99results about How to "Low inhibitory concentration" patented technology

The invention discloses mild shampoo and bath bubbles for infants. According to the characteristics of hair and skin of infants, the shampoo and bath bubbles are prepared by selecting disodium cocoyl glutamate, cocamidopropyl betaine and sodium lauryl and glycoside hydroxypropylsulfonate as a surfactant system, selecting camellia-seed oil, alpha-glucan oligosaccharide/inulin compound as a regulating component and selecting flos chrysanthemi indici extract and ethyl lauroyl arginate HCl as a preservative system. The shampoo and bath bubbles are prepared from compatible raw materials, have good cleaning effect and mild and non-irritant performance, and can be used for reinforcing skin barrier to give intimate care to infants.

The invention discloses an organosilicon quaternary ammonium long-acting antibacterial product and a preparation method of the organosilicon quaternary ammonium long-acting antibacterial product. The product comprises a first organosilicon quaternary ammonium antibacterial component, a second organosilicon quaternary ammonium antibacterial component and a third synergistic component, wherein the first organosilicon quaternary ammonium antibacterial component is dimethyl alkyl [3-(trimethoxysilyl) propyl] ammonium halide containing C10-C16 alkyl, and the halogen is preferably Cl (chlorine) and Br (bromine); the second organosilicon quaternary ammonium antibacterial component is dimethyl alkyl [3-(trimethoxysilyl) propyl] ammonium halide containing C18-C30 carbon chains, and the halogen is preferably F (fluorine), Cl (chlorine) and I (iodine); the third synergistic component is selected from a group comprising tea polyphenol, aloe and chitosan or a group comprising composition of polyphenol, aloe and chitosan. The antibacterial agent has broad-spectrum antibacterial performance, lasts long, is poisonless, has no irritation to the skin, is especially applicable to sensitive parts of the skin and is a good choice in daily life, wound treatment and operation assistance.

The invention discloses a novel compound 3,3'-(3,4-dichlorobenzylidene)-bis-4-hydroxycoumarin with a strong antibacterial effect which is optimized by transforming the structure of bishydroxycoumarin compounds, and provides a preparation method thereof, wherein the chemical structure and crystal structure are obtained. The novel compound 3,3'-(3,4-dichlorobenzylidene)-bis-4-hydroxycoumarin has an antibacterial application value in preparation of a medicine resisting staphylococcus aureus (ATCC29213), methicillin-resistant staphylococcus aureus (MRSA, XJ7502), USA300 (LAC) and vancomycin-resistant staphylococcus aureus (Mu20ATCC700699).

The invention discloses a preparation method of a dual bacteriostatic cinnamyl aldehyde microcapsule, which comprises the following steps of: dissolving chitosan in glacial acetic acid to prepare chitosan solution; adding cellulose and performing enzymolysis reaction to obtain modified chitosan solution; dissolving Arabic gum in water to prepare Arabic gum solution; adding cinnamyl aldehyde, and emulsifying and dispersing at high speed to obtain emulsion; dropwise adding the modified chitosan solution into the emulsion, performing coagulation reaction, adding geniposide, and solidifying; and leaching, drying, and thus obtaining the dual bacteriostatic cinnamyl aldehyde microcapsule. The preparation method has the advantages that cinnamyl aldehyde bacteriostatic component loss is reduced, irritation and spicy of cinnamyl are covered, and cinnamyl aldehyde is slowly released in high-temperature and high-humidity environments; the modified chitosan and cinnamyl aldehyde simultaneously have dual bacteria-resistant effects, and can generate a good bacteria-resistant effect when added into a minced fish product; bacteria-resistant concentration is low, the lowest bacteria-resistant concentration of Escherichia coli can reach 0.10 percent, and the lowest bacteria-resistant concentration of staphylococcus aureus can reach 0.15 percent.

The invention relates to a chitosan quaternary ammonium salt hydrogel antibacterial dressing and a preparation method thereof, and belongs to the field of biomedicine. The chitosan quaternary ammoniumsalt hydrogel antibacterial dressing is prepared from the following raw materials in parts by weight: 0.1-5 parts of a chitosan quaternary ammonium salt, 0.1-5 parts of an organosilicon quaternary ammonium salt, 1-8 parts of a cellulose derivative, 5-20 parts of glycerol and 80-120 parts of purified water. The chitosan quaternary ammonium salt hydrogel antibacterial dressing provided by the invention has a good antibacterial effect, stability and a wide application range, and has a good therapeutic effect on wound healing.

