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92 results about "Bisbenzimidazole" patented technology
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A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis.
Organic photovoltaic cell incorporating electron conducting exciton blocking layers
ActiveUS20120235125A1Improve power conversion efficiencyFinal product manufactureNanoinformaticsFill factorWide gap
The present disclosure relates to photosensitive optoelectronic devices comprising a compound blocking layer located between an acceptor material and a cathode, the compound blocking layer comprising: at least one electron conducting material, and at least one wide-gap electron conducting exciton blocking layer. For example, 3,4,9,10 perylenetetracarboxylic bisbenzimidazole (PTCBI) and 1,4,5,8-napthalene-tetracarboxylic-dianhydride (NTCDA) function as electron conducting and exciton blocking layers when interposed between the acceptor layer and cathode. Both materials serve as efficient electron conductors, leading to a fill factor as high as 0.70. By using an NTCDA / PTCBI compound blocking layer structure increased power conversion efficiency is achieved, compared to an analogous device using a conventional blocking layers shown to conduct electrons via damage-induced midgap states.
Owner:RGT UNIV OF MICHIGAN
Method for preparing 2-(((1H-benzo[d]imidazolyl-2-yl)methyl)(1-phenmethyl-1H-benzo[d]imidazolyl-2-yl)amino)acetic acid
The invention belongs to the field of chemical synthesis, relates to a method for preparing 2-(((1H-benzo[d]imidazolyl-2-yl)methyl)(1-phenmethyl-1H-benzo[d]imidazolyl-2-yl)amino)acetic acid and concretely relates to the 2-(((1H-benzo[d]imidazolyl-2-yl)methyl)(1-phenmethyl-1H-benzo[d]imidazolyl-2-yl)amino)acetic acid and a preparation method of an intermediate compound for synthesis of the 2-(((1H-benzo[d]imidazolyl-2-yl)methyl)(1-phenmethyl-1H-benzo[d]imidazolyl-2-yl)amino)acetic acid. The 2-(((1H-benzo[d]imidazolyl-2-yl)methyl)(1-phenmethyl-1H-benzo[d]imidazolyl-2-yl)amino)acetic acid shown in the formula VII is a dibenzoimidazolyl amino acid compound having potential biological activity. The method provides a train of thought for similar compound synthesis and also provides a raw material for pharmacological research on the similar compounds.
![Method for preparing 2-(((1H-benzo[d]imidazolyl-2-yl)methyl)(1-phenmethyl-1H-benzo[d]imidazolyl-2-yl)amino)acetic acid](https://images-eureka.patsnap.com/patent_img/04d1e744-2793-4cea-ab10-84d30a14c627/196575dest_path_image006.PNG "Method for preparing 2-(((1H-benzo[d]imidazolyl-2-yl)methyl)(1-phenmethyl-1H-benzo[d]imidazolyl-2-yl)amino)acetic acid")
![Method for preparing 2-(((1H-benzo[d]imidazolyl-2-yl)methyl)(1-phenmethyl-1H-benzo[d]imidazolyl-2-yl)amino)acetic acid](https://images-eureka.patsnap.com/patent_img/04d1e744-2793-4cea-ab10-84d30a14c627/209223dest_path_image007.PNG "Method for preparing 2-(((1H-benzo[d]imidazolyl-2-yl)methyl)(1-phenmethyl-1H-benzo[d]imidazolyl-2-yl)amino)acetic acid")
![Method for preparing 2-(((1H-benzo[d]imidazolyl-2-yl)methyl)(1-phenmethyl-1H-benzo[d]imidazolyl-2-yl)amino)acetic acid](https://images-eureka.patsnap.com/patent_img/04d1e744-2793-4cea-ab10-84d30a14c627/241891dest_path_image007.PNG "Method for preparing 2-(((1H-benzo[d]imidazolyl-2-yl)methyl)(1-phenmethyl-1H-benzo[d]imidazolyl-2-yl)amino)acetic acid")
Owner:史慎德
Method for preparing phosphate-doped polybenzimidazole membrane electrode for fuel cell
