318 results about "MICROBIAL CONCENTRATION" patented technology

The invention relates to the technical field of water quality monitoring, in particular to a water quality monitoring analysis method and system of a water conservancy system. The method comprises the following steps: acquiring area scale and water area type distribution, and carrying out sensing planning layout and water quality index real-time monitoring to obtain a water conservancy system water quality index data set; performing regional water quality index distribution coupling and regional time step division on the water conservancy system to obtain a corresponding water conservancy pH value, water conservancy dissolved oxygen concentration, water conservancy turbidity, water conservancy heavy metal concentration and water conservancy microorganism concentration; performing microorganism growth efficiency evaluation and microorganism pollution attenuation analysis on the water conservancy microorganism concentration to obtain a water conservancy area microorganism pollution degradation attenuation rate; and performing water quality pollution anomaly quantification and anomaly category decision management on the water quality index data set of the water conservancy system to generate a water quality anomaly category management strategy so as to execute corresponding regional water quality category management work of the water conservancy system. The accuracy and efficiency of water quality monitoring can be improved.

The invention belongs to the technical field of antibacterial peptides, and particularly relates to an antibacterial peptide and application thereof. The amino acid sequence of the antibacterial peptide is shown as SEQ ID NO: 1, the number of amino acids is small, the synthesis cost is low, the antibacterial peptide has high antibacterial activity on gram-negative bacteria and gram-positive bacteria, the minimum inhibitory concentration of the antibacterial peptide on acinetobacter baumannii, escherichia coli, pseudomonas aeruginosa and staphylococcus aureus is 4.68-37.5 mu g / mL, and the antibacterial peptide has the advantages of broad-spectrum antibacterial property, good stability and good application prospect. No obvious cytotoxicity and hemolysis effect exist; moreover, end-to-end amido bond cyclization is carried out, so that the antibacterial activity is further enhanced, the antibacterial effect on acinetobacter baumannii, escherichia coli, pseudomonas aeruginosa and staphylococcus aureus is enhanced by 2-4 times, and the minimum inhibitory concentration is reduced to 2.34-9.38 mu g / mL; after the end-to-end amido bonds are cyclized, the plasma stability and safety of the antibacterial peptide are further improved, and the cytotoxicity and hemolysis are reduced.

The invention relates to the field of animal breeding, and discloses a pig beta defensin compound preparation which comprises pig beta defensin PBD1, PBD2 and PBD114, and the weight ratio of the PBD1 to the PBD2 to the PBD114 is 1: 1: 1. The porcine beta defensin PBD1, the porcine beta defensin PBD2 and the porcine beta defensin PBD114 are recombinant proteins, and are respectively expressed in escherichia coli BL21 (DE3) PLysS competent cells by a pET-32a expression vector. Through the synergistic effect of the defensins PBD1, PBD2 and PBD114, the minimum inhibitory concentration (MIC) of the EPEC is reduced to 18.75 mu g / mL from 75 mu g / mL of single defensins, and is reduced by 75%; within 24 hours, the bacteriostasis rate of the compound preparation reaches 90%, and the inhibition effect on EPEC is remarkably improved.

The invention belongs to the field of biological medicine, and particularly relates to an antibacterial peptide for inhibiting staphylococcus aureus and pseudomonas aeruginosa and application of the antibacterial peptide. The antibacterial peptide CAMP648NC is a novel cationic antibacterial peptide, the minimum inhibitory concentrations of the antibacterial peptide CAMP648NC to pathogenic bacteria staphylococcus aureus and pseudomonas aeruginosa are 16 [mu] g / mL and 32 [mu] g / mL respectively, the antibacterial peptide CAMP648NC has extremely low cytotoxicity, and after human skin keratinocytes HaCat and bronchial epithelial cells BEAS-2B are treated by the antibacterial peptide CAMP648NC with the concentration of 128 [mu] g / mL for 24 hours, the survival rates of 110.4% and 87.3% are still kept. Due to the characteristics, the compound shows extremely high medical drug antibacterial value, and alternative medicinal resources are provided for clinically resisting the two human pathogenic bacteria in the future.