The present invention relates to pleuromutilin antibiotic derivatives represented by a general formula (I), pharmaceutically acceptable salts, prodrugs, solvates or stereoisomers thereof, wherein R<2>, Q<1>, Q<2>, m and X are defined in an instruction. The present invention further relates to preparation methods of the compounds, drug compositions containing the compounds, drug preparations containing the compounds, and applications of the compounds in preparation of drugs for treatment and/or prevention of diseases caused by microorganisms.

The invention discloses a novel antibacterial antiviral feed additive for a livestock and poultry breeding industry. The novel antibacterial antiviral feed additive is composed of plume poppy, lightyellow sophora root, macleaya microcarpa, yucconin, tea saponin, Origanum vulgare L., narcissus seed and pagodatree flower bud powder and also comprises a hydrophilic aluminosilicate as a carrier. The novel antibacterial antiviral feed additive has the advantages that specific active components of natural plants can directly or indirectly kill viruses, have strong antibacterial effects and a wide antibacterial spectrum and compared with the common drugs such as berberine hydrochloride, penicillin and aureomycin, the specific active components have stronger activities of resisting some bacteria; in feeding, antibiotic drugs are avoided and mycotoxins are reduced and good effects of treating and preventing avian pasteurellosis, escherichia coli, bacillus rhusiopathiae suis, cholera fowl, white scour of piglets, and pullorum disease are obtained; and the novel antibacterial antiviral feed additive can resist stress and coccidium and remove heavy metals and drug residues.

The invention discloses a method for rapidly determining drug tolerance of a strain. The method comprises the following steps: A, preparing nutrient fluid containing methyl thiazolyl tetrazolium; B, preparing bacterial suspension; C, preparing antibiotic solution; D, adding the nutrient fluid containing the methyl thiazolyl tetrazolium, the antibiotic solution and the bacterial suspension into holes of a culture plate, and performing serial dilution on the antibiotic solution; and E, scanning and determining the diluent in real time, and determining the drug tolerance of the strain to antibiotic according to the scanning result. Compared with the prior art, the method has the advantages of simply, rapidly, economically and high-efficiently determining the drug tolerance of the strain.

The invention discloses a preparation method of a novel chitosan-g-antibacterial peptide polymer. The preparation method comprises following steps: at first, synthesizing two amino acid derivatives: lysine-N-carboxylic acid anhydride and valine-N-carboxylic acid anhydride; taking chitosan as a main chain; and grafting a polypeptide chain, which is prepared from lysine-N-carboxylic acid anhydride and valine-N-carboxylic acid anhydride through ring opening polymerization, to the amino groups of chitosan to prepare the chitosan-g-antibacterial peptide polymer. In a neutral medium, the prepared chitosan-g-antibacterial peptide polymer has the advantages of low minimal inhibitory concentration and low minimal bactericidal concentration; at the same time, the synthesis method is simple, the synthesis raw material cost is low, large scale production is easily realized, and due to the antibacterial performance in a neutral medium, the polymer has a high potential application value in the antibacterial field.

The present invention relates to a disinfection liquid. The chlorhexidine gluconate bath disinfection liquid comprises, by weight, 1.5-2.5% of CHG, 0.3-1.5% of a compound preservative, 0.5-2.0% of a thickening agent, 2.0-10.0% of a surfactant, 0.5-5.0% of a skin moisturizing agent, 0.5-5.0% of a moisturizing agent, 0.1-2.0% of a penetrant, a proper amount of a pH value regulating agent, and the balance of water. The preparation method comprises: adding a sufficient amount of water to a reaction kettle, heating to a temperature of 50 DEG C, adding the thickening agent under stirring, completely swelling after 30 min, sequentially adding the surfactant, the skin moisturizing agent, the moisturizing agent, the penetrant and the pigment, uniformly mixing, then adding the CHG, stirring for 10 min, cooling to a room temperature, adding the preservative and the essence, stirring for 5 min, adjusting the material liquid to achieve the weak alkaline state, standing, and defoaming. According to the present invention, the CHG can quickly penetrate into the skin stratum corneum and can be adsorbed on the stratum corneum so as to achieve the rapid, complete and durable sterilization purpose.

The invention provides a microcapsule containing a plant characteristic aroma and a preparation method of the microcapsule. The microcapsule is prepared from, by weight, 3-7 parts of fever-trees, 15-25 parts of orange peel, 1-5 parts of thyme, 1-4 parts of vanilla, 3-6 parts of cortex cinnamomi and 10-20 parts of lavandula angustifolia. The microcapsule has the advantages that various materials have mutual synergistic effects, synergize with one other and mutually enhance the antibacterial properties, thereby enhancing the antibacterial property of the microcapsules; by adding plant extracts such as the orange peel and the lavandula angustifolia, the aroma of the microcapsule is enriched, and the effective time of air freshening is greatly prolonged.