The invention discloses a method for preparing a phosphate-doped polybenzimidazole membrane electrode for a fuel cell. On the one hand, 4,4'-oxybis(benzoic acid) and 3,3',4,4'-biphenyltetramine serve as monomers to prepare poly[2,2'-(p-oxy- diphenylene)-5-5'-bisbenzimidazole], the poly[2,2'-(p-oxy-diphenylene)-5-5'-bisbenzimidazole] is cast to form a membrane, and the membrane is doped with phosphate to prepare an electrolyte membrane with good mechanical strength; on the other hand, in the process of preparing a phosphate-doped gas diffusion electrode, poly-[2,2'-(m-phenylene)-5,5'-bisbenzimidazole] is prepared into the gas diffusion electrode in the presence of a platinum / carbon catalyst, the gas diffusion electrode is doped with phosphate, the components are uniformly distributed, strong-volatility acid is not used in the process, and a process of mixing solid materials does not exist. The membrane electrode prepared by the method can be used for hydrogen-oxygen fuel cell power generation under the conditions that the temperature is higher than 100 DEG C and the humidification is not carried out. The open-circuit voltage is 0.845V, and the maximum power density is 191mW / cm<2> (560mA / cm<2>, 0.34V) under the conditions that the temperature of the fuel cell is 150DEG C and the humidification is not carried out. The preparation method has the advantages of controllable conditions in the technological process and good repeatability of the process.
Owner:SHANGHAI JIAO TONG UNIV
Transition metal catalyst for oligomerization and polymerization of ethylene and its prepn process and use
ActiveCN101020695AConvenient researchEasy to implementOrganic-compounds/hydrides/coordination-complexes catalystsHydrocarbonsHigh activityBisbenzimidazole
The present invention discloses serial 2, 6-bisbenzimidazole pyridyl chromium halide complexes in the structure as shown. The present invention also discloses the preparation process of these novel complexes, composite catalyst including these novel complexes and their application in oligomerization and polymerization of ethylene. The complexes of the present invention are prepared with simple cheap materials, and have great modification space and high activity for oligomerization and polymerization of ethylene.
Owner:CHINA PETROLEUM & CHEM CORP
Polybenzimidazole containing ether ketone/ether sulfone structure as well as sulfonated polymer and preparation method thereof
Owner:ZHEJIANG UNIV OF TECH
Aromatic diamine containing imidazolyl and preparation method thereof
The invention discloses an aromatic diamine containing imidazolyl and a preparation method thereof. Tetramines aromatic and aminobenzoic acid are taken as raw materials, and an imidazole ring is formed by reaction between carboxyl and o-amino in a polyphosphoric acid medium, thus preparing 2,2'-bi(4-amino phenyl)-5,5'-bisbenzimidazole, 2,2'-bi(3-amino phenyl)-5,5'-bisbenzimidazole, 2,2'-bi(4-amino phenyl)bisbenzimidazole, 2,2'-bi(3-amino phenyl)bisbenzimidazole, 2,2'-bi(4-amino phenyl)imidazopyridine or 2,2'-bi(3-amino phenyl)imidazopyridine which belong to a novel aromatic diamine containing imidazolyl that is an important monomer raw material for preparing various polyamides and polyimides, so as to enrich the variety of the aromatic diamine containing imidazolyl and polymers, and have broad application prospect in the fields of high-performance fibers, fuel cells and the like.