The invention provides a recombinant chicken antibacterial peptide aiming at drug-resistant staphylococcus aureus, and belongs to the technical field of veterinarians. The recombinant chicken antibacterial peptide is expressed through genetic engineering recombinant escherichia coli. Three natural chicken antibacterial peptide active regions are fused, and two disulfide bonds are introduced to stabilize the structure of the recombinant chicken antibacterial peptide and enhance the affinity of the recombinant chicken antibacterial peptide to staphylococcus aureus outer membrane protein. The minimum inhibitory concentration of the recombinant chicken antibacterial peptide to the drug-resistant staphylococcus aureus is obviously lower than that of three natural chicken antibacterial peptides, and the formation of a biomembrane of a USA300 strain of the drug-resistant staphylococcus aureus can be thoroughly inhibited when the minimum inhibitory concentration is 8 mu g / mL. The recombinant chicken antibacterial peptide has a good antibacterial effect on different drug-resistant staphylococcus aureus separated from a chicken house, and can effectively solve the infection problem of the drug-resistant staphylococcus aureus in the chicken house.

The invention relates to the technical field of monitoring analysis, and discloses a microplastic degradation process monitoring system based on microbiological treatment, which comprises the following modules: a microbiological culture module for culturing microorganisms in a microplastic degradation process and adjusting a plurality of parameters through an environmental reactor to maintain the activity of the microorganisms; the data monitoring and processing module is used for monitoring and acquiring a plurality of key indexes of the micro-plastics in the degradation liquid in the degradation process through a plurality of sensors, removing and supplementing abnormal data, and finally synchronously uploading non-abnormal data to the cloud through the Internet of Things node; and the intelligent analysis platform comprises a degradation prediction unit and a reporting unit. Through one-way comparison and relevance comparison, abnormal data monitored by the sensor are removed, the microplastic degradation efficiency is predicted by using the living environment of microorganisms, the concentration of the microorganisms and a degradation kinetic model, and the microplastic degradation efficiency can be comprehensively analyzed in combination with multiple parameters during microplastic degradation analysis.

The invention provides a modified antibacterial peptide, and belongs to the technical field of antibacterial peptides. The invention provides a modified antibacterial peptide. The modified antibacterial peptide comprises at least one of a first antibacterial peptide, a second antibacterial peptide, a third antibacterial peptide, a fourth antibacterial peptide, a fifth antibacterial peptide and a sixth antibacterial peptide, the amino acid sequences of the first antibacterial peptide, the second antibacterial peptide, the third antibacterial peptide, the fourth antibacterial peptide, the fifth antibacterial peptide and the sixth antibacterial peptide are shown as SEQ ID NO.1-SEQ ID NO.6 in sequence. On the basis of prevotelin-2, the modified antibacterial peptide is obtained by reducing negative charge amino acid, increasing positive charge amino acid, introducing hydrophobic amino acid, adjusting or deleting an amino acid sequence and optimizing a polypeptide structure. In-vitro minimum inhibitory concentration determination results show that compared with an initial peptide, the modified antibacterial peptide has significantly enhanced antibacterial activity on bacteria and fungi, and also has an obvious bactericidal effect on clinical drug-resistant bacteria.

The invention relates to a preparation method and application of recombinant canine lactoferrin and peptide thereof, aiming at codon preference of host cells, canine lactoferrin genes are optimized, the full length of canine lactoferrin and the lactoferrin peptide are successfully expressed by virtue of an escherichia coli expression system, and the recombinant canine lactoferrin and the peptide thereof are identified by virtue of a minimum inhibitory concentration experiment. It is proved that the canine lactoferrin and the peptide thereof have the inhibiting capacity on pathogenic bacteria such as staphylococcus aureus, salmonella typhimurium and staphylococcus pseudointermedius, and the antibacterial activity MIC of the canine lactoferrin on the staphylococcus aureus, the salmonella typhimurium and the staphylococcus pseudointermedius is 1.5 mg / mL; the antibacterial activity MIC of the dog lactoferrin peptide to staphylococcus aureus is equal to 0.75 mg / mL, and the dog lactoferrin peptide shows high antibacterial ability.

