Application of norharmane in improvement of antibiotic antibacterial activity

A technology of methyl harman base and desmethyl harman, which is applied in the application field of desmethyl harman base in improving the antibacterial activity of antibiotics, and achieves the effects of enhancing the antibacterial activity, reducing the bacteriostatic concentration and reducing the occurrence of adverse reactions

Active Publication Date: 2020-09-08
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a kind of application of norharmane in improving the antibacterial activity of antibiotics in order to overcome the current problem of bacterial drug resistance

Method used

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  • Application of norharmane in improvement of antibiotic antibacterial activity
  • Application of norharmane in improvement of antibiotic antibacterial activity
  • Application of norharmane in improvement of antibiotic antibacterial activity

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Embodiment 1: Norharmane and antibiotic joint antibacterial action assay

[0026] 1. Materials

[0027] 1.1 Drugs and reagents

[0028] Norharmane, Shanghai Taosu Biochemical Technology Co., Ltd.;

[0029] Polymyxin B, TCI (Shanghai) Chemical Industry Development Co., Ltd.;

[0030] Imipenem-cilastatin sodium, Zhuhai United Laboratories Co., Ltd.;

[0031] Levofloxacin, TCI (Shanghai) Chemical Industry Development Co., Ltd.;

[0032] Ofloxacin, Shanghai Bofeimeike Reagent Co., Ltd.;

[0033] Methanol, Shanghai Lingfeng Chemical Reagent Co., Ltd.;

[0034] Sodium chloride, Shanghai Shisi Hewei Chemical Co., Ltd.;

[0035] Sodium hydroxide, Shanghai Shisi Hewei Chemical Co., Ltd.;

[0036] Peptone, BD difco;

[0037] Yeast powder, BD difco company;

[0038] Agar powder, BD difco company;

[0039] Norharmane mother solution: norharmane was dissolved in methanol to make a 5000 μg / mL mother solution, polymyxin B, imipenem-cilastatin sodium, levofloxacin and ofloxac...

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Abstract

The invention discloses an application of norharmane in improvement of antibiotic antibacterial activity. When norharmane is combined with antibiotic polymyxin B, imipenem-cilastatin sodium or levofloxacin for application, the antibacterial activity on drug-resistant pseudomonas aeruginosa can be enhanced, and a synergistic antibacterial effect can be generated. According to the method for obviously improving the killing capacity of the antibiotics on the drug-resistant pseudomonas aeruginosa, the dosage of the antibiotics required for achieving the same treatment effect is greatly reduced, and a research direction is provided for the development of new drugs and the new use of old drugs.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to the application of norharmane in improving the antibacterial activity of antibiotics. Background technique [0002] Since the discovery of penicillin in 1928, the discovery and use of antibiotics has played a huge role in promoting human health and social progress. However, since the late 1970s, the research and development of new antibiotics has gradually slowed down, and no antibiotics with a new structure have been on the market since 1984. Correspondingly, the problem of antibiotic resistance is rapidly intensifying. Drug-resistant bacterial infections are spreading all over the world, and the infection rate is on the rise. Resistance to various structural types of clinical antibiotics has emerged one after another, and the speed has exceeded the current rate of new antibiotics. The speed of research and development has become a super broad-spectrum drug-resistant bacteria, which ser...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/437A61K38/12A61K31/407A61K31/198A61K31/5383A61P31/04
CPCA61K31/437A61K38/12A61K31/407A61K31/198A61K31/5383A61P31/04A61K2300/00
Inventor 王鸿陈建伟陆瑶嘉章华伟魏斌
Owner ZHEJIANG UNIV OF TECH
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