Owner:SHANGHAI JIAO TONG UNIV
Ring metal iridium photosensitizers, synthesis thereof and application thereof in hydrogen preparation by photocatalytic reduction of water
InactiveCN103360429ASimple post-processingEasy to handleGroup 8/9/10/18 element organic compoundsHydrogen productionIridiumSynthesis methods
The invention discloses ring metal iridium photosensitizers, synthesis thereof and application thereof. The synthesis of the iridium photosensitizers comprises: placing chlorine-bridge dipolymer [Ir(tfmppy)(mu-Cl)]2 and bis(benzimidazole) into a mixed solvent of methanol and dichloromethane, and then adding Na2CO3 for reflux reaction; after the reaction, cooling, drying the solvent by rotary evaporation, then obtaining a target product through column chromatography. The column chromatography developing agent is a mixture of ethyl acetate and hexane, and the ratio of the ethyl acetate to the hexane is between 1:1 and pure ethyl acetate. Through use of the synthesis method, single-core and dual-core iridium photosensitizers can be simultaneously obtained, and post-treatment is simple, and the pure product can be obtained through simple column chromatography method. Compared with hydrogen preparation by photocatalytic reduction of water with a conventional single-core iridium photosensitizer, the single-core iridium photosensitizer of the invention has good performance of hydrogen preparation by photocatalytic reduction of water, and the dual-core iridium photosensitizer is more active than the single-core iridium photosensitizer.
Owner:NANJING UNIV OF SCI & TECH
Bipolar phosphorescent host compounds, preparation method, application and electroluminescent device
ActiveCN103524497AImprove efficiencyIncrease chance of compoundingOrganic chemistrySolid-state devicesCarbazoleSuzuki reaction
The invention discloses bipolar phosphorescent host compounds, a preparation method, an application and an electroluminescent device. The bipolar phosphorescent host compounds are bisbenzimidazole and dicarbazole derivatives and have a structural general formula shown in a drawing in the specification, wherein in the structural general formula, when R1, R2 or R3 is a formula in the specification, the other two are H; when R1, R2 or R3 is a formula in the specification, the other two are H. The bisbenzimidazole / dicarbazole derivatives contain the same di(9-phenylcarbazole)group and benzimidazole group. The bipolar phosphorescent host compounds, the preparation method, the application and the electroluminescent device have the beneficial effects that the two groups of carbazole and benzimidazole are connected by adopting 3-position of carbazole through typical Suzuki reaction, so that the triplet levels of the bipolar phosphorescent host compounds can still well meet blue phosphorescent devices due to lower reduction of the conjugated structures of the bipolar phosphorescent host compounds while the bipolar phosphorescent host compounds maintain the bipolar transmission performances of the two groups.
Owner:TCL CORPORATION
Applications of bisbenzimidazole bicarbazole compound in specific binding nucleic acid G-quadruplex structure and anti-tumor drug
ActiveCN103728294AEasy to synthesizeEasy to storeOrganic active ingredientsOrganic chemistryHydrogenFluorescence spectrometry
The invention relates to a bisbenzimidazole bicarbazole compound, in particular to applications of the bisbenzimidazole bicarbazole compound in a specific binding nucleic acid G-quadruplex structure and an anti-tumor drug. The bisbenzimidazole bicarbazole compound and a nucleic acid sample to be detected are incubated in a buffer solution with a pH (Potential of Hydrogen) value of 6-8; an absorption peak of an ultraviolet-visible absorption spectrum within the range of 390-440nm is obviously enhance through observation; or whether a fluorescence spectrum has a fluorescence peak between within the range of 430-540 is observed to detect whether the nucleic acid sample to be detected is nucleic acid in the G-quadruplex structure. The bisbenzimidazole bicarbazole compound is added into a culture solution containing tumor cells as a drug, cultured together with the tumor cells, and used for inhibiting tumor cell proliferation, or the bisbenzimidazole bicarbazole compound is used for inhibiting the tumor cell proliferation as a most active ingredient of the drug. A method has the advantages of simplicity, quickness and cheapness.