The invention discloses a novel peptide deformylase inhibitor containing spiro-three-membered ring and spiro-five-membered ring types. The novel peptide deformylase inhibitor containing the spiro-three-membered ring and spiro-five-membered ring types has antibacterial activity and anti-tumor activity. The peptide deformylase inhibitor containing the spiro-three-membered ring and spiro-five-membered ring types can serve as a novel antibacterial agent, by inhibiting the activity of peptide deformylase needed in synthesis of bacterium proteins, the novel peptide deformylase inhibitor is effective on multiple antibiotic resistant Gram-positive bacterium strains, the synthesis process of proteins of human bodies is not affected, and accordingly bacteria are killed selectively. The peptide deformylase inhibitor containing the spiro-three-membered ring and spiro-five-membered ring types can further serve as a novel anti-cancer drug; by inhibiting peptide deformylase in mitochondria of cancer cells, energy balance of the cells can be affected, accordingly mitochondrial membranes are depolarized, ATP is used up, and cell apoptosis is promoted; and the novel peptide deformylase inhibitor has good inhibiting activity to multiple cancer cell bacterial strains such as colorectal cancer cell bacterial strains, lung cancer cell bacterial strains, gastric cancer cell bacterial strains and liver cancer cell bacterial strains at the low concentration.

The invention provides an application of sodium butyl in mould proof of feeds, which is used for preventing and curing aspergillus flavus, aspergillus fumigatus, penicillium curinum thom, penicilliumislandicum, fusarium moniliforme sheld, fusarium graminearum or the mixed mould which is extracted from the moulding feeds. The minimum bacteriostat concentration of the sodium butyl to the mixed mould is 62mg/kg; the minimum bacteriostat concentration to the aspergillus flavus and aspergillus fumigatus is 62mg/kg; the minimum bacteriostat concentration to the penicillium curinum thom, penicilliumislandicum, fusarium moniliforme sheld and fusarium graminearum is 88mg/kg; after being processed for 30 minutes at the high temperature of 121 DEG C, the minimum bacteriostat concentration of the sodium butyl is 62mg/kg; and when the pH value respectively equals to 5.5 and 7.5, the minimum bacteriostat concentrations of the sodium butyl are respectively 88mg/kg, 130mg/kg and 140mg/kg. The invention provides the bacteriostat concentration of the sodium butyl to several types of moulds under different conditions, and lays a foundation for the sodium butyl to be served as mould proof agent in feed production.

The invention relates to a compound biological preservative, which is characterized by compounding 300-800mg / L of monosodium fumarate with 200-500mg / L of poly lysine in accordance with the ratio of 1:9-11:1 and then adding 0.02-0.04% of tea polyphenol. The compound biological preservative has the characteristics of high efficiency, safety and no toxic and side effect, is good in broad-spectrum antibacterial property, is low in minimum inhibitory concentration, can not only inhibit the growth of bacterial colony in food, but also can maintain the moisture content, sensory quality and a variety of flavor components, and the compound biological preservative is suitable for the preservation of food, is especially suitable for casual fish sheet preservation, and has the very good application prospect.

The present invention relates to the technical field of medicine, specifically to a composition, which contains a compound (a), a pharmaceutically acceptable salt, an ester, a solvate or a stereoisomer thereof, and at least a carbapenem antibiotic or a derivative thereof, wherein the compound (a) has a structure represented by a formula (I) defined in the specification. The invention further relates to uses of the composition in preparation of drugs for prevention and/or treatment of infectious diseases caused by bacteria, wherein preferably the bacteria have drug resistance caused by beta-lactamase.

The invention relates to a vaginal mucosa antibacterial gel and a preparation method thereof, aiming to solve the technical problem that conventional gynecological gels are easy to damage acid and alkali balance and microbial flora balance in the vagina when used for treatment on inflammation. The vaginal mucosa antibacterial gel comprises extract of Fructus Sophorae, extract of Rosa chinensis, Carbomer, Tween 80, glycerol, poloxamer 188 and methylparaben. The preparation method includes the steps of firstly, weighing the raw material respectively; secondly, mixing glycerol, Tween 80 and purified water uniformly, and then adding in poloxamer 188, extract of Fructus Sophorae and extract of Rosa chinensis; thirdly, weighing 0.3 g of Carbomer, adding in 20 g of purified water until completelyswelling to obtain a swelling solution; fourthly, adding a suspension solution into the swelling solution, and then adding in methylparaben to obtain the product. The gel keeps acid and alkali balance in the vagina without damaging the microbial flora balance therein when used for treatment of female vaginal inflammation, that is to say, the gel can achieve good treatment effect while avoiding damages to micro-ecology of the vagina.