The invention relates to an enzyme response antibacterial carbon dot and a preparation method and application thereof.The carbon dot takes a copper-doped carbon dot as a core and is covalently grafted with a hyaluronic acid shell layer through amidation reaction to form a composite nano material Cu-CDs (at) HA, specifically, soluble copper salt and folic acid are subjected to a hydrothermal reaction to obtain the copper-doped carbon dot, carboxyl is activated through EDC / NHS in a buffer system, and the carbon dot is prepared. And performing grafting reaction with hyaluronic acid to obtain a target product. The hyaluronidase-containing antibacterial composition can be specifically degraded and release antibacterial components under the action of hyaluronidase, shows good bacterial responsive bactericidal performance, has the minimum inhibitory concentrations of 8 g / mL and 16 g / mL for staphylococcus aureus and escherichia coli respectively, and has peroxidase-like activity and free radical scavenging capacity. The antibacterial carbon dots can be used for preparing intelligent wound dressings, antibacterial coatings and other biomedical materials, and have the advantages of responsive drug release, efficient antibacterial property and promotion of wound repair.

The invention provides a cooling tower cleaning period decision-making method based on filler layer resistance characteristic online identification, which comprises the following steps: acquiring multi-dimensional time sequence data such as differential pressure, water temperature, conductivity, turbidity and microbial concentration based on a multi-source sensor, and constructing a structured trend characteristic matrix through time synchronization, abnormal value elimination and statistical characteristic extraction; in combination with expert knowledge, constructing a multi-modal combined pollution knowledge graph, and learning pollution factor interaction weights by using a graph neural network to realize causal reasoning of combined pollution mechanisms such as scaling, biological slime and the like; according to the method, an abnormal causal chain path is efficiently matched in a knowledge graph by adopting improved A * search, causes and evolution stages are output, automatic attribution and intelligent cleaning suggestion optimization are realized, and the resistance abnormity diagnosis accuracy and the adaptability of a cleaning strategy are improved by continuously feeding back diagnosis results and dynamically expanding a knowledge graph structure.

The invention provides an antibacterial peptide CN-3 and application thereof, and relates to the technical field of peptide inhibitors. The amino acid sequence of the antibacterial peptide CN-3 is GPGGAWAAKVIS, and is as shown in SEQ ID NO. 1. The minimum inhibitory concentration (MIC) of the antibacterial peptide CN-3 to staphylococcus aureus and escherichia coli is 5.0 mg / mL. According to the antibacterial peptide CN-3 and the application thereof, the CN-3 has staphylococcus aureus and escherichia coli bacteriostatic activity, and plays a role by destroying bacterial cell membranes; cN-3 is not easy to generate drug resistance, low in cytotoxicity and high in cell selectivity, and can be used for preparing an antibacterial composition for treating staphylococcus aureus and escherichia coli infection.

The invention relates to the technical field of antibacterial peptides, in particular to application of an antibacterial peptide RV-18-ack in preparation of an antifungal product. The antibacterial peptide RV-18-acy disclosed by the invention comprises a polypeptide RV-18 of which the amino acid sequence is shown as SEQ ID NO. 1. The antibacterial peptide RV-18-ack is a polypeptide capable of forming an amphiphilic alpha helical structure, can form nanoparticles in a self-assembly manner, has broad-spectrum antifungal activity, can damage fungal cell membranes in a targeted manner to play a bactericidal role, shows a relatively good antibacterial role on candida albicans, has the minimum inhibitory concentration of 2.344-75 mu M, and is free of cytotoxicity and hemolysis; besides, the antibacterial peptide RV-18-ack contains 18 amino acids, and all the amino acids are L-type amino acids, so that the production cost is greatly reduced, and the antibacterial peptide RV-18-ack is expected to become a novel broad-spectrum antifungal candidate drug and has a good application prospect in the aspect of resisting super fungi.