Owner:INST OF CHEM CHINESE ACAD OF SCI
Terphenyl bridged double-benzimidazoles compound as well as synthesis method and application thereof
The invention provides a terphenyl bridged double-benzimidazoles compound as well as a synthesis method and application thereof. The invention takes cyanophoric phenyloboricacid and aromatic dibromide (such as 1,4-dibromo-benzene, 2-fluorine-1, 4-dibromo-benzene, 2,5-dibromo-toluene) as raw materials; under the catalysis of organic palladium and inorganic base, a series of terphenyl compounds with di-cyan can be synthesized by the Suzuki coupling reaction; and then a series of terphenyl bridged double-benzimidazoles compounds can be obtained by adding 1 time of di-cyano-terphenyl compounds and 2-2.4 times of o-phenylenediamine compounds, taking polyphosphoric acid as the catalyst and carrying out the condensation reaction for 6-24 hours under 180-240 degrees C.. The compound can be applied to the fields such as light emitting devices, photovoltaic cells, organic light-emitting diodes and the like as the organic blue-light material or the electron transport material.
Owner:NANJING UNIV OF TECH
Bis-Benzimidazole Derivatives As Hepatitis C Virus Inhibitors
InactiveUS20120135953A1Improved profileToxic reductionBiocideOrganic chemistryBenzimidazole derivativeHcv hepatitis c virus
Inhibitors of HCV replication of formula Iincluding stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein R and R′ have the meaning as defined herein.The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
Owner:JANSSEN SCI IRELAND UC
Combination composed of SEBS recycled materials and high-strength halogen-free flame-retardant insulating material prepared from combination
The invention discloses a combination composed of SEBS recycled materials. The combination comprises sulfonated SEBS recycled materials, MAH-g-PP, sulfonated polybenzimidazole modified graphene oxide, 2, 2'-bis(4-carboxyl phenoxy)biphenyl-4,4'-diamine and 1-10 weight parts of 2, 2'-bis(4-(1H-benzimidazole-2-base) phenoxy) benzidine. The invention further discloses a high-strength halogen-free flame-retardant insulating material obtained prepared from the combination and a preparation method of the high-strength halogen-free flame-retardant insulating material.
Owner:HEILONGJIANG XINDA ENTERPRISE GRP
Bis-benzimidazoles and related compounds as potassium channel modulators
The present invention provides a genus of bis-benzimidazole compounds, methods and pharmaceutical compositions that are useful as modulators of potassium ion channels. The compounds of the invention are of use in both therapeutic and diagnostic methods.
Owner:ICAGEN INC
Benzimidazole pyridine complex and method for preparing same
InactiveCN102964374ASimple methodGood antitumor activityOrganic active ingredientsLead organic compoundsThermal insulationHuman breast
The invention discloses a benzimidazole pyridine complex and a method for preparing the same. The method is that Pb(NO3)2, 2, 6-bisbenzimidazole pyridine (bbp) and 5-nitroisophthalicacid (nipa) are proportionally weighed according to the molar ratio of 1:1:(1-0.5) to be put into a container and are added with water to be stirred for 10-15 minutes; then, the stirred raw material liquid is poured into a reactor, the reactor is covered to be heated to 160-165 DEG C, and then, thermal insulation reaction is carried out for 115-120 hours; and a gradient heating method is adopted to cool the raw material liquid to room temperature so as to obtain a colorless blocky crystal complex, i.e. the benzimidazole pyridine complex [Pb2(nipa) (Hbbp)2]n.nH2O is obtained. The benzimidazole pyridine complex has the characteristics of good stability and obvious functions in inhibiting three types of human cancer cells of human breast cancer cells, lung cancer cells and cervical cancer cells, and provides guidance for the research and development of an anticancer complex.
Owner:YULIN NORMAL UNIVERSITY
Metal iridium catalyst with 2, 2'-bis-benzimidazole ligand and method for synthesizing N-methylated primary amine
ActiveCN109420525ANo harmImprove economyCarboxylic acid nitrile preparationOrganic compound preparationIridiumReaction temperature
The invention discloses a metal iridium catalyst with a 2, 2'-bis-benzimidazole ligand and a method for synthesizing N-methylated primary amine, an iridium metal complex containing the bis-benzimidazole ligand is used as a catalyst to activate methylation reaction of wide-source and low-toxicity methanol and an aromatic primary amine. Compared with the prior art, the method disclosed by the invention has the advantages that only a weak alkali needs to be added in the reaction process, the reaction temperature is 120 DEG C, and nitrogen protection, high temperature and high pressure, long-timereaction and other harsh conditions are not needed; meanwhile, a by-product only comprises water, and cause no environment pollution; therefore, the method has a wide development prospect.
