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Composition for treating skin superficial mycosis

A composition and fungal disease technology, applied in the field of medicine, can solve problems such as inability to achieve an ideal therapeutic effect, not conducive to market promotion and use, and lack of biological activity, so as to achieve a clear targeting mechanism, reduce individual dosage, and avoid resistance The effect of bacteria

Inactive Publication Date: 2018-11-23
中微知著药物手性技术(大连)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The raw material of the composition prepared with racemic muscone has no biological activity and cannot play an ideal therapeutic effect. Therefore, this composition is not conducive to market promotion and use, and is also not conducive to foreign patients' acceptance.
Therefore, the practicability is poor, and whether the compatibility and bioactivity utilization is suitable also needs to be verified.

Method used

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  • Composition for treating skin superficial mycosis
  • Composition for treating skin superficial mycosis
  • Composition for treating skin superficial mycosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067]

[0068] Preparation:

[0069] Step (1) Grind 20g of aquatin into fine powder, cross 80 mesh sieves, and dissolve in 100g of ethanol to make mixed solution P, dissolve 10g of L-musketone in 100g of ethanol to make mixed solution A, mix The solutions P and A are mixed uniformly to prepare the mixed solution PA;

[0070] Step (2) Put the mixed solution PA prepared in step (1) in a glass reactor and heat it to 35-40°C under constant stirring (the solubility is best in the range of 35°C-40°C), keep it for 15-20min, and stir Add 800g of ethanol at the same time, keep stirring at a constant speed of 35-40°C for 20-30min to mix well, stop heating, cool down to room temperature naturally, and react with a Φ10mm hose connected from a compressed air bottle with a pressure of 0.08Mpa Introduce the bottom of the material into the feeding port of the kettle, age by bubbling for 60 minutes, and then age by bubbling for another 60 minutes after an interval of 2 to 4 hours, and let...

Embodiment 2

[0072]

[0073]

[0074] Preparation:

[0075] Step (1) Grind 200g salicylic acid into fine powder, cross 80 mesh sieves, and dissolve in 2000g ethanol to make mixed solution Y, dissolve 20g L-muscarone in 200g ethanol to make mixed solution A, mix the mixed solution Y and A are mixed to obtain a mixed solution YA;

[0076] Step (2) Put the mixed solution YA prepared in step (1) in a glass reactor and heat it to 35-40°C under constant stirring, keep it for 15-20 minutes, add 800g of ethanol while stirring, and stir at a constant speed of 35-40°C Keep for 20-30 minutes under the same conditions until mixing, stop heating, and cool down to room temperature naturally, then introduce a Φ10mm hose connected from a compressed air bottle with a pressure of 0.08Mpa to the bottom of the material through the feeding port of the reactor, and age by bubbling 60 minutes, after an interval of 2 to 4 hours, then bubbling and aging for 60 minutes, and standing for 24 hours to obtain a ...

Embodiment 3

[0078]

[0079] Preparation:

[0080] Step (1) Grind 40g of fenugreek and 100g of salicylic acid into fine powder, pass through an 80 mesh sieve, and dissolve in 1400g of ethanol to make a mixed solution PY, dissolve 30g of L-musketone in 300g of ethanol to make a mixed solution PY For solution A, mix the mixed solution PY and A evenly to prepare the mixed solution PYA;

[0081] Step (2) Place the mixed solution PYA prepared in step (1) in a glass reactor and heat it to 35-40°C under constant stirring, keep it for 15-20min, and add the remaining amount of ethanol (1300g) and 100g 1,3-propanediol, keep stirring at 35-40°C for 20-30 minutes until evenly mixed, stop heating, cool down to room temperature naturally, and pass a Φ10mm hose connected from a compressed air bottle with a pressure of 0.08Mpa through Introduce the bottom of the material into the feeding port of the reaction kettle, age by bubbling for 60 minutes, and then age by bubbling for another 60 minutes after ...

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Abstract

The invention relates to a raw material formula which is prepared by artificially synthesizing endangered wild animal traditional Chinese medicinal materials and especially relates to an external-usedrug for treating skin superficial mycosis through an artificially-synthesized levo muscone and plant traditional Chinese medicinal material chemical extractive formula, an external-use preparation prepared from the composition and a preparation method of the external-use preparation. The external-use drug has obvious anti-inflammatory, sterilizing and itching reliving effects on the skin superficial mycosis, has a short treating cycle, can promote infiltration and absorption of infection focus patches and can accelerate damaged skin parts to gradually restore normal skin functions.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a traditional Chinese medicine composition, in particular to a composition for treating superficial skin mycosis. Background technique [0002] Fungal dermatosis, also known as skin mycosis, refers to a superficial fungal infection caused by pathogenic fungi invading the epidermis. This type of skin disease has the characteristics of widespread prevalence, high incidence, strong infectivity, easy recurrence, and difficult to cure. There are many traditional medicine treatment methods for superficial fungal skin diseases, many of which are still in use today. In recent years, due to the extensive use of a large number of broad-spectrum antibiotics, corticosteroid hormones, and immunosuppressants, the body’s immunity has declined, and the incidence of fungi has also decreased. increasing day by day. Among the existing drugs for treating tinea pedis and jock itch, hormone drugs are usually...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/60A61K31/366A61K31/122A61K9/08A61K9/06A61K9/107A61K47/10A61P31/10A61P17/00
CPCA61K9/06A61K9/08A61K9/107A61K31/122A61K31/366A61K31/60A61K47/10A61K2300/00
Inventor 王晰马丽华
Owner 中微知著药物手性技术(大连)有限公司
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