The invention discloses a vehicle-mounted microbial environment management system based on multi-mode sterilization control and a method thereof, and relates to the technical field of vehicle-mounted air purification and microbial control. The system comprises a microorganism sensing module used for collecting and detecting the concentration of microorganisms in air in a vehicle in real time, a state monitoring module used for feeding back the irradiation state of an ultraviolet light source and the activity state of a photocatalytic material, and a control module used for judging the pollution risk level based on multi-source information fusion and generating a control instruction. The safety and interaction module is used for passenger state detection and remote control interaction, and the ultraviolet disinfection module, the photocatalytic purification module and the ozone release module cooperatively execute disinfection operation according to a control instruction. Through a closed loop mechanism of pollution detection, risk determination, safety verification, linkage control and effect verification, high-precision, intelligent, safe and reliable vehicle-mounted microbial environment management is realized, the operation efficiency and the use safety of the system are improved, and the system is suitable for various intelligent cabins and high-standard vehicle-mounted environment control application scenes.

The present invention provides use of a C-JUN N-terminal kinase inhibitor, SU3327, in the preparation of a medicament for enhancing the efficacy of polymyxin against bacterial infection, and use of a composition of SU3327 and polymyxin in the preparation of a medicament for an enhanced efficacy against bacterial infection, wherein the polymyxin is preferably Polymyxin E. The invention not only shows an enhanced antibacterial activity of polymyxin by SU3327 in synergy through minimum inhibitory concentration tests in checkerboard assays and in vitro bacterial growth curves, but also confirms the ability of SU3327 to enhance polymyxin along with its effectiveness in vivo in the experiments with a model of mice infected with drug resistant bacteria at the animal level. The invention provides a new use of SU3327 in enhancing antibacterial activities of polymyxin antibiotics, resolving the technical problems such as clinical resistance to polymyxin, low clinical therapeutic index of polymyxin, etc.

The invention relates to the technical field of fan control, and discloses a fan rotating speed adjusting method and system based on a dynamic pollution load. The method comprises the following steps: collecting a target PM2.5 concentration, a target VOC concentration and a target microorganism concentration of each monitoring point, and calculating a comprehensive pollution load index of each monitoring point; traversing boundary critical points in all the monitoring points based on the comprehensive pollution load index and generating a boundary identification vector; the real-time pressure drop of the air inlet side and the air outlet side of the filter element in each fan is collected, and the pressure difference compensation gain is calculated; calculating a target reference rotating speed for all monitoring points in the responsible sector of each fan; and calculating the average pollution load index of the responsible sector of each fan, executing fuzzy reasoning to obtain a rotating speed increment, and generating a PWM duty ratio according to the target reference rotating speed and the rotating speed increment to drive each fan. The technical problems of space pollution response lag and energy consumption imbalance are solved, and the performance of the air purification system is improved.

The invention discloses application of chlorogenic acid in preparation of a product for resisting carbapenem-resistant klebsiella pneumoniae, and belongs to the technical field of medicines. It is verified that chlorogenic acid has a good in-vitro killing effect on carbapenem-resistant klebsiella pneumonia, growth of the carbapenem-resistant klebsiella pneumonia can be inhibited, the minimum inhibitory concentration is 20 mg / mL, and a biological membrane of the carbapenem-resistant klebsiella pneumonia can be effectively destroyed. The invention provides the inhibition effect of chlorogenic acid on carbapenem-resistant klebsiella pneumoniae, and the chlorogenic acid has wide application value in the fields of medicines and the like.