Owner:NANJING UNIV OF SCI & TECH
Polyaryletherketone imidazole and preparation method thereof
The invention discloses polyaryletherketone imidazole and a preparation method thereof. The general structural formula of the polyaryletherketone imidazole is FORMULA. The invention further relates to a preparation method of the polyaryletherketone imidazole. The preparation method comprises the steps of: regarding aromatic diacid and o-phenylenediamine as reactants to obtain a bis-benzimidazole compound under catalysis of a polyphosphoric acid and phosphoric acid system; regarding aromatic ketone difluoride and the bis-benzimidazole as reactants, sulfolane as a solvent and chlorobenzene as a water remover to obtain arone imidazole intermediate body under catalysis condition of anhydrous potassium carbonate; and adding aromatic diphenol in the reaction system to obtain a target product polyaryletherketone imidazole after a further reaction. The polyaryletherketone imidazole prepared by the invention is good in heat resistance, mechanical property and solubility, low in preparation cost and simple in operation process.
Owner:LASER FUSION RES CENT CHINA ACAD OF ENG PHYSICS
Zinc metal organic framework material, and preparation method and application thereof
ActiveCN107011525AImprove stabilityImprove adsorption capacityOther chemical processesWater contaminantsCrystal systemSpace group
The invention discloses a zinc metal organic framework material. A molecular formula of a porous material is C28H17N505Zn, a crystal system is homocline, a space group is P21 / c, and cell parameters are shown in the description, wherein alpha is equal to 90 degrees, beta is equal to 104.1960(10) degrees, gamma is equal to 90 degrees, and the number of molecules in a unit cell is two; and a chemical general formula of the porous material is Zn(phenDIB)L0.5, wherein L is azoxybenzene-3,3',5,5'-tetracarboxylic acid, and phenDIB is 1,4-bisbenzimidazole-benzene; and the material is a porous material with high stability, has apparent absorption effect for cationic dye such as methylene blue, rhodamine B, and can realize the selective absorption separation for the cationic dye from different types of mixed dye containing the cationic dye, the absorbed separated dye can also be desorbed and recycled and can be used as an environment-friendly absorption material, the zinc metal organic framework material can be prepared by adopting a simple solvent thermal method, and the application prospect is good.
Owner:NINGBO UNIV
Perfluoro alkyl substituted perylene bis diimines and derivative and preparation method thereof
The present invention provides a perfluoroalkyl substituted 3, 4, 9, 10-perylene double diimine, the derivative perfluoroalkyl substituted dibenzimidazoles perylene and the preparation methods. In the method, the bromine substituted 3, 4, 9, 10-perylene double diimine or bromide substituted dibenzimidazole perylene and the perfluorine iodine substituted alkyl are used as the raw materials; the copper powder or copper-tin alloy powder is used as the catalyst; the reaction is done for 1 to 72 hours in the organic solvent at the temperature between 40 and 160 DEG C; the Br on the garland of raw material is replaced by the perfluoroalkyl to produce the perfluoroalkyl substituted 3, 4, 9, 10-perylene double diimine or the perfluoroalkyl substituted double benzimidazoles perylene of the good solubility, thermal stability and stability.
Owner:DALIAN UNIV OF TECH
Lyotropic liquid crystal systems based on aromatic tetracarboxylic bisbenzoimidazole derivatives and methods for making
ActiveUS20110317102A1Liquid crystal compositionsOrganic chemistryCrystallographyBenzimidazole derivative
Compounds derived from aromatic tetracarboxyl bisbenzoimidazoles are disclosed. These compounds are capable of forming liquid crystal systems that can produce optically isotropic or anisotropic films with desirable optical properties. Formulae (I) or (II), or a salt thereof; wherein y is an integer in the range from 0 to about 4.