The invention provides a method for constructing a photocatalytic anti-bacterial and anti-fouling material with a ring opening method, belongs to the technical field of anti-bacterial and anti-fouling materials, and relates to a photocatalytic anti-bacterial and anti-fouling material constructed on the basis of an epoxy group and primary amino group ring opening polymerization process in the anti-bacterial and anti-fouling field, in particular to a method for preparing a photocatalytic antibacterial agent constructed on the basis of the ring opening method and an application of the photocatalytic antibacterial agent in the surface anti-bacterial field. The method is simple and feasible and easy to operate, and a synthetic polymer has higher anti-bacterial and anti-fouling efficiency.

The invention belongs to the technical field of food preservation and particularly relates to a natural mixed bacteriostatic agent and a preparation method thereof. The natural mixed bacteriostatic agent comprises chlorogenic acid, dihydromyricetin and procyanidine. The natural mixed bacteriostatic agent is prepared by the steps of mixing chlorogenic acid, dihydromyricetin and procyanidine in a certain proportion, adding a certain amount of water solution, adequately stirring to dissolve, and regulate the pH value of the solution. The natural mixed bacteriostatic agent has relatively good inhibition effect to 11 different bacteria including staphylococcus aureus, escherichia coli, Shigella flexneri, proteus mirabilis, Pseudomonas aeruginosa and the like and is expected to be used as an environment-friendly, safe and efficient preservative to be applied to food processing.

The invention provides an amido pyrimidine compound with a novel structure as shown in a formula (I) and a preparation method and application of the amido pyrimidine compound. The amido pyrimidine compound is a compound shown as the formula (I), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer or tautomer thereof and the like. The amido pyrimidine compound provided bythe invention has a relatively good proliferation inhibition effect on various cancer cells; according to the present invention, the compound has characteristics of low tumor cell inhibition concentration, significantly-improved compound activity, good tumor cell selectivity and good solubility, and is expected to be a specific drug for treatment of malignant tumor cell abnormal proliferation diseases caused by EGFR mutation.

The invention discloses application of 2,6-bis(2-benzimidazolyl) pyridine in preparation of a carbapenem-resistant pseudomonas aeruginosa infection drug. Through circular dichroism, fluorescent real-time quantitative PCR and other methods, it is found that 2, 6-bis (2-benzimidazolyl) pyridine can form a G-quadruplex structure with a core sequence of a MexA gene in pseudomonas aeruginosa, thereby inhibiting expression of the MexA gene. A susceptibility testing verifies that 2, 6-bis (2-benzimidazolyl) pyridine can reduce the drug resistance of carbapenem-resistant pseudomonas aeruginosa to meropenem. When the usage amount of the 2, 6-bis (2-benzimidazolyl) pyridine is 5 <mu>M, the minimum inhibitory concentration of the carbapenem-resistant pseudomonas aeruginosa strain can be reduced to 2<mu> g/ml, and the effect of treating carbapenem-resistant pseudomonas aeruginosa infection by using meropenem is achieved.

The invention discloses a nano-material antibacterial health care protection pad for women and belongs to the technical field of sanitation supplies. The protection pad comprises a net face layer, a traditional Chinese medicine layer, a water absorption layer, a waterproof layer and an adhesive layer which are laminated from top to bottom in sequence, and the net face layer is nano-silver antibacterial non-woven fabric which is soaked in a traditional Chinese medicine immersion solution and dried and comprises the following components including nano-silver, 5,5-dimethylhydantoin, chitosan, eggshell powder, polyethylene, ES fibers and negative ion fibers; the traditional Chinese medicine immersion solution is extracted from the following traditional Chinese medicine raw materials includingangelica sinensis, rhizoma cyperi, honeysuckle, dandelions, folium artemisiae argyi, dried fructus crataegi and medicated leaven, dried lumbricus and motherwort; the traditional Chinese medicine layercomprises the following medicine including saffron crocus, common cnidium fruits, fructus forsythia, houttuynia cordata, belvedere fruits, rhizoma coptidis, radix sophorae flavescentis, angelica sinensis and radix bupleuri. By adopting a reinforcement system composed of 5,5-dimethylhydantoin, chitosan and polyethylene, the antibacterial performance of the protection pad for women is improved.