The invention provides a bacteriostatic agent aiming at yersinia enterocolitica and application, the bacteriostatic agent comprises a compound solution of lipoic acid and protocatechualdehyde, and when the lipoic acid and the protocatechualdehyde act synergistically, the minimum inhibitory concentrations to the yersinia enterocolitica are 0.625 mg / mL and 0.3125 mg / mL respectively. The yersinia enterocolitica biofilm is inhibited and / or removed through the lipoic acid and protocatechuic aldehyde compound liquid, and the problem that drugs for treating the yersinia enterocolitica infection are prone to drug resistance is solved.

The present invention discloses the application of 12-ketolithocholic acid in the preparation of anti-Veillonella products. The first test showed that 12-ketolithocholic acid has good activity in inhibiting atypical Veillonella. Specifically, by measuring the minimum inhibitory concentration required to inhibit 50% of the tested ATCC 17744 strain, the results showed that the bacteria in the blank control wells without drugs grew significantly, while the MIC50 of 12-ketolithocholic acid for atypical Veillonella was 294.7 μg / ml. Therefore, the new use of 12-ketolithocholic acid provided by the present invention provides a reference for the clinical prevention and control of epidemics caused by Veillonella.

The invention discloses an ozone dosage dynamic control method and system for an ozone biochemical coupling system, and belongs to the technical field of water treatment. According to the method, the ozone adding amount is dynamically optimized, so that the synergistic interaction of ozone oxidation and biochemical treatment is realized, and the ozone consumption is remarkably reduced on the premise of ensuring that the effluent quality reaches the standard. Based on real-time monitoring data of ozone unit inlet water TOC1, ozone unit outlet water TOC2, biochemical unit outlet water TOC3, biochemical unit microorganism concentration MLVSS and biochemical unit dissolved oxygen concentration O2, the system adopts a double-closed-loop control strategy: standard reaching of biochemical unit outlet water TOC3 * is taken as a final constraint target, and ozone unit outlet water TOC2 * is taken as a dynamic adjustment target; and dynamically adjusting the ozone adding amount in real time according to an ozone adding algorithm. The device has the advantages that the ozone dosage can be adjusted in real time according to the fluctuation of incoming water, and the respective treatment effects of ozone modification and biochemical treatment are exerted. Overall, stable addition of ozone and stable standard reaching of biochemical effluent can be realized, and the addition amount of ozone can be reduced. And the operation cost is saved for sewage treatment.

The invention discloses a modified chitosan-based antibacterial material as well as a preparation method and application thereof, and belongs to the technical field of antibacterial materials. The ciprofloxacin grafted quaternized chitosan is successfully synthesized by taking the chitosan as a raw material, and the water solubility and the antibacterial ability of the chitosan are effectively improved. The antibacterial diameters of the ciprofloxacin grafted quaternized chitosan prepared by the preparation method disclosed by the invention on escherichia coli and staphylococcus aureus are respectively 35.34 to 39.06 mm and 40.45 to 44.51 mm, and the minimum MIC (Minimum Inhibitory Concentration) and MBC (Minimum Mass Chitosan) can reach 0.0005 mg / mL. In addition, the antibacterial material has an obvious inhibition effect on colletotrichum gloeosporioides and aspergillus niger, and the highest antifungal rates respectively reach 53.81 + / -2.17% and 54.88 + / -1.3%. Compared with the raw materials, the antibacterial ability is greatly improved, and the grafted and modified composite material is environment-friendly and can be used for antibacterial food packaging materials.

The invention relates to the field of antibiosis of natural products, in particular to application of geraniin in inhibition of staphylococcus aureus or a staphylococcus aureus biological membrane. The geraniin disclosed by the invention has a remarkable inhibiting effect on staphylococcus aureus, also has a remarkable inhibiting and clearing effect on a mature staphylococcus aureus biological membrane, and has the potential of being developed into a novel antibacterial drug. The effective concentration acting on a biological membrane is obviously lower than the direct minimum inhibitory concentration of geraniin to staphylococcus aureus. The inhibition characteristic of the geraniin on the biological membrane possibly has important value in solving the clinical biological membrane related drug resistance problem, and the geraniin can be used for treating bacterial infection disease recurrence caused by the stubborn biological membrane.

