Preparation method of cellulose-based antibacterial material dialdehyde cellulose-lysine

A technology of dialdehyde cellulose and lysine, which is applied in the fields of botanical equipment and methods, chemicals for biological control, biocides, etc., can solve the problems of lysine deficiency, etc. A wide range of effects

Active Publication Date: 2018-03-02
江苏灵源沂岸科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Usually vegetarians have a higher incidence, and some athletes can also develop lysine deficiency if they do not follow a proper diet

Method used

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  • Preparation method of cellulose-based antibacterial material dialdehyde cellulose-lysine
  • Preparation method of cellulose-based antibacterial material dialdehyde cellulose-lysine
  • Preparation method of cellulose-based antibacterial material dialdehyde cellulose-lysine

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Dialdehyde cellulose and lysine with a degree of oxidation of 67.7% were weighed according to a molar ratio of 1:1.2, added to 100 times distilled water, adjusted to pH 10 with 10% sodium hydroxide, at 40°C , placed in a water bath constant temperature shaker to react for 8h;

[0039] (2) After the reaction finishes, the centrifugal precipitation is dried;

[0040] (3) antibacterial material is carried out antibacterial experiment to sarcinina;

[0041] The MIC of the bacteriostatic material to Sarcina is 7.5mg / mL; the lysine content of the bacteriostatic material is about 11.53g / 100g.

Embodiment 2

[0043] (1) Dialdehyde cellulose and lysine with a degree of oxidation of 67.7% were weighed according to a molar ratio of 1:1.2, added to 100 times distilled water, adjusted to pH 10 with 10% sodium hydroxide, at 40°C , placed in a water bath constant temperature shaker to react for 8h;

[0044] (2) After the reaction finishes, the centrifugal precipitation is dried;

[0045] (3) Antibacterial material is carried out antibacterial experiment to Escherichia coli;

[0046] The MIC of the bacteriostatic material to Escherichia coli is 7.5mg / mL; the lysine content of the bacteriostatic material is about 11.30g / 100g.

Embodiment 3

[0048] (1) Dialdehyde cellulose and lysine with a degree of oxidation of 67.7% were weighed according to a molar ratio of 1:1.2, added to 100 times distilled water, adjusted to pH 10 with 10% sodium hydroxide, at 40°C , placed in a water bath constant temperature shaker to react for 8h;

[0049] (2) After the reaction finishes, the centrifugal precipitation is dried;

[0050] (3) Antibacterial material is carried out antibacterial test to Staphylococcus aureus;

[0051] The MIC of the bacteriostatic material to Staphylococcus aureus is 30mg / mL; the lysine content of the bacteriostatic material is about 10.53g / 100g.

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Abstract

The invention relates to a novel cellulose-based antibacterial material, which is mainly produced via the steps of: controlling reaction temperature, time, pH value and oxidization ratio of dialdehydecellulose in order to perform a reaction to the dialdehyde cellulose and lysine, and when the reaction is finished, performing centrifugal separation and drying and grinding the product. The antibacterial material has excellent antibacterial activity, and can reach 30 mg / ml in minimum inhibitory concentration (MIC) against Gram negative bacteria, such as Escherichia coli, and 7.5 mg / ml in MIC against Gram positive bacteria, such as staphylococcus aureus, with penicillin as a positive control and an LB liquid culture medium as a negative control; under special conditions, the antibacterial material can completely growth of bacteria. The antibacterial material has simple process and is free of toxic and side effect. The raw material, cellulose, has abundant sources and is environment friendly. The invention supplies a new idea for researching and developing novel antibacterial materials.

Description

[0001] The invention relates to a synthesis method of a cellulose-based antibacterial material for inhibiting bacterial growth. It does not use traditional antibiotics for antibacterial, but uses dialdehyde cellulose to react with lysine to generate a compound containing a Schiff base structure to inhibit bacterial growth, which belongs to the innovative field of antibacterial material synthesis. Background technique [0002] Chitin is widely found in arthropod shells and fungal cell walls. Chitosan is a natural amino polysaccharide obtained by deacetylation of chitin. It has no toxic side effects and has good biodegradability and biocompatibility. , and its superior biological activity has attracted extensive attention of researchers at home and abroad. [0003] As early as 1979, Allan et al. reported on chitosan, and they found that chitosan had antibacterial activity against various bacteria and fungi. People have started extensive research on chitosan for this characteris...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B15/06A01N43/16A01P1/00
CPCA01N43/16C08B15/06
Inventor 张黎明于海峰管苹何希宏张智涵戴玉杰
Owner 江苏灵源沂岸科技股份有限公司
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