Organosilicon quaternary ammonium long-acting antibacterial product and preparation method thereof

A technology of organic silicon quaternary ammonium salt and antibacterial products, which is applied in the field of antibacterial agents, can solve the problems of high equipment requirements, skin irritation, and high requirements, and achieve good antibacterial properties, long antibacterial time, and adaptability Good results

Active Publication Date: 2015-07-29
江西领行生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] All these antibacterial agents have defects in varying degrees during use: the cost of inorganic antibacterial agents is high, and the antibacterial effect is slow; organic antibacterial agents are often irritating to the skin, have low safety, and poor antibacterial durability; natural antibacterial agents The agent has poor broad-spectrum and is unstable to light, heat and chemicals
Such as U.S. Patent US6613755, it is proposed to use ultra-pure water as the medium, and the purity resistivity of water is required to reach more than 18 megohm centimeters, so that a stable silane quaternary ammonium salt solution can be obtained, and various stable disinfectant hand sanitizers and facial cleansers can be made. etc., but the preparation of ultrapure water requires high equipment, and it is difficult for domestically produced pure water for the electronics industry to reach a resistivity of 18 megohm cm, and ultrapure water has high requirements for packaging containers and the surrounding environment, which is difficult practical
US6087319 adopts adding a large amount of propylene glycol ether, alkyl quaternary ammonium salt and acrylic surfactant in water to obtain a stable aqueous solution, but the cost is relatively increased, and there is no guarantee for antibacterial effect and w

Method used

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  • Organosilicon quaternary ammonium long-acting antibacterial product and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032]Weigh 0.5g of tea polyphenols, 0.4g of dimethyldodecyl[3-(trimethoxysilyl)propyl]ammonium chloride and 0.6g of propylene glycol into the preparation container, heat to 45°C at 1000rpm Stir for 10min, then add 0.5g dimethyloctadecyl [3-(trimethoxysilyl) propyl] ammonium chloride, keep the temperature and rotating speed inconvenient and continue to stir for 10min to obtain a stable and uniform solution, then add 98g Deionized water is made into the long-acting antibacterial product of the present invention. The bacteriostatic concentration of gained product to escherichia coli is 134ppm.

Embodiment 2

[0034] Weigh 5g of chitosan, 1g of dimethyldodecyl[3-(trimethoxysilyl)propyl]ammonium bromide and 2g of propylene glycol into the preparation container, heat to 55°C, stir at 800rpm for 10min, Then add 2g dimethyloctadecyl [3-(trimethoxysilyl) propyl] ammonium chloride, keep the temperature and rotating speed inconvenient and continue to stir for 10min to obtain a stable and uniform solution, then add 90g deionized water to prepare The long-acting bacteriostasis product of the present invention. The bacteriostatic concentration of gained product to escherichia coli is 42ppm.

Embodiment 3

[0036] Weigh 1g of chitosan, 0.6g of dimethyldodecyl[3-(trimethoxysilyl)propyl]ammonium bromide and 1g of propylene glycol into the preparation container, heat to 60°C, and stir for 10min at 800rpm , followed by adding 0.8g dimethyloctadecyl [3-(trimethoxysilyl) propyl] ammonium chloride, keeping the temperature and rotating speed inconvenient and continuing to stir for 10 min to obtain a stable and uniform solution. The bacteriostatic concentration of gained product to escherichia coli is 35ppm.

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Abstract

The invention discloses an organosilicon quaternary ammonium long-acting antibacterial product and a preparation method of the organosilicon quaternary ammonium long-acting antibacterial product. The product comprises a first organosilicon quaternary ammonium antibacterial component, a second organosilicon quaternary ammonium antibacterial component and a third synergistic component, wherein the first organosilicon quaternary ammonium antibacterial component is dimethyl alkyl [3-(trimethoxysilyl) propyl] ammonium halide containing C10-C16 alkyl, and the halogen is preferably Cl (chlorine) and Br (bromine); the second organosilicon quaternary ammonium antibacterial component is dimethyl alkyl [3-(trimethoxysilyl) propyl] ammonium halide containing C18-C30 carbon chains, and the halogen is preferably F (fluorine), Cl (chlorine) and I (iodine); the third synergistic component is selected from a group comprising tea polyphenol, aloe and chitosan or a group comprising composition of polyphenol, aloe and chitosan. The antibacterial agent has broad-spectrum antibacterial performance, lasts long, is poisonless, has no irritation to the skin, is especially applicable to sensitive parts of the skin and is a good choice in daily life, wound treatment and operation assistance.

Description

technical field [0001] The invention relates to the field of antibacterial agents, in particular the invention relates to a long-acting antibacterial product containing organosilicon quaternary ammonium salt and a preparation method thereof. Background technique [0002] Bacteria have been one of the major threats to human health, and for centuries people have tried to kill the bad bacteria and encourage the growth of the good ones. The antibacterial agents currently used in the market mainly include three categories: inorganic antibacterial agents, organic antibacterial agents and natural antibacterial agents. Inorganic antibacterial agents mainly include metal ion type and photocatalytic type. Metal ion type includes silver series, zinc series and copper series. Through physical adsorption, ion exchange and other methods, silver, copper, zinc and other metals (or metal ions) ) is fixed on the surface of porous materials such as fluorspar and silica gel to make antibacteri...

Claims

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Application Information

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IPC IPC(8): A01N55/10A01P1/00A01P3/00A61K31/695A61P31/04A61P31/02A61P31/10A61K8/97A61K8/58A61Q19/10A61Q17/00
CPCY02A50/30
Inventor 刘红英张哲然
Owner 江西领行生物科技有限公司
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