The invention provides a medical disinfection parameter control method and a sterilization device, and relates to the technical field of disinfection robotics.The method comprises the steps that microorganism types and microorganism concentrations are rendered to a to-be-disinfected three-dimensional area, and a three-dimensional target space is constructed; performing simulation modeling according to the disinfection attribute data and the three-dimensional target space to generate a disinfection twinborn model; carrying out disinfection scheme optimization by using the disinfection twinborn model and by taking meeting of an expected disinfection index as a constraint, so as to obtain an optimized disinfection scheme; and performing disinfection effect influence analysis according to the environment temperature and the environment humidity, and generating disinfection influence deviation to compensate the optimized disinfection scheme so as to obtain an optimal disinfection scheme. By means of the control method, the technical problems that according to an existing disinfection robot control method, due to the fact that a matched disinfection scheme cannot be set according to the state of the to-be-disinfected area, excessive disinfection or insufficient disinfection is likely to occur, and the area disinfection quality is poor can be solved, and the effects of improving the disinfection quality and efficiency and saving disinfection resources can be achieved.

The invention relates to the technical field of medicines, and particularly discloses application of a Xinjiang medicine mulberry extract in preparation of a medicine for treating or preventing periapical periodontitis, which is technically characterized in that the Xinjiang medicine mulberry extract is found and proved to have a remarkable inhibition effect on periapical periodontitis key pathogenic bacterium enterococcus faecalis for the first time, the minimum inhibitory concentration (MIC) is 0.604 mg / mL, and the Xinjiang medicine mulberry extract has a remarkable inhibition effect on the periapical periodontitis key pathogenic bacterium enterococcus faecalis. The minimum bactericidal concentration (MBC) is 1.875 mg / mL, and a biological membrane can be effectively inhibited and removed; in-vivo experiments of a rat periapical periodontitis model prove that the extract can remarkably reduce the number of bacteria in root canals and relieve periapical bone destruction, the curative effect is equivalent to that of calcium hydroxide, and the extract is non-toxic to main organs and high in biocompatibility. The invention provides a new candidate and a clear technical scheme for developing an efficient and low-toxicity natural plant source root canal disinfectant.

The invention discloses an antibacterial polypeptide AuGF and application of the antibacterial polypeptide AuGF in preparation of a medicine for treating and / or preventing bacterial infection. The amino acid sequence of the polypeptide is as follows: SEQ ID NO.1: GLFIKIIKIKIAKSF; the antibacterial polypeptide AuGF disclosed by the invention has broad-spectrum antibacterial activity, can effectively solve the problem of bacterial drug resistance, and has a remarkable bacteriostatic effect on various bacteria including staphylococcus aureus, streptococcus mutans, actinobacillus, methicillin-resistant staphylococcus aureus and the like; the compound provided by the invention has the advantages of simple preparation process and low cost, can play a significant role at low concentration, has low minimum inhibitory concentration on various pathogenic bacteria, has strong bacteriostatic ability, and is beneficial to reduction of side effects and improvement of drug safety; the antibacterial polypeptide AuGF can also be used as a bacteriostatic additive to be applied to articles of daily use, provides an effective bacteriostatic means for daily cleaning and skin care, and has a wide market application prospect.