Owner:NITTO DENKO CORP
Nitrogenous multitooth transition metal complex and preparation method thereof
InactiveCN103012446ASimple structureCobalt organic compoundsOrganic/organic-metallic materials magnetismNitrogenCadmium Cation
The invention relates to a nitrogenous multitooth transition metal complex is composed of a material represented by the general formula C28H32+2mN6+2xO2+m+6xCl2yM, wherein M is zinc or cadmium or cobalt, 0<=m<=0.53, x is 0 or 1, and y is 0 or 1; and x and y are not 0 at the same time, and x and y are not 1 at the same time. The preparation method comprises the following steps: preparing a 2,2'-(1,4-dimethylphenyl-1',1'-diyl)bibenzimidazole ligand, and preparing the nitrogenous multitooth transition metal complex. The prepared nitrogenous multitooth transition complex has magnetic property and fluorescence, and can be used for functional metal organic materials.
Owner:NORTHWEST UNIV
Bibenzimidazole derivative with PPARgamma exciting agent activity and application thereof
A compound or its salt, their preparations and uses in treatment of PPAR gamma acceptor related diseases are disclosed. The compound is selective PPAR gamma agonist and has specific excitation activity. It can be used to treat diabetes mellitus or metabolic syndrome.
Owner:SHANGHAI ALLIST PHARM CO LTD
2,3-double benzimidazole pyridine cobalt (II) coordination compound and application thereof in pharmacy
InactiveCN105017335AGrowth inhibitionInduce apoptosisOrganic chemistry methodsCobalt organic compoundsSpace groupApoptosis
The invention discloses a 2,3-double benzimidazole pyridine cobalt (II) coordination compound. The crystal structure of the compound belongs to a triclinic system, the space group of the compound is P1, and the molecular formula is C[38]H[24]CoN[10]. Co (II) atoms are penta-coordinated. The invention further discloses the application of the 2,3-double benzimidazole pyridine cobalt (II) coordination compound in pharmacy. The 2,3-double benzimidazole pyridine cobalt (II) coordination compound can restrain the growth of human hepatoma carcinoma cells Hep-G2, induce the apoptosis of the human hepatoma carcinoma cells Hep-G2, preventing the human hepatoma carcinoma cells Hep-G2 from being in the G2 phase and affect on DNA in a non-classical insertion mode.
Owner:GUANGXI MEDICAL UNIVERSITY
Lung carcinoma cell inhibitor and preparation method of lung carcinoma cell inhibitor
InactiveCN102872023ASimple methodImprove stabilityOrganic active ingredientsNickel organic compoundsLung cancerBisbenzimidazole
The invention discloses a lung carcinoma cell inhibitor and a preparation method of the lung carcinoma cell inhibitor. According to the preparation method, Ni(NO3)2.6H2O, 2,6-bisbenzimidazole pyridine; and 5-hydroxyisophthalic acid are weighed according to a mol ratio being (0.5-1):1:1; then, water is added and solution is put into a container, the PH value of the solution is regulated to 8.0 to 9.0 by triethylamine, and the solution is uniformly stirred; next, the stirred raw material liquid is put into a reaction kettle, a cover is sealed, the temperature is raised to 110 to 130 DEG C, and then, the heat insulation reaction is carried out for 70 to 90 hours; and a gradient temperature reduction method is adopted for lowering the raw material liquid to the room temperature, and green acicular crystal complexes are obtained, i.e., the lung carcinoma cell inhibitor is obtained. The lung carcinoma cell inhibitor disclosed by the invention has the characteristics of good stability and high inhibition capability, and guide is provided for the lung cancer resistance medicine development.
