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Amlodipine or flunarizine and fluconazole combined antifungal product and application thereof

A kind of technology of amlodipine and flunarizine, which is applied in the field of medicine and achieves the effects of expanding the scope of application, reducing adverse reactions and reducing the dosage of drugs

Inactive Publication Date: 2015-03-04
QIANFOSHAN HOSPITAL OF SHANDONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Such as penicillins, there are many varieties, but only some varieties, such as piperacillin, have anti-Pseudomonas aeruginosa effect, while most varieties have no effect on this bacteria

Method used

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  • Amlodipine or flunarizine and fluconazole combined antifungal product and application thereof
  • Amlodipine or flunarizine and fluconazole combined antifungal product and application thereof
  • Amlodipine or flunarizine and fluconazole combined antifungal product and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Example 1 Determination of FLC and CCB combined antifungal effect

[0024] 1. Materials

[0025] 1.1 Drugs and reagents

[0026] Fluconazole (FLC), Shandong Chengchuang Pharmaceutical Technology Development Co., Ltd.;

[0027] Amlodipine (minocycline, AML), Meilun Biological Co., Ltd.;

[0028] Flunarizine hydrochloride (FNZ), China National Institutes for Food and Drug Control;

[0029] CHROMagar Candida Chromogenic Medium, Zhengzhou Bosai Biological Engineering Co., Ltd.;

[0030] TTC-Sapauer agar, Hangzhou Tianhe Microbiological Reagent Co., Ltd.;

[0031] Sodium hydroxide, state-owned Shandong Shanxian Organic Chemical Factory, batch number 940420;

[0032] Potassium dihydrogen phosphate, Shanghai Xinbao Fine Chemical Factory, batch number 200602132;

[0033] Dimethyl sulfoxide (DMSO), Tianjin Guangcheng Chemical Reagent Co., Ltd.;

[0034] RPMI 1640 API powder, American GIBCO company;

[0035] 3-(N-morpholino)propanesulfonic acid (MOPS), Jinan Pengyuan Biot...

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Abstract

The invention discloses an amlodipine or flunarizine and fluconazole combined antifungal product and an application thereof. When amlodipine and fluconazole are combined to be applied, the effective concentration ratio of fluconazole to amlodipine is equal to 1:8 (mu g / ml); and when flunarizine and fluconazole are combined to be applied, the effective concentration ratio of fluconazole to flunarizine is equal to 1:16 (mu g / ml). When amlodipine and fluconazole are combined to be applied, the minimum inhibitory concentrations of amlodipine and fluconazole are respectively 8mu g / ml and 1mu g / ml; and the minimum inhibitory concentrations of flunarizine and fluconazole are respectively 16mu g / ml and 1mu g / ml. A calcium ion channel blocking agent is widely applied to clinic and has an antifungal synergistic effect on FLC, so that the application range can be widened, the minimum effective concentration of FLC can be reduced, the dosage of an antifungal drug can be reduced, and furthermore the untoward effects of the drug are reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an antifungal product of amlodipine or flunarizine combined with fluconazole and an application thereof. Background technique [0002] In recent years, with the increase of immunocompromised populations (malignant tumors, AIDS, autoimmune diseases, etc.), the development of techniques such as catheter intubation and organ transplantation, the widespread use of broad-spectrum antibiotics, corticosteroids and immunosuppressants, fungal The incidence of infection increased dramatically (Odds FC. Pathogenesis of Candida infections. J Am Acad Dermatol. 1994, 31: S2-S5). Studies have shown that more than one-third of the isolates of fungal infections suffered by AIDS patients in the late stage show drug resistance, especially for azole drugs, and the drug resistance rate is as high as 65% (Saltanat H, Li H, Geng XH et al. Clinical distribution and drug resistance of candi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422A61K31/495A61P31/10A61K31/4196
CPCA61K31/4196A61K31/4422A61K31/495A61K2300/00
Inventor 孙淑娟刘书源刘卫国时海燕时银萍
Owner QIANFOSHAN HOSPITAL OF SHANDONG
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