The present invention discloses a sesquiterpene glycoside compound and its preparation method and application. A new sesquiterpene glycoside ligulariatinside A is isolated and identified from the n-butanol extraction part of 95% ethanol extract from the root of Ligularia glossata by multiple chromatographic methods such as macroporous resin column chromatography, positive and reverse phase silica gel column chromatography and high performance liquid chromatography, as well as spectral methods. The molecular formula of the new sesquiterpene glycoside ligulariatinside A is determined to be C 21 H 34 O7, the structure is (3 S ,4 R ,5 R ,7 R )‑11‑hydroxy‑11,12‑dihydronootkatone‑11‑ O ‑ β ‑D‑glucopyranoside enriches the chemical diversity of Ligularia officinalis. Bacterial inhibition experiments revealed that the new sesquiterpenoid glycoside exhibits inhibitory activity against Vibrio anguillarum, with a minimum inhibitory concentration (MIC) of 50 μg / mL, laying the foundation for the development of new antibacterial drugs.

The present invention relates to a method for screening compounds for bactericidal activity using thermostable luciferase and based on a real-time bioluminescence measurement. The present invention further relates to a method for determining the sensitivity of a bacterial sample originating from a subject suffering from a bacterial infection to a group of known antibiotics and to a method for assessing the minimum inhibitory concentration (MIC) of a bactericidal compound.

The invention discloses an antifungal peptide targeting fusarium oxysporum as well as a preparation method and application thereof, and belongs to the technical field of microorganisms. According to the present invention, the polypeptide specifically bound with Fusarium oxysporum is obtained through screening, and the sequence of the polypeptide is WYHRSHPQWNHW; the antifungal peptide WY-66-10 is formed by hybridizing and fusing the targeted structural domain and the weak-activity antibacterial peptide 66-10, the antifungal peptide WY-66-10 can kill fusarium oxysporum in a targeted manner, the minimum inhibitory concentration is improved by 30 times or more compared with that of the original polypeptide 66-10, and the targeted antifungal peptide WY-66-10 still keeps relatively weak cytotoxicity and hemolytic activity at the concentration of 128 mu M, and can be used for preparing the antifungal peptide WY-66-10. The method has good application values of targeting specific microorganisms, saving antibacterial resources and maintaining micro-ecological balance.

The present invention relates to a bacterial strain of Streptococcus salivarius with oral probiotic properties and a minimum inhibitory concentration of at least 500 ppm.

The invention belongs to the technical field of medical chemistry, and discloses a 5-O-carbon mould amine tylosin lactone derivative with a double-target combined antibacterial effect as well as a preparation method and application of the 5-O-carbon mould amine tylosin lactone derivative. The derivative is a compound as shown in a formula I, and pharmaceutically acceptable salt, eutectic, tautomer, polymorphic substance, solvate, prodrug or isotope labeled compound thereof. The compound can act on a bacterial ribosome 50S subunit and DNA topoisomerase IV at the same time, and shows an excellent antibacterial effect in an antibacterial activity test, and the minimum inhibitory concentration (MIC) reaches 0.0625 mu g / mL. The compound has the advantages of being high in antibacterial activity, wide in antibacterial spectrum and capable of achieving rapid sterilization, and a new choice is provided for developing drugs with antibacterial activity.

The invention discloses a high-throughput screening method for antibacterial peptides capable of being prepared into medicines based on multi-dimensional attribute evaluation, belongs to the cross technical field of bioinformatics and innovative medicine research and development, and is suitable for an input candidate antibacterial peptide sequence set. The method comprises the following steps: carrying out antibacterial activity preliminary prediction and sorting operation on an input candidate sequence aiming at a target pathogen so as to obtain a pre-selected subset; performing multi-dimensional evaluation on the pre-selected subset based on a plurality of preset druggability indexes; in the evaluated sequence, the minimum inhibitory concentration (MIC) value of the sequence is further predicted, and finally the target antibacterial peptide is screened out according to the predicted MIC value. According to the method, through a layered and multi-module linkage screening process and application of the optimized machine learning model, the antibacterial peptide with high activity and good patent medicine potential is efficiently and accurately screened out, the screening efficiency is remarkably improved, and the research and development risk is reduced.