Owner:YULIN NORMAL UNIVERSITY
Terphenyl bridged-bis-benzimidazole quaternary ammonium compound, synthetic method and application thereof
InactiveCN101851210AImprove transmission performanceHigh fluorescence quantum efficiencyOrganic chemistryFluorescence/phosphorescenceAmmonium compoundsSynthesis methods
The invention provides an organic luminescent material, i.e. a terphenyl bridged-bis-benzimidazole quaternary ammonium compound, a preparation method and application thereof. The preparation method comprises the following steps: taking inorganic base as an acid-binding agent, and leading one time of a terphenyl bridged-bis-benzimidazole compound and 4-12 times of halogenated hydrocarbon or halogenated alkene (such as methyl iodide, bromoethane and allyl bromide) in an organic solvent to react for 6-18 hours to obtain a series of the terphenyl bridged-bis-benzimidazole quaternary ammonium compounds. The compound can be used as the organic luminescent material and applied to the fields such as a luminescent device, a photocell, an organic light-emitting diode, a bio-fluorescent probe or a novel fluorescent tracer for a water treatment agent and the like.
Owner:NANJING UNIV OF TECH
Method for enhancing fracture tensile strength of PBI/HP3O4 cast by sol-gel method
A method for enhancing the breaking tensile strength of a PBI / H3PO4 film which is cast by a sol-gel method is characterized in that the powders of poly2, 2'-(metaphenylene)-5, 5'- bisbenzimidazole (PBI) are mixed with a phosphoric acid (H3PO4) solution, and is heated up to the temperature of 190 to 200 DEG C under the condition of nitrogen environment to form homogeneous reddish-brown PBI-H3PO4 sol; then the PBI-H3PO4 sol is dumped on a flat plate, and the high temperature sol is horizontally spread on the flat plate by a film blade to form high temperature PBI-H3PO4 sol film with 0.05 to 0.50mm thickness, the sol film is gelated into the film under the condition of freezing and then is prepared into phosphoric doped PBI film with enhanced breaking tensile strength, which satisfies a proton exchange film fuel cell for the requirements of acid doping level aspects of film electrolyte, by the phosphoric acid solution immerse method, the phosphoric acid solution heating treatment method or the organic solvent heating treatment method. The method of the invention has a short operating cycle and simple, convenient and feasible processing steps, and is easy to operate; the breaking tensile strength of the PBI-H3PO4 film being treated by enhancement is 6 to 16 MPa.
Owner:NORTHEASTERN UNIV
Method for synthesizing 1H,1'H-(2,2'-bis-benzimidazole)-5,5'-diamine
The invention discloses a method for synthesizing 1H, 1'H-(2,2'-bis-benzimidazole)-5,5'-diamine. The method comprises the steps of obtaining N,N'-bis(2,4-dinitrophenyl)oxamide through condensation reaction between oxalyl chloride and 2,4-dinitraniline, obtaining N,N'-bis(2,4-diaminophenyl)oxamide through catalytic hydrogenation of the N,N'-bis(2,4-dinitrophenyl)oxamide and obtaining the 1H,1'H-(2,2'-bis-benzimidazole)-5,5'-diamine through dehydration cyclization of the N,N'-bis(2,4-diaminophenyl)oxamide. The method disclosed by the invention has a shorter synthesizing path, high technological safety, convenience to operate, lower production cost, higher reaction yield and especially smaller environmental pollution, so that the method is suitable for industrial production; in addition, raw materials of the method are cheap and easy to obtain.
Owner:CHANGZHOU SUNLIGHT PHARMA
Preparation method of bisbenzimidazole group-containing phenanthroline-type derivative and organic light-emitting device (OLED)
InactiveCN104761550AImprove thermal stabilityGood symmetryOrganic chemistrySolid-state devicesOrganic light emitting devicePhenanthroline
The invention provides a bisbenzimidazole group-containing phenanthroline-type organic semiconductor material, which is excellent in thermo-stability, solubility and film-forming property. An optical-spectrum test proves that the maximum light-emitting wavelength of the material is in the range of blue light. Meanwhile, because that the structure of the light-emitting material contains phenanthroline and two bisbenzimidazole groups, the light-emitting material is good in symmetry, excellent in charge transfer capacity and high in glass-transition temperature. In addition, a crystallization effect can be prevented.
