Antifungal products of ribavirin alone or combined with fluconazole and its application

A joint application, ribavirin technology, applied in the field of medicine

Active Publication Date: 2020-06-30
QIANFOSHAN HOSPITAL OF SHANDONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, it is widely used in the prevention and treatment of viral diseases clinically, but there is no report on whether it has antifungal effect

Method used

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  • Antifungal products of ribavirin alone or combined with fluconazole and its application
  • Antifungal products of ribavirin alone or combined with fluconazole and its application
  • Antifungal products of ribavirin alone or combined with fluconazole and its application

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Embodiment Construction

[0032] It should be noted that the following detailed description is exemplary and intended to provide further explanation of the present invention. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0033] It should be noted that the terminology used here is only for describing specific embodiments, and is not intended to limit exemplary embodiments according to the present invention. As used herein, unless the context clearly dictates otherwise, the singular is intended to include the plural, and it should also be understood that when the terms "comprising" and / or "comprising" are used in this specification, they mean There are features, steps, operations and / or combinations thereof.

[0034] As introduced in the background art, antifungal drugs commonly used in the prior art have inherent drug resistance or acquire drug resistance quickl...

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Abstract

The invention discloses an antifungal product of ribavirin alone or in combination with fluconazole. The antifungal effect of the ribavirin alone or in combination with fluconazole on candida albicansis studied; the effective concentration of ribavirin alone varies from 2 to 8 microns / ml; when ribavirin is combined with fluconazole, the antibacterial activity of fluconazole against drug-resistantcandida albicans can be enhanced, the synergistic antifungal effect can be produced, and a research direction of the development of new drugs and new use of old drugs is provided for reversing the resistance of drug-resistant candida albicans to triazole antifungal drugs. Fluconazole-resistant candida albicans (MIC>512 microns / ml) can be significantly decreased with the combination of drugs, combined application of 1 micron / ml of ribavirin and 025-1 micron / ml of fluconazole can kill more than 80% of fungus, and the effect is higher with the increase of the concentration.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to antifungal products used alone or in combination with fluconazole and applications thereof. Background technique [0002] In recent years, with the rapid development of medical technology, the clinical use of broad-spectrum antibiotics, glucocorticoids and immunosuppressants, the development of in vivo interventional therapy, organ transplantation and other technologies, the incidence of invasive fungal infection has been increasing (Kriengkauykiat J, Ito JI, Dadwal SS. Epidemiology and treatment approaches in management of invasive fungal infections. Clinical epidemiology. 2011; 3:175-91). At present, there are only a limited number of antifungal drugs commonly used clinically, such as azoles, polyenes, echinocandins, and allylamines (Cui J, Ren B, Tong Y, Dai H, Zhang L. Synergistic combinations of antifungals and anti-virulence agents to fight against Candida albicans. Virul...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7056A61K31/4196A61P31/10
CPCA61K31/4196A61K31/7056A61P31/10A61K2300/00
Inventor 孙淑娟张敏于翠香杨新美
Owner QIANFOSHAN HOSPITAL OF SHANDONG
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