-toxicity shoot killing agent can increase yield and improve fruit quality.

The invention provides triazole compounds containing olefine ether structure, and a preparation method and application thereof. The compounds provided by the invention have strong antifungal effects on various fungi, especially shallow fungi. Compared with the existing antifungal drugs used in clinic, the invention has the advantages of high efficiency, low toxicity and wide antifungal spectrum, and can be used for preparing new antifungal drugs. The structural general formula of the triazole compounds is disclosed in the specification, wherein R is F, Cl or Br.

The present invention discloses one kind of antifungal medicine composition for treating superficial fungous diseases. The antifungal medicine composition contains cell synthesis factor inhibitor type immunological inhibitor; azepexole or allyl amine type antifungal agent; and pharmaceutically acceptable carrier. The immunological inhibitor and the antifungal agent account for 0.001-99.9 % of the total composition and has weight ratio of 0.01-100. The composition of the present invention may be used in treating tinea corporis, tinea capitis, tinea manuum and other superficial fungous diseases.

The invention relates to the technical field of medicines and particularly relates to pseudolarix acid derivatives with the structure shown in a formula (1) (the detailed definitions of all groups are shown in the specification). The compounds have favorable activity for various tumor cells such as human lung cancer, colon cancer, breast cancer and the like; besides, the compounds show better antifungal activity. The invention also discloses a composition and preparation method of the pseudolarix acid derivatives as well as the application of the seudolarix acid derivatives in preparation of antitumor medicaments, antifungal medicaments or anti-angiogenesis medicaments.

The invention provides a dairy cow nipple disinfection preparation. The active ingredients mainly consist of the following raw materials in parts by weight: 100-200 parts of lightyellow sophora roots,100-200 parts of dandelions, 50-100 parts of creeping euphorbia and 75-150 parts of liquorice. The invention also provides a preparation method of the dairy cow nipple disinfection preparation. The dairy cow nipple disinfection preparation is simple in preparation method, does not freeze under the environment of minus 5 DEG C, is convenient to use, has moisturizing effect and no irritation to skin, and can treat both symptoms and root causes in the aspect of preventing and treating dairy cow mastitis. Moreover, the product is safe, has no influence on foods, and has no toxic or side effect onlivestock bodies.

The invention relates to the technical field of traditional Chinese medicines and in particular relates to a traditional Chinese medicine composition for treating lung diseases. The traditional Chinese medicine composition for treating lung diseases is prepared fromherba ephedrae, raw gypsum, Chinese yams, rhizoma bletillae, roots of sessile stemona, tatarian aster roots, flos farfarae, hairyveinagrimonia herb, burdock fruits, fructus aristolochiae, common hogfennel roots, fried apricot kernels, willowleafswallowwort rhizome, balloonflower roots, dried tangerine or orange peel, radix ophiopogonis, lucid asparagus roots, lily bulbs, Chinese white olive, radix adenophorae, honey-fried mulberry bark, snake gourd fruits, mint, Sichuan fritillary bulbs, Zhejiang fritillary bulbs, honeysuckle flowers, fried wild jujube seeds, Chinese magnoliavine fruits, mulberry leaves, licorice roots, ginger, earthwormsin areas of Guangdong,Guangxi, etc., radix ampelopsis, Chinese holly leaves, bombyx batryticatus, radishes, fresh lotus roots, rhizoma belamcandae, donkey-hide gelatin, rock candy, honey and pear syrup. Compared with a conventional prescription, the traditional Chinese medicine composition eliminates potential addiction and drug toxicity which maybe caused by a pericarpium papaveris component in a conventional medicine, and is high in security, definite in treatment effect on cough,cough variant asthma and chronic obstructive pulmonary diseases after infection, rigorous in formula, appropriate in compatibility, capable of hitting thepathogenesis and remarkable in medicinal effect improvement.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for relieving cough and resolving phlegm. The traditional Chinese medicine composition for relieving cough and resolving phlegm is composed of ephedra, gypsum, yam, Baiji, Baibu, asters, coltsfoot, Agrimony, Arctium, Aristolochia, Qianhu, fried almond, Baiqian, Platycodon grandiflorum, tangerine peel, wheat Asparagus, asparagus, lily, green fruit, ginseng, mulberry peel, melon, mint, Chuanbei, Zhebei, honeysuckle, fried jujube kernels, schisandra, mulberry leaves, licorice, ginger, Candida, white leeks, Compared with the existing formula, it eliminates the potential addiction and drug toxicity that may be caused by the existence of the poppy shell in the existing medicine. It has higher safety and has definite curative effect on post-infection cough, cough variant asthma and chronic obstructive pulmonary disease.

The invention relates to a dermatopathy therapeutic medicine compositions and its preparation method, in particular a propylene amine antimycotics, and suprarenal hormones medicinal compositions and its preparation method.

The invention relates to a substituted triazolone benzyl amine triazole antifungal compound, i.e. 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[N-methyl-N-(2-substituted-2H-1,2,4-triazol-3-one-4-yl) benzylaminoformyl]-2-propanols compounds, their salts and their preparation process. The compounds has very strong antimycotic effect.

The invention relates to the technical field of medicine, and provides a class of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-((piperidine oxadiazole side chain substituted))-2-propanol compound, which comprises cis-trans-isomers of the compound and any mixture of these forms or medical salts thereof. The chemical structure of the compound is as shown in a formula (I) in the Specification. The invention further provides a preparation method of the compound, and an application in the preparation of an antifungal drug. Antifungal experiments show that the compound has excellent antifungal effect for various shallow and deep funguses; compared with an existing antifungal drug such as fluconazole in clinical application, the compound has the advantages of high efficiency, low toxicity and wide antifungal spectrum, and can be used for preparing new antifungal drugs.

The invention discloses an antifungal product of ribavirin alone or in combination with fluconazole. The antifungal effect of the ribavirin alone or in combination with fluconazole on candida albicansis studied; the effective concentration of ribavirin alone varies from 2 to 8 microns / ml; when ribavirin is combined with fluconazole, the antibacterial activity of fluconazole against drug-resistantcandida albicans can be enhanced, the synergistic antifungal effect can be produced, and a research direction of the development of new drugs and new use of old drugs is provided for reversing the resistance of drug-resistant candida albicans to triazole antifungal drugs. Fluconazole-resistant candida albicans (MIC>512 microns / ml) can be significantly decreased with the combination of drugs, combined application of 1 micron / ml of ribavirin and 025-1 micron / ml of fluconazole can kill more than 80% of fungus, and the effect is higher with the increase of the concentration.