Owner:JILIN OPTICAL & ELECTRONICS MATERIALS
Application of dibenzimidazolamine compound to preparation of antimicrobial medicine
InactiveCN105287522ASimple structureStrong antimicrobial activity in vitroAntibacterial agentsOrganic active ingredientsAntifungalMonilinia laxa
The invention provides an application of a dibenzimidazolamine compound to preparation of an antimicrobial medicine. The dibenzimidazolamine compound has a structure shown as formula (I), and is simple in structure. The dibenzimidazolamine compound is relatively good in in-vitro antimicrobial activity, and performs quite high inhibitory activity of gram positive bacteria, such as staphylococcus aureus, methicillin-resistant staphylococcus aureus, bacillus subtilis, and micrococcus luteus, gram negative bacteria, such as escherichia coli, proteus vulgaris, pseudomonas aeruginosa, and salmonella typhi, and fungi, such as candida utilis, aspergillus flavus, saccharomyces cerevisiae, candida albicans, and candida. The dibenzimidazolamine compound is used for preparing an antibacterial and / or antifungal medicine.
Owner:LINYI UNIVERSITY
Application of 2,6-bis(2-benzimidazolyl) pyridine in preparation of carbapenem-resistant pseudomonas aeruginosa infection drug
ActiveCN111658646AInhibition of active effluxLow inhibitory concentrationAntibacterial agentsOrganic active ingredientsMeropenemBisbenzimidazole
The invention discloses application of 2,6-bis(2-benzimidazolyl) pyridine in preparation of a carbapenem-resistant pseudomonas aeruginosa infection drug. Through circular dichroism, fluorescent real-time quantitative PCR and other methods, it is found that 2, 6-bis (2-benzimidazolyl) pyridine can form a G-quadruplex structure with a core sequence of a MexA gene in pseudomonas aeruginosa, thereby inhibiting expression of the MexA gene. A susceptibility testing verifies that 2, 6-bis (2-benzimidazolyl) pyridine can reduce the drug resistance of carbapenem-resistant pseudomonas aeruginosa to meropenem. When the usage amount of the 2, 6-bis (2-benzimidazolyl) pyridine is 5 <mu>M, the minimum inhibitory concentration of the carbapenem-resistant pseudomonas aeruginosa strain can be reduced to 2<mu> g / ml, and the effect of treating carbapenem-resistant pseudomonas aeruginosa infection by using meropenem is achieved.
Owner:HENAN UNIVERSITY OF TECHNOLOGY
Human breast cancer cell inhibitor and preparation method thereof
InactiveCN102973573ASimple methodHigh activityOrganic active ingredientsAntineoplastic agentsRoom temperatureHuman breast
The invention discloses a human breast cancer cell inhibitor and a preparation method thereof. The preparation method comprises the following steps of: weighing Zn(NO3)2.6H2O, 2,2'-bis-benzimidazole (Bibim), and 5-hydroxyisoph (OH-H2Bdc) in a molar ratio of (2-3):1:(1-2); adding water and putting into a container, regulating the pH value of the liquid to be between 8.0 and 9.0 with triethylamine; putting the stirred raw material in a reaction kettle, sealing the cover, and heating to a temperature of between 100 and 110 DEG C to react for 45 to 56 hours in an insulating state; and cooling to room temperature by adopting gradient cooling method to obtain a colorless block crystal complex [Zn(OH-H2Bdc)(Bibim)]n, namely the human breast cancer cell inhibitor. The human breast cancer cell inhibitor has the characteristics of good stability and strong inhibition capability, and provides guidance to research and development of anti-human breast cancer medicines.
Owner:霍尔果斯美环亿速信息技